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Faculty Detail    
Name JOHN F KEARNEY
  
Campus Address SHEL 410 Zip 2182
Phone  (205) 934-6557
E-mail  jfk@uab.edu
Other websites Kearney Lab Page
Publication Listing
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Secondary  Pathology   Pathology Chair Office Professor
Primary  Microbiology  Microbiology Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Center for AIDS Research  Center for AIDS Research Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Hughes Med-Grad Fellowship Program 
Immunology 
Medical Scientist Training Program 

Biographical Sketch 
John F. Kearney, Professor, completed his Ph.D. studies in immunology at the University of Melbourne, Australia and carried out postdoctoral studies at UAB with Drs. Cooper and Lawton on in vitro models of immunoglobulin isotope switching. He joined the Microbiology staff in 1977 and has continued his studies on B cell differentiation. In 1978 he spent a year with Dr. Klaus Rajewsky in Cologne, Germany where he learned hybridoma technology and also isolated one of the most widely used fusing plasmacytomas. He has since exploited this technique as well as transgenic and knockout mice to dissect out complexities of immune regulation. His outside interests include road biking and gardening.



Research/Clinical Interest
Title
Focus on fundamental cellular and molecular mechanisms involved in the development of a diverse B cell repertoire
Description
The Kearney laboratory research addresses the “hygiene hypothesis” that links the increase in autoimmune and allergic phenomena such as Type 1 diabetes and allergic asthma in humans to excessively sanitary conditions provided to our children early in life. These are significant public health problems worldwide, associated with an alarming decrease in the age of onset. These studies revolve around development of the immune system, immune responses to the pathogens and opportunistic pathogens (Bacillus anthracis, Streptococcus pneumoniae, groups A and B streptococci, Enterobacter cloacae, Aspergillus fumigatus) and in addition the application of monoclonal antibody techniques for spore detection of the bioterrorism agent Bacillus anthracis detection.

Keywords
B Cells, B Cell Development, Hybridomas, Transgenic and Knockout Mice, Immunoregulation, B. anthracis