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C SCOTT SWINDLE
CH19 445 Zip 2041
Stem cell self-renewal, hematopoiesis, leukemogenesis
My research is focused on both normal hematopoiesis and leukemia. I am interested in understanding molecular mechanisms that facilitate hematopoietic stem cell (HSC) self-renewal, a property that is necessary to maintain homeostasis of the hematopoietic system. By genetically modifying murine HSC using retroviral gene delivery or gene-targeted mouse strains, we are able to address the role of various genes and pathways in the regulation of self-renewal. I am particularly interested in transcription factors involved in this process, with much of my work focused on Hox genes and core-binding factor. Understanding mechanisms regulating HSC self-renewal should facilitate development of technologies to expand human HSC ex vivo, which has applications for bone marrow transplantation and gene therapy. A second major focus of my research investigates mechanisms of leukemogenesis, with particular focus on core binding factor associated acute myeloid leukemias (INV16 and t(8;21)). Using mouse models of these diseases, we are able to address the roles of various oncogenes and mutations in promotion of AML. We are also using mouse models to identify potential leukemic stem cell markers, which are subsequently investigated using human AML specimens.
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