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Faculty Detail    
Name RONADIP RALPH BANERJEE
  
Campus Address SHEL 1210 Zip 0000
Phone
E-mail  ronadip@uab.edu
Other websites Banerjee lab website
UAB Endocrinology division
     

Education
Undergraduate  Stanford University    1997  B.S. Biological Sciences with Honors 
Graduate  University of Pennsylvania School of Medicine    2003  Ph.D. Cell and Molecular Biology 
Medical School  University of Pennsylvania School of Medicine    2005  M.D. 
Residency  Stanford Hospital and Clinics    2007  Internal Medicine 
Fellowship  Stanford Hospital and Clinics    2011  Endocrinology and Metabolism 

Certifications
Diplomate, American Board of Internal Medicine  2008 
Diplomate, ABIM Endocrinology and Metabolism  2010 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Endocrinology, Diabetes & Metabolism Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cell, Molecular, & Developmental Biology 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Ronadip R. Banerjee is an Assistant Professor of Medicine in the Division of Endocrinology at the University of Alabama at Birmingham School of Medicine, which he joined in 2016. Previously, he was an Instructor in Medicine at Stanford University School of Medicine. He completed postgraduate medical training at Stanford Hospital and Clinics, including a residency in Internal Medicine and a clinical fellowship in Endocrinology. Dr. Banerjee performed postdoctoral research in the lab of Dr. Seung Kim, (Stanford University Department of Developmental Biology) studying mechanisms of hormonal regulation of beta-cell proliferation and functional adaptation, particularly during pregnancy. Ron obtained his M.D. and Ph.D. degrees in the University of Pennsylvania School of Medicine. During that time, he completed his doctoral thesis research in the laboratory of Dr. Mitchell A. Lazar, contributing to the initial discovery of the adipocyte secreted hormone, resistin, and generating and characterizing the resistin knockout mouse. Dr Banerjee has been the recipient of the Roy G. Williams Award to a student for basic medical science research from the University of Pennsylvania, a Mentored Clinical Scientist Development Award (K08) from the NIDDK/NIH, and a American Diabetes Association Junior Faculty Development Award. He was recently awarded an R01 from the NIH/NIDDK. Dr. Banerjee also maintains a clinical practice at the Kirklin Clinic of UAB Hospital, focused on general endocrinology, and is co-director and co-founder of the UAB Multidisciplinary Endocrine Tumors clinic.

Society Memberships
Organization Name Position Held Org Link
Endocrine Society  Member  https://www.endocrine.org/ 
UAB Comprehensive Diabetes Center  Member  https://www.uab.edu/medicine/diabetes/ 
 



Research/Clinical Interest
Title
Pancreatic Beta-Cell Biology; Molecular mechanisms of beta-cell adaptation during pregnancy and dysregulation in gestational diabetes
Description
My lab is studying how hormones regulate metabolism, with a particular focus on glucose homeostasis. We use the pancreatic beta-cell as our model system. These amazing cells sense and integrate inputs from numerous hormones and metabolites to regulate secretion of hormones, including insulin, that in turn regulate metabolism in many tissues. The failure of beta-cells to produce sufficient insulin underlies the development of diabetes mellitus. Our work has demonstrated a critical role for prolactin receptor (PRLR) and lactogen signaling in the beta-cell adaptations required to maintain euglycemia during pregnancy. Defective PRLR signaling in mice results in gestational diabetes mellitus (GDM). We are currently investigating targets of PRLR signaling responsible for maternal adaptation of beta-cells during pregnancy, and how these pathways may be deranged in GDM. Additionally, we are interested in molecular mechanisms underlying gestational beta-cell expansion and regression to pre-pregnancy levels following parturition. We are also exploring roles for PRLR regulation of maternal adaptation in other tissues during gestation. To do so, we use cutting-edge techniques in molecular and cellular biology, genetics and developmental biology to study these questions in mice and humans. Our ultimate aim is to use information from these studies to identify pathways and targets that can be exploited to develop new therapies for diabetes in humans.

