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Faculty Detail    
Name DEBASISH CHATTOPADHYAY
Professor
 
Campus Address ZRB 218 Zip 0000
Phone  (205) 934-0124
E-mail  dchattop@uabmc.edu
Other websites
     

Education
Graduate  Jadavpur University    1989  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  General Clinical Research Center  Minority Health & Research Center Professor
Secondary  Microbiology  Microbiology Professor
Primary  Medicine  Med - Infectious Diseases Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Secondary  Chemistry  Chemistry Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Assistant Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Microbiology 

Biographical Sketch 
Dr. Debasish Chattopadhyay received his BS in Chemistry and MS in Biochemistry from Calcutta University, India. He obtained Ph.D. degree in Chemistry from Jadavpur University, India in 1989. He conducted his postdoctoral research at the Upjohn Company in Michigan. This work was part of an NIH funded collaborative effort involving several academic institutions and pharmaceutical industries for the discovery of potent antiretroviral drugs. Dr. Chattopadhyay's work focussed on the structure-function analysis of target enzymes its application in drug development. Dr. Chattopadhyay joined the University of Alabama in 1994 and was recruited as an Assistant Professor in the School of Medicine in 1998. Dr. Chattopadhyay was promoted to the Associate Professor rank in 2007 and to the Professor rank in 2013.



Research/Clinical Interest
Title
Structure-Function Analysis of Proteins
Description
I am interested in globally significant infectious diseases. My research focuses on discovering strategies for developing drugs and vaccines targeting infectious pathogens. I am also involved in the application of structure-based approaches in developing chemotherapeutic agents targeting Retinoid X Receptor.

