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Faculty Detail    
Name SHI WEI
MD, PhD
 
Campus Address NP 3542 Zip 6823
Phone
E-mail  swei@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He obtained additional clinical subspecialty training at Emory, Mt. Sinai and Harvard Universities. Dr. Wei is board certified in Anatomic and Clinical Pathology. He joined the faculty at UAB in July, 2008 and is currently a Tenured Professor. Dr. Wei is currently Associate Division Director of Anatomic Pathology and heads the Surgical Pathology Section.

Society Memberships
Organization Name Position Held Org Link
American Medical Association  Member  http://www.ama-assn.org 
American Society of Clinical Pathology  Fellow  http://ascp.org 
Arthur Purdy Stout Society  Member  http://www.apssociety.com/ 
Association of Directors of Anatomic and Surgical Pathology  Member  http://www.adasp.org 
Chinese American Pathologists Association  Member  https://www.capa-ht.org/ 
College of American Pathologists  Alabama Delegate, CAP House of Delegates  http://www.cap.org 
Digital Pathology Association  Member  https://digitalpathologyassociation.org/ 
International Skeletal Society  Member  http://www.internationalskeletalsociety.com 
International Society of Bone and Soft Tissue Pathology  Member  http://www.isbstp.org 
International Society of Breast Pathology  Member  https://isbpath.org/ 



Research/Clinical Interest
Title
Description
Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, muskuloskeletal and genitourinary pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, evaluation of prognostic factors in breast cancer and malignant bone tumors, and tumor bone metastasis. He has published more than 120 manuscripts in these areas in some of the leading peer-reviewed journals, of which he first- or senior-authored approximately two-thirds. Dr. Wei is a Senior Scientist at UAB Comprehensive Cancer Center, Experimental Therapeutics Program.

