UASOM Faculty Profiles

Faculty Detail


Name	UPENDER MANNE Director, Translational Anatomic Pathology Co-Director, UAB Tissue Bioreposity
Campus Address	SHEL 811
Phone	(205) 934-4276
E-mail	upendermanne@uabmc.edu
Other websites	Google Scholar Research Gate

Faculty Appointment(s)

Appointment Type Department Division Rank

Primary Clinical Pathology Anatomic Pathology Professor

Secondary Epidemiology Epidemiology Professor

Secondary Surgery - General Surgery Surgery - Gen Surg Gastrointestinal Section Professor

Center Comprehensive Cancer Center Comprehensive Cancer Center Professor

Center Minority Health & Research Center Minority Health & Research Center Professor

Center Nutrition Sciences Research Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations

Cancer Biology

Integrative Biomedical Sciences

Medical Scientist Training Program

Molecular and Cellular Pathology Program

Pathobiology and Molecular Medicine

Biographical Sketch

Dr. Manne earned his M.S. in Biochemistry, Histochemistry, Parasitology, and Zoonosis, as well as his Ph.D. in energy metabolic pathways of an endoparasite from Osmania University, Hyderabad, India. His postdoctoral training included molecular immunology and vaccine development for malaria at the Malaria Research Center in Delhi, India; research on Helicobacter infections and mucosal immunology in the Department of Microbiology, at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia; and extensive work in histopathology, tissue sciences, molecular tumor biology, cancer biomarker development, experimental therapeutics, computational biology, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). Additionally, he earned certification in bioinformatics at UAB.

Dr. Manne’s research on demographic differences in colorectal and breast cancers and population-based biomarker development has received significant national and international recognition. In 2009, as part of the President’s Cancer Panel, he focused on ‘Biologic Differences Among Ancestry Groups and Their Clinical Implications in Cancer Care,’ contributing to the 2010 President’s Report titled ‘America’s Demographic and Cultural Transformation: Implications for the Cancer Enterprise.’ For over two decades, he serves as the Principal Investigator of a Comprehensive Cancer Research Partnership (U54) between the UAB O’Neal Comprehensive Cancer Center, Tuskegee University (Tuskegee, AL), and Morehouse School of Medicine (Atlanta, GA). In recent years, he also led a partnership (P20) with Alabama State University (Montgomery, AL) to reduce cancer burden through innovative, multidisciplinary, collaborative, population-based cancer control and prevention research. These programs, funded by the National Cancer Institute (NCI) of the National Institutes of Health (NIH), have contributed significantly to education, training, and community outreach.

Society Memberships

Organization Name Position Held Org Link

American Association for Cancer Research Active member

American Society of Clinical Oncology Active member

Research/Clinical Interest

Title
Translational research in grastrointestinal malignancies and breast cancer
Description
Dr. Manne’s current research focuses on population-based translational studies in human malignancies, with an emphasis on gastrointestinal (GI) cancers, including colorectal, pancreatic, and liver cancers, as well as breast cancer. His laboratory, funded by the NCI and the Susan G. Komen Foundation, investigates molecular markers to identify molecular targets, aggressive tumor phenotypes, predict chemotherapy efficacy, and assess clinical outcomes. His collaborative research group comprises experts in molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. His studies have demonstrated that the clinical utility of molecular biomarkers varies based on tumor location, stage, ancestry, age, and gender (male and female). To validate these findings, his lab evaluates hundreds of GI cancer samples from African American and non-Hispanic Caucasian patients collected from multiple institutions. By integrating molecular markers with epidemiological, environmental, and socio-economic data, his team aims to understand region-specific and ancestry-based differences in cancer biology. These biomarker discovery and bioinformatics approaches will aid in developing predictive models for personalized patient care. Dr. Manne’s research interests also extend to genomics, proteomics, and computational biology for the identification of early-stage cancer biomarkers. Specifically, his work focuses on identifying molecular signatures in benign colonic epithelium at risk of developing colorectal neoplasms, as well as pre-malignant lesions in various cancers. These studies will contribute to the evaluation of molecular and pathological characteristics of cancer specimens and aid in the development of assays for early detection, diagnosis, prognosis, and treatment.

Selected Publications

Manne U, Weiss HL, Myers RB, Danner OK, Moron C, Srivastava S, Grizzle WE. Nuclear accumulation of p53 in colorectal adenocarcinoma: prognostic significance differs with race and location of the tumor. CANCER, 1998; 83(12): 2456-67. 9874449

Manne U, Myers RB, Moron C, Poczatek RB, Dillard S, Weiss HL, Brown D, Srivastava S, Grizzle WE. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. INT. J. CANCER, 1997;74(3): 346-58. 9221816

Manne U, Myers RB, Srivastava S, Grizzle WE. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. J. NATL. CANCER. INST., 1997; 89(8): 585-6. 9106651

Matthews KS, Estes JM, Conner MG, Manne U, Whitworth JM, Huh WK, Alvarez RD, Straughn JM Jr, Barnes MN, Rocconi RP.Lynch syndrome in women less than 50 years of age with endometrial cancer. Obstet Gynecol. 2008 May;111(5):1161-6. 8448750

Doidge C, Crust I, Lee A, Buck F, Hazell S, Manne U: Therapeutic immunisation against helicobacter infection. LANCET,1994; 343 (8902):914-5. 7908372

Katkoori VR, Basson MD, Bond VC, Manne U, Bumpers HL.Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers.Oncotarget. 2015;6(29):27763-77. 6318034

Karthikeyan SK, Xu N, Ferguson Rd JE, Rais-Bahrami S, Qin ZS, Manne U, Netto GJ, S Chandrashekar D, Varambally S. Identification of androgen response-related lncRNAs in prostate cancer. Prostate. 2023 May;83(6):590-601. 3676020

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Keywords

Colorectal Cancer, GI malignancies, Breast Cancer, Molecular Biomarkers, Ancestry Differences, Population-based Studies, ancer Control & Prevention