Faculty Detail    Name SILVIO HECTOR LITOVSKY Professor   Campus Address HSB 175G Zip 6823 Phone  (205) 996-5410 E-mail  slitovsky@uabmc.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Clinical Pathology  Anatomic Pathology Professor Center  Comprehensive Cardiovascular Ctr  Comprehensive Cardiovascular Ctr Professor Center  Minority Health & Research Center  Minority Health & Research Center Professor Center  Nephrology Research & Training Center  Nephrology Research & Training Center Professor

Graduate Biomedical Sciences Affiliations Molecular and Cellular Pathology Program

Society Memberships Organization Name Position Held Org Link Society of Cardiovascular Pathology, United States and Canadian Academy of Pathology, Cardiac Electrophysiologic Society, College of American Pathologists

Selected Publications  Allon M, Litovsky SH, Tey JCS, Sundberg CA, Zhang Y, Chen Z, Fang Y, Cheung AK, Shiu YT: Abnormalities of vascular histology and collagen fiber orientation in patients with advanced chronic kidney disease. J Vasc Access 2018 May1:1129729   29742957  Norwood TG, Westbrook BC, Johnson DB, Litovsky SH, Terry NL, McKee SB, Gertler AS, Moslehi JJ, Conry RM: Smoldering myocarditis following immune checkpoint blockade. J Immunother Cancer 2017;21:5(1):91   29157297  Yamada T, Yoshida N, Itoh T, Litovsky SH, Doppalapudi H, McElderry HT, Kay GN: Idiopathic ventricular arrhythmias originating from the parietal band: Electrocardiographic and electrophysiological characteristics and outcome of catheter ablation. Circ Arrhythm Electrophysiol 2017;10(8):e005099   28794085  McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME: Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. J Mol Cell Cardiol 2017;110:80-95   28736261  Yamada T, Yoshida N, Doppalapudi H, Litovsky SH, McElderry HT, Kay GN: Efficacy of an anatomical approach in radiofrequency catheter ablation of idiopathic ventricular arrhythmias originating from the left ventricular outflow tract. Circ Arrhythm Electrophysiol. 2017;10:e004959   28500177  Giordano S, Zhao X, Chen YF, Litovsky SH, Hage F, Townes TM, Sun CW, Wu LC, Oparil S, Xing D. Induced pluripotent stem cell-derived endothelial cells overexpressing interleukin-8 receptors A/B and/or C-C chemokine receptors 2/5 inhibit vascular injury response. Stem Cells Trans Med 2017;6:1168-77   28233474  Yamada T, Doppalapudi H, Litovsky SH, McElderry HT, Kay GN: Challenging radiofrequency catheter ablation of idiopathic ventricular arrhythmias oroginatin from the left ventricular summit near the left main coronary artery. Circ Arrhythm Electrophysiol 2016; 9(10) pii: e004202   27729345  Shiu YT, Litovsky SH, Cheung AK, Pike DB, Tey JC, Zhang Y, Young CJ, Robbin M, Hoyt K, Allon M: Preoperative vascular medial fibrosis and arteriovenous fistula development. Clin J Am Soc Nephrol 2016;11:1615-23   27577243  Ahmed MI, Guichard JL, Rajasekaran NS, ... Litovsky S, .... McGiffin DC, Dell’Italia LJ: Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function. J Thorac Cardiovasc Surg 2016; 152:1059-70   27464577  Patibandla PK, Rajasekaran NS, Shelar SB, Giridharan GA, Litovsky SH, Sethu P: Evaluation of the effect of diminishid pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function. J Heart Lung Transplant. 2016;35:930-2   27138701  Halushka MK, Angelini A, Bartolini G,.....Litovsky SH,............., Thiene G, Veinot JP, van der Wal AC,: Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology. II. Noninflammatory degenerative diseases-nomenclature and diagnostic critera. Cardiovasc. Pathol. 2016;25:247-57  27031798  Shelar SB, Narashimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS: Disruption of nuclear factor (erythroid-derived-2)- like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle. FASEB J. 2016 [Epub ahead of print]   26839378  Stone JR, Bruneval P, Angelini A, .....Litovsky SH,............., van der Wal AC, Veinot JP: Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology. I. Inflammatory diseases. Cardiovascular Pathol. 2015;24:267-78  26051917  Allon M, Robbin ML, Umphrey HR, Young CJ, Deierhoi MH, Goodman J, Hanaway M, Lockhart ME, Barker-Finkel J, Litovsky S: Preoperative Arterial Microcalcification and Clinical Outcomes of Arteriovenous Fistulas for Hemodialysis. Am J Kidney Dis. 2015 Feb 18. pii: S0272-6386(15)00021-9. doi: 10.1053/j.ajkd.2014.12.015   25700554  Litovsky SH, Kelly DR, Law MA, Dabal RJ, Daniel RL, Cleveland DS, Pearce FB: Shone variant with large eustachian valve: implication for repair and heart transplantation.. Cardiovasc Pathol. 