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Faculty Detail    
Name SHANNON M BAILEY
Professor		  
Campus Address VH G019 Zip 0019
Phone
E-mail
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Education
Undergraduate  University of Oklahoma    1985  BS in Zoology 
Graduate  University of Oklahoma Health Sciences Center    1996  Ph.D. in Pharmacology  


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Associate Professor
Secondary  Pharmacology/Toxicology   Pharmacology/Toxicology Chair's Office Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Medicine  Ctr Cardiovasc Bio (Org Ret) Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Received Bachelor of Science in Zoology from the University of Oklahoma in 1989 Received PhD in Pharmacology from the University of Oklahoma Health Science Center, College of Medicine in 1996, Dissertation advisor: Lester A. Reinke, Dissertation title: Potential Mechanisms of Hepatic Ischemia-Reperfusion Injury. Postdoctoral Research Fellow, Department of Biochemistry, Wake Forest University School of Medicine from 3/96-2/99, Postdoctoral advisor: Carol C. Cunningham Instructor, Department of Biochemistry, Wake Forest University School of Medicine from 3/99-9/00 Assistant Professor, Department of Biochemistry, Wake Forest University School of Medicine from 10/00-8/01 Assistant Professor, Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham from 9/01-9/06 Associate Professor, Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham from 10/06 - 1/12; Associate Professor, Department of Pathology, Division of Molecular and Cellular Pathology, School of Medicine from 2/12 - 9/13; Professor, Department of Pathology, Division of Molecular and Cellular Pathology, School of Medicine from 10/14 - present

Society Memberships
Organization Name Position Held Org Link
American Association for the Study of Liver Diseases  member  http://www.aasld.org/ 
American Physiological Society  member  http://www.aps.org/ 
International Society for Biomedical Research on Alcoholism   member  http://www.isbra.com/ 
Research Society on Alcoholism  member  http://www.rsoa.org/ 
Society for Free Radical Biology and Medicine  Editorial Board; member  http://www.sfrbm.org 
 



Research/Clinical Interest
Title
Molecular mechanisms of chronic alcohol and obesity induced fatty liver disease
Description
My research investigates how genetic, environmental, and life-style factors influence the initiation, progression, and severity of liver diseases and how these alterations impact risk for cardiovascular disease. Our studies are important for identifying a link between the severity of alcohol and obesity-related fatty liver disease (i.e., steatohepatitis) and increased risk for cardiovascular disease. Principal areas are focused on understanding how disruption in redox signaling pathways and changes to mitochondria, contribute to pathology (liver disease, cardiovascular disease, and cancer). We are also interested in determining how disruption in cellular circadian rhythms or ‘clocks’ contribute to liver disease. We are actively studying the role of the molecular clock in lipid, glycogen and mitochondrial metabolism.