Selected Publications 
Publication PUBMEDID
Pepin, M.E., Bickerton, H.H., Bethea, M., Hunter, C. S., Wende, A.R., and Banerjee, R.R. Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islet. Endocrinology, 2019 May 1;160(5):1150-1163. doi: 10.1210/en.2018-00991.  31004482 
Berry, R., McGinnis, G.R., Banerjee, R.R., Young, M.E., and S. J. Frank. Differential tissue response to growth hormone in mice. FEBS Open Bio. 2018 May 23; 8(7): 1146-1154.   29988606 
Banerjee, R.R. Piecing together the puzzle of pancreatic islet adaptation in pregnancy. Annals of the New York Academy of the Sciences. 2018 Jan;1411(1):120-139.   29377199 
Banerjee RR, Bhatnagar S. ASF1B chaperones histone 3.3 to the beta-cell cycle dance. Cell Cycle. 2017 Jan 17;16(2):161-162.  27860543 
Banerjee, R. R., Cyphert, H.A., Chakravarti, H., Gu. X., Liu, Y., Conrad, L., Goodrich, L., Stein, R., and Kim, S.K. Gestational diabetes from inactivation of prolactin receptor and MafB in islet -cells. Diabetes. 2016 Aug;65(8):2331-41. doi: 10.2337/db15-1527. Epub 2016 May 23.
 		 27217483 
Banerjee, R. R., Marina, N., Katznelson, L., and Feldman, B.F. Mifepristone Treatment of Cushing’s Syndrome in a Pediatric Patient. Pediatrics. 2015 Nov;136(5):e1377-81. Epub 2015 Oct 12.
 		 26459648 
Graveleau, G., Zaha, V.G., Mohajer, A., Banerjee, R.R., Dudley-Rucker, N., Steppan, C.M., Rajala, M.W., Scherer, P.E., Ahima, R.S., Lazar, M.A., Abel, E.D. Mouse and Human Resistin Impair Glucose Transport in Primary Mouse Cardiomyocytes and Oligomerization is Required for this Biological Action. Journal of Biological Chemistry. 280(36): 31679-85. 9 Sept. 2005  15983036 
Rajala, M.W., Qi, Y., Patel, H.R., Takahashi, N., Banerjee, R., Pajvani, U.B., Sinha, M.K., Gingerich, R.L., Scherer, P.E., Ahima, R.S. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes. 53(7): 1671-9. July 2004.
 		 15220189 
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M.W., Pocai, A., Scherer, P.E., Steppan, C.M., Ahima, R. S., Obici, S., Rossetti, L., and Lazar, M. A. Regulation of fasted blood glucose by resistin. Science. 303: 1195-1198. 20 February 2004  14976316 
Banerjee, R. R. and Lazar, M. A. Resistin: molecular history and prognosis. Journal of Molecular Medicine. 81(4): 218-226. April 2003.
 		 12700889 
Banerjee, R. R., and Lazar M.A. Dimerization of Resistin and Resistin-Like Molecules is Determined by a Single Cysteine. Journal of Biological Chemistry. 276 (28): 25970-25973. 13 Jul. 2001.   11358969 
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., and Lazar, M. A. The hormone resistin links obesity to diabetes. Nature. 409: 307-312. 18 Jan. 2001  11201732 
Steppan, C. M., Brown, E. J., Wright, C. M., Bhat, S, Banerjee, R. R., Dai, C. Y., Enders, G. H., Silberg, D. G., Wen, X., Wu, G. D., and Lazar, M. A. A family of tissue-specific resistin-like molecules. Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 502-506. 16 Jan 2001.   11209052 
Hays, S.L., Firmenich, A.A., Massey, P. Banerjee, R. and Berg, P. Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA. Molecular and Cellular Biology. 18(7): 4400-6, Jul. 1998.   9632824 
 

Keywords
diabetes mellitus, prolactin receptor, beta-cell biology, pregnancy, transcriptional regulation