2015 Mar-Apr;24(2):124-7. doi: 10.1016/j.carpath.2014.10.002. Epub 2014 Oct 16   25455258  Liu J, Wang P, Zou L, Qu J, Litovsky S, Umeda P, Zhou L, Chatham J, Marsh SA, Dell'Italia LJ, Lloyd SG: High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats. . Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H598-608. doi: 10.1152/ajpheart.00058.2014. Epub 2014 Jun 13.   24929857  Ren Z, Litovsky S, Eckhoff DE, DuBay DA:Hemorrhagic shock one month following uncomplicated liver transplantation. Am J Transplant. 2014 Jun;14(6):1461-3. doi: 10.1111/ajt.12551   24854025   Zheng J, Wei CC, Hase N, Shi K, Killingsworth CR, Litovsky SH, Powell PC, Kobayashi T, Ferrario CM, Rab A, Aban I, Collawn JF, Dell'Italia LJ: Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog. PLoS One. 2014 Apr 14;9(4):e94732. doi: 10.1371/journal.pone.0094732. eCollection 2014.   24733352  Collins He, He L, Zou L, Litovsky SH, Yang Q, Young ME, Marchase RB, Chatham JC: Stromal Interaction Molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Am J Physiol Heart Circ Physiol 2014 Feb 28 [Epub ahead of print]  24585777  Heath JM, Sun Y, Yuan K, Bradley WE, Litovsky SH, Dell'italia LJ, Chatham JC, Wu H, Chen Y: Activation of AKT by O-Linked N-Acetylglucosamine induces vascular calcification in diabetes mellitus. Circ Res. 2014;114:1094-102.  24526702  Yeager D, Chen YS, Litovsky SH, Emelianov S: Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: afeasible study. Theranostic. 2013:4:36-46.  24396514  Feng W, Chumley P, Allon M, George J, Scott DW, Patel RP, Litovsky SH, Jaimes EA: The transcription factor e26 transformation-specific sequence-1 mediates neointima formation in arteriovenous fistula. J Am Soc Nephrol. 2014:25:475-87  24203999  Yamada T, Lau YR, Litovsky SH, Thomas McElderry H, Doppalapudi H, Osorio J, Plumb VJ, Neal Kay G: Prevalence and clinical, electrocardiographic, and electrophysiologic characteristics Ventricular arrhythmias orgination from the noncoronary sinus of Valsalva. Heart Rhythm. 2013:10:1605-12  23969069  Allon M, Robbin ML, Young CJ, Deierhoi MH, Goodman J, Hanaway M, Lockhart ME, Litovsky S:Preoperative venous intimal hyperplasia, postoperative arteriovenous sistula stenosis, and clinical fistulas outcomes. Clin J Am Soc Nephrol.2013;8:1750-5   23813559  Sharifov OF, Nayyar G, Ternovoy VV, Mishra VK, Litovsky SH, Palgunachari MN, Garber DW, Anantharamaiah GM, Gupa H: Cationic peptide mR 18L with lipid lowering properties inhibits LPS-induced systemic and liver inflammation in rats. Biochem Biophys Res Commun. 2013;436:705-10.  23791744  Allon M, Litovsky S, Young CJ, Deierhoi MH, Goodman J, Hanaway M, Lockhart ME, Robbin ML: Pre-existing vascular pathology correlation with arteriovenous graft outcomes in hemodialysis patient. Am J Kidney Dis 2013;62:1122-9  23746379  Hull TD, Bolisetty S, deAlmeida AC, Litovsky SH, Prabhu SD, Agarwal A, George JF: Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase. Lab Invest. 2013:93:868-79.  23732814  Killingsworth CR, Melnik SB, Litovsky SH, Ideker RE, Walcott GP: Evaluation of acute cardiac and chest wall damage after shocks with a subcutaneous implantable cardioverter-defibrillator in swine. Pacing Clin Electrophysiol.2013:36:1265-72   23713608  Scott DW, Dunn TS, Ballestas ME, Kitovsky SH, Patel RP:Identification of a high-mannose 1-CAM glycoform. effects of 1CAM-1 hypoglycosylation on monocyte adhesion and outside in signaling. Am J Physiol. 2013;305:C228-37  23703526  Sharifov OF, Xu X, Gaggar A, grizzle WE, Mishra VK, Honavar J, Litovsky SH, Palgunachari MN, White Cr, Anantharamaiah GM, Gupta H:Anti-inflammatory mechanisms of apolipoprotein A-1 mimetic peptide in acute respiratory distress syndrome secondary to sepsis. PloS One 2013:8:e64486.  23691230  Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MK:Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford)2013;52:1529-33.  