Medical School |
Nanchang University, Nanchang, China |
|
|
M.D. |
Residency |
Huazhong University of Science and Technology, Wuhan, China |
|
|
Obstetrics and Gynecology |
Graduate |
Medical University of Vienna, Vienna, Austria |
|
1994 |
Ph.D. |
Residency |
Washington University School of Medicine, St. Louis, Missouri |
|
2002 |
Clinical Pathology |
Fellowship |
Washington University School of Medicine, St. Louis, Missouri |
|
2003 |
Transfusion Medicine/Hemostasis |
|
Board Certificate, American Board of Pathology |
2003-Current |
Board Certificate, American Board of Blood Banking/Transfusion Medicine |
2003-Current |
Medical License, Commonwealth of Pennsylvania |
2003-Current |
Medical License, State of New Jersey |
2008-Current |
Medical License, State of Alabama |
2014-Current |
|
Biochemistry and Molecular Genetics Program |
Biochemistry and Structural Biology |
Cancer Biology |
Cell, Molecular, & Developmental Biology |
Immunology |
Integrative Genetics Graduate Program |
Medical Scientist Training Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Cao W, Abdelgawwad MS, Li J, Zheng XL. Apolipoprotein B100/Low-Density Lipoprotein Regulates Proteolysis and Functions of von Willebrand Factor under Arterial Shear. Thromb Haemost. 2019 Sep 7. doi: 10.1055/s-0039-1696713. [Epub ahead of print] |
31493779 |
Zheng L, Zhang D, Cao W, Song W, Zheng XL. Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy. Blood. 2019 Aug 13. pii: blood.2019001040. doi: 10.1182/blood.2019001040. [Epub ahead of print] |
31409673 |
Rottensteiner H, Seyfried BK, Kaufmann S, Fiedler C, Dong JF, Zheng XL, Plaimauer B, Scheiflinger F. Identification of cysteine thiol-based linkages in ADAMTS13 in support of a non-proteolytic regulation of von Willebrand factor. J Thromb Haemost. 2019 Aug 8. doi: 10.1111/jth.14602. [Epub ahead of print] |
31393047 |
McDaniel JK, Abdelgawwad MS, Hargett A, Renfrow MB, Bdeir K, Cao W, Cines DB, Zheng XL. Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols. J Thromb Haemost. 2019, 17(4):596-606. |
30741476 |
Abdelgawwad M, Cao W, Zheng L, Kocher NK, Williams LA, and Zheng XL. Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated with Thrombotic Thrombocytopenic Puprura. Arterioscler Thromb Vasc Biol (ATVB). 2018 Nov;38(11):2731-2743. doi: 10.1161/ATVBAHA.118.311407. |
30354235 |
Staley EM, Cao W, Pham HP, Kim CH, Kocher NK, Zheng L, Gangaraju R, Lorenz RG, Williams LA, Marques MB, Zheng XL. Clinical factors and biomarkers predicting outcome in patients with immune-mediated thrombotic thrombocytopenic purpura. Haematologica. 2018 Aug 31. pii: haematol.2018.198275. doi: 10.3324/haematol.2018.198275. |
30171022 |
Kumar MA, Cao W, Pham HP, Raju D, Nawalinski K, Maloney-Wilensky E, Schuster J, and Zheng XL. Relative Deficiency of Plasma ADAMTS13 Activity and Elevation of Human Neutrophil Peptides in Patients with Traumatic Brain Injury. J Neurotruma. 2018 Aug 14. doi: 10.1089/neu.2018.5696. |
29848170 |
Russell RT, McDaniel JK, Cao WJ, Shroyer M, Wagener BM, Zheng XL (corr. au.) and Pittet JF. Low Plasma ADAMTS13 Activity is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Pediatric Trauma. Thromb Haemost. 2018 Apr;118(4):676-687. doi: 10.1055/s-0038-1636528. |
29618154 |
Joly BS, Zheng XL and Veyradier A. Understanding thrombotic microangiopathies in children. Inten. Care Med., 2018 Sep;44(9):1536-1538. doi: 10.1007/s00134-018-5059-2. |
29368057 |
Staley EM, Simmons SC, Feldman AZ, Lorenz RG, Marques MB, Williams LA 3rd, Zheng XL, Pham HP. Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literature. Transfusion. 2018 Feb;58(2):456-460. doi: 10.1111/trf.14448. |
29230832 |
