Undergraduate |
University of Science and Technology of China |
|
1985 |
BS |
Graduate |
UT Southwestern Medical Center at Dallas |
|
1991 |
PhD |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Pathology |
Molecular & Cellular Pathology |
Professor |
Secondary |
Cell, Developmntl, & Integrative Biology |
Cell, Developmntl, & Integrative Biology |
Associate Professor |
Secondary |
Neurobiology |
Neurobiology |
Assistant Professor |
Center |
Neurology |
Alzheimer's Disease Center |
Professor |
Center |
Civitan International Research Center |
Civitan International Research Center |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
General Clinical Research Center |
Comprehensive Neuroscience Center |
Professor |
Center |
General Clinical Research Center |
Ctr for Free Radical Bio |
Professor |
Center |
Neurology |
Ctr Neurodegeneration & Exp Ther (CNET) |
Professor |
Center |
GL Ctr for Craniofacial, Oral, & Dental Disorders |
GL Ctr for Craniofacial, Oral, & Dental Disorders |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor |
Center |
Nutrition Sciences |
Nutrition Obesity Res Ctr (NORC) |
Professor |
|
Cell, Molecular, & Developmental Biology |
Cellular and Molecular Biology Program |
Integrative Genetics Graduate Program |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Neuroscience |
Neuroscience Graduate Program |
Pathobiology and Molecular Medicine |
|
Organization Name |
Position Held |
Org Link |
Association for Neuron and Disease (AND) |
member |
|
Birmingham Chinese Professor Association (BCPA) |
member |
|
Society of Chinese Bioscientists in America (SCBA) |
member |
|
Chinese Biologic Investigator Society (Ray Wu society) |
member |
|
Society for Free Radical Biology and Medicine (SFRBM) |
VP |
|
|
Publication |
PUBMEDID |
Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokeland T, Ouyang X, Zhang J, Duncan SR, Thannickal VK, Darley-Usmar VM, Deshane JS (2018) Exosomal Transfer of Mitochondria from Airway Myeloid-Derived Regulatory Cells to T cells. Redox Biology Accepted |
|
Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napieralo M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland A (2017) Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro. ACS Chemical Biology accepted |
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Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado B, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME (2018) Temporal partitioning of adaptive responses of the murine heart to fasting: a guide for experimental design. Life Sciences 197:30-39 |
29410090 |
Zhang J, Culp ML, Craver JG, Darley-Usmar V (2017) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease. J Neurochem in press |
29341130 |
Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation. Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ. J Biol Chem. 2017 Dec 8. pii: jbc.RA117.000444. doi: 10.1074/jbc.RA117.000444. [Epub ahead of print] |
29222329 |
Neurobiol Dis. 2017 Dec 2;110:68-81. doi: 10.1016/j.nbd.2017.11.006. [Epub ahead of print] The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.
Nelson MP1, Boutin M2, Tse TE3, Lu H1, Haley ED3, Ouyang X1, Zhang J4, Auray-Blais C2, Shacka JJ5. |
29196214 |
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J. Mol Brain. 2017 Jul 19;10(1):32. doi: 10.1186/s13041-017-0311-1. |
28724388 |
Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons. Dodson M, Wani WY, Redmann M, Benavides GA, Johnson MS, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J. Autophagy. 2017 Aug 24:1-13. doi: 10.1080/15548627.2017.1356948. [Epub ahead of print] |
28837411 |
Bernard K, Logsdon NJ, Herranz VM, Benavides GA, Zhang J, Darley-Usmar VM, Thannickal VJ (2017) NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis in Lung Fibroblasts via a Nuclear Factor Erythroid- Derived 2-like 2 (Nrf2)-Dependent Pathway. J Biol Chem In press |
