Faculty Detail   
Campus Address SHEL 1202 Zip 2182
Phone  (205) 934-7037
E-mail  htse@uab.edu
Other websites PubMed

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Microbiology  Microbiology Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Ctr Nanoscale Mat & Biointegration  Ctr Nanoscale Mat & Biointegration Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor

Graduate Biomedical Sciences Affiliations

Biographical Sketch 
Virginia Tech, B.S. 1992
University of Colorado Health Sciences Center, Ph.D. 1999
Colorado State University, Post-doctoral fellow 2001
University of Pittsburgh, Post-doctoral fellow 2009

Research/Clinical Interest
The role of oxidative stress on autoimmune Type 1 diabetes
My research seeks to understand the synergy of oxidative stress and autoimmune destruction of insulin-secreting pancreatic beta-cells in Type 1 diabetes (T1D). Oxidative stress and the generation of free radicals are not only important effector molecules in pancreatic beta-cell death, but they also serve to enhance autoimmune responses in T1D. We have focused on dissipating free radicals as a potential target to preserve pancreatic beta-cells and to mediate immune tolerance and suppression of autoreactive T cell responses. To address the significance of free radical synthesis and T1D, we have developed unique animal models to further understand the interplay of free radicals and dysregulated autoimmune responses in T1D. In combination with the knowledge gained from our animal models, we have also initiated translational studies to characterize the efficacy of a powerful catalytic antioxidant to dissipate oxidative stress as a novel immunotherapeutic treatment for the prevention of T1D.

Selected Publications 
Click URL under “Faculty Detail” above to link to current publications on PubMed   

Autoimmunity, Type 1 diabetes, Reactive Oxygen Species, T cell, Innate Immunity, Inflammation