Ping Z., A. Soni, L.A. Williams III, H.P. Pham, M.K. Base, and X.L. Zheng. Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma. TH Open 2017 Jul;1(2):e113-e121. |
29152610 |
Xiao J, Feng Y, Li X, Li W, Fan L, Liu J, Zeng X, Chen K, Chen X, Zhou X, Zheng XL (corr. au.), and Chen S. Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development. Arterioscler Thromb Vasc Biol. (ATVB) 2017 Sep;37(9):1748-1756. |
28751574 |
Saha M, McDanniel J, and Zheng XL. Pathogenesis, Diagnosis, And Potential Novel Therapeutics for Thrombotic Thrombocytopenic Purpurpa. J. Thromb. Haemost. 2017 Oct;15(10):1889-1900. |
28662310 |
Kim CH, Simmons SC, Williams Iii LA, Staley EM, Zheng XL, Pham HP. ADAMTS13 test and/or PLASMIC clinical score in management of acquired thrombotic thrombocytopenic purpura: a cost-effective analysis. Transfusion. 2017 Nov;57(11):2609-2618. |
28646526 |
Kumar M, Cao WJ, McDaniel JK, Pham HP, Raju D, Nawalinski K, Frangos S, Kung S, Zager E, Kasner SE, Levine JM, Zheng XL. Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid hemorrhage. Thromb. Haemost. 2017; 117(4):691-699. |
28102428 |
Ueda Y, Mohammed I, Song D, Gullipalli D, Zhou L, Sato S, Wang Y, Gupta S, Cheng Z, Wang H, Bao J, Mao Y, Brass L, Zheng XL, Miwa T, Palmer M, Dunaief J, Song WC. Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood. 2017; 129(9):1184-1196. |
28057640 |
Nguyen GN, George LA, Siner JI, Davidson RJ, Zander CB, Zheng XL, Arruda VR, Camire RM, Sabatino DE. Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. J Thromb Haemost. 2017;15(1):110-121. |
27749002 |
Cao WJ, and Zheng XL. Conformational quiescence of ADAMTS13 prevents proteolytic promiscuity: comment. J Thromb Haemost. 2017;15(3):586-589. |
28055145 |
Williams III LA, Drwiega JC, Cao W, Pham HP, Bertoli LF, and Zheng XL. Acquired autoimmune thrombotic thrombocytopenic purpura in a case of severe hemophilia A. Haemophilia. 2016; 22(6):e565-e567. |
27704646 |
Zheng L, Mao Y, Abdelgawwad MS, Kocher NK, Li M, Dai X, Li B, and Zheng XL. Therapeutic Efficacy of Platelet Glycoprotein Ib Antagonist Anfibatide in Murine Models of Thrombotic Thrombocytopenia Purpura. Blood Adv. 2016 1:75-83. |
28480350 |
Cao W, Pham HP, Williams LA, McDaniel J, Siniard RC, Lorenz RG, Marques MB, Zheng XL. Human Neutrophil Peptides And Complement Factor Bb In Pathogenesis Of Acquired Thrombotic Thrombocytopenic Purpura. Haematologica. 2016; 101(11):1319-1326. |
27662014 |
Pillar V.G., Bao J., Zander C.B., McDaniel J.K., Chetty P.S., Seeholzer S.H., Bdeir K., Cines D.B., Zheng X.L. Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP. Blood. 2016;28(1):110-9. |
27207796 |
Ostertag EM, Kacir S, Thiboutot M, Gulendran G, Zheng XL, Cines DB, Siegel DL. ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro. Transfusion. 2016;56(7):1763-74. |
27040144 |
Ostertag EM, Bdeir K, Kacir S, Thiboutot M, Gulendran G, Yunk L, Hayes VM, Motto DG, Poncz M, Zheng XL, Cines DB, Siegel DL. ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion. 2016;56(7):1775-85. |
27040023 |
Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L. Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood. 2016;127(4):464-72 |
26518435 |
Casina VC, Hu W, Mao JH, Lu RN, Hanby HA, Picken B, Kan ZY, Lim WK, Mayne L, Ostertag EM, Kacir S, Siegel DL, Englander SW, and Zheng XL. High resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome. Proc Natl Acad Sci USA. 2015;112:9620-5. |
26203127 |
Zander CB, Cao W, Zheng XL. ADAMTS13 and von Willebrand factor interaction. Curr Opin Hematol. 2015;22:452-9. |
26186678 |
Zheng XL. ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura. Annu Rev Med. 2015; 66: 211-25. |
25587650 |
