Back to Main

Faculty Detail    
Campus Address ZRB 240 Zip 0006
Phone  (205) 934-4204
Other websites

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Med - Infectious Diseases  Med - Infectious Diseases Professor

Biographical Sketch 
Dr. Edward Hook III is Professor of Medicine and Epidemiology and Director of the STD Control Program for the Jefferson County (Alabama) Department of Health.

Research/Clinical Interest
Dr. Hook’s laboratory has emphasized diagnostic testing for Neisseria gonorrhoeae, Chlamydia trachomatis and syphilis, providing a platform for a wide variety of studies. His laboratory is one of 5 CDC-funded reference laboratories for the Gonococcal Isolate Surveillance Project which has monitored trends in gonococcal epidemiology and antimicrobial resistance in the U.S. since 1988. In addition, data generated by his and Dr. Schwebke’s laboratories (see below) has reflected collaboration with other faculty of the Infectious Diseases Division and other Departments within the School of Medicine (Obstetrics and Gynecology, Pediatrics and Microbiology) and other UAB Schools (Public Health, Social and Behavioral Sciences). Dr. Hook’s recent work has included: studies of health behavior and behavioral interventions for STD/HIV risk reduction; assessment of STD epidemiology; clinical trials of new therapeutic agents; and clinical evaluation of new diagnostic tests for diagnosis of gonorrhea, chlamydial infection and syphilis. Major ongoing research efforts include his role as PI on a randomized trial evaluation of non-invasive screening for gonococcal and chlamydial infections in adolescents seeking care at hospital emergency rooms and as Protocol Chair for a randomized trial evaluation of azithromycin for treatment of syphilis. Dr. Hook’s research is currently supported thought UAB’s multi-project NIAID-funded STD CRC (PI, E. W. Hook), the NIAID-funded STD Clinical Trials Unit (CTU) [M. Cohen, UNC PI, E. W. Hook, Co-PI), and several other grants from NIH and the CDC.

Selected Publications 
Publication PUBMEDID
Stamm WE, Hicks BC, Martin DH, Leone P, Hook EW III, Cooper RH, Cohen MS, et al. Azithromycin for empiric treatment of nongonococcal urethritis syndrome: A randomized, double-blind study. JAMA 1995;274:545-549.   
Ching S, Lee H, Hook EW III, Jacobs MR, Zenilman J. Ligase chain reaction for detection of Neisseria gonorrhoeae in urogenital swabs. J Clin Micro 1995;33:3111-3114.   
Quinn TC, Gaydos C, Bobo SL, Hook EW III, Viscidi R, Rompalo A. Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships. JAMA 1996:276;1737-1742.   
Hook EW III, Smith K, Mullin C, Stephens J, Rinehardt L, Pate MS, Lee HH. Diagnosis of genitourinary Chlamydia trachomatis infections in women by using ligase chain reaction on patient-obtained vaginal swabs. J Clin Micro 1997;35:2133-2135.   
Hook EW III, Ching SF, Stephens J, Hardy KF, Smith K, Lee HH. Diagnosis of Neisseria gonorrhoeae infections in women by using ligase chain reaction on patient-obtained vaginal swabs. J Clin Micro 1997;35:2129-2132.   
Hook EW III, Richey CM, Leone P, Bolan G, Spalding C, Henry K, Clarke P, Smith M, Celum CL. Delayed presentation to clinics for sexually transmitted diseases by symptomatic patients: a potential contributor to continuing std morbidity. Sex Transm. Dis. 1997;24:443-448.   
Oh MK, Richey CM, Pate MS, Brown PR, Hook EW III. High prevalence of Chlamydia trachomatis infections in adolescent females not having pelvic examinations: utility of PCR-based urine screening in urban adolescent clinic setting. J. Adolescent Health 1997;21:80-86.   
Schwebke JR, Salder R, Sutton JM, Hook EW III. Positive screening tests for gonorrhea and chlamydia infection fail consistently to treatment of patients attending a sexually transmitted disease clinic. Sex Transm Dis. 1997;24:181-184.   
Oh K, Smith KR, Kilmer D, O’Cain M, Johnson J, Hook EW III. Urine based screening of adolescents in detention to guide treatment for gonococcal and chlamydial infections: translating research into intervention. Arch Pediatr Adol Med 1998;152:52-56.   
Paris M, Gotuzzo E, Goyzueta G, Aramburu J, Caceres CF, Castellano T, Jordan NN, Vermund SH, Hook EW III. Prevalence of gonococcal and chlamydial infections in commercial sex workers in a Peruvian Amazon city. Sex Transm Dis 1999;26:103-107.