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Faculty Detail    
Professor, Department of Pathology
Campus Address WTI 320B Zip 3300
Other websites

Undergraduate  Purdue University    1979  none 
Undergraduate  University of Tennessee    1981  B.A. 
Medical School  University of Tennessee Center for the Health Sciences    1983  none 
Medical School  University of Alabama School of Medicine    1985  M.D. 
Residency  George Washington University    1989  Anatomic and Clinical Pathology 
Fellowship  George Washington University    1990  Surgical Pathology and Cytopathology 

American Board of Pathology Certification in Anatomic and Clinical Pathology  1990 
American Board of Pathology, Added Qualification in Cytopathology  1994 
American Board of Pathology, Voluntary Recertification (1-1-2014 to 12-30-2024)  2014 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cellular and Molecular Biology Program 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 
Public Health 

Biographical Sketch 
Dr. Frost received her B.A. in Liberal Arts from the University of Tennessee at Knoxville (1981) after two years in electrical engineering at Purdue University. She obtained her MD degree from the University of Alabama at Birmingham (1985), followed by residency training in Anatomic and Clinical Pathology and a combined Surgical Pathology and Cytopathology Fellowship at the George Washington University (1985-1990). She was a faculty member of the Departments of Pathology at Georgetown University (1990-1991) and George Washington University (1991-1997) before joining the faculty at UAB (1997). Dr. Frost has practiced as a diagnostic surgical pathologist, cytopathologist, and autopsy pathologist. Her research is focused in breast cancer, particularly stromal-epithelial interactions in breast cancer. She was honored with the Leonard H. Robinson Award for Excellence in Resident Education in Anatomic Pathology in 1998 and was nominated for the UAB Presidentís Award for Excellence in Teaching in 2013.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research (AACR)     
American Society of Cytopathology     
United States and Canadian Academy of Pathology     

Research/Clinical Interest
Stromal-Epithelial Cell Interactions in the Development and Progression of Breast Cancer
Dr. Frostís research is focused on understanding the effects of the microenvironment of the breast on breast carcinogenesis and the progression of breast cancer, with the ultimate goal of identifying new targets for prevention or treatment of invasive and metastatic disease. Most recently, she is collaborating with Dr. Joel Berry in the Department of Bioengineering, Dr. Jessy Deshane in the Department of Medicine and Dr. Renata Jaskula-Sztul in the Department of Surgery on the development of novel tissue-mimetic platforms, including immunocompetent models, for use in the study and treatment of cancer, including breast cancer. One of these tissue mimetic platforms is being utilized to study the role of biomechanical forces in invasive cancer and ductal carcinoma in situ of the breast. Dr. Frost also collaborates with Dr. Doug Hurst in the Department of Pathology on the role of neutrophils and adiponectin in invasive breast carcinoma.

Selected Publications 
Publication PUBMEDID
Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model. Goliwas KF, Richter JR, Pruitt HC, Araysi LM, Anderson NR, Samant RS, Lobo-Ruppert SM, Berry JL, Frost AR
Sci Rep. 2017 Oct 26;7(1):14167.
Marshall LE, Goliwas KF, Miller LM, Penman AD, Frost AR, Berry JL. Flow-perfusion bioreactor system for engineered breast cancer surrogates to be used in preclinical testing. J Tissue Eng Regen Med. 2017 Apr;11(4):1242-1250.
Marshall LE, Koomullil R, Frost AR, Berry JL. Computational and Experimental Analysis of Fluid Transport Through Three-Dimensional Collagen-Matrigel Hydrogels. Ann Biomed Eng. 2017 Apr;45(4):1027-1038.
Goliwas KF, Marshall LE, Ransaw EL, Berry JL, Frost AR. A recapitulative three-dimensional model of breast carcinoma requires perfusion for multi-week growth. J Tissue Eng. 2016 Jul 29;7:2041731416660739.   27516850 
Goliwas KF, Miller LM, Marshall LE, Berry JL, Frost AR. Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates.
J Vis Exp. 2016 May 9;(111). 
Spann AL, Yuan K, Goliwas KF, Steg AD, Kaushik DD, Kwon YJ, Frost AR. The presence of primary cilia in cancer cells does not predict responsiveness to modulation of smoothened activity. Int J Oncol. 2015 Jul;47(1):269-79.
Frost AR, Eltoum IE, Siegal GP, Emmert-Buck MR, Tangrea MA. Laser Microdissection. Curr Protoc Mol Biol. 2015 Oct 1;112:25A.1.1-30.
Libby EF, Frost AR, Demark-Wahnefried W, Hurst DR. Linking adiponectin and autophagy in the regulation of breast cancer metastasis. J Mol Med (Berl). 2014 Oct;92(10):1015-23  24903246 
Frost AR, Hurst DR, Shevde LA, Samant RS. The influence of the cancer microenvironment on the process of metastasis. Int J Breast Cancer 2012:756257.   22570792 
Kwon YJ, Hurst DR, Steg AD, Yuan K, Vaidya KS, Welch DR, Frost AR. Gli1 promotes metastasis and enhances migration and invasion via up-regulation of MMP-11 in ER- negative breast cancer. Clinical & Experimental Metastasis 2011;28(5):437-49.   21442356 
Yuan K, Frolova N, Xie Y, Wang D, Cook L, Kwon YJ, Steg AD, Serra R, Frost AR. Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues. J Histochem Cytochem. 2010 Oct;58(10):857-70.  20530462  
Xu L, Kwon YJ, Frolova N, Steg AD, Yuan K, Johnson MR, Grizzle WE, Desmond RA, Frost AR. Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer. Breast Cancer Res Treat. 2010 Aug;123(1):59-712009 Nov 10.   19902354 
Sadlonova A, Bowe DB, Novak Z, Mukherjee S, Duncan VE, Page GP, Frost AR. Identification of Molecular Distinctions between Normal Breast-Associated Fibroblasts and Breast Cancer-Associated Fibroblasts. Cancer Microenvironment 2009 2 (1):9-21, Epub 2009 March 19.  19308679 
Talley LI, Chhieng DC, Bell WC, Grizzle WE, Frost AR. Immunohistochemical detection of EGFR, p185erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women. Biotech Histochem. 2008 Feb;83(1):5-14  18568671 
Sadlonova A, Gault SR, Bowe DB, Dumas NA, Van Tine BA, Mukherjee S, Frolova N, Page GP, Welch DR, Novak L, Frost AR. Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease. Am J Pathol 2007 Mar;170(3):1064-76.  17322389 
Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP, Welch DR, Lobo-Ruppert SM, Ruppert JM, Johnson MR, Frost AR. Hedgehog signaling and response to cyclopamine differs in epithelial and stromal cells in benign breast and breast cancer.
Cancer Biology & Therapy 2006; 5(6):674-83.
Sadlonova A, Novak Z, Johnson MR, Bowe DB, Gault SR, Page GP, Thottassery JV, Welch DR, Frost AR. Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture. Breast Cancer Res. 2005;7(1):R46-59. Epub 2004 Nov 08.

breast cancer, tumor-stromal interactions, tissue-mimetic models