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Faculty Detail    
Name UPENDER MANNE
Director, Translational Anatomic Pathology
Co-Director, UAB Tissue Bioreposity
 
Campus Address WTI 420A Zip 3300
Phone  (205) 934-4276
E-mail  upendermanne@uabmc.edu
Other websites Google Scholar
Research Gate
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Secondary  Surgery   Surgery - Gen Surg Gastrointestinal Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Minority Health & Research Center Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Manne obtained his M.S. (Biochemistry, Histochemistry, Parasitology, Zoonosis) and Ph.D. (energy metabolic pathways of endoparasites) degrees from Osmania University, Hyderabad, India. His postdoctoral training was in molecular immunology and vaccine development for malaria (Malaria Research Center, Delhi, India); in helicobacter infections (School of Microbiology, University of New South Wales, Sydney, Australia); and in histopathology, molecular tumor biology, cancer biomarker development, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). He also received certification in bioinformatics at UAB. Dr. Manne’s research on racial disparity in colorectal and breast cancers has received considerable national and international recognition. In 2009, as part of the Presidents Cancer Panel, Dr. Manne focused on “Biologic differences between ethnic groups and their clinical implications in cancer care,” and devoted to the topic, “America’s demographic and cultural transformation: implications for the cancer enterprise.” Currently, he is the Principal Investigator of two Comprehensive Cancer Research Partnership between UAB Comprehensive Cancer Center and Tuskegee University, Tuskegee, AL and Morehouse School of Medicine, Atlanta, GA (U54); and Alabama State University, Montgomery, AL (P20) to Reduce Cancer Health Disparities by implementing innovative, multi-disciplinary, collaborative, population-based cancer control and prevention research and has contributed to education, training, and community outreach activities. These two programs are funded by the National Cancer Institute of the National Institute of Health.

Society Memberships
Organization Name Position Held Org Link
American Society of Clinical Oncology  Active member   
American Association for Cancer Research  Active member   



Research/Clinical Interest
Title
Translational research in grastrointestinal malignancies and breast cancer
Description
Dr. Manne’s present efforts are focused on population-based translational research for human neoplasias, with emphasis on colorectal and breast cancers. His laboratory, with projects funded by the National Cancer Institute and the Susan G. Komen Foundation, is evaluating molecular markers to identify aggressive phenotypic features of tumors to predict the efficacy of chemotherapeutic regimens and to assess clinical outcomes. Dr. Manne’s research and collaborative groups include experts in the fields of molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. For evaluating the clinical utility of genetic and phenotypic abnormalities in colorectal cancer, his group has developed strategies demonstrating that the utility of molecular biomarkers varies according to the anatomic location of tumors within the colorectum and with tumor stage, race/ethnicity, age, and gender. To validate the clinical utility of genetic and phenotypic markers, Dr. Manne’s laboratory is evaluating hundreds of colorectal cancer samples derived from African American and non-Hispanic Caucasian ethnic/racial backgrounds and collected from different institutions. Established molecular markers with be merged with other epidemiological, environmental, and socio-economic features to find the basis for racial disparities in colorectal and breast malignancies. Results from approaches involving biomarker discovery and bioinformatics will aid in developing predictive models specific for individual patients. The research interests of Dr. Manne also include use of genomics and proteomics for identification of early markers of cancers, specifically, identification of molecular signatures of benign colonic epithelium, which is at risk of developing colorectal neoplasias, and of other pre-malignant lesions. These studies will aid in the evaluation of molecular and pathologic characteristics of specimens and in the development of assays that relate to early detection, diagnosis, prognosis, and treatment of cancers.

Selected Publications 
Publication PUBMEDID
Katkoori VR, Jia X, Shanmugam C, Wan W, Meleth S, Bumpers H, Grizzle WE, Manne U.Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma.Clin Cancer Res. 2009;15(7):2406-16.  19339276 
Meleth S, Chatla C, Katkoori VR, Anderson B, Hardin JM, Jhala NC, Bartolucci A, Grizzle WE, Manne U.Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker database.Cancer Inform. 2007 Mar 2;3:115-22.  19455238 
Hines RB, Chatla C, Bumpers HL, Waterbor JW, McGwin G Jr, Funkhouser E, Coffey CS, Posey J, Manne U.Predictive capacity of three comorbidity indices in estimating mortality after surgery for colon cancer.J Clin Oncol. 2009 Sep 10;27(26):4339-45.  19652054 
Hines RB, Shanmugam C, Waterbor JW, McGwin G Jr, Funkhouser E, Coffey CS, Posey J, Manne U.Effect of comorbidity and body mass index on the survival of African-American and Caucasian patients with colon cancer.Cancer. 2009 Dec 15;115(24):5798-806.
 
19937953 
Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S.Smad signaling is required to maintain epigenetic silencing during breast cancer progression.Cancer Res. 2010 Feb 1;70(3):968-78.
 