Selected Publications 
Publication PUBMEDID
Wei S., Siegal G.P. (Eds.) (2013) Atlas of Bone Pathology. Springer.    
Jhala KN, Wei S, Lopez-Ben RR, Siegal GP. Bizarre Parosteal Osteochondromatous Proliferation-like Lesion Originating in Soft Tissue: Report of a Case. Open Journal of Pathology 2012 Apr;(2)2:38-41. DOI: 10.4236/ojpathology.2012.22008.   
Hameed O., Wei S., Siegal G. P. (Eds.) (2011) Frozen Section Library: Bone. Springer.   
Wei S, Hameed O. Spindle Cell Lesions of the Breast with Emphasis on the Differential Diagnosis. The Open Breast Cancer Journal. http://www.bentham.org/open/tobcanj/openaccess2.htm. 2010 Pp 95-100.   
Wei S, Siegal GP. Targeting p38 MAPK for the treatment of inflammatory arthritis. Future Rheumatology. 2008;3(1):37-42.   
Wei S, Seino Y. Calcium metabolism in renal tubular disorders. Kidney and Dialysis 1994;37:300-3.   
Wei S, Fukuda N, Tanaka, H, Seino Y. The vitamin D receptors in patients with secondary hyperparathyroidism. Bio Clinica 1994;9:738-40.    
Kubo T, Wei S, Seino Y. Vitamin D metabolites. Internal Medicine 1993;71:1155-6.   
Wei S, Tanaka H, Kubo T, Seino Y. A simple assay for 24,25(OH)2D and its clinical application. Kidney and Metabolic Bone Disease 1997;10:203-10.   
Ono T, Kanzaki S, Wei S, Moriwake T, Tanaka H, Seino Y. Growth hormone (GH) treatment increases serum levels of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-3 and IGFBP-5 in children with GH deficiency. Clinical Endocrinology 1996;44:29-32.   
Ono T, Kanzaki S, Yamanaka Y, Wei S, Kubo T, Tanaka H, Seino Y. Serum level of estradiol measured by high sensitive RIA and gonadotropin responsiveness to LHRH in prepubertal and pubertal females. Clinical Endocrinology 1995;43:67-71.   
Wei S, Tanaka H, Seino Y. The influence of vitamin D on calcium sensitivity in patients with secondary hyperparathyroidism. Clinical Calcium 1995;5:1588-91.   
Wei S, Tanaka H, Liu L, Yumita S, Seino Y. Two radioimmunoassay systems for 1,25-dihydroxyvitamin D: Cross-reactivities of various vitamin D metabolites. Vitamins 1998;72:607-11.   
Wei S, Tanaka H, Seino Y. Vitamin D. Clinical Endocrinology 1998;46:212-24.   
Wei S, Seino Y. Vitamin D receptor polymorphism and bone mineral density. Internal Medicine 1998;81:159-60.   
Eleazer PD, Rhodes SC, Horn DM, DeVilliers P, Wei S, Novak L, Dohm ED, Weems RA, Litaker MS. In Vivo Evaluation of an Experimental Root-End Filling Material versus MTA. Open Journal of Animal Sciences. 2013 Jul;3A:19-23. doi: 10.4236/ojas.2013.33A003.   
Wei, S., Stevens, T.M. (2014). Benign Tumors and Tumor-Like Conditions of Bone. In: L. M. McManus, R. N. Mitchell (Eds.), Pathobiology of Human Disease (pp. 838-855). Elsevier.   
Wei, S., Kerr, E. H. (2014). Malignant Tumors of Bone. In: L. M. McManus, R. N. Mitchell (Eds.), Pathobiology of Human Disease (pp. 856-873). Elsevier.   
Harada, S., Wei, S., Siegal, G.P. (2014) Molecular Pathology of Osteosarcoma. In: D. Heymann (Ed.), Bone Cancer, Second Edition: Primary Bone Cancers and Bone metastases (pp. 213-222). Academic Press.   
Hameed O., Wei S., Desouki M. M., Umphrey H. (Eds.) (2015) Advances in Surgical Pathology: Breast Cancer. Lippincott Williams & Wilkins.   
Wei, S. (2015) Lesions Characterized by Osteoid Deposition and Non-Aggressive Radiology Located on Bone Surface. In: A. T. Deyrup, G. P. Siegal (Eds.), Practical Orthopedic Pathology (pp103-110). Elsevier.   
Nguyen TL, Grizzle WE, Zhang K, Hameed O, Siegal GP, Wei S. Syndecan-1 Overexpression is Associated with Non-luminal Subtypes and Poor Prognosis in Advanced Breast Cancer. Am J Clin Pathol. 2013 Oct;140(4):468-74. doi: 10.1309/AJCPZ1D8CALHDXCJ.  24045542 
Brandwein-Gensler M, Wei S. Envisioning the Next WHO Head and Neck Classification. Head Neck Pathol. 2014 Mar;8(1):1-15. doi: 10.1007/s12105-014-0529-5. Epub 2014 Mar 5  24595418 
Ma Y, Wei S, Peker D. An Extremely Rare Primary Gallbladder Myxoid Liposarcoma Associated with Amplification of DDIT3 Gene. J Gastrointestin Liver Dis. 2014 Dec;23(4):460-1.  25532011 
Cui X, Harada S, Shen D, Siegal GP, Wei S. The Utility of Phosphohistone H3 in Breast Cancer Grading. Appl Immunohistochem Mol Morphol. 2015 Nov-Dec;23(10):689-95. doi: 10.1097/PAI.0000000000000137.  25611243 
Liu R, Bin Y, Wei S, Yang W, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu C, Wang L. FOXP3-microRNA-146-NF-kB axis and therapy for precancerous lesions in prostate. Cancer Res. 2015 Feb 23. pii: canres.2109.2014. [Epub ahead of print]  25712341  
Paluri RK, Morgan CJ, Mooney DJ, Mgbemena O, Yang ES, Wei S, Kouba E, Naik G, El Mouallem NR, Poston T, Jones B, Nix J, Bolger GB,Deshazo M, Sonpavde G. Effect of African-American Race on Tumor Recurrence After Radical Cystectomy for Urothelial Carcinoma of the Bladder. Clin Genitourin Cancer. 2015 Mar 6. pii: S1558-7673(15)00036-1. doi: 10.1016/j.clgc.2015.02.010. [Epub ahead of print].  25868964 