Selected Publications 
Publication PUBMEDID
Mantena SK, Vaughn Jr DP, Andringa KK, Eccleston HB, King AL, Abrams GA, Doeller JE Kraus DW, Darley-Usmar VM, and Bailey SM. High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. Biochem J 417(1):183-193 (2009). (PMC2637578)  18752470 
Bailey SM, Mantena SK, Cakir Y, Chhieng D, Pinkerton KE, and Ballinger SW. Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE-/- mouse: implications for a "multi-hit" hypothesis of fatty liver disease. Free Radic Biol Med 46:928-938 (2009). (PMC2775483)  19280709 
Andringa KK, King AL, Eccleston HE, Mantena SK, Landar A, Jhala NC, Dickinson DA, Squadrito GL, and Bailey SM. Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatment: novel molecular targets of disease and hepatoprotection. Am J Physiol Gastrointest Liver Physiol 298(5):G732-745 (2010). (PMC2867419)  20150243 
Bearer CF, Bailey SM, and Hoek JB. Advancing alcohol biomarkers research. Alcohol Clin Exp Res 34(6): 941-945 (2010).  20374221 
Hill BG, Dranka BP, Bailey SM, Lancaster, JR, and Darley-Usmar VM. What part of NO don’t you understand? Some answers to the cardinal questions in nitric oxide biology. J Biol Chem 285(26):19699-19704 (2010).   20410298 
Andringa KK and Bailey SM. Detection of protein thiols in mitochondrial oxidative phosphorylation complexes and associated proteins. Methods Enzymol 474:83-108 (2010).  20609906 
King AL, Swain TM, Dickinson DA, Lesort MJ, and Bailey SM. Chronic ethanol consumption enhances sensitivity to Ca2+-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver. Am J Physiol Gastrointest Liver Physiol 299(4):G954-966 (2010). (PMC2957342)  20651005 
Oliva CR, Diers A, McClugage SG, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE. Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. J Biol Chem 285(51)39759-67 (2010). (PMC30000957)  20870728 
Eccleston HB, Andringa KK, Betancourt AM, King AL, Mantena SK, Swain, TM, Tinsley HN, Nolte RN, Nagy TR, Abrams GA, and Bailey SM. Chronic exposure to a high fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice. Antioxid Redox Signal 15(2):447-459 (2011). (PMC3118652)  20919931 
Feldstein AE and Bailey SM. Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. Antioxid Redox Signal 15(2):421-424 (2011). (PMC3118602).  21254858 
Zelickson BR, Benavides GA, Johnson MS, Chacko BK, Venkatraman A, Landar A, Betancourt AM, Bailey SM, and Darley-Usmar V. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim Biophys Acta 1807(12):1573-1582 (2011). (PMC3217123)  21971515 
Kharbanda KK, Todero SL, King AL, Osna NA, McVicker BL, Tuma DJ, Wisecarver JL, and Bailey SM. Betaine treatment prevents chronic ethanol-induced steatosis and alterations to the mitochondrial respiratory chain proteome. Int J Hepatol 2012:962183 (2012). (PMC3235488)   22187660 
Stein A, Mao Z, Morrison JP, Fanucchi MV, Postlethwait EM, Patel RP, Kraus DW, Doeller JE, and Bailey SM. Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats. J Appl Physiol 112(10):1659-1669 (2012). (PMC3365405)  22403348 
Carey HV, Martin SL, Horwitz BA, Yan L, Bailey SM, Podrabsky J, Ortiz RM, Storz JF, Wong RP, and Lathrop DA. Harnessing evolutionary adaptations to advance biomedicine: elucidating nature’s solution to heart, lung, and blood diseases, and sleep disorders. Circ Res 110(7):915-921 (2012). (PMC3321354)  22461362 
Mitchell T, Chacko B, Ballinger SW, Bailey SM, Zhang J, and Darley-Usmar V. Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. Biochem Soc Trans 41(1):127-133 (2013). PMCID: PMC3582193  23356271 
Filiano-Upton A, Swain TM, Johnson R, Young ME, Gamble KL, and Bailey SM. Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus. PLoS One 8(8):e71684 (2013). PMCID: PMC3741117  23951220 
King AL, Swain TM, Mao Z, Udoh U, Oliva CR, Betancourt AM, Griguer CR, Crowe DR, Lesort M, and Bailey SM. Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice. Am J Physiol Gastrointest Liver Physiol 306(4):G265-277 (2014) PMCID: PMC 3920122  24356880 
Betancourt AM, King AL, Fetterman JL, Millender-Swain T, Finely RD, Oliva CR, Crowe DR, Ballinger SW, and Bailey SM. Mitochondrial-nuclear genome interactions in nonalcoholic fatty liver disease in mice. Biochem J (2014) 461(2):223-232. PMCID: PMC4086355  24758559  
Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, and Darley-Usmar V. The bioenergetic health index: a new concept in mitochondrial translational research. Clin Sci 127(6):367-373 (2014). (PMC4202728)  24895057 
