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Faculty Detail    
Name UPENDER MANNE
Director, Translational Anatomic Pathology
Co-Director, UAB Tissue Bioreposity		  
Campus Address SHEL 811
Phone  (205) 934-4276
E-mail  upendermanne@uabmc.edu
Other websites Google Scholar
Research Gate
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Clinical Pathology  Anatomic Pathology Professor
Secondary  Epidemiology  Epidemiology Professor
Secondary  Surgery - General Surgery  Surgery - Gen Surg Gastrointestinal Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Minority Health & Research Center  Minority Health & Research Center Professor
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Manne earned his M.S. in Biochemistry, Histochemistry, Parasitology, and Zoonosis, as well as his Ph.D. in energy metabolic pathways of an endoparasite from Osmania University, Hyderabad, India. His postdoctoral training included molecular immunology and vaccine development for malaria at the Malaria Research Center in Delhi, India; research on Helicobacter infections and mucosal immunology in the Department of Microbiology, at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia; and extensive work in histopathology, tissue sciences, molecular tumor biology, cancer biomarker development, experimental therapeutics, computational biology, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). Additionally, he earned certification in bioinformatics at UAB. Dr. Manne’s research on demographic differences in colorectal and breast cancers and population-based biomarker development has received significant national and international recognition. In 2009, as part of the President’s Cancer Panel, he focused on ‘Biologic Differences Among Ancestry Groups and Their Clinical Implications in Cancer Care,’ contributing to the 2010 President’s Report titled ‘America’s Demographic and Cultural Transformation: Implications for the Cancer Enterprise.’ For over two decades, he serves as the Principal Investigator of a Comprehensive Cancer Research Partnership (U54) between the UAB O’Neal Comprehensive Cancer Center, Tuskegee University (Tuskegee, AL), and Morehouse School of Medicine (Atlanta, GA). In recent years, he also led a partnership (P20) with Alabama State University (Montgomery, AL) to reduce cancer burden through innovative, multidisciplinary, collaborative, population-based cancer control and prevention research. These programs, funded by the National Cancer Institute (NCI) of the National Institutes of Health (NIH), have contributed significantly to education, training, and community outreach.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research  Active member   
American Society of Clinical Oncology  Active member   
 



Research/Clinical Interest
Title
Translational research in grastrointestinal malignancies and breast cancer
Description
Dr. Manne’s current research focuses on population-based translational studies in human malignancies, with an emphasis on gastrointestinal (GI) cancers, including colorectal, pancreatic, and liver cancers, as well as breast cancer. His laboratory, funded by the NCI and the Susan G. Komen Foundation, investigates molecular markers to identify molecular targets, aggressive tumor phenotypes, predict chemotherapy efficacy, and assess clinical outcomes. His collaborative research group comprises experts in molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. His studies have demonstrated that the clinical utility of molecular biomarkers varies based on tumor location, stage, ancestry, age, and gender (male and female). To validate these findings, his lab evaluates hundreds of GI cancer samples from African American and non-Hispanic Caucasian patients collected from multiple institutions. By integrating molecular markers with epidemiological, environmental, and socio-economic data, his team aims to understand region-specific and ancestry-based differences in cancer biology. These biomarker discovery and bioinformatics approaches will aid in developing predictive models for personalized patient care. Dr. Manne’s research interests also extend to genomics, proteomics, and computational biology for the identification of early-stage cancer biomarkers. Specifically, his work focuses on identifying molecular signatures in benign colonic epithelium at risk of developing colorectal neoplasms, as well as pre-malignant lesions in various cancers. These studies will contribute to the evaluation of molecular and pathological characteristics of cancer specimens and aid in the development of assays for early detection, diagnosis, prognosis, and treatment.

Selected Publications 
Publication PUBMEDID
Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC, Grizzle WE.The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.Hum Pathol. 2000 Sep;31(9):1068-73.  11014573 
Manne U, Weiss HL, Grizzle WE. Bcl-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas. INT. J. CANCER, 2000; 89(5): 423-30.  11008204 
Piyathilake CJ, Johanning GL, Frost AR, Whiteside MA, Manne U, Grizzle WE, Heimburger DC, Niveleau A.Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assay.Biotech Histochem. 2000 Nov;75(6):251-8.  11131565 
Manne U, Weiss HL, Grizzle WE. Racial differences in the prognostic usefulness of MUC1 and MUC2 in colorectal adenocarcinomas. CLIN.CANCER RES. 6(10):4017-25, 2000.   11051251  
Grizzle WE, Manne U, Jhala NC, Weiss HL. Molecular characterization of colorectal neoplasia in translational research. ARCH. PATHOL.LAB. MED.,2001; 125(1): 91-8(Review).  11151060 
Gibbons MD, Manne U, Carroll WR, Peters GE, Weiss HL, Grizzle WE.Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. Laryngoscope. 2001 Aug;111(8):1373-8.  11568571 
Manne U, Gary BD, Oelschlager DK, Weiss HL, Frost AR, Grizzle WE. Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas. CLIN. CANCER RES., 2001; 7(11): 3495-503.  11705868 
Grizzle WE, Manne U, Weiss HL, Jhala NC, Talley L. Molecular staging of coloretal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2 MUC1 and p27kip-1. INT. J. CANCER.,2002; 97(4): 403-9 (Review).  11802199 
Miller CR, Gustin AN, Buchsbaum DJ, Vickers SM, Manne U, Grizzle WE, Cloud GA, Diasio RB, Johnson MR.Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro. Anal Biochem. 2002 Feb 15;301(2):189-99.  11814289 
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung. Clin Cancer Res. 2002 Mar;8(3):734-44.  11895903 
Piyathilake CJ, Frost AR, Manne U, Weiss H, Heimburger DC, Grizzle WE.Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers.Chest. 2003 Jan;123(1):181-6.  12527620 
TAlvarez RD, Conner MG, Weiss H, Klug PM, Niwas S, Manne U, Bacus J, Kagan V, Sexton KC, Grubbs CJ, Eltoum IE, Grizzle WE. The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trial.Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):114-9.  12582020 
Chhieng DC, Benson E, Eltoum I, Eloubeidi MA, Jhala NC, Jhala D, Siegal GP, Grizzle WE, Manne U. MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. CANCER., 2003; 99(6): 635-71.   14681945 
Manne U, Jhala NC, Jones J, Weiss HL, Chatla C, Meleth S. Suarez-Cuervo C, Grizzle WE. Prognostic significance of p27kip-1 expression in colorectal adenocarcinomas is associated with tumor stage. CLIN. CANCER RES.,2004; 10(5):1743-52.  15014027  
Alexander D, Chatla C, Funkhouser E, Meleth S, Grizzle WE, Manne U.Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma. Cancer. 2004 Jul 1;101(1):66-76.
 		 15221990  
Manne U, Alexander D, Chatla C. Re: Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma.
Cancer. 2004 Dec 15;101(12):2900.  		 15494973 
Alexander D, Nirag Jhala, Chatla C, Funkhouser E, Coffey C, Grizzle WE, Manne U. High grade tumor differentiation is a poor prognostic indicator of African Americans with colonic adenocarcinomas. Cancer 2005, 103:2163-2170.  15816050  
Manne U, Srivastava RG, Srivastava S. Keynote review: Recent advances in biomarker application in cancer diagnosis and treatment. Drug Discovery Today 2005, 10: 965-976.  16023055 
Chatla C, Jhala NC, Katkoori VR, Alexander D, Meