Cell, Molecular, & Developmental Biology  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name PRASANNA KRISHNAMURTHY
 
Campus Address VH G094 Zip 0019
Phone  (20-5) -691
E-mail  prasanak@uab.edu
Other websites PrasannaLab website
     

Education
Undergraduate  Bangalore Veterinary College    1998  DVM 
Graduate  Indian Veterinary Research Institute    2000  MVSc 
Graduate  Indian Veterinary Research Institute    2003  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Dept of Biomedical Engineering  Dept of Biomedical Engineering Associate Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cell, Molecular, & Developmental Biology 

Biographical Sketch 
Dr. Krishnamurthy completed his Bachelors in Veterinary Medicine from Bangalore Veterinary College and earned his Ph.D. in Veterinary Pathology from the Indian Veterinary Research Institute, India. He held faculty appointments at the Feinberg Cardiovascular Research Institute, School of Medicine at Northwestern University in Chicago, Illinois and Houston Methodist Research Institute before joining UAB. Dr.Krishnamurthy directs a research program focusing on understanding mechanisms of cardiovascular diseases and developing novel therapeutic strategies to promote cardiac regeneration and repair. Dr. Krishnamurthy’s laboratory is supported through funds from National Institutes of Health (NIH-R01) and American Heart Association (GIA and Postdoctoral).

Society Memberships
Organization Name Position Held Org Link
American Heart Association  Member   
European Society of Cardiology  Member   
Indian Association of Veterinary Pathologists  Member   
Inflammation Research Association  Member   
International Society for Interferon and Cytokine Research  Member   
Society for Immunology and Immunopathology  Member   
Society of Toxicology  Member   



Research/Clinical Interest
Title
Molecular mechanisms of cardiovascular diseases & stem cell-mediated regeneration and repair.
Description
Dr. Krishnamurthy’s laboratory focuses on several broad research areas: I) to study the molecular mechanisms involved in the progression of cardiovascular diseases II) understand how diabetes influences cardiovascular pathophysiology III) develop novel therapeutic strategies- to enhance stem cell therapeutic benefits (involving adult cells and induced pluripotent stem cells) and to promote cardiac regeneration and repair. Our laboratory uses molecular biology and modern classical research tools along with relevant surgical mouse models of cardiac diseases including myocardial infarction (LAD ligation), ischemia reperfusion and hypertrophy (ANG-II and TAC induced). Long-term goal of these studies is to identify new targets that can aid in development of future drugs and new therapies for prevention and treatment of cardiovascular disease complications in diabetes.

Selected Publications 
Publication PUBMEDID
MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.
Suresh Babu S, Thandavarayan RA, Joladarashi D, Jeyabal P, Krishnamurthy S, Bhimaraj A, Youker KA, Krishnamurthy P.
Sci Rep. 2016 Nov 9;6:36207. doi: 10.1038/srep36207. 
27827458 
Bone Marrow Progenitor Cell Therapy-Mediated Paracrine Regulation of Cardiac miRNA-155 Modulates Fibrotic Response in Diabetic Hearts
Kishore R, Verma SK, Mackie AR, Vaughan EE, Abramova TV, Aiko I, Krishnamurthy P.
PLOS ONE. 2013 Apr;8(4):doi:10.1371/journal.pone.0060161.
 
23560074  
Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration.
Darukeshwara J, Thandavarayan RA, Sahana S Babu, Krishnamurthy P.
International Journal of Molecular Sciences. 2014; 15(9):15891-15911.doi:10.3390/ijms150915891 
25207600 
RNA stabilizing proteins as molecular targets in cardiovascular pathologies.
Sahana S Babu, Darukeshwara J, Jeyabal P, Thandavarayan RA, Krishnamurthy P.
Trends Cardiovasc Med. 2015 Feb 20. pii: S1050-1738(15)00057-2. doi: 10.1016/j.tcm.2015.02.006. 
25801788 
Enhancer-associated long noncoding RNAs: A novel frontier with new perception in cardiac regeneration.
Jeyabal P, Thandavarayan RA, Babu SS, Krishnamurthy P.
Editorial Commentary. Trends Cardiovasc Med. 2015 Feb 23. pii: S1050-1738(15)00061-4. doi: 10.1016/j.tcm.2015.02.010. 
25812420  
Sirtuin-6 deficiency exacerbates diabetes induced impairment of wound healing.
Thandavarayan RA, Garikipati VN, Darukeshwara J, Suresh Babu S, Jeyabal P, Verma SK, Mackie AR, Khan M, Arumugam S, Watanabe K, Kishore R, Krishnamurthy P.
Exp Dermatol. 2015 May 23. doi: 10.1111/exd.12762. 
26010430 
MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Jeyabal P, Thandavarayan RA, Joladarashi D, Babu SS, Krishnamurthy S, Bhimaraj A, Youker KA, Kishore R, Krishnamurthy P.
Biochem Biophys Res Commun., 2016 Feb 17. pii: S0006-291X(16)30254-6. doi: 10.1016/j.bbrc.2016.02.065. 
26898797 
Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377.
Darukeshwara J, Garikipati VN, Thandavarayan RA, Verma SK, Mackie AR, Khan M, Gumpert AM, Bhimaraj A, Youker KA, Uribe C, Suresh Babu S, Jeyabal P, Kishore R, Krishnamurthy P.
J Am Coll Cardiol. 2015 Nov 17;66(20):2214-26. doi: 10.1016/j.jacc.2015.09.009 
26564600 

Keywords
Myocardial infarction, Heart failure, Stem cells, Cardiovascular regeneration and therapeutics, metabolic diseases, wound healing