Bailey SM, Udoh US, and Young ME. Circadian regulation of metabolism. J Endocrinol 222(2):R75-96 (2014). (PMCID: PMC4109003)  24928941 
Andringa KK, Udoh US, Landar A, and Bailey SM. Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats. Redox Biol 2C:103-1047 (2014). (PMCID: PMC4297939)  25454745 
Theis W, Andringa KK, Dickinson DA, Postlethwait EM, and Bailey SM. Ozone inhalation modifies the rat liver proteome. Redox Biol 2:52-60 (2014). (PMCID: PMC4297937)  25544660 
Stein A, Kraus DW, Doeller JE, and Bailey SM.Inhalation exposure model of hydrogen sulfide (H2S)-induced hypometabolism in the male Sprague-Dawley rat. Methods Enzymol 555:19-35 (2015)  25747473 
Udoh US, Swain TM, Filiano AN, Gamble KL, Young ME, and Bailey SM. Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice. Am J Physiol Gastrointest Liver Physiol 308(11):G964-G974 (2015). (PMCID: PMC4451320)  258579999 
Udoh US, Valcin JA, Gamble KL, and Bailey SM. The molecular circadian clock and alcohol-induced liver injury. Biomolecules 5(4):2504-2537 (2015). (PMCID: PMC4693245)  26473939 
Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, Gamble KL, and Young ME. Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice. Biochim Biophys Acta 1861(10): 1579-95 (2016) (PMCID: PMC4917492)  26721420 
He L, Hamm JA, Reddy A, Sams D, Peliciari-Garcia RA, McGinnis GR, Bailey SM, Chow CW, Rowe GC, Chatham JC, and Young ME. Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism. Am J Physiol Heart Circ Physiol 310(11): H1520-H1532 (2016) (PMCID: PMC4935513)  27084392 
Souza-Smith F, Lang CH, Nagy LE, Bailey SM, Parson LH, and Murray G. Physiological processes underlying organ injury in alcohol abuse, Am J Physiol Endocrinol Metab311(3):E605-619 (2016) (PMCID: PMC:5142006)  27436613 
King AL, Mantena SK, Andringa KK, Millender-Swain T, Dunham-Snary K, Oliva CR, Griguer CE, and Bailey SM. The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bio-energetic function in a rat model of alcohol-induced fatty liver disease, Redox Biol v.9: 188-197 (2016). (PMCID: PMC5007436)   27566282 
Oliva CR, Markert T, Ross LJ, White EL, Rasmussen L, Zhang W, Everts M, Bailey SM, Suto MJ, and Griguer CE. Identification of small molecule inhibitors of human cytochrome c oxidase that target chemoresistant glioma cells. J Biol Chem291(46):24188-24199 (2016) (PMCID:PMC5104942)  27679486 
Udoh US, Valcin JA, Swain TM, Filiano AN, Gamble KL, Young ME, and Bailey SM. Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen content in mice. Am J Physiol Gastrointest Liver Physiol 314(3):G4431-G447 (2018). (PMCID: PMC5899240)  29191941 
Bailey SM. Emerging role of circadian clock disruption in alcohol-induced liver disease. Am J Physiol Gastrointest Liver Physiol 315(3): G364-G373 (2018). (PMCID: in progress)  29848023 
Singal AK and Bailey SM. Cellular abnormalities and emerging biomarkers in alcohol associated liver disease. Gene Expr Liver Research 19(1): 49-60 (2018). (PMCID: PMC6290320)   30086817  
Oliva CR, Halloran B, Hjelmeland AB, Vazquez A, DeNicola G, Bailey SM, Sarkaria JN, and Griguer CE. IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling. Cell Commun Signal 16(1): 61 (2018). (PMCID:PMC6148802)   30231881 
Mukherji A, Bailey SM, Staels B, and Baumert TF. The circadian clock and liver function in health and disease. J Hepatol, in press (2019). (PMCID:PMC in progress)   30930223  
Jiang C, Stewart LT, Kuo HC, McGilberry W, Wall SB, Liang B, van Groen T, Bailey SM, Tipple TE, Jones DP, McMahon LL, and Liu RM. Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOε3, but not APOε4, targeted replacement mice. Neurobiol Aging 81: 9-21 (2019) (PMCID:PMC6732233)  31207469 
De Luca M, Vecchie D, Athmanathan B, Gopalkrishna S, Valcin JA, Swain TM, Sertie R, Wekesa K, Rowe GC, Bailey SM, and Nagareddy PR. Genetic deletion of Syndecan-4 alters body composition, metabolic phenotypes, and the function of metabolic tissues in female mice fed a high-fat diet. Nutrients 11(11):2810 (2019). (PMCID:PMC in progress)  31752080 
Saini V, Chinta KC, Reddy VP, Stein A, Lamprecht DA, Glasgow JN, Aejazur Rahman MD, Mackenzie JS, Truebody BE, Adamson J, Bailey SM, Moellering DR, Lancaster JR, Steyn AJC. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth, and pathogenesis. Nat Commun 11(1):557 (2020) (PMCID:OMC6987094)   31992699 
 

Keywords
Molecular mechanisms of alcohol and obesity induced liver diseases; Mitochondrial dysfunction in disease; Molecular bioenergetics; Circadian biology; Functional proteomics; Nitric oxide; Free radical biology; Toxicology