Soni A, Weil A, Wei S, Jaffe KA, Siegal GP. Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones. World J Orthop. 2015 Aug 18;6(7):559-63. doi: 10.5312/wjo.v6.i7.559. eCollection 2015 Aug 18.  26301184 
Park JW, Liu MC, Yee D, Yau C, van 't Veer LJ, Symmans WF, Paoloni M, Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt DW, Pusztai L, Moulder SL, Lang JE, Viscusi RK, Euhus DM, Haley BB, Khan QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst GL, Sanil A,Esserman LJ, Berry DA; I-SPY 2 Investigators. Adaptive Randomization of Neratinib in Early Breast Cancer. N Engl J Med. 2016 Jul 7;375(1):11-22. doi: 10.1056/NEJMoa1513750.  27406346 
Soni A, Wei S. Primary Renal Ewing Sarcoma in an Adult. Urology. 2016 Oct 6. pii: S0090-4295(16)30652-5. doi: 10.1016/j.urology.2016.09.033. [Epub ahead of print]  27720971 
Inoue M, Ross FP, Erdmann JM, Abu-Amer Y, Wei S, Teitelbaum SL. Tumor necrosis factor alpha regulates alpha(v)beta5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology. 2000 Jan;141(1):284-90.  10614649 
Wei S, Teitelbaum SL, Wang MW, Ross FP. Receptor activator of nuclear factor-kappa b ligand activates nuclear factor-kappa b in osteoclast precursors. Endocrinology. 2001 Mar;142(3):1290-5.  11181547  
Wei S, Wang MW, Teitelbaum SL, Ross FP. Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling. J Biol Chem. 2002 Feb 22;277(8):6622-30. Epub 2001 Nov 21.  11719504 
Feng X, Takeshita S, Namba N, Wei S, Teitelbaum SL, Ross FP. Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function. Endocrinology. 2002 Dec;143(12):4868-74.   12446614  
Wang MW, Wei S, Faccio R, Takeshita S, Tebas P, Powderly WG, Teitelbaum SL, Ross FP. The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. J Clin Invest. 2004 Jul;114(2):206-13.  15254587  
Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva MJ, Abu-Amer Y, Ross FP, Teitelbaum SL. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol. 2004 Oct 15;173(8):4838-46.  15470024  
Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005 Feb;115(2):282-90.  15668736 
Liu W, Wang S, Wei S, Sun L, Feng X. Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4. Liu W, Wang S, Wei S, Sun L, Feng X. J Biol Chem. 2005 Dec 30;280(52):43064-72. Epub 2005 Oct 31.  16260781  
Wei S, Siegal GP. p38 MAPK as a potential therapeutic target for inflammatory osteolysis. Adv Anat Pathol. 2007 Jan;14(1):42-5.  17198310  
Wei S, Siegal GP. Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets. Pathol Res Pract. 2008;204(10):695-706. Epub 2008 Aug 30.  18757139  
Wei S, Carroll W, Lazenby A, Bell W, Lopez R, Said-Al-Naief N. Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome. Ann Diagn Pathol. 2008 Dec;12(6):415-25. Epub 2007 Oct 24.  18995206  
Wei S, Said-Al-Naief N, Hameed O. Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas: A Tissue Microarray and Pooled Literature Review Study. Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):393-402.  19417624 
Wei S, Conner MG, Zhang K, Siegal GP, Novak L. Juxtatumoral stromal reactions in uterine endometrioid adenocarcinoma and their prognostic significance. Int J Gynecol Pathol. 2010 Nov;29(6):562-7.  20881855 
Wei S, Li Y, Siegal GP, Hameed O. Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs. Ann Diagn Pathol. 2011 Apr;15(2):79-83. Epub 2010 Dec 16.  21163679 
Kragel C, Wei S. Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report. J Med Case Reports. 2011 Jun 29;5(1):248.  21714864 
Wei S, Pan Z, Siegal GP, Winokur TS, Carroll AJ, Jhala D. Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts. Hum Pathol. 2012 Jan;43(1):121-6. Epub 2011 Jul 5.  21733556 
Cheng J, Liu J, Shi Z, Xu D, Luo S, Feng X, Siegal GP and Wei S. Interleukin-4 Inhibits RANKL-induced NFATc1 Expression via STAT6: A Novel Mechanism Mediating Its Blockade of Osteoclastogenesis. J Cell Biochem. 2011 Nov;112(11):3385-92. doi: 10.1002/jcb.23269.  21751242 
Abdel-Aal AK, Gaddikeri S, Saddekni S, Oser RF, Underwood E, Wei S. Primary Leiomyosarcoma of the Inferior Vena Cava Invading the Right Atrium: A Technique for Intraluminal Biopsy Through a Transvenous Approach. Vasc Endovascular Surg. 2011 Nov;45(8):743-6. Epub 2011 Sep 13.  21914679 
Bai S, Jhala N, Adsay NV, Wei S. Sclerosing Epithelioid Fibrosarcoma of the Pancreas: Report of a Case and Review of Literature with Emphasis on the Differential Diagnosis. Ann Diagn Pathol. 2013 Apr;17(2):214-6. doi: 10.1016/j.anndiagpath.2011.06.006. Epub 2011 Nov 4.  22056035 
Cheng J, Liu J, Xu D, Luo S, Wei S, Feng X. Molecular mechanisms of the biphasic effects of interferon gamma on osteoclastogenesis. J Interferon Cytokine Res. J Interferon Cytokine Res. 2012 Jan;32(1):34-45. doi: 10.1089/jir.2011.0019. Epub 2011 Dec 5.   22142221 

Keywords
Breast Pathology; Muskuloskeletal Pathology; Genitourinary Pathology