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Faculty Detail    
Name SHI WEI
MD, PhD
 
Campus Address NP 3542 Zip 6823
Phone
E-mail  swei@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He obtained additional clinical subspecialty training at Emory, Mt. Sinai and Harvard Universities. Dr. Wei is board certified in Anatomic and Clinical Pathology. He joined the faculty at UAB in July, 2008 and is currently a Tenured Professor. Dr. Wei heads the Surgical Pathology Section at the Division of Anatomic Pathology, Department of Pathology, and directs the Surgical Pathology Fellowship Program.

Society Memberships
Organization Name Position Held Org Link
American Medical Association  Member  http://www.ama-assn.org 
American Society of Clinical Pathology  Fellow  http://ascp.org 
Arthur Purdy Stout Society  Member  http://www.apssociety.com/ 
Association of Directors of Anatomic and Surgical Pathology  Member  http://www.adasp.org 
Chinese American Pathologists Association  Member  https://www.capa-ht.org/ 
College of American Pathologists  Alabama Delegate, CAP House of Delegates  http://www.cap.org 
Digital Pathology Association  Member  https://digitalpathologyassociation.org/ 
International Skeletal Society  Member  http://www.internationalskeletalsociety.com 
International Society of Bone and Soft Tissue Pathology  Member  http://www.isbstp.org 
International Society of Breast Pathology  Member  https://isbpath.org/ 



Research/Clinical Interest
Title
Description
Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, muskuloskeletal and genitourinary pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, evaluation of prognostic factors in breast cancer and malignant bone tumors, and tumor bone metastasis. He has published more than a hundred manuscripts in these areas in some of the leading peer-reviewed journals, of which he first- or senior-authored approximately two-thirds. Dr. Wei is a Senior Scientist at UAB Comprehensive Cancer Center, Experimental Therapeutics Program. He co-directs the Pathology Research Core Laboratory.

Selected Publications 
Publication PUBMEDID
Li M, Liu J, Li S, Feng Y, Yi F, Wang L, Wei S,* Cao L.* Autophagy related 7 modulates tumor progression in triple-negative breast cancer. Lab Invest. In Press. *Co-corresponding authors.   
Wu L, Yi B, Wei S, Yao D, He Y, Naik G, Bae S, Liu XM, Yang WH, Sonpavde G, Liu R, Wang L. Loss of Foxp3 and Tsc1 Accelerate Prostate Cancer Progression through a Synergistic Transcriptional and Post-translational Regulation of c-MYC. Cancer Res. 2019 Feb 7. pii: canres.2049.2018. doi: 10.1158/0008-5472.CAN-18-2049. [Epub ahead of print]   30733194 
Yang Y, Wang HX, Zhang L, Huo W, Li XD, Qi RQ, Song XY, Wei S, Gao XH, Han S, Cao L. Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect. Int J Biol Sci. 2019 Jan 1;15(3):568-578. doi: 10.7150/ijbs.29759. eCollection 2019.   30745843 
Fasciano D, Wei S, Li R, Siegal GP. Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome. Pathol Res Pract. 2018 Aug 7. pii: S0344-0338(18)30787-8. doi: 10.1016/j.prp.2018.08.003. [Epub ahead of print]   30100356 
Sharma NS, Lal CV, Li JD, Lou XY, Viera L, Abdallah T, King R, Sethi J, Kanagarajah P, Restrepo-Jaramillo R, Sales-Conniff A, Wei S, Jackson PL, Blalock JE, Gaggar A, Xu X. The Neutrophil Chemoattractant Peptide Proline-Glycine-Proline Is Associated With Acute Respiratory Distress Syndrome (ARDS). Am J Physiol Lung Cell Mol Physiol. 2018 Aug 9. doi: 10.1152/ajplung.00308.2017. [Epub ahead of print]   30091378 
Kurundkar A, Gao X, Zhang K, Britt JP, Siegal GP, Wei S. Comparison of AJCC Anatomic and Clinical Prognostic Stage Groups in Breast Cancer: Analysis of 3322 Cases From a Single Institution. Clin Breast Cancer. 2018 Jul 17. pii: S1526-8209(18)30230-1. doi: 10.1016/j.clbc.2018.07.013. [Epub ahead of print].   30077697 
