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Faculty Detail    
Name GLENN C ROWE
Assistant Professor
 
Campus Address MCLM 280 Zip 0005
Phone  (20-5) -100
E-mail  gcrowe@uab.edu
Other websites Complete List of Published Work
Research Lab Website
     

Education
Undergraduate  Brandeis University, Waltham MA    2001  BS Biology 
Graduate  Yale University, New Haven CT    2003  MS Molecular Biology 
Graduate  Yale University, New Haven CT    2007  PhD Molecular Biology 
Graduate  Harvard Medical School, Boston MA    2012  Post-Doc Cardiovascular 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Assistant Professor
Secondary  Biomedical Engineering  Biomedical Engineering Assistant Professor
Secondary  Medicine  Med - Endocrinology, Diabetes & Metabolism Assistant Professor
Center  Comprehensive Cardiovascular Ctr  Comprehensive Cardiovascular Ctr Assistant Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Assistant Professor
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Assistant Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Assistant Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Glenn C. Rowe received his B.S. in Biology from Brandeis University (2001) and his Ph.D. in Molecular, Cellular and Developmental Biology from Yale University (2007) where he studied the transcriptional regulation of factors that control bone and adipose tissue homeostasis. He completed his post-doctoral training at the Beth Israel Deaconess Medical Center, where his work focused on the role of transcriptional coactivators in regulating mitochondrial metabolism. He joined the University of Alabama at Birmingham faculty in 2014 where he is currently Assistant Professor of Medicine in the Division of Cardiovascular Disease. His research interest focuses on understanding the cellular and molecular mechanisms underlying metabolism in the cardiovascular and musculoskeletal system. Dr. Rowe has a K01 Career Development award through the NIH-NIAMS, and is also a recent recipient of the UAB Pittman Scholar Award (2016).

Society Memberships
Organization Name Position Held Org Link
2012- Member, American Heart Association     
2013- Early Career Member, The Endocrine Society     
2016- Member, American Diabetes Association     
2016- Member, American Physiological Society     



Research/Clinical Interest
Title
Exercise-Induced Metabolic Adaptations in Striated Muscle
Description
The research interest of the Rowe laboratory focuses on understanding the molecular pathways that influence mitochondrial metabolism in response to diet and exercise, in order to improve mitochondrial function and reduce the deleterious effects of the metabolic syndrome. Specifically, the lab studies the PGC-1 family of transcriptional coactivators and the molecular pathways they regulate in striated muscle to maintain normal mitochondrial function (including biogenesis, oxidative capacity and dynamics) and normal metabolic function. The laboratory utilizes a variety of molecular techniques, cell-based assays as well as genetically modified mouse models to understand the molecular mechanisms that control mitochondrial function. Projects in the lab revolve around the following areas 1.) the study of mitochondrial dynamics in response to exercise, 2.) the effect of exercise on angiogenesis and mitochondrial metabolism, 3.) the characterization of new regulators of mitochondrial metabolism in striated muscle and 4.) contribution of mitochondrial function to whole body energy homeostasis.

Selected Publications 
Publication PUBMEDID
Adult Expression of PGC-1alpha and beta in Skeletal Muscle is Not Required for Endurance Exercise-Induced Enhancement of Exercise Capacity. Ballmann C, Tang Y, Bush Z, Rowe GC. Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E928-E938.  27780821 
The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila. Mendez S, Watanabe L, Hill R, Owens M, Moraczewski J, Rowe GC, Riddle NC, Reed LK. PLoS One. 2016 Oct 13;11(10):e0164706.  27736996 
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. Nat Med. 2016 Apr;22(4):421-6.  26950361 
Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice. Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, Rowe GC, Arany Z, Prolla TA, Tarnopolsky MA. Skelet Muscle. 2016 Jan 31;6:7.  26834962 
PGC-1alpha induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z. Circ Res. 2014 Aug 15;115(5):504-17.  25009290  
Running forward: new frontiers in endurance exercise biology. Rowe GC, Safdar A, Arany Z. Circulation. 2014 Feb 18;129(7):798-810.  24550551 
Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor gamma; coactivator (PGC)-alpha. Thom R, Rowe GC, Jang C, Safdar A, Arany Z. J Biol Chem. 2014 Mar 28;289(13):8810-7.  24505137 
Post-natal induction of PGC-1alpha protects against severe muscle dystrophy independently of utrophin. Chan MC, Rowe GC, Raghuram S, Patten IS, Farrell C, Arany Z. Skelet Muscle. 2014 Jan 22;4(1):2. doi: 10.1186/2044-5040-4-2.  24447845 
Genetic models of PGC-1 and glucose metabolism and homeostasis. Rowe GC, Arany Z. Rev Endocr Metab Disord. 2014 Mar;15(1):21-9.  24057597 
Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Cell Rep. 2013 May 30;3(5):1449-56.  23707060 
PGC-1alpha is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle. Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. PLoS One. 2012;7(7):e41817.  22848618 
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Nature. 2012 May 9;485(7398):333-8.  22596155 
Skeletal muscle transcriptional coactivator PGC-1alpha; mediates mitochondrial, but not metabolic, changes during calorie restriction. Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2931-6.  22308395 
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA. Nature. 2011 Oct 5;478(7367):114-8.  21979051 
PGC-1beta regulates angiogenesis in skeletal muscle. Rowe GC, Jang C, Patten IS, Arany Z. Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E155-63.  21364124 
Metabolic signatures of exercise in human plasma. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Sci Transl Med. 2010 May 26;2(33):33ra37.  20505214 
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21401-6.  19966219 

Keywords
striated muscle, mitochondria, transcriptional regulation, metabolism, exercise