Selected Publications 
Publication PUBMEDID
Manne K, Chattopadhyay D, Agarwal V, Blom AM, Khare B, Chakravarthy S, Chang C, Ton-That H, Narayana SVL.(2020)
Novel structure of the N-terminal helical domain of BibA, a group B streptococcus immunogenic bacterial adhesin. Acta Crystallogr D Struct Biol. 2020 Aug 1;76(Pt 8):759-770. doi: 10.1107/S2059798320008116. Epub 2020 Jul 27 
32744258 
Schormann N, Campos J, Motamed R, Hayden KL, Gould JR, Green TJ, Senkovich O, Banerjee S, Ulett GC, Chattopadhyay D. (2020) Chlamydia trachomatis glyceraldehyde 3-phosphate dehydrogenase: Enzyme kinetics, high-resolution crystal structure, and plasminogen binding. Protein Sci. 2020 Dec;29(12):2446-2458. doi: 10.1002/pro.3975. Epub 2020 Oct 30.  33058314 
Bowman L, Motamed R, Lee P, Aleem K, Berawala AS, Hayden KL, Bzik DJ, Chattopadhyay D.(2020)
A simple and reliable method for determination of optimum pH in coupled enzyme assays. Biotechniques. 2020 Apr;68(4):200-203. doi: 10.2144/btn-2019-0126. Epub 2020 Feb 14.  
32056453 
Muzny CA, Taylor CM, Swords WE, Tamhane A, Chattopadhyay D, Cerca N, Schwebke JR.(2019)An Updated Conceptual Model on the Pathogenesis of Bacterial Vaginosis.J Infect Dis. 2019 Sep 26;220(9):1399-1405. doi: 10.1093/infdis/jiz342.   31369673 
Manne K, Narayana SVL, Chattopadhyay D.(2019)Crystal structure of the N-terminal domain of the fibronectin-binding protein PavA from Streptococcus pneumoniae. Acta Crystallogr F Struct Biol Commun. 2019 Oct 1;75(Pt 10):657-662. doi: 10.1107/S2053230X19012160. Epub 2019 Sep 24.   31584015 
Acharya D, Sullivan MJ, Duell BL, Goh KGK, Katupitiya L, Gosling D, Chamoun MN, Kakkanat A, Chattopadhyay D, Crowley M, Crossman DK, Schembri MA, Ulett GC. (2019). Rapid Bladder Interleukin-10 Synthesis in Response to Uropathogenic Escherichia coli Is Part of a Defense Strategy Triggered by the Major Bacterial Flagellar Filament FliC and Contingent on TLR5.mSphere. 2019 Nov 27;4(6):e00545-19. doi: 10.1128/mSphere.00545-19.  31776239  
Schormann N, Hayden KL, Lee P, Banerjee S, Chattopadhyay D.(2019) An overview of structure, function, and regulation of pyruvate kinases.Protein Sci. 2019 Oct;28(10):1771-1784. doi: 10.1002/pro.3691. Epub 2019 Aug 12.   31342570 
Hall CE, Hagan LM, Bergmann-Leitner E, Tosh DM, Bennett JW, Regules JA, Chuang I, Angov E, Dutta S, Chattopadhyay D, Yadava A.(2019) Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens. Infect Immun. 2019 Feb 21;87(3):e00541-18. doi: 10.1128/IAI.00541-18. Print 2019 Mar.   30559218 
Schormann N, Ayres CA, Fry A, Green TJ, Banerjee S, Ulett GC, Chattopadhyay D.(2016)Crystal Structures of Group B Streptococcus Glyceraldehyde-3-Phosphate Dehydrogenase: Apo-Form, Binary and Ternary Complexes. PLoS One. 2016 Nov 22;11(11):e0165917. doi: 10.1371/journal.pone.0165917. eCollection 2016.  27875551  
Carey AJ, Sullivan MJ, Duell BL, Crossman DK, Chattopadhyay D, Brooks AJ, Tan CK, Crowley M, Sweet MJ, Schembri MA, Ulett GC (2016)Uropathogenic Escherichia coli Engages CD14-Dependent Signaling to Enable Bladder-Macrophage-Dependent Control of Acute Urinary Tract Infection. J Infect Dis. 2016 Feb 15;213(4):659-68. doi: 10.1093/infdis/jiv424.   26324782 
Chattopadhyay D, Swingle MR, Salter EA, Wood E, D'Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, Banerjee S, Forbes D, Wierzbicki A, Honkanen RE (2016)Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem Pharmacol. 2016 Jun 1;109:14-26. doi: 10.1016/j.bcp.2016.03.011   27002182 
Davis MI, Pragani R, Fox JT, Shen M, Parmar K, Gaudiano EF, Liu L, Tanega C, McGee L, Hall MD, McKnight C, Shinn P, Nelson H, Chattopadhyay D, D'Andrea AD, Auld DS, DeLucas LJ, Li Z, Boxer MB, Simeonov A (2016) Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates Cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models. J Biol Chem. 2016 Sep 28. pii: jbc.M116.738567  27681596  
Schormann N, Banerjee S., Ricciardi R & Chattopadhyay D. (2013) “Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase” Acta Cryst. F. Struct Biol Cryst Comm. 69, 1328-1334  24316823 
Schormann N, Zhukovskaya N, Bedwell G, Nuth M, Gillilan R, Prevelige PE, Ricciardi RP, Banerjee S, Chattopadhyay D.(2016) Poxvirus Uracil-DNA Glycosylase - an Unusual Member of the Family I Uracil-DNA Glycosylases.Protein Sci. 2016 Sep 29. doi: 10.1002/pro.3058  27684934 
Schormann N, Ricciardi R & Chattopadhyay D. (2014) Uracil-DNA glycosylases- Structural and functional perspectives on an essential family of DNA repair enzymes. Protein Sci. 23, 1667-1685   25252105 
Jordan SJ, Olivera AL, Hernandez JN, Oster RA, Chattopadhyay D, Branch OH & Rayner JC (2011) Malaria immunoepidemiology in low transmission: Correlation of infecting genotype and immune response to domains of Plasmodium falciparum Merozoite Surface Protein-3. Infection & Immunity 79, 2070-2078  21383051 
Chattopadhyay D, Carey AJ, Dramsi S, Caliot E, Layton JR, Bohnsack JF, Webb RI, Adderson E & Ulett G (2010) Phylogenetic Lineage and Pilus Protein Spb1/SAN1518 Affect Opsonin-Independent Phagocytosis and Intracellular Survival of Group B Streptococcus. Microbes & Infection. 79, 2070-2078.  21238599 
Ayres CA, Schormann N, Senkovich O, Fry A, Banerjee S & Chattopadhyay D (2014) Structure of Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase holoenzyme reveals a novel surface. Acta Cryst. F. Struct Biol Cryst Comm. 70, 1333-1339.   25286935 
Schormann N, Ricciardi R, Chattopadhyay D (2014) Uracil-DNA glycosylases- Structural and functional perspectives on an essential family of DNA repair enzyme. Protein Sci. 2014 Dec;23(12):1667-85. doi: 10.1002/pro.2554. Epub 2014 Oct 25  25252105 
Cook WJ, Senkovich O, Hernandez A, Speed H, Chattopadhyay D. (2014) Biochemical and Structural Characterization of Cryptosporidium parvum Lactate Dehydrogenase. Int J Biol Macromol. 2014 Dec 24. pii: S0141-8130(14)00823-X. doi: 10.1016/j.ijbiomac.2014.12.019  25542170 
Cook WJ, Senkovich O, Aleem K, Chattopadhyay D (2012)Crystal structure of Cryptosporidium parvum pyruvate kinase

