Faculty Detail    Name JIANHUA ZHANG   Campus Address BMR2 534 Zip 2186 Phone  (205) 996-5153 E-mail Other websites googlescholar

 Education

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Joint Pathology  Molecular & Cellular Pathology Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Dept of Biomedical Engineering  Dept of Biomedical Engineering Professor Secondary  Neurobiology  Neurobiology Professor Center  Alzheimer's Disease Center  Alzheimer's Disease Center Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Professor Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor Center  Ctr for Free Radical Bio  Ctr for Free Radical Bio Professor Center  Ctr Neurodegeneration & Exp Ther (CNET)  Ctr Neurodegeneration & Exp Ther (CNET) Professor Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor Center  UAB Immunology Institute  UAB Immunology Institute Professor Center  UWIRC Microbiome Center  UWIRC Microbiome Center Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Integrative Genetics Graduate Program  Medical Scientist Training Program  Molecular and Cellular Pathology Program  Neuroscience  Neuroscience Graduate Program  Pathobiology and Molecular Medicine

Society Memberships Organization Name Position Held Org Link Association for Neuron and Disease (AND)  member    Birmingham Chinese Professor Association (BCPA)  member    Chinese Biologic Investigator Society (Ray Wu society)  member    Society for Free Radical Biology and Medicine (SFRBM)  VP  sfrbm.org  Society of Chinese Bioscientists in America (SCBA)  member    Women in Autophagy  member  womeninautophagy.com