Broadwater DR, Conant JL, Czuchlewski DR, Hall JM, Wei S, Siegal GP, Peker D. Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the Literature. Clin Lymphoma Myeloma Leuk. 2018 Aug 1. pii: S2152-2650(18)30371-9. doi: 10.1016/j.clml.2018.07.286. [Epub ahead of print]   30077697 
Zhang Y, Yi F, Wang L, Wang Z, Zhang N, Wang Z, Li Z, Song X, Wei S,* Cao L.* Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration. Int J Biol Sci 2018; 14(9):1081-1089. doi:10.7150/ijbs.24692. *Co-corresponding authors.  29988990 
Wei S, Siegal GP. Surviving at a distant site: The organotropism of metastatic breast cancer. Semin Diagn Pathol. 2017 Nov 16. pii: S0740-2570(17)30135-1. doi: 10.1053/j.semdp.2017.11.008. [Epub ahead of print].  29174933 
Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde LA, Samant RS. Conditional knockout of N-Myc and STAT Interactor Disrupts Normal Mammary Development and Enhances Metastatic Ability of Mammary Tumors. Oncogene. 2018 Jan 12. doi: 10.1038/s41388-017-0037-7. [Epub ahead of print]  29326438 
Shen T, Gao C, Zhang K, Siegal GP, Wei S. Prognostic Outcomes in Advanced Breast Cancer: The Metastasis-free Interval is Important. Hum Pathol. 2017 Oct 12. pii: S0046-8177(17)30361-1. doi: 10.1016/j.humpath.2017.10.002. [Epub ahead of print].  29031733  
Wang K, Shen T, Siegal GP, Wei S. The CD4/CD8 Ratio of Tumor-infiltrating Lymphocytes at the Tumor-host Interface Has Prognostic Value in Triple Negative Breast Cancer. Hum Pathol. 2017 Oct 6. pii: S0046-8177(17)30357-X. doi: 10.1016/j.humpath.2017.09.012. [Epub ahead of print].  28993275  
Lopez L, Rodriguez MG, Siegal GP, Wei S. Extraskeletal Aneurysmal Bone Cyst: Report of a Case and Review of the Literature. Pathol Res Pract. 2017 Nov;213(11):1445-1449. doi: 10.1016/j.prp.2017.07.001. Epub 2017 Jul 6. PMID: 28756986   28756986  
Zhu H, Sun J, Wei S, Wang D, Brandwein M. Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review. Head Neck Pathol. 2017 Jun;11(2):146-151. doi: 10.1007/s12105-016-0747-0. Epub 2016 Aug 4.   27492446 
Li R, Zhang K, Siegal GP, Wei S. Clinical and pathological factors related to brain relapse-free survival in breast cancer patients-reply. Hum Pathol. 2017 Jun 24. pii: S0046-8177(17)30229-0. doi: 10.1016/j.humpath.2017.05.028. [Epub ahead of print]  28655640 
Zhou Y, Wei S. Not Your Typical Renal Cyst. Am J Med. 2017 Jul 4. pii: S0002-9343(17)30637-X. doi: 10.1016/j.amjmed.2017.06.006. [Epub ahead of print]  28687266 
Cui X, Wei S. Carcinoma in Situ Involving Sclerosing Adenosis: Seeking the Salient Histological Characteristics to Prevent Overdiagnosis. Ann Clin Lab Sci. 2017 Sep;47(5):529-534.  29066477 
Ullman D, Gordetsky J, Siegal GP, Prieto-Granada GN, Wei S, Stevens TM. PAX8 expression in solitary fibrous tumor: A potential diagnostic pitfall. Appl Immunohistochem Mol Morphol. 2017 Jul 26. doi: 10.1097/PAI.0000000000000561. [Epub ahead of print]  28749793  
Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L. Diagnostic Utility of IDH1/2 Mutations to Distinguish Dedifferentiated Chondrosarcoma from Undifferentiated Pleomorphic Sarcoma of Bone. Hum Pathol. 2017 May 25. pii: S0046-8177(17)30172-7. doi: 10.1016/j.humpath.2017.05.015. [Epub ahead of print]  28552826 
Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, Yang WH, Cui R, Liu R, Wang D. MicroRNA-200c and 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res. 2017 Jun 21;19(1):73. doi: 10.1186/s13058-017-0858-x  28637482 
Li R, Zhang K, Siegal GP, Wei S. Clinicopathologic Factors Associated with Survival in Patients with Breast Cancer Brain Metastasis. Hum Pathol. 2017 Apr 17. pii: S0046-8177(17)30109-0. doi: 10.1016/j.humpath.2017.03.022. [Epub ahead of print]  28428107 
