Medical Scientist Training Program  http://www.mstp.uab.edu    Back to Main

Faculty Detail    
Name JIANHUA ZHANG
  
Campus Address BMR2 534 Zip 2186
Phone  (20-5) -153
E-mail  zhanja@uab.edu
Other websites googlescholar
     

Education
Undergraduate  University of Science and Technology of China     1985  BS 
Graduate  UT Southwestern Medical Center at Dallas    1991  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Neurobiology  Neurobiology Assistant Professor
Center  Neurology   Alzheimer's Disease Center Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  General Clinical Research Center  Ctr for Free Radical Bio Professor
Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Integrative Genetics Graduate Program 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Neuroscience 
Neuroscience Graduate Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Zhang graduated from University of Science and Technology of China. She received her PhD from University of Texas Southwestern Medical Center at Dallas. She then worked as a postdoctoral associate in the Whitehead Institute for Biomedical Research, and as a Research Assistant Professor in University of Cincinnati College of Medicine. She joined UAB in 2005, and promoted to professor in 2019.

Society Memberships
Organization Name Position Held Org Link
Association for Neuron and Disease (AND)  member   
Birmingham Chinese Professor Association (BCPA)  member   
Society of Chinese Bioscientists in America (SCBA)  member   
Chinese Biologic Investigator Society (Ray Wu society)  member   
Society for Free Radical Biology and Medicine (SFRBM)  VP   
 



Research/Clinical Interest
Title
Mechanisms and regulation of autophagy-lysosomal pathway in health and diseases
Description
We focus on the integrated mechanisms regulating metabolism, redox signaling and cell death. We use genetic models and system biology tools to identify novel approaches to promote healthy aging, and to attenuate cardiovascular, neurodegenerative and inflammatory diseases. We have positions open for a postdoc and a graduate student. Highly motivated, rigorous and talented individuals are encouraged to apply.

Selected Publications 
Publication PUBMEDID
Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokeland T, Ouyang X, Zhang J, Duncan SR, Thannickal VK, Darley-Usmar VM, Deshane JS (2018) Exosomal Transfer of Mitochondria from Airway Myeloid-Derived Regulatory Cells to T cells. Redox Biology Accepted   
Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napieralo M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland A (2017) Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro. ACS Chemical Biology accepted   
Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado B, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME (2018) Temporal partitioning of adaptive responses of the murine heart to fasting: a guide for experimental design. Life Sciences 197:30-39  29410090 
Zhang J, Culp ML, Craver JG, Darley-Usmar V (2017) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease. J Neurochem in press  29341130  
Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation.
Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ.
J Biol Chem. 2017 Dec 8. pii: jbc.RA117.000444. doi: 10.1074/jbc.RA117.000444. [Epub ahead of print]
 		 29222329 
Neurobiol Dis. 2017 Dec 2;110:68-81. doi: 10.1016/j.nbd.2017.11.006. [Epub ahead of print]
The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.