28049732 |
Redmann M, Wani W, Volpicelli-Daley L, Darley-Usmar V, Zhang J (2017) Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biology 11:429-437 |
28068606 |
Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J (2017) Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biology 11:73-81 PMCID:PMC5124357 |
27889640 |
Redmann M, Darley-Usmar V, Zhang J (2016) The role of autophagy, mitophagy and lysosomal functions in modulating cellular bioenergetics and survival in the context of redox and proteotoxic damage: implications for age dependent neurodegenerative diseases. Aging and Disease 7:150-162 PMCID:PMC4809607 |
27114848 |
Wani W, Chatham J, Darley-Usmar V, McMahon L, Zhang J (2017) O-GlcNAcylation and neurodegeneration. BRB in press |
27497832 |
Wende AR, Young M, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM (2017) Free Radical Biology and Medicine In press |
27242268 |
Radhakrishnan RK, Narasimhan M, Shanmugam G, Devarajan A, Palaniappan S, Zhang J, Halade G, Darley-Usmar VM, Hoidal JR, Rajasekaran NS (2016) Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. J Transl Med. 14 (1), 86 |
27048381 |
A Hjelmeland, J Zhang (2016) Metabolic, autophagic, and mitophagic activities in cancer initiation and progression biomedical journal |
27372165 |
E Hervouet, J · Zhang, M · Boyer-Guittaut (2016) ROS and Epigenetics. In book: Reactive Oxygen Species in Biology and Human Health, pp.519-533 |
|
Aggarwal S, Mannam P, Zhang J. (2017) Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.Am J Physiol Lung Cell Mol Physiol. |
27402690 |
Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches.Redox Biol. 2015;4:242-59. doi: 10.1016/j.redox.2015.01.003. Epub 2015 Jan 13. |
25618581 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky et al Autophagy. 2016 Jan 2;12(1):1-222. |
26799652 |
Matthew Dodson, Matthew Redmann, Namakkal S Rajasekaran, Victor Darley-Usmar, Jianhua Zhang (2015)KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochemical Journal 469:347-55 |
26205490 |
Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S (2015) Upregulation of autophagy decreases chlorine gas-induced mitochondrial injury and lung inflammation. Free radical biology and medicine 85:83-94 |
25881550 |
Sheshadri N, Catanzaro J, Bott A, Sun Y, Ullman E, Chen E, Pan J-A, Wu S, Crawford H, Zhang J, Zong WX (2014) SCCA1/SerpinB3 promotes epithelial-mesenchymal transition and oncogenic transformation via unfolded protein response and IL-6 signaling. Cancer Research 74(21):6318-29 |
25213322 |
Wani W, Boyer-Guittaut M, Dodson M, Chatham J, Darley-Usmar V, Zhang J (2015) Regulation of autophagy by protein post-translational modification. Laboratory Investigation 95(1):14-25. |
25365205 |
Giordano S, Dodson M, Ravi S, Redmann M, Ouyang X, Darley Usmar VM, Zhang J. (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J Neurochem. Jul 31. doi: 10.1111/jnc.12844. [Epub ahead of print] |
25081478 |
AL Levonen, BG Hill, E Kansanen, J Zhang, VM Darley-Usmar (2014) Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics. Free Radical Biology and Medicine 71, 196-207 |
24681256 |
Chacko B, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal A, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: A new concept in translational research. Clinical Science |
24895057 |
Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar VM, Zhang J (2014) Mitophagy mechanisms and role in human diseases. International Journal of Biochemistry and Cell biology 53:127-33 |
24842106 |
Michaël Boyer-Guittaut, Laura Poillet, Qiuli Liang, Elodie Bôle-Richard, Xiaosen Ouyang, Gloria A Benavides, Fatima-Zahra Chakrama, Annick Fraichard, Victor M Darley-Usmar, Gilles Despouy, Michèle Jouvenot, Régis Delage-Mourroux, Jianhua Zhang (2014). The role of GABARAPL1 (GEC1) in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy 10 (6), 986-1003 |
24879149 |