PLoS One. 2012;7(10):e46875. doi: 10.1371/journal.pone.0046875.  
23056503 
Sartmatova D, Nash T, Schormann N, Nuth M, Ricciardi R, Banerjee S, Chattopadhyay D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):295-301 
23519808 
Schormann N, Banerjee S, Ricciardi R, Chattopadhyay D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1328-34. 
24316823 
Cook, W. J., Senkovich, O. & Chattopadhyay, D. (2011) Crystal Structure of Plasmodium falciparum ARF GTPase Activating Protein. Acta Cryst. F. Struct Biol Cryst Commn. 67, 1339-1344  22102228 
Schormann, N., Sommers, C., Prichard, M., Noah, J., Nuth M., Ricciardi, R.P. & Chattopadhyay, D. (2011) Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for developing antiviral agents” Antiomicrob. Chemother. 55, 5054-5062


 
21844323  
Smith, C. D., Chattopadhyay, D. & Pal, B. (2011) Crystal structure of Plasmodium falciparum phosphoglycerate kinase: evidence for anion binding in the basic patch. Biochem. Biophys. Res. Commun. 412, 203-206
 
21798238  
Chattopadhyay, D., Corey, A., Dramsi, S., Caliot, E., Layton, J. R., Bohnsack, J. F., Webb, R. I., Adderson, E. & Ulett, G. (2010) “Phylogenetic Lineage and Pilus Protein Spb1/SAN1518 Affect Opsonin-Independent Phagocytosis and Intracellular Survival of Group B Streptococcus” Microbes & Infection. 79, 2070-2078  21238599 
Cook, W. J., Senkovich, O., Holder, A. A. & Chattopadhyay, D. (2010) “Structure of Plasmodium falciparum ADP-ribosylation factor” Acta Cryst. F. Struct Biol Cryst Commn. 66, 1426-1431 (cover page).  21045287 
Schormann, N., Velu, S., Murugesan, S., Senkovich, O., Walker, K., Chenna, B., Shinkre, B., Desai, A., & Chattopadhyay, D. (2010) “Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase” Bioorg. Med. Chem. 18, 4056-4066  20452776 
Schormann N, Senkovich O, Walker K, Wright DL, Anderson AC, Rosowsky A, Ananthan S, Shinkre B, Velu S, Chattopadhyay D. (2008) "Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function" Proteins 73, 889-901  18536013 
Schorann, N., Grigorian, A., Samal, A., Raman, K., DeLucas, L. & Chattopadhyay, D. (2007)
"Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly". BMC Struct. Biol. 7, 45
 
17605817 
Prichard, M., Keith, K. A., Johnson M., Harden, E. A., Luo, M., Qiu, S., Chattopadhyay, D. Fan, X., Torrence, P. F. & Kern, E. R. (2007) “Selective Activation of Antiviral Drugs by the Vaccinia Virus Thymidine Kinase” Antimicrob. Agent Chemother. 51, 1795-1803.

