Cancer Biology  Back to Main

Faculty Detail    
MD. Ph D.
Campus Address KAUL 742 Zip 0024
Phone  (205) 934-7308
Other websites

Graduate  University of Miyazaki, Miyazaki Medical College, Japan    2002  PhD 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cellular and Molecular Biology Program 
Genetics and Genomic Sciences 

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research   Member    

Research/Clinical Interest
Cancer Cell Biology and Cancer Genetics
My research interest focuses on molecular biology of human diseases including cancer and chronic disease specifically in the molecular mechanisms of development and progression of cancer involved protein interactions in cell signaling pathways.

Selected Publications 
Publication PUBMEDID
1. Liu RH*, Kurose T, Matsukura S. Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats. Metabolism. 2001; 50(1):79-85. (*Corresponding Author).
2. Liu RH, Mizuta M, Kurose T, Matsukura S. Early events involved in the development of insulin resistance in Zucker fatty rat. Int J Obes Relat Metab Disord. 2002; 26(3):318-26.
3. Liu RH, Mizuta M, Matsukura S. Long-term oral nicotine administration reduces insulin resistance in obese rats. Eur J Pharmacol. 2003; 458(1-2): 227-34.
4. Liu RH, Mizuta M, Matsukura S. The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes. J Pharmacol Exp Ther. 2004; 310(1): 52-8.
5. Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, Liu R, Guinther N, Lima J, Zhou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. A dinucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genetics, 2007; 3(4): 508-17.
6. Zuo T*, Liu R*(* first co-author), Zhang H, Chang X, Liu Y, Wang L, Zheng P and Liu Y. FOXP3 is a novel transcription repressor for the breast cancer oncogene SKP2. J Clin Invest, 2007; 117(12): 3765-73.
7. Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med., 2008; 205(10): 2397-408.
8. Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, Zheng P. Laforin negatively regulates cell cycle progression through GSK-3b dependent mechanisms. Mol Cell Biol. 2008; 28 (23): 7236-44.
9. Liu R, Wang L, Chen C, Katoh H, Chen C, Zheng P, Liu Y. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/4 association to the locus. Cancer Res. 2009; 69 (6): 2252-9.
10. Wang L*, Liu R*(* first co-author), Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009; 16 (4): 336-46.

11. Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011; 71 (6): 2162-71.
12. Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Tri-Methylation for Gene Activation through Recruiting MOF and Displacing H3K4 Demethylase. Mol Cell. 2011; 44(5): 770-84.
13. Wang L, Liu R, Li D, Lin S, Fang X, Backer G, Kain M, Rammoham K, Zheng P, Liu Y. A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. Am J Transl Res. 2012; 4(3): 347-56.
14. Wang CM, Liu R, Wang L, Yang WH. Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1. Int J Mol Sci. 2013; 14(11): 22331-45.
15. Wang CM, Liu R, Wang L, Nascimento L, Brennan VC, Yang WH. SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cells. Int J Mol Sci. 2014;15(6):10233-51.
16. Ye P, Liu Y, Chen C, Tang F, Wu Q, Wang X, Liu CG, Liu X, Liu R, Liu Y, Zheng P. An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation. Mol Cell. 2015 Feb 19;57(4):708-20.
17. Wang L*, Liu R*(* first co-author), Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W, Zhang P, Jiang T, Bassetti MF, Jube S, Sun Y, Zhang Y, Zheng P, Liu Y. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nature Communications, 2015 Jan 20; 6:5909.
18. Liu R*, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L*. FOXP3 controls an miR-146/NFκB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Res. 2015; 75(8):1703-13 (*Co-corresponding Author).
19. Liu R*, Yi B, Wei S, Yang WH, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu CG, and Wang L*. FOXP3-miRNA146-NF-κB axis and therapy for precancerous lesion in prostate. Cancer Res. 2015;75 (8):1714-24 (*Co-corresponding Author).
20. Parker DJ, Iyer A, Shah SK, Moran A, Hjelmeland AB, Basu MK, Liu R Mitra K. A novel mitochondrial pool of Cyclin E, regulated by Drp1, is linked to cell density dependent cell proliferation. J Cell Sci. 2015 Nov 15; 128 (22):4171-82.
21. Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LLH, Yang WH, Lillard JW, Zhang X, Wang L, Liu R*. Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells. Clin Cancer Res. 2016; 22:2545-54. doi: 10.1158/1078-0432.CCR-15-1927. (*Corresponding Author).
22. Zhang G, Wang C, Sun M, Li J, Wang B, Jin C, Hua P, Song G, Zhang Y, Nguyen LL, Cui R, Liu R, Wang L, Zhang X. Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells. Oncotarget. 2016 Mar 3. doi: 10.18632/oncotarget.7898.
23. Zhang Y, Li B, Zhang X, Sonpavde GP, Jiao K, Zhang A, Zhang G, Sun M, Chu C, Li F, Wang L, Cui R, Liu R*. CD24 Is a Genetic Modifier for Risk and Progression of Prostate Cancer. Molecular Carcinogenesis. 2017 Feb;56(2):641-650. doi: 10.1002/mc.22522. (*Corresponding Author).
24. Daubenspeck JM, Liu R, Dybvig K. Rhamnose Links Moonlighting Proteins to Membrane Phospholipid in Mycoplasmas. PLOS ONE. 2016 Sep 7;11(9):e0162505. doi: 10.1371/journal.pone.0162505. eCollection 2016.
25. Gao S, Wang Y, Wang M, Li Z, Zhao Z, Chen D, Wu R, Yuan Z, Wang XR, Cui R, Wang L, Ouyang L Liu R* MicroRNA-155, induced by FOXP3 though a transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer. Oncotarget. 2017 Jun 20;8(25): 41451-41464. doi: 10.18632/oncotarget.17816. (*Corresponding Author).
26. Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, Yang WH, Cui R, Liu R*, Wang L. MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res. 2017; 19 (1):73. doi: 10.1186/s13058-017-0858-x. (*Co-corresponding Author).
27. Luo Y, Li B, Zhang G, He Y, Bae JH, Hu F, Cui R, Liu R, Wang Z, Wang L.Integrated Oncogenomic Profiling of Copy Numbers and Gene Expression in Lung Adenocarcinomas without EGFR Mutations or ALK Fusion. J Cancer. 2018 Feb 28;9(6):1096-1105. doi: 10.7150/jca.23909. 2018.
28. Ou J, Si Y, Goh K, Yasui N, Guo Y, Song J, Wang L, Jaskula-Sztul R, Fan J, Zhou L, Liu R, Liu X1. Bioprocess development of antibody-drug conjugate production for cancer treatment. PLoS One 2018 Oct 23;13(10):e0206246. doi: 10.1371/journal.pone.0206246.
29. Wu L, Yi B, Yao D, He Y, Naik GN, Bea S, Liu X, Yang WH, Sonpavde G, Liu R*, and Wang L*. Losses of Foxp3 and Tsc1 Accelerate Prostate Cancer Progression through a Synergistic Transcriptional and Post-translational Regulation of c-MYC. Cancer Research. 2019 Feb 7. pii: canres.2049.2018. doi: 10.1158/0008-5472.CAN-18-2049. [Epub ahead of print]. (*Co-corresponding Author).
30. Wang Y, Li X, Liu W, Li B, Chen D, Hu F, Wang L, Liu X, Cui R and Liu R*. MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer. Oncogene, 2019 Feb 26.doi: 10.1038/s41388-019-0760-3. [Epub ahead of print]. (*Corresponding Author).