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Faculty Detail    
Name UPENDER MANNE
Director, Translational Anatomic Pathology
Co-Director, UAB Tissue Bioreposity
 
Campus Address WTI 420A Zip 3300
Phone  (205) 934-4276
E-mail  upendermanne@uabmc.edu
Other websites Google Scholar
Research Gate
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Secondary  Surgery   Surgery - Gen Surg Gastrointestinal Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Minority Health & Research Center Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Manne obtained his M.S. (Biochemistry, Histochemistry, Parasitology, Zoonosis) and Ph.D. (energy metabolic pathways of endoparasites) degrees from Osmania University, Hyderabad, India. His postdoctoral training was in molecular immunology and vaccine development for malaria (Malaria Research Center, Delhi, India); in helicobacter infections (School of Microbiology, University of New South Wales, Sydney, Australia); and in histopathology, molecular tumor biology, cancer biomarker development, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). He also received certification in bioinformatics at UAB. Dr. Manne’s research on racial disparity in colorectal and breast cancers has received considerable national and international recognition. In 2009, as part of the Presidents Cancer Panel, Dr. Manne focused on “Biologic differences between ethnic groups and their clinical implications in cancer care,” and devoted to the topic, “America’s demographic and cultural transformation: implications for the cancer enterprise.” Currently, he is the Principal Investigator of two Comprehensive Cancer Research Partnership between UAB Comprehensive Cancer Center and Tuskegee University, Tuskegee, AL and Morehouse School of Medicine, Atlanta, GA (U54); and Alabama State University, Montgomery, AL (P20) to Reduce Cancer Health Disparities by implementing innovative, multi-disciplinary, collaborative, population-based cancer control and prevention research and has contributed to education, training, and community outreach activities. These two programs are funded by the National Cancer Institute of the National Institute of Health.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research  Active member   
American Society of Clinical Oncology  Active member   



Research/Clinical Interest
Title
Translational research in grastrointestinal malignancies and breast cancer
Description
Dr. Manne’s present efforts are focused on population-based translational research for human neoplasias, with emphasis on colorectal and breast cancers. His laboratory, with projects funded by the National Cancer Institute and the Susan G. Komen Foundation, is evaluating molecular markers to identify aggressive phenotypic features of tumors to predict the efficacy of chemotherapeutic regimens and to assess clinical outcomes. Dr. Manne’s research and collaborative groups include experts in the fields of molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. For evaluating the clinical utility of genetic and phenotypic abnormalities in colorectal cancer, his group has developed strategies demonstrating that the utility of molecular biomarkers varies according to the anatomic location of tumors within the colorectum and with tumor stage, race/ethnicity, age, and gender. To validate the clinical utility of genetic and phenotypic markers, Dr. Manne’s laboratory is evaluating hundreds of colorectal cancer samples derived from African American and non-Hispanic Caucasian ethnic/racial backgrounds and collected from different institutions. Established molecular markers with be merged with other epidemiological, environmental, and socio-economic features to find the basis for racial disparities in colorectal and breast malignancies. Results from approaches involving biomarker discovery and bioinformatics will aid in developing predictive models specific for individual patients. The research interests of Dr. Manne also include use of genomics and proteomics for identification of early markers of cancers, specifically, identification of molecular signatures of benign colonic epithelium, which is at risk of developing colorectal neoplasias, and of other pre-malignant lesions. These studies will aid in the evaluation of molecular and pathologic characteristics of specimens and in the development of assays that relate to early detection, diagnosis, prognosis, and treatment of cancers.

Selected Publications 
Publication PUBMEDID
Alexander D, Nirag Jhala, Chatla C, Funkhouser E, Coffey C, Grizzle WE, Manne U. High grade tumor differentiation is a poor prognostic indicator of African Americans with colonic adenocarcinomas. Cancer 2005, 103:2163-2170.  15816050  
Manne U, Alexander D, Chatla C. Re: Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma.
Cancer. 2004 Dec 15;101(12):2900.  
15494973 
Alexander D, Chatla C, Funkhouser E, Meleth S, Grizzle WE, Manne U.Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma. Cancer. 2004 Jul 1;101(1):66-76.
 
