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Faculty Detail    
Name SUZANNE E. LAPI
Cyclotron Facility Director
Associate Professor of Radiology
Associate Professor of Chemistry
 
Campus Address WTI 310F Zip 6830
Phone  (20-5) -689
E-mail  lapi@uab.edu
Other websites www.lapilab.com
     

Education
Graduate  Simon Fraser University    2007  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Radiology   Radiology Chair Office Professor
Center  Neurology   Alzheimer's Disease Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 

Biographical Sketch 
Suzanne E. Lapi, Ph.D. completed her undergraduate studies and Ph.D. at Simon Fraser University in Burnaby, BC, Canada. She went on to complete a postdoctoral appointment at UCSF working with Henry VanBrocklin, PhD on the development of imaging agents for PSMA in prostate cancer before being recruited as a faculty member at Washington University in St. Louis where she ultimately stayed on as a tenured Associate Professor until 2015. Dr. Lapi is currently an Associate Professor of Radiology and Chemistry and Cyclotron Facility Director where she oversees production of PET radionuclides and radiopharmaceuticals for preclinical and clinical trials. Her research interests are in the development and translation of new PET radionuclides and imaging agents. She is very interested in moving imaging agents forward to clinical use and she is currently producing isotopes and radiopharmaceuticals for several clinical trials. In particular, Dr. Lapi has extensive experience in the preclinical and clinical research use of 89Zr antibodies. Dr. Lapi has over 50 publications and a track record of grants in the area of isotope production, molecular imaging and training of the next generation of radiochemists. She is President of the Radiopharmaceutical Sciences Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and has been a Board member of the Nuclear Division of the American Chemical Society (ACS) for the past 4 years. She is a board member of the International Society of Radiopharmaceutical Sciences (ISRS) and has been active in many projects with the International Atomic Energy Agency (IAEA). She also continues to be a strong advocate of radiopharmaceutical sciences and the training of future radiochemists.

Society Memberships
Organization Name Position Held Org Link
Amercial Chemical Society  Nuclear Division Board Member  http://www.nucl-acs.org/ 
Society of Nuclear Medicine and Molecular Imaging  Board Member  https://www.snmmi.org/ 



Research/Clinical Interest
Title
Radiopharmaceuticals for Molecular Imaging
Description
My research includes the production and purification of novel radioisotopes for biomedical applications with a focus on metal radionuclides. Our group also has significant interest in radiochemistry development of new molecular imaging agents and translation of these agents into clinical trials.

Selected Publications 
Publication PUBMEDID
Last two years (from 65 total)

Wooten, A.L. Lewis, B.C., Lapi, S.E. (2015) Cross-sections of (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes Applied Radiation and Isotopes 96; 154-161

Richards V.N., Rath N., Lapi S.E. (2015) Production and separation of 186gRe from proton bombardment of 186WC. Nuclear Medicine and Biology 6:530-5

Aweda, T., Zhang, S., Mupanomunda, C., Burkemper, J., Seong Heo, G. Bandara, N., Lin, M., Cutler, C.S., Cannon, C.L., Youngs, W.J., Lapi, S.E. (2015) Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer Journal of Labelled Compounds and Radiopharmaceuticals 58(6):234-41

Zheleznyak, A., Garbow, J.R., Neeman, M., Lapi, S.E. (2015) Preclinical PET imaging of acute hyperoxia therapy of chronic hypoxia during pregnancy Molecular Imaging 14:366-72.

Mastren, T., Marquez, B.V., Sultan, D., Bollinger, E., Eisenbeis, P., Voller, T., Lapi, S.E. (2015) Cyclotron production of high specific activity 55Co and in vivo evaluation of the stability of 55Co metal-chelate-peptide complexes Molecular Imaging 14:11-22

Mastren, T., Pen, A., Loveless, S., Marquez, B., Bolliger, E., Marois, B., Hubley, N., Broan, K., Morrissey, D., Peaslee, G., Lapi, S.E. (2015) Harvesting 67Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron Laboratory Analytical Chemistry 87(20)10323-9

Burkemper, J.L., Huang, C., Li, A., Yuan, Rich, K., McConathy, J., Lapi, S.E. (2015) Synthesis and Biological Evaluation of (S)-amino-2-methyl-4-[76Br]-bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging Journal of Medicinal Chemistry 58(21)8542-52

Bandara, N., Cherkuri, K., Zheleznyak, A., Griffith, D.A., Limberakis, C., Tess, D.A., Chen, J., Waterhouse, R., Lapi, S.E. (2016) Evaluation of 64Cu and 68Ga Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β-cell Imaging Molecular Imaging and Biology 18(1) 90-8

Wright, B.D., Whittenberg, J., Desai, A., DiFelice, C., Kenis, P.J.A, Lapi, S.E., Reichert, D. (2016) Microfluidic Preparation of an 89Zr-Labeled Trastuzumab Single Patient Dose Journal of Nuclear Medicine 57 (5) 747-52

Lange, S.E.S., Zheleznyak A., Studer, M.,, O’Shannessy D.J., Lapi S.E., Van Tine B.A. (2016) Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET Applications Oncotarget 7 (11) 13082-92

Nie, X., Randolph, G.J., Elvington, A., Bandara, N., Zheleznyak, A. Gropler, R.J., Woodard, P.K., Lapi, S.E. Imaging of hypoxia in mouse atherosclerotic plaques with 64Cu-ATSM Nuclear Medicine and Biology, 43(9)534-542

Wooten AL, Lewis BC, Szatkowski DJ, Sultan DH, Abdin KI, Voller TF, Liu Y, Lapi S.E. Calibration setting numbers for dose calibrators for the PET isotopes 52Mn, 64Cu, 76Br, 86Y, 89Zr, 124I. Appl Radiat Isot 113:89-95.

Gordon L, Lapi SE, Anderson C, Schwarz SW; SNMMI Committee on Women in Nuclear Medicine. Working Together to Advance Women in Nuclear Medicine. J Nucl Med. 2016 Sep;57(9):14N

Graaf MD, Marquez BV, Yeh NH, Lapi SE, Moeller KD. New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of Concept. ACS Chem Biol. 2016 Sep 1.

Nie X, Randolph GJ, Elvington A, Bandara N, Zheleznyak A, Gropler RJ, Woodard PK, Lapi SE. Imaging of Hypoxia in Mouse Atherosclerotic Plaques with (64)Cu-ATSM. Nucl Med Biol. 2016 Sep;43(9):534-42.

Jin, H., Yang, H., Zhang, Y.,Zhange, X., Rosenberg, A.J., Liu, Y., Lapi, S.E., Tu, Z. (2016) A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury. J Nuci Cardiol. 2016 Feb 2.
2

Laforest, R., Lapi, S.E., Oyama, R., Bose, R.,Tabchy, A., Marquez-Nostra, B.V., Burkemper, J., Wright, B.D., Frye, J., Frye, S. Siegel, B.A., Dehdashti, F. (2016) [89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer. Mol Imaging and Biology. 2016 May 4.

Nie X., Laforest R., Elvington A., Randolph GJ., Zheng J., Voller T., Abendschein DR., Lapi SE., Woodard PK. PET/MR imaging of hypoxic atherosclerosis using 64Cu-ATSM in a rabbit model. J Nucl Med. 2016 Jul 7. pii: jnumed.116.172544.
 
 

Keywords
PET, Cyclotron, radioisotopes,