Nelson MP1, Boutin M2, Tse TE3, Lu H1, Haley ED3, Ouyang X1, Zhang J4, Auray-Blais C2, Shacka JJ5. 		 29196214  
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.
Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J.
Mol Brain. 2017 Jul 19;10(1):32. doi: 10.1186/s13041-017-0311-1.
 		 28724388  
Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons.
Dodson M, Wani WY, Redmann M, Benavides GA, Johnson MS, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J.
Autophagy. 2017 Aug 24:1-13. doi: 10.1080/15548627.2017.1356948. [Epub ahead of print]
 		 28837411 
Bernard K, Logsdon NJ, Herranz VM, Benavides GA, Zhang J, Darley-Usmar VM, Thannickal VJ (2017) NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis in Lung Fibroblasts via a Nuclear Factor Erythroid- Derived 2-like 2 (Nrf2)-Dependent Pathway. J Biol Chem In press  28049732 
Redmann M, Wani W, Volpicelli-Daley L, Darley-Usmar V, Zhang J (2017) Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biology 11:429-437  28068606 
Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J (2017) Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biology 11:73-81 PMCID:PMC5124357  27889640 
Redmann M, Darley-Usmar V, Zhang J (2016) The role of autophagy, mitophagy and lysosomal functions in modulating cellular bioenergetics and survival in the context of redox and proteotoxic damage: implications for age dependent neurodegenerative diseases. Aging and Disease 7:150-162 PMCID:PMC4809607  27114848 
Wani W, Chatham J, Darley-Usmar V, McMahon L, Zhang J (2017) O-GlcNAcylation and neurodegeneration. BRB in press  27497832  
Wende AR, Young M, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM (2017) Free Radical Biology and Medicine In press  27242268  
Radhakrishnan RK, Narasimhan M, Shanmugam G, Devarajan A, Palaniappan S, Zhang J, Halade G, Darley-Usmar VM, Hoidal JR, Rajasekaran NS (2016) Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. J Transl Med. 14 (1), 86  27048381 
A Hjelmeland, J Zhang (2016) Metabolic, autophagic, and mitophagic activities in cancer initiation and progression
biomedical journal 		 27372165  
E Hervouet, J · Zhang, M · Boyer-Guittaut (2016) ROS and Epigenetics. In book: Reactive Oxygen Species in Biology and Human Health, pp.519-533   
Aggarwal S, Mannam P, Zhang J. (2017) Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.Am J Physiol Lung Cell Mol Physiol.  27402690  
Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches.Redox Biol. 2015;4:242-59. doi: 10.1016/j.redox.2015.01.003. Epub 2015 Jan 13.  25618581 
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky et al Autophagy. 2016 Jan 2;12(1):1-222. 		 26799652 
Matthew Dodson, Matthew Redmann, Namakkal S Rajasekaran, Victor Darley-Usmar, Jianhua Zhang (2015)KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochemical Journal 469:347-55  26205490  
Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S (2015) Upregulation of autophagy decreases chlorine gas-induced mitochondrial injury and lung inflammation. Free radical biology and medicine 85:83-94  25881550 
Sheshadri N, Catanzaro J, Bott A, Sun Y, Ullman E, Chen E, Pan J-A, Wu S, Crawford H, Zhang J, Zong WX (2014) SCCA1/SerpinB3 promotes epithelial-mesenchymal transition and oncogenic transformation via unfolded protein response and IL-6 signaling. Cancer Research 74(21):6318-29  25213322 
Wani W, Boyer-Guittaut M, Dodson M, Chatham J, Darley-Usmar V, Zhang J (2015) Regulation of autophagy by protein post-translational modification. Laboratory Investigation 95(1):14-25.  25365205  
Giordano S, Dodson M, Ravi S, Redmann M, Ouyang X, Darley Usmar VM, Zhang J. (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J Neurochem. Jul 31. doi: 10.1111/jnc.12844. [Epub ahead of print]  25081478 
AL Levonen, BG Hill, E Kansanen, J Zhang, VM Darley-Usmar (2014) Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics. Free Radical Biology and Medicine 71, 196-207  24681256 
Chacko B, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal A, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: A new concept in translational research. Clinical Science   24895057 
Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar VM, Zhang J (2014) Mitophagy mechanisms and role in human diseases. International Journal of Biochemistry and Cell biology 53:127-33  24842106 