15221990  
Manne U, Jhala NC, Jones J, Weiss HL, Chatla C, Meleth S. Suarez-Cuervo C, Grizzle WE. Prognostic significance of p27kip-1 expression in colorectal adenocarcinomas is associated with tumor stage. CLIN. CANCER RES.,2004; 10(5):1743-52.  15014027  
Chhieng DC, Benson E, Eltoum I, Eloubeidi MA, Jhala NC, Jhala D, Siegal GP, Grizzle WE, Manne U. MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. CANCER., 2003; 99(6): 635-71.   14681945 
TAlvarez RD, Conner MG, Weiss H, Klug PM, Niwas S, Manne U, Bacus J, Kagan V, Sexton KC, Grubbs CJ, Eltoum IE, Grizzle WE. The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trial.Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):114-9.  12582020 
Piyathilake CJ, Frost AR, Manne U, Weiss H, Heimburger DC, Grizzle WE.Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers.Chest. 2003 Jan;123(1):181-6.  12527620 
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung. Clin Cancer Res. 2002 Mar;8(3):734-44.  11895903 
Miller CR, Gustin AN, Buchsbaum DJ, Vickers SM, Manne U, Grizzle WE, Cloud GA, Diasio RB, Johnson MR.Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro. Anal Biochem. 2002 Feb 15;301(2):189-99.  11814289 
Grizzle WE, Manne U, Weiss HL, Jhala NC, Talley L. Molecular staging of coloretal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2 MUC1 and p27kip-1. INT. J. CANCER.,2002; 97(4): 403-9 (Review).  11802199 
Manne U, Gary BD, Oelschlager DK, Weiss HL, Frost AR, Grizzle WE. Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas. CLIN. CANCER RES., 2001; 7(11): 3495-503.  11705868 
Gibbons MD, Manne U, Carroll WR, Peters GE, Weiss HL, Grizzle WE.Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. Laryngoscope. 2001 Aug;111(8):1373-8.  11568571 
Grizzle WE, Manne U, Jhala NC, Weiss HL. Molecular characterization of colorectal neoplasia in translational research. ARCH. PATHOL.LAB. MED.,2001; 125(1): 91-8(Review).  11151060 
Piyathilake CJ, Johanning GL, Frost AR, Whiteside MA, Manne U, Grizzle WE, Heimburger DC, Niveleau A.Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assay.Biotech Histochem. 2000 Nov;75(6):251-8.  11131565 
Manne U, Weiss HL, Grizzle WE. Racial differences in the prognostic usefulness of MUC1 and MUC2 in colorectal adenocarcinomas. CLIN.CANCER RES. 6(10):4017-25, 2000.   11051251  
Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC, Grizzle WE.The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.Hum Pathol. 2000 Sep;31(9):1068-73.  11014573 
Manne U, Weiss HL, Grizzle WE. Bcl-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas. INT. J. CANCER, 2000; 89(5): 423-30.  11008204 
Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE.The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung.Hum Pathol. 2000 Apr;31(4):482-7.  10821496 
Poczatek RB, Myers RB, Manne U, Oelschlager DK, Weiss HL, Bostwick DG, Grizzle WE.Ep-Cam levels in prostatic adenocarcinoma and prostatic intraepithelial neoplasia.J Urol. 1999 Oct;162(4):1462-6.  10492238 
Myers RB, Oelschlager D, Manne U, Coan PN, Weiss H, Grizzle WE.Androgenic regulation of growth factor and growth factor receptor expression in the CWR22 model of prostatic adenocarcinoma. Int J Cancer. 1999 Jul 30;82(3):424-9.  10399960 
Urban D, Myers R, Manne U, Weiss H, Mohler J, Perkins D, Markiewicz M, Lieberman R, Kelloff G, Marshall M, Grizzle W.Evaluation of biomarker modulation by fenretinide in prostate cancer patients.Eur Urol. 1999;35(5-6):429-38.  10325501 
Myers RB, Oelschlager DK, Coan PN, Frost AR, Weiss HL, Manne U, Pretlow TG, Grizzle WE.
J Urol. 1999 Mar;161(3):945-9.Changes in cyclin dependent kinase inhibitors p21 and p27 during the castration induced regression of the CWR22 model of prostatic adenocarcinoma.J Urol. 1999 Mar;161(3):945-9. 
10022731 
Agarwal S, Behring M, Hale K, Al Diffalha S, Wang K, Manne U, Varambally S. MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer. Transl Oncol. 2019 Nov;12(11):1461-1467.   31421459 
Kumar S, Stokes J 3rd, Singh UP, Scissum Gunn K, Acharya A, Manne U, Mishra M. Targeting Hsp70: A possible therapy for cancer.Cancer Lett. 2016;374(1):156-66.  26898980 

Keywords
Colorectal Cancer, GI malignancies, Breast Cancer, Molecular Biomarkers, Racial/Ethnic Disparities, Cancer Control & Prevention