Pickens B, Mao Y, Li D, Siegel DL, Poncz M, Cines DB, and Zheng XL. Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura. Blood. 2015;125 (21):3326-34. |
25800050 |
Zheng XL. ADAMTS13, lucky to have a hydrophobic pocket. Blood. 2015;125 (12):1852-3. |
25792731 |
Lu RN, Yang S, Wu HM, Zheng XL. Unconjugated Bilirubin Inhibits Proteolytic Cleavage of von Willebrand Factor by ADAMTS13 Protease. J Thromb Haemost. 2015;13(6):1064-72. |
25782102 |
Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS, Rader DJ, Reilly MP. Knockout of Adamts7, A Novel CAD Locus in Humans, Reduces Atherosclerosis in Mice. Circulation. 2015;131(13):1202-13. |
25712206 |
Zheng XL. DNase, ADAMTS13, and iPAD4: good for the heart. Blood. 2014;123:10-1. |
24385497 |
Grillberger R, Casina VC, Turecek PL, Zheng XL, Rottensteiner H, Scheiflinger F. Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura. Haematologica. 2014;99:e58-60. |
24532042 |
Chen J, Zhou H, Diacovo A, Zheng XL, Emsley J, Diacovo TG. Exploiting the kinetic interplay between GPIb-VWF binding interfaces to regulate hemostasis and thrombosis. Blood. 2014;124:3799-807. |
25293780 |
Bao J, Xiao J, Mao Y, Zheng XL. Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner. Arterioscler Thromb Vasc Biol. (ATVB) 2014;34:397-407. |
24357063 |
Skipwith CG, Haberichter SL, Gehrand A, Zheng XL. Compromised shear-dependent cleavage of type 2N von Willebrand factor variants by ADAMTS13 in the presence of factor VIII. Thromb Haemost. 2013;110:202-4. |
23636243 |
Jin SY, Xiao J, Bao J, Zhou S, Wright JF, Zheng XL. AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura. Blood. 2013;121:3825-9, |
23515928 |
Cao W, Sabatino DE, Altynova E, Lange AM, Casina VC, Camire RM, Zheng XL. Light chain of factor VIII is sufficient for accelerating cleavage of von Willebrand factor by ADAMTS13 metalloprotease. J Biol Chem. 2012;287:32459-66 |
22854959 |
Jin SY, Tohyama J, Bauer RC, Cao NN, Rader DJ, Zheng XL. Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. Arterioscler Thromb Vasc Biol. (ATVB) 2012;32:1817-23. |
22652598 |
Zheng XL. ADAMTS13 meets MR, then what? Blood. 2012;119:3652-4. |
22517873 |
Wroblewska A, van Haren SD, Herczenik E, Kaijen P, Ruminska A, Jin SY, Zheng XL, van den Biggelaar M, ten Brinke A, Meijer AB, Voorberg J. Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice. Blood. 2012;119:5294-300. |
22498747 |
Jian C, Xiao J, Gong L, Skipwith CG, Jin SY, Kwaan HC, Zheng XL. Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. Blood. 2012;119:3836-43. |
22289888 |
Xiao J, Jin SY, Xue J, Sorvillo N, Voorberg J, Zheng XL. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis. Arterioscler Thromb Vasc Biol. (ATVB) 2011;31:2261-9. |
21799176 |
Jobes D, Wolfe Y, O'Neill D, Calder J, Jones L, Sesok-Pizzini D, Zheng XL. Toward a definition of "fresh" whole blood: an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion. Transfusion. 2011;51:43-51. |
20663116 |
Skipwith CG, Cao W, Zheng XL. Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. J Biol Chem. 2010;285:28596-603. |
20605782 |
Zheng XL, Wu HM, Shang D, Falls E, Skipwith CG, Cataland SR, Bennett CL, Kwaan HC. Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Haematologica. 2010;95:1555-62. |
20378566 |
Jin SY, Skipwith CG, Zheng XL. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor. Blood. 2010;115:2300-10. |
20075158 |
Raife TJ, Cao W, Atkinson BS, Bedell B, Montgomery RR, Lentz SR, Johnson GF, Zheng XL. Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. Blood. 2009;114:1666-74. |
19541819 |
Laje P, Shang D, Cao W, Niiya M, Endo M, Radu A, DeRogatis N, Scheiflinger F, Zoltick PW, Flake AW, Zheng XL. Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy. Blood. 2009;113:2172-80. |
19141866 |
|
|