 
17325220 
Sartmatova D, Nash T, Schormann N, Nuth M, Zhukovskaya N, Ricciardi R, Banerjee S & Chattopadhyay D (2013) Crystallization and preliminary X-ray diffraction analysis of three recombinant mutants of Vaccinia virus uracil DNA glycosylase. Acta Cryst. F. Struct Biol Cryst Commn. 69, 295-301  23519808 
Senkovich, O., Bhatia, V., Garg, N. & Chatopadhyay, D. (2005) “Lipophilic Antifolate Trimetrexate is a Potent Inhibitor of Trypanosoma cruzi” Antimicrob. Chemother. Antimicrob. Chemother. 49, 3234-323  16048931 
Senkovich, O., Cook, W. J., Mirza, S., Holligshead, S. K., Protasevich, I. I., Briles, D. E. & Chattopadhyay, D. (2007) Structure of a Complex of Human Lactoferrin N-lobe with Pneumococcal Surface Protein A Provides Insight into Microbial Defense Mechanism". J. MOl. Biol. 370, 701-713.  157543335 
Costanzo, M. J, Yabur, S. C, Almond Jr., H. R., Andrade-Gordon, P, Corcoran, T. W., de Garavilla, L., Kauffman, J. A., Abraham, W. M., Recacha, R, Chattopadhyay, D. and Maryanoff, B. E. (2003) “Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone” J. Med. Chem. 46, 3865-3876  12930148 
Quevillon, E., Spielmann, T., Brahimi, K., Chattopadhyay, D., Yeraman, E. & Langsley, G. (2003) “The Plasmodium falciparum family of RabGTPases.” Gene 306, 13-25  12657463 
Senkovich, O., Pal, B., Schormann, N.S. & Chattopadhyay, D. (2003) “Trypanosoma cruzi genome encodes a pteridine reductase 2 protein.” Mol. Biochem. Parasitol. 127. 89-92  12615341 
Greco, M.N., Hawkins, M.J., Powell, E.T., Almond, H.R., Corcoran, T.W., Garavilla,L., Kauffman, J.A., Recacha, R., Chattopadhyay, D., Andrade-Gordon, P. & Maryanoff, B.E. (2002) “Nonpeptide inhibitors of Cathepsin G: optimization of a novel b-ketophosphonic acid lead by structure-based drug design”. J. Am. Chem. Soc. 124, 3810-3811.  11942800 
Recacha, R., Costanzo, M.J., Maryanoff, B. & Chattopadhyay, D. (2002) “Crystal Structure of Human Carbonic Anhydrase II Complexed with an Anticonvulsant Sugar Sulfamate.” Biochem. J. 361, 437-441.  11802772 
Chattopadhyay, D., Langsley, G., Carson, M., Recacha, R., DeLucas, L.J. & Smith, C. D. (2000) “Crystal structure of the Nucleotide Binding Domain of Plasmodium falciparum Rab6 GTPase in the GDP Bound Form”. Acta Cryst D. Biol. Crystallography 56, 937-944  10944329 
Costanzo, M. J, Yabur, S. C, Almond Jr., H. R., Andrade-Gordon, P, Corcoran, T. W., de Garavilla, L., Kauffman, J. A., Abraham, W. M., Recacha, R, Chattopadhyay, D. and Maryanoff, B. E. (2003) “Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone” J. Med. Chem. 46, 3865-3876  12930148 
Schormann, N., Senkovich, O., Ananthan, S. & Chattopadhyay, D. (2003) “Docking and Biological Activity of Pteridine Analogs: Search for Inhibotors of Pteridine Reductase Enzymes from Trypanosoma cruzi.” THEOCHEM 635, 37-44   

Keywords
Structural biology, Protein structure function, Malaria, Chagas' disease, Parasitic disease, Small pox, Bacterial pneumoniae