Michaël Boyer-Guittaut, Laura Poillet, Qiuli Liang, Elodie Bôle-Richard, Xiaosen Ouyang, Gloria A Benavides, Fatima-Zahra Chakrama, Annick Fraichard, Victor M Darley-Usmar, Gilles Despouy, Michèle Jouvenot, Régis Delage-Mourroux, Jianhua Zhang (2014). The role of GABARAPL1 (GEC1) in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy 10 (6), 986-1003  24879149 
Giordano S, Darley-Usmar V, Zhang J. (2013) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. 2: 82–90.   24494187 
Hengartner CJ, Thompson CM, Zhang J, Chao DM, Liao SM, Koleske AJ, Okamura S, Young RA.Association of an activator with an RNA polymerase II holoenzyme.Genes Dev. 1995 Apr 15;9(8):897-910.  7774808 
Zhang, J., Liao, S.-M., Jeffrey, D.A., Koleske, A.J., Thompson, C.M., Chao, D.M., Viljoen, M., van Vuuren, H.J.J. & Young, R.A. (1995). A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193-196 (co-first author)  7877695 
Zhang, J., Liu, X., Scherer, D.C., Van Kaer, L., Wang, X. & Xu, M. (1998). Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl. Acad. Sci. USA 95: 12480-12485 with commentary by Susan Cory: “Cell death throes”  9770511  
Zhang, J., Wang, X., Bove, K. & Xu, M. (1999). DNA fragmentation factor 45 deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J. Biol. Chem. 274:37450-37454  10601318  
Zhang, J. & Xu, M. (2002). Apoptotic DNA degradation and tissue homeostasis. Trends Cell Biol 12:84-89  11849972  
Zhang, J., Zhang, D., McQuade, J.S., Behbehani, M., Tsien, J. & Xu, M. (2002). C-fos regulates neuronal excitability and survival. Nature Genet 30:416-420  11925568 
Zhang, J., McQuade, J.S., Vorhees, C. & Xu, M. (2002). Hippocampal expression of c-fos is not essential for spatial learning. Synapse 46:91-99   12211087 
Zhang, J., Dong, M., Li, L., Fan, Y., Pathrie, P., Dong, J., Olivares-Villagom, D., Lou, D., Wells, J., Van Kaer, L., Wang, X. & Xu, M. (2003). Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc. Natl. Acad. Sci. USA 100:15782-15787   14663139  
Zhang, L., Lou, D., Jiao, H., Zhang, D., Wang, X., Xia, Y., Zhang, J. & Xu, M. (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J. Neurosci. 24 3344-3354  15056714  
Zhang, D., Zhang, L., Zhang, Q., Tang, Y., Lou, D., Sharp, F.R., Zhang, J. & Xu, M. (2005) Gene expression changes induced by repeated cocaine administration through the dopamine D1 receptors. Neuropsychopharmacology 30, 1443-1454.  15770241  
Jianhua Zhang, Lu Zhang, Hongyuan Jiao, Qi Zhang, Dongsheng Zhang, Danwen Lou, Jonathan L. Katz, and Ming Xu (2006) c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Journal of Neuroscience 26: 13287-13296  17182779 
Shacka J, Lu J, Xie Z, Uchiyama Y, Roth K, Zhang J (2007) “Kainic Acid Induces Early and Transient Autophagic Stress in Mouse Hippocampus” Neuroscience letter 414, 57-60  17223264  
Qianjun Li, Huashi Li, Bradley J. Blitvich and Jianhua Zhang (2007) The Aedes albopictus inhibitor of Apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosis Insect Molecular Biology. 16:93-105  17257212  
Shacka J, Roth K, Zhang J (2008) The Autophagy-Lysosomal Degradation Pathway: Role in Neurodegenerative Disease and Therapy Frontiers in bioscience (review) 13:718-36  17981582 
Ness J, Harvey C, W Jason, Roth K, Carroll S, Zhang, J (2007) Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. J Neuroscience Res 86:1115-24  18030677  
SB Caine, M Thomsen, KI Gabriel, JS Berkowitz, LH Gold, GF Koob, S Tonegawa, J Zhang, M Xu (2007) Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knockout Mice. J Neurosci 27:13140-13150  18045908 
Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG. Walls KC, Shacka JJ, Roth KA, Zhang J (2008) Lysosomal enzyme cathepsin D protects against neuronal alpha-synuclein aggregation and toxicity. Molecular Brain 1:17  19021916 
Qiao L, Zhang J (2009) Effect of inhibition of lysosomal functions on proteasomal activity. Neurosci Lett 456:15-19.  19429125  
Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem. 2010 Apr 2;285(14):10497-507. Epub 2010 Feb 1.  20123985  
Schneider L, Zhang J (2010) Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease Molecular Neurodegeneration. Molecular Neurodegeneration 5:14.  20388210 
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Keywords
Autophagy, Parkinson's Disease, Alzheimer's disease, heart disease, lysosomes, mitochondria, redox signaling