Selected Publications  Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production G Yang, W Song, J Xu, JL Postoak, F Cheng, J Martinez, J Zhang, L Wu, ...2020 Cellular & molecular immunology, 1-16  33235386  Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications J Chatham, M Young, J Zhang 2020 Current Opinion in Pharmacology 57, 1-12  32937226   Role of O-linked N-acetylglucosamine (O-GlcNAc) protein modification in cellular (patho) physiology JC Chatham, J Zhang, AR Wende 2020 Physiological Reviews  32730113  Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia D Fil, BK Chacko, R Conley, X Ouyang, J Zhang, VM Darley-Usmar, ...2020 Disease models & mechanisms 13 (7)  32586831  Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective MI Hossain, JM Marcus, JH Lee, PL Garcia, VK Singh, JJ Shacka, J Zhang, ...2020 Autophagy, 1-19  32450052  Differential Effects of REV-ERBa/b Agonism on Cardiac Gene Expression, Metabolism, and Contractile Function in a Mouse Model of Circadian Disruption. S Mia, MS Kane, MN Latimer, CJ Reitz, R Sonkar, GA Benavides, ...2020 American journal of physiology. Heart and circulatory physiology  32357113  Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory X Ouyang, I Ahmad, MS Johnson, M Redmann, J Craver, WY Wani, ...2020 Laboratory Investigation 100 (9), 1238-1251  32350405  Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function: PIK3C3/VPS34 in T cell metabolism and function G Yang, W Song, JL Postoak, J Chen, J Martinez, J Zhang, L Wu, ...2020 Autophagy, 1-12  32268825  Role and Mechanisms of Mitophagy in Liver Diseases X Ma, T McKeen, J Zhang, WX Ding 2020 Cells  32244304  MitoQ regulates redox-related non-coding RNAs to preserve mitochondrial network integrity in pressure overload heart failure S Kim, J Song, P Ernst, MN Latimer, CM Ha, KY Goh, W Ma, ...2020 Am J Physiol Heart Circ Physiol 318 (3), H682-H695  32004065  Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine BG Hill, S Shiva, S Ballinger, J Zhang, V Darley-Usmar 2019 Biological Chemistry  31815377  Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart Beating J Zhang, J Chatham, ME Young 2020 Annual review of physiology 82  31589825  Acute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover JLN Wright, GA Benavides, MS Johnson, W Wani, X Ouyang, L Zou, ...2019 American Journal of Physiology-Cell Physiology 316 (6), C862-C875  30865517  Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokeland T, Ouyang X, Zhang J, Duncan SR, Thannickal VK, Darley-Usmar VM, Deshane JS (2018) Exosomal Transfer of Mitochondria from Airway Myeloid-Derived Regulatory Cells to T cells. Redox Biology. Vol 18, pages 54-64  29986209  Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napieralo M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland A (2017) Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro. ACS Chemical Biology 13 (8), 2048-2057  29905460  Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture Matthew Redmann, Gloria A. Benavides, Willayat Yousuf Wani, Taylor F ...2018 Redox Biology 17, 59-69  29677567  Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado B, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME (2018) Temporal partitioning of adaptive responses of the murine heart to fasting: a guide for experimental design. Life Sciences 197:30-39  29410090  Zhang J, Culp ML, Craver JG, Darley-Usmar V (2017) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease. J Neurochem in press  29341130   Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation. Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ. J Biol Chem. 2017 Dec 8. pii: jbc.RA117.000444. doi: 10.1074/jbc.RA117.000444. [Epub ahead of print]   29222329  Neurobiol Dis. 2017 Dec 2;110:68-81. doi: 10.1016/j.nbd.2017.11.006. [Epub ahead of print] The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein. Nelson MP1, Boutin M2, Tse TE3, Lu H1, Haley ED3, Ouyang X1, Zhang J4, Auray-Blais C2, Shacka JJ5.  29196214   Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons. Dodson M, Wani WY, Redmann M, Benavides GA, Johnson MS, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J. Autophagy. 2017 Aug 24:1-13. doi: 10.1080/15548627.2017.1356948. [Epub ahead of print]   28837411  O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J. Mol Brain. 2017 Jul 19;10(1):32. doi: 10.1186/s13041-017-0311-1.   28724388   Redmann M, Wani W, Volpicelli-Daley L, Darley-Usmar V, Zhang J (2017) Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biology 11:429-437  28068606  Bernard K, Logsdon NJ, Herranz VM, Benavides GA, Zhang J, Darley-Usmar VM, Thannickal VJ (2017) NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis in Lung Fibroblasts via a Nuclear Factor Erythroid- Derived 2-like 2 (Nrf2)-Dependent Pathway. J Biol Chem In press  28049732  Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J (2017) Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biology 11:73-81 PMCID:PMC5124357  27889640  Wani W, Chatham J, Darley-Usmar V, McMahon L, Zhang J (2017) O-GlcNAcylation and neurodegeneration. BRB in press  27497832   Aggarwal S, Mannam P, Zhang J. (2017) Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.Am J Physiol Lung Cell Mol Physiol.  27402690   A Hjelmeland, J Zhang (2016) Metabolic, autophagic, and mitophagic activities in cancer initiation and progression biomedical journal  27372165   Wende AR, Young M, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM (2017) Free Radical Biology and Medicine In press  27242268   Redmann M, Darley-Usmar V, Zhang J (2016) The role of autophagy, mitophagy and lysosomal functions in modulating cellular bioenergetics and survival in the context of redox and proteotoxic damage: implications for age dependent neurodegenerative diseases. Aging and Disease 7:150-162 PMCID:PMC4809607  27114848  Radhakrishnan RK, Narasimhan M, Shanmugam G, Devarajan A, Palaniappan S, Zhang J, Halade G, Darley-Usmar VM, Hoidal JR, Rajasekaran NS (2016) Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. J Transl Med. 14 (1), 86  27048381  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky et al Autophagy. 2016 Jan 2;12(1):1-222.  26799652  Matthew Dodson, Matthew Redmann, Namakkal S Rajasekaran, Victor Darley-Usmar, Jianhua Zhang (2015)KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochemical Journal 469:347-55  26205490   Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S (2015) Upregulation of autophagy decreases chlorine gas-induced mitochondrial injury and lung inflammation. Free radical biology and medicine 85:83-94  25881550  Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches.Redox Biol. 2015;4:242-59. doi: 10.1016/j.redox.2015.01.003. Epub 2015 Jan 13.  25618581  Wani W, Boyer-Guittaut M, Dodson M, Chatham J, Darley-Usmar V, Zhang J (2015) Regulation of autophagy by protein post-translational modification. Laboratory Investigation 95(1):14-25.  25365205   Sheshadri N, Catanzaro J, Bott A, Sun Y, Ullman E, Chen E, Pan J-A, Wu S, Crawford H, Zhang J, Zong WX (2014) SCCA1/SerpinB3 promotes epithelial-mesenchymal transition and oncogenic transformation via unfolded protein response and IL-6 signaling. Cancer Research 74(21):6318-29  25213322  Giordano S, Dodson M, Ravi S, Redmann M, Ouyang X, Darley Usmar VM, Zhang J. (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J Neurochem. Jul 31. doi: 10.1111/jnc.12844. [Epub ahead of print]  25081478  Chacko B, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal A, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: A new concept in translational research. Clinical Science   24895057  Michaël Boyer-Guittaut, Laura Poillet, Qiuli Liang, Elodie Bôle-Richard, Xiaosen Ouyang, Gloria A Benavides, Fatima-Zahra Chakrama, Annick Fraichard, Victor M Darley-Usmar, Gilles Despouy, Michèle Jouvenot, Régis Delage-Mourroux, Jianhua Zhang (2014). The role of GABARAPL1 (GEC1) in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy 10 (6), 986-1003  24879149  Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar VM, Zhang J (2014) Mitophagy mechanisms and role in human diseases. International Journal of Biochemistry and Cell biology 53:127-33  24842106  AL Levonen, BG Hill, E Kansanen, J Zhang, VM Darley-Usmar (2014) Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics. Free Radical Biology and Medicine 71, 196-207  24681256  Giordano S, Darley-Usmar V, Zhang J. (2013) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. 2: 82–90.   24494187  M Dodson, Q Liang, MS Johnson, M Redmann, N Fineberg, VM Darley-Usmar, J Zhang, Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy 9 (12), 18-30  24145463  Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J. Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.Free Radic Biol Med. 2013 Sep 19. pii: S0891-5849(13)00609-6. doi: 10.1016/j.  24056030  Zhang J (2013) Autophagy and mitophagy in cellular damage control. Redox Biology. 1:19-23  23946931  Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM.Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived beta-cells. Am J Physiol Endocrinol Metab. 2013 Jul 2. [Epub ahead of print]  23820623  Biochem J. 2013 Jun 17. [Epub ahead of print]Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.Liang Q, Benavides GA, Vasilopoulos A, Gius D, Darley-Usmar V, Zhang J.  23767918  Dodson M, Darley-Usmar V, Zhang J.Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling. Free Radic Biol Med. 2013 May 20. pii: S0891-5849(13)00224-4.   23702245  Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold P-Y, Boyer-Guittaut M, Delage-Mourroux R (2012) Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. PlosOne 2013 May 15;8(5):e63133  23690988  First Prev   1 2 of  2  Next Last