23674817  Alston EA, Brotta BC, Misra VK, Athanasuleas CL, Anderson PG, Litovsky SH: Histologic analysis of a covered stent implanted for pseudoaneurysm in a coronary artery. Cardiovasc Pathol 2013;22:e19-21   23478012  Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R, Emelianov S: Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood. Opt Lett 2012;37:1244-6  23069134  Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R, Emelianov S: In vivo intravascular ultrasound-guided photoacoustic imaging of lipid in plaques using an animal model of atherosclerosis. Ultrasound Med Biol 2012;38:2098-103  23069134  Admaski J, Hanna C, Reddy V, Litovsky SH, Evans C, Marques M: Multiorgan failure and bone marrow necrosis in three adults with Sickle cell-β+-Thalassemia. Am J Hematol 2012;87:621-4  22374850  Gladden JD, Ahmed MI, Litovsky SH, Schiros CG, Lloyd SG, Gupta H, Denney TS jr., Darley-Usmar V, McGiffin DC, Dell’Italia LJ: Oxidative stress and myocardial remodeling in chronic mitral regurgitation. Am J Med Sci 2011;342:114-9   21795957  Allon M, Litovsky SH, Young CJ, Deierhoi MH, Goodman J, Hanaway M, Lockhart ME, Robbin ML: Medial fibrosis, vascular calcification, intimal hyperplasia, and arteriovenous fistula maturation. Am J Kidney Dis. 2011;58:437-43  21719173  Kirschner R, Toth L, Varga-Szemes A, Simor T, Suranyi, Kiss P, Ruzsics, Toth A, Baker R, Brott BC, Litovsky SH, Elgavish A, Elgavish GA: Differentiation of acute and four-week old myocardial infarct with Gd(ABE-DTTA)-enhanced CMR. J Cardiovasc Magn Reson 2010;7:12-22   21546192  Kirschner R, Vargas-Szemes A, Brott BC, Litovsky S, Elgavish A, Elgavish GA, Simor T:Quantification of myocardial viabitlity distribution with Gd(DTPA) bolus-enhanced, signal intensity-based percent infarct mapping. Magn Reson Imaging. 2011;29:650-8  21546192  Pearce FB, Litovsky SH, Dabal RJ, Robin N, Dure LJ, George JF, Kirklin JK. Pathologic features of dilated cardiomyopathy with localized noncompaction in a child with deletion 1p36 syndrome. Congenit Heart Dis. 2012;7:59-61  21492410  Yamada T, Doppalapudi H, McElderry HT, Okada T, Murakami Y, Inden Y, Yoshida Y, Yoshida N,Murohara T, Epstein AE, Plumb VJ, Litovsky SH, Kay GN: Electrocardiographic and electrophysiological characteristics in idiopathic ventricular arrhythmias originating from the papillary muscles in the left ventricle: relevance for catheter ablation. Circ Arrhythm Electrophysiol. 2010;3:324-31   20558848  Wang B, Su JL, Amirian J, Litovsky SH, Smalling R, Emelianov S: Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging. Optic Express 2010;18:4889-97   20389501  Ahmed MI, Gladden JD, Litovsky SH, Lloyd SG, Gupta H, Inusah S, Denney T, Powell P, McGiffin DC, Dell’Italia LJ: Increased oxidative stress and myofibrillar degeneration in patients with chronic isolated chronic mitral regurgitation and ejection fraction >60%. J Am Coll Cardiol 2010;55:671-9  20170794  Desai RV, Gupta R, Litovsky SH, Nath H, Gupta H, Singh SP, Evanochko WT, Knobloch JE, Lloyd SG. X-ray angiography and magnetic resonance imaging to distinguish interarterial from septal courses of anomalous left coronary artery: an ex vivo heart model. J. Invasive Cardiol. 2009;21:648-52   19966369  Wang B, Su J, Amirian J, Litovsky SH, Smalling R, Emelianov S: On the possibility to detect lipid in atherosclerotic plaqes using intravascular photacoustic imaging. Conf Proc IEEE Eng Med Biol Soc 2009;1:4767-70   19964847  Yamada T, Litovsky SH, Kay GN: The left ventricular ostium: An anatomic concept relevant to idiopathic ventricular arrhythmias. Circ Arrhythmia Electrophysiol 2008;1:396-404,   19808434  Haidari M, Wyde PR, Litovsky SH, Vela D, Ali M, Casscells SW, Madjid M. Influenza virus directly infects, inflmes and resides in the arteries of atherosclerotic and normal mice. Atherosclerosis 2010;208:90-6   19665123  Sethuraman S, Amirian JH, Litovsky SH, Smalling RW, Emelianov SY. Ex vivo characterization of atherosclerosis using intravascular photoacoustic imaging. Opt Express 2007;15:16657-66   19550952  Knight CS, Tallaj JA, Rayburn BK, Pamboukian SV, Bourge R, Kirklin JK, McGiffin D, Litovsky SH: Bradycadia and syncope as a presentation of cardiac allograft rjection involving the conduction system. Cardiovas Pathol 2010;19:117-20   19144548  Ruzsics B, Suranyi P, Kiss P, Brott BC, Singh SS, Litovsky SH, Aban I, Lloyd SG, Simor T, Elgavish GA, Gupta H: Automated multidetector computed tomography evaluation of subacutely infarcted myocardium. 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