Tian W, Dorn D, Wei S, Shah RB, Sanders RD, Gordetsky J. GATA3 Expression in Benign Prostate Glands with Radiation Atypia: a Diagnostic Pitfall. Histopathology. Histopathology. 2017 Mar 17. doi: 10.1111/his.13214. [Epub ahead of print]  28316088  
Wei S, Qian X, Henderson-Jackson EB, Bui, M. Soft Tissue Tumor Immunohistochemistry Update: Illustrative Examples of Diagnostic Pearls to Avoid Pitfalls. Arch Pathol Lab Med. 2017 Aug;141(8):1072-1091. doi: 10.5858/arpa.2016-0417-RA.  28745570 
Wei S, Siegal GP. Metastatic Organotropism: An Intrinsic Property of Breast Cancer Molecular Subtypes. Adv Anat Pathol. 2017 Jan 16. doi: 10.1097/PAP.0000000000000140. [Epub ahead of print]  28098572  
Wielgos ME, Rajbhandari R, Cooper TS, Wei S, Nozell SE, Yang ES. Let-7 Status is Crucial for PARP1 Expression in HER2-overexpressing Breast Tumors. Mol Cancer Res. 2016 Dec 28. pii: molcanres.0287.2016. doi: 10.1158/1541-7786.MCR-16-0287-T. [Epub ahead of print]  28031413 
Ma Y, Siegal GP, Wei S. Reacquisition of E-cadherin Expression in Metastatic Deposits of Signet-Ring Cell Carcinoma of the Upper Gastrointestinal System: A Potential Anchor for Metastatic Deposition. J Clin Pathol. 2017 Jun;70(6):528-532. doi: 10.1136/jclinpath-2016-203959. Epub 2016 Nov 18.   27864451 
Soni A, Wei S. Primary Renal Ewing Sarcoma in an Adult. Urology. 2016 Oct 6. pii: S0090-4295(16)30652-5. doi: 10.1016/j.urology.2016.09.033. [Epub ahead of print]  27720971 
Shen T, Siegal GP, Wei S. Clinicopathologic Factors Associated with De Novo Metastatic Breast Cancer. Pathol Res Pract. 2016 Sep 22. pii: S0344-0338(16)30274-6. doi: 10.1016/j.prp.2016.09.007. [Epub ahead of print]  27692496 
Zhao J, Yu H, Liu Y, Gibson S, Yan Z, Xu X, Gaggar A, Li P-K, Li C, Wei S, Benveniste E, Qin H. Protective Effect of Suppressing STAT3 Activity in LPS-induced Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L868-L880. doi: 10.1152/ajplung.00281.2016. Epub 2016 Sep 16.  27638904 
Weaver AN, Cooper TS, Wei S, Carroll WR, Rosenthal EL, Yang ES. DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery. Head Neck. 2016 Aug 10. doi: 10.1002/hed.24562. [Epub ahead of print]  27507640 
Ghatalia P, Yang ES, Lasseigne BN, Ramaker RC, Cooper SJ, Chen D, Sudarshan S, Wei S, Guru AS, Zhao A, Cooper T, Della Manna DL,Naik G, Myers RM, Sonpavde G. Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential NewTherapeutic Targets. PLoS One. 2016 Aug 30;11(8):e0160924. doi: 10.1371/journal.pone.0160924. eCollection 2016  27574806  
Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ,Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ; I-SPY 2 Investigators. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 7;375(1):23-34. doi: 10.1056/NEJMoa1513749.  27406347 
Park JW, Liu MC, Yee D, Yau C, van 't Veer LJ, Symmans WF, Paoloni M, Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt DW, Pusztai L, Moulder SL, Lang JE, Viscusi RK, Euhus DM, Haley BB, Khan QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst GL, Sanil A,Esserman LJ, Berry DA; I-SPY 2 Investigators. Adaptive Randomization of Neratinib in Early Breast Cancer. N Engl J Med. 2016 Jul 7;375(1):11-22. doi: 10.1056/NEJMoa1513750.  27406346 
Necchi A, Eigl BJ, Yang ES, Bae S, Chandrashekar D, Chen D, Naik G, Mehta A, Giannatempo P, Colecchia M, Gordetsky J, Wei S, Cooper T, Varambally S, Sonpavde G. Gene expression profiling of advanced penile squamous cell carcinoma receiving cisplatin-based chemotherapy improves prognostication and identifies potential therapeutic targets. Eur Urol Focus. 2016 Aug 27. pii: S2405-4569(16)30109-2. doi: 10.1016/j.euf.2016.08.001.   28753783 
Agosto-Arroyo E, Isayeva T, Wei S, Almeida JS, Harada S. Differential Gene Expression in Breast Ductal Carcinoma In-Situ Based on HER2 Oncogene Status. Cancer Control. Cancer Control. 2017 Jan;24(1):102-110.  28178722 