20086175 
Katkoori VR, Suerez-Curvo C, Shanmugam C, Bumpers, H, Posey J, Grizzle, WE, Manne U. Bax expression is a prognostic and predictive marker in colorectal cancer. J. Gastrointest Oncol, 2010;1:76-89.   22811811 
Grizzle WE, Srivastava S, Manne U. Translational pathology of neoplasia. Cancer Biomark. 2010;9(1-6):7-20 (Review).  22112467 
Wang CW, Manne U, Reddy VB, Oelschlager DK, Katkoori VR, Grizzle WE, Kapoor R.Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples.J Biomed Opt,2010; 15(6):067005.  21198209 
Atha DH, Manne U, Grizzle WE, Wagner PD, Srivastava S, Reipa V.Standards for immunohistochemical imaging: a protein reference device for biomarker quantitation. J Histochem Cytochem. 2010 Nov;58(11):1005-14.  20805583 
Anderson B, Hardin JM, Alexander DD, Grizzle WE, Meleth S, Manne U. Comparison of the predictive qualities of three prognostic models of colorectal cancer.Front Biosci (Elite Ed)., 2010 Jun 1;2:849-56.  20515758  
Shanmugam C, Jhala NC, Katkoori VR, Wan W, Meleth S, Grizzle WE, Manne U.Prognostic value of mucin 4 expression in colorectal adenocarcinomas.Cancer. 2010 Aug 1;116(15):3577-86.  20564074  
Manne U, Shanmugam C, Bovell L, Katkoori VR, Bumpers HL:miRNAs as biomarkers for management of patients with colorectal cancer.Biomark Med. 2010 Oct;4(5):761-70.  20945991  
Manne U, Shanmugam C, Katkoori VR, Bumpers HL, Grizzle WE.Development and progression of colorectal neoplasia (Review).Cancer Biomark., 2011;9(1-6):235-65.  22112479 
Kennedy RD, Bylesjo M, Kerr P, Davison T, Black JM, Kay EW, Holt RJ, Proutski V, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, McDyer F, Mulligan K, Mussen J, O'Brien E, Oliver G, Walker SM, Mulligan JM, Wilson C, Winter A, O'Donoghue D, Mulcahy H, O'Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe OF, Winqvist O, Manne U, Shanmugam C, Ramaswamy S, Leon EJ, Smith WI Jr, McDermott U, Wilson RH, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG, Harkin DP.Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue. J Clin Oncol. 2011 Dec 10;29(35):4620-6.  22067406 
Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey JA Jr, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U.Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer.J Hematol Oncol. 2011, 28;4:25.  21619690 
Bowman E, Oprea G, Okoli J, Gundry K, Rizzo M, Gabram-Mendola S, Manne U, Smith G, Pambuccian S, Bumpers HL. Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients.Breast J. 2012 May-Jun;18(3):242-7.   22583194 
Tuupanen S, Yan J, Turunen M, Gylfe AE, Kaasinen E, Li L, Eng C, Culver DA, Kalady MF, Pennison MJ, Pasche B, Manne U, de la Chapelle A, Hampel H, Henderson BE, Le Marchand L, Hautaniemi S, Askhtorab H, Smoot D, Sandler RS, Keku T, Kupfer SS, Ellis NA, Haiman CA, Taipale J, Aaltonen LA.Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583. Cancer Genet. 2012 Jan-Feb;205(1-2):25-33.  22429595 
Bovell L, Shanmugam C, Katkoori VR, Zhang B, Vogtmann E, Grizzle WE, Manne U.miRNAs are stable in colorectal cancer archival tissue blocks.Front Biosci (Elite Ed). 2012 Jan 1;4:1937-40.  22202009 
Samuel T, Fadlalla K, Mosley L, Katkoori V, Turner T, Manne U.Dual-mode Interaction between Quercetin and DNA-damaging Drugs in Cancer Cells.Anticancer Res. 2012 Jan;32(1):61-71.  22213289 
Katkoori VR, Shanmugam C, Jia X, Vitta SP, Sthanam M, et al. () Prognostic Significance and Gene Expression Profiles of p53 Mutations in Microsatellite-Stable Stage III Colorectal Adenocarcinomas. PLoS ONE, 2012;7(1): e30020. doi:10.1371/journal.pone.0030020  22276141 
Gales D, Clark C, Manne U, Samuel T.The Chemokine CXCL8 in Carcinogenesis and Drug Response. ISRN Oncol. 2013;2013:859154 (Review).   24224100 
Katkoori VR, Manne K, Vital-Reyes VS, Rodríguez-Burford C, Shanmugam C, Sthanam M, Manne U, Chatla C, Abdulkadir SA, Grizzle WE.Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53. Biotech Histochem. 2013 Jan;88(1):38-46.  23167625 
Bovell LC, Putcha BD, Samuel T, Manne U.Clinical implications of microRNAs in cancer.Biotech Histochem. 2013 Oct;88(7):388-96  23647010 
Vogtmann E, Shanmugam C, Katkoori VR, Waterbor J, Manne U.Socioeconomic status, p53 abnormalities, and colorectal cancer.J Gastrointest Oncol. 2013 Mar;4(1):40-4.   23450636 

Keywords
Colorectal Cancer, GI malignancies, Breast Cancer, Molecular Biomarkers, Racial/Ethnic Disparities, Cancer Control & Prevention