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Faculty Detail    
Professor of Medicine, Division of Nephrology;
Executive Vice Dean, UAB School of Medicine
Campus Address ZRB 629
Phone  (205) 996-6680
Other websites Physician Profile
O'Brien Center

ABIM Internal medicine  2007 
ABIM Interrnal Medicine - Nephrology  2008 

Faculty Appointment(s)
Appointment Type Department Division Rank
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cardiovascular Ctr  Comprehensive Cardiovascular Ctr Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor
Primary  Medicine  Med - Nephrology Professor
Secondary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Associate Professor
Secondary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Molecular Genetics Program 
Biochemistry and Structural Biology 
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Hughes Med-Grad Fellowship Program 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Agarwal graduated with honors from Kasturba Medical College in India. He completed his residency at the Postgraduate Institute of Medical Education and Research in India, where he also completed a nephrology fellowship. Dr. Agarwal was a nephrology fellow at the University of Minnesota Hospital and Clinic in Minneapolis. He then joined the Division of Nephrology, Hypertension, and Transplantation at the University of Florida in Gainesville as an assistant professor and was promoted to tenured associate professor. He was promoted to the rank of Professor at UAB in October 2005 and was named the Thomas E. Andreoli Professor of Nephrology in September 2006. He was appointed Division Director for Nephrology at UAB in January 2008 and served in this role through September 2021. He has also served as Vice Chair for Research for the UAB Department of Medicine from 2009-2014. He was appointed to the Marie S. Ingalls Endowed Chair in Nephrology Leadership in April 2011 and served as Interim Chairman for the UAB Department of Medicine (August 1, 2011-August 31, 2012). Dr. Agarwal also served as the Interim Senior Vice President and Dean, UAB School of Medicine from Feb 2013-Oct 2013. He is currently the Hilda Anderson Endowed Chair in Nephrology and Executive Vice Dean for the UAB Heersink School of Medicine.

Society Memberships
Organization Name Position Held Org Link
Association of American Physicians     
Southern Society for Clinical Investigation     
American Physiological Society     
Society for Free Radical Biology     
International Society of Nephrology     
National Kidney Foundation     
American Clinical and Climatological Association     
American Society for Clinical Investigation     
American Society of Nephrology  Councilor   

Research/Clinical Interest
Regulation of heme oxygenase gene expression in kidney and vascular injury
Dr. Agarwal's principal interests in clinical nephrology include acute kidney injury, specifically in the intensive care unit setting, toxic nephropathies, fluid and electrolyte disorders, glomerular disorders, progression of renal disease, and diabetic nephropathy. His long term goals are to pursue a career in academic nephrology with the primary focus being on basic research, teaching and patient care. His goal is to apply knowledge gained from bench research to the bedside, enabling research to be a significant contributor to advancement in clinical medicine. Dr. Agarwal’s research program has provided critical insights regarding the protective nature and significance of heme oxygenase-1 (HO-1) in acute kidney injury (AKI), and the molecular regulation of the human HO-1 gene. His research efforts include three main areas. (i) His laboratory is studying the molecular regulation of the human HO-1 gene in renal and vascular injury. Induction of this gene occurs as an adaptive and beneficial response to injury and is protective in several clinically important conditions such as acute kidney injury, transplant rejection and atherosclerosis. Studies have identified key regulatory regions in the human HO-1 gene that mediate induction in response to stimuli such as heme, cytokines, nitric oxide and growth factors. (ii) The functional significance of HO-1 gene expression is also being evaluated in animal models of acute kidney injury and chronic kidney disease following cutaneous exposure to arsenicals using knockout and cell specific HO-1 expression (e.g. proximal tubules, myeloid cells). (iii) His laboratory is also exploring the role of lymphangiogenesis in the pathogenesis of AKI and AKI to CKD.

