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Faculty Detail    
Campus Address LHRB 621 Zip 0006
Phone  (205) 975-2021
Other websites Physician Profile

Medical School  National Defense Medical College    1998  MD 

ECFMG  2004 
American Board of Internal Medicine  2009 
American Board of Internal Medicine-Nephrology  2012 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Associate Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Associate Professor

Biographical Sketch 
Dr. Takamitsu Saigusa earned his Medical Degree from the National Defense Medical College (NDMC) in Japan. He subsequently completed his Medical residency and Nephrology fellowship at the NDMC hospital. After serving his obligation years as a medical officer for the Japanese Self Defense Force, he moved to the US in 2006 for further medical training where he completed his Medical residency at the Long Island College Hospital in Brooklyn NY in 2009. He then moved to the Medical University of South Carolina (MUSC) for T32 a Nephrology fellowship under the tutelage of his mentor Dr. P. Darwin Bell to study fluid transport in collecting duct cells from a cystic kidney disease model with abnormal primary cilia. He joined the Division of Nephrology at MUSC as an Assistant Professor in 2012. He has presented at various regional forums and National conferences which he received multiple honors and awards including a prestigious Renal Section Research Recognition Award from the American Physiological Society. In 2015, he was awarded a NIH K08 grant from the NIDDK to study the mechanism for hypertension in polycystic kidney disease. He joined the Division of Nephrology at the University of Alabama at Birmingham in 7/2016.

Society Memberships
Organization Name Position Held Org Link
American Physiological Society  Member   
American Society of Nephrology  Member   

Research/Clinical Interest
Renal Mechanism for Hypertension in PKD
His research focuses in polycystic kidney disease (PKD), supported by NIH grant titled "Renal mechanism for hypertension in PKD". His current work includes testing antisense oligonucleotides that suppress renin angiotensin components in autosomal dominant PKD (Pkd1 mice) and autosomal recessive PKD mouse model (cilia: Ift88 mice). These drug may better suppress intrarenal RAS compared to currently available RAS inhibitors and has a potential to be a therapy for PKD. His research also focuses on why certain PKD patients rapidly develop kidney cyst faster than others by studying an accelerated kidney cystic mouse model. One modifying factor that accelerates cyst growth in PKD mice is renal hypertrophy triggered by protein load or unilateral nephrectomy. His lab is currently studying how concomitant renal hypertrophic signaling in PKD kidneys accelerates cystogenesis by investigating kidney immune cells which is activated during renal hypertrophy. His clinical interests includes polycystic kidney disease, tuberous sclerosis complex, chronic kidney disease and hypertension.

Selected Publications 
Publication PUBMEDID   

Polycystic Kidney Disease, Tuberous Sclerosis complex, Hypertension, Chronic Kidney Disease