Giordano S, Darley-Usmar V, Zhang J. (2013) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. 2: 82–90. |
24494187 |
Hengartner CJ, Thompson CM, Zhang J, Chao DM, Liao SM, Koleske AJ, Okamura S, Young RA.Association of an activator with an RNA polymerase II holoenzyme.Genes Dev. 1995 Apr 15;9(8):897-910. |
7774808 |
Zhang, J., Liao, S.-M., Jeffrey, D.A., Koleske, A.J., Thompson, C.M., Chao, D.M., Viljoen, M., van Vuuren, H.J.J. & Young, R.A. (1995). A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193-196 (co-first author) |
7877695 |
Zhang, J., Liu, X., Scherer, D.C., Van Kaer, L., Wang, X. & Xu, M. (1998). Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl. Acad. Sci. USA 95: 12480-12485 with commentary by Susan Cory: “Cell death throes” |
9770511 |
Zhang, J., Wang, X., Bove, K. & Xu, M. (1999). DNA fragmentation factor 45 deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J. Biol. Chem. 274:37450-37454 |
10601318 |
Zhang, J. & Xu, M. (2002). Apoptotic DNA degradation and tissue homeostasis. Trends Cell Biol 12:84-89 |
11849972 |
Zhang, J., Zhang, D., McQuade, J.S., Behbehani, M., Tsien, J. & Xu, M. (2002). C-fos regulates neuronal excitability and survival. Nature Genet 30:416-420 |
11925568 |
Zhang, J., McQuade, J.S., Vorhees, C. & Xu, M. (2002). Hippocampal expression of c-fos is not essential for spatial learning. Synapse 46:91-99 |
12211087 |
Zhang, J., Dong, M., Li, L., Fan, Y., Pathrie, P., Dong, J., Olivares-Villagom, D., Lou, D., Wells, J., Van Kaer, L., Wang, X. & Xu, M. (2003). Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc. Natl. Acad. Sci. USA 100:15782-15787 |
14663139 |
Zhang, L., Lou, D., Jiao, H., Zhang, D., Wang, X., Xia, Y., Zhang, J. & Xu, M. (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J. Neurosci. 24 3344-3354 |
15056714 |
Zhang, D., Zhang, L., Zhang, Q., Tang, Y., Lou, D., Sharp, F.R., Zhang, J. & Xu, M. (2005) Gene expression changes induced by repeated cocaine administration through the dopamine D1 receptors. Neuropsychopharmacology 30, 1443-1454. |
15770241 |
Jianhua Zhang, Lu Zhang, Hongyuan Jiao, Qi Zhang, Dongsheng Zhang, Danwen Lou, Jonathan L. Katz, and Ming Xu (2006) c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Journal of Neuroscience 26: 13287-13296 |
17182779 |
Shacka J, Lu J, Xie Z, Uchiyama Y, Roth K, Zhang J (2007) “Kainic Acid Induces Early and Transient Autophagic Stress in Mouse Hippocampus” Neuroscience letter 414, 57-60 |
17223264 |
Qianjun Li, Huashi Li, Bradley J. Blitvich and Jianhua Zhang (2007) The Aedes albopictus inhibitor of Apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosis Insect Molecular Biology. 16:93-105 |
17257212 |
Shacka J, Roth K, Zhang J (2008) The Autophagy-Lysosomal Degradation Pathway: Role in Neurodegenerative Disease and Therapy Frontiers in bioscience (review) 13:718-36 |
17981582 |
Ness J, Harvey C, W Jason, Roth K, Carroll S, Zhang, J (2007) Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. J Neuroscience Res 86:1115-24 |
18030677 |
SB Caine, M Thomsen, KI Gabriel, JS Berkowitz, LH Gold, GF Koob, S Tonegawa, J Zhang, M Xu (2007) Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knockout Mice. J Neurosci 27:13140-13150 |
18045908 |
Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG. Walls KC, Shacka JJ, Roth KA, Zhang J (2008) Lysosomal enzyme cathepsin D protects against neuronal alpha-synuclein aggregation and toxicity. Molecular Brain 1:17 |
19021916 |
Qiao L, Zhang J (2009) Effect of inhibition of lysosomal functions on proteasomal activity. Neurosci Lett 456:15-19. |
19429125 |
Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem. 2010 Apr 2;285(14):10497-507. Epub 2010 Feb 1. |
20123985 |
Schneider L, Zhang J (2010) Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease Molecular Neurodegeneration. Molecular Neurodegeneration 5:14. |
20388210 |
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