Selected Publications 
Publication PUBMEDID
Cui T, Schopfer FJ, Zhang J, Chen K, Ichikawa T, Baker PR, Batthyany C, Chacko BK, Feng X, Patel RP, Agarwal A, Freeman BA, Chen YE. Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. J Biol Chem. 2006 Nov 24;281(47):35686-98.  17339405 
Hock TD, Liby K, Wright MM, McConnell S, Schorpp-Kistner M, Ryan TM, Agarwal A. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem. 2007 Mar 2;282(9):6875-86.   17204476 
Kirkby K, Baylis C, Agarwal A, Croker B, Archer L, Adin C. Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo. Am J Physiol Renal Physiol. 2007 Feb;292(2):F888-94.   17032942 
Sikorski EM, Uo T, Morrison RS, Agarwal A.Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cells. 1: J Biol Chem. 2006:281(34):24423-30.  16816389 
Wright MM, Schopfer FJ, Baker PR, Vidyasagar V, Powell P, Chumley P, Iles KE, Freeman BA, Agarwal A. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4299-304.  16537525 
Hill-Kapturczak N, Agarwal A. Carbon monoxide: from silent killer to potential remedy. Am J Physiol Renal Physiol. 2006;290:F787-8.  16527924  
Chen S, Wasserfall C, Kapturczak MH, Atkinson M, Agarwal A. Freeze-thaw increases adeno-associated virus transduction of cells. Am J Physiol Cell Physiol. 2006:291(2):C386-92.   16510845 
Zhou H, Liu H, Porvasnik SL, Terada N, Agarwal A, Cheng Y, Visner GA. Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension. Lab Invest. 2006;86:62-71.  16357868 
Basireddy M, Isbell TS, Teng X, Patel RP, Agarwal A. Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney. Am J Physiol Renal Physiol. 2006;290:F779-86.  16278276 
Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ. IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol. 2005;16:3651-60.  16251240 
Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005;65:4789-98.  15930299 
Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Hauswirth WW, Madsen KM, Croker BP, Berns, KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin-10 attenuates neointimal proliferation and inflammation in aortic allografts via a heme oxygenase dependent pathway. Proceedings of The National Academy of Sciences, USA 2005;102:7251-7256.   15878989 
Brusko TM, Wasserfall CH, Agarwal A, Kapturczak MH, Atkinson MA. An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells. J Immunol. 2005;174:5181-6.
Chen S, Kapturczak MH, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human Gene Therapy 2005;16:235-247.  15761263 
Adin CA, Croker BP, Agarwal A. Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated perfused rat kidney. American Journal of Physiology, Renal Physiology 2005;288:F778-F784.  15561977 
Kapturczak MH, Wasserfall C, Brusko T, Campbell-Thompson M, Ellis TM, Atkinson MA, Agarwal A. Heme Oxygenase-1 Modulates Early Inflammatory Responses: Evidence from the Heme Oxygenase-1 Deficient Mouse. American Journal of Pathology 2004;165:1045-1053.  15331427 
Chen S, Segal MS, Agarwal A. “Lumen digestion” technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice. Biotechniques 2004;37:84-89.  15283205 
Hock TD, Nick HS, Agarwal A. Upstream stimulatory factors, USF1 and USF2 bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription. Biochemical Journal 2004;383:209-218.  15242350 
Sikorski EM, Hock TD, Hill-Kapturczak N, Agarwal A. The story so far…..Molecular regulation of the heme oxygenase-1 gene in renal injury. Invited review. American Journal of Physiology (Renal). 2004;286:F425-F441.  14761930 
Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human MnSOD: Evolutionary conservation of product inhibition. Journal of Biological Chemistry 2004;279:12769-12776.  14688256 
Zhou X, Yang G, Davis CA, Doi SQ, Hirszel P, Wingo CS, Agarwal A. Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells. Kidney International 2004;65:139-147.  14675044 

heme oxygenase, acute kidney injury, transplant nephrology, lymphangiogenesis