Shen T, Zhang K, Siegal GP, Wei S. Prognostic Value of E-cadherin and B-catenin in Triple Negative Breast Cancer. Am J Clin Pathol. 2016 Oct 25. pii: aqw183. [Epub ahead of print]  2778079 
Weaver AN, Burch MB, Cooper TS, Della Manna DL, Wei S, Ojesina AI, Rosenthal EL, Yang ES. Notch signaling activation is associated with mortality and FGF1-mediated invasion in squamous cell carcinoma of the oral cavity. Mol Cancer Res. Mol Cancer Res. 2016 Jun 27. pii: molcanres.0114.2016. [Epub ahead of print]  27353029  
Cramer SL, Wei S, Merrow AC, Pressey JG. Gorham-Stout Disease Successfully Treated with Sirolimus and Zoledronic Acid Therapy. J Pediatr Hematol Oncol. 2016 Apr;38(3):e129-32. doi: 10.1097/MPH.0000000000000514.   26886375 
Ma Y, Ren Z, Conner MG, MD, Siegal GP, Wei S. Reduced E-cadherin and Aberrant Beta-catenin Expression Are Associated with Advanced Disease in Signet Ring Cell Carcinomas. Appl Immunohistochem Mol Morphol. 2017 Jul;25(6):432-438. doi: 10.1097/PAI.0000000000000317.   26808130 
Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo R-J, Lu C, Nguyen LH, Yang W-H, Lillard JW, Zhang X, Wang L and Liu R. Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells. Clin Cancer Res. 2015 Dec 28. pii: clincanres.1927.2015. [Epub ahead of print].  26712693 
Ren Z, Li Y, Shen T, Hameed O, Siegal GP, Wei S. Prognostic Factors in Advanced Breast Cancer: Race and Receptor Status Are Significant after Development of Metastasis. Pathol Res Pract. 2016 Jan;212(1):24-30. doi: 10.1016/j.prp.2015.11.003.   26616114 
Jules J, Wang S, Shi Z, Liu J, Wei S, Xu Feng X. The IVVY Motif and Tumor Necrosis Factor Receptor Associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor kappa B (RANK) Cooperate to Induce Osteoclastogenesis. J Biol Chem. 2015 Sep 25;290(39):23738-50. doi: 10.1074/jbc.M115.667535.  26276390 
Shen T, Brandwein-Gensler M, Hameed O, Siegal GP, Wei S. Characterization of Estrogen Receptor Negative/Progesterone Receptor Positive Breast Cancer. Hum Pathol. 2015 Nov;46(11):1776-84. doi: 10.1016/j.humpath.2015.07.019.   26363528 
Shen T, Shi Q, Velosa C, Bai S, Thompson T, Simpson R, Wei S, Brandwein-Gensler M. Sinonasal Renal Cell-Like Adenocarcinomas: Robust Carbonic Anhydrase Expression. Hum Pathol. 2015 Nov;46(11):1598-606. doi: 10.1016/j.humpath.2015.06.017.  26299508 
Soni A, Weil A, Wei S, Jaffe KA, Siegal GP. Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones. World J Orthop. 2015 Aug 18;6(7):559-63. doi: 10.5312/wjo.v6.i7.559. eCollection 2015 Aug 18.  26301184 
Wei, S. (2015) Lesions Characterized by Osteoid Deposition and Non-Aggressive Radiology Located on Bone Surface. In: A. T. Deyrup, G. P. Siegal (Eds.), Practical Orthopedic Pathology (pp103-110). Elsevier.   
Hameed O., Wei S., Desouki M. M., Umphrey H. (Eds.) (2015) Advances in Surgical Pathology: Breast Cancer. Lippincott Williams & Wilkins.   
Wei S. Papillary lesions of the breast: an update. Arch Pathol Lab Med. 2016 Jul;140(7):628-43. doi: 10.5858/arpa.2015-0092-RA.  27362568  
Stevens T, Kovalovsky A, Velosa C, Shi Q, Dai Q, Bell W, Wei S, Althof P, Sanmannn J, Sweeny L, Carroll W, Siegal G, Bullock M, Brandwein-Gensler M. Mammary analogue secretory carcinoma, low grade salivary duct carcinoma, and their mimickers: a comparative study. Mod Pathol. 2015 Aug;28(8):1084-100. doi: 10.1038/modpathol.2015.64.   26089091 
Stanley J, Klepczyk L, Keene K, Wei S, Li Y, Forero A, Grizzle W, LoBuglio AF and Yang ES. PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers. Breast Cancer Res Treat. Breast Cancer Res Treat. 2015 Apr;150(3):569-79. doi: 10.1007/s10549-015-3359-6. Epub 2015 Apr 2.  25833211  

Keywords
Breast Pathology; Muskuloskeletal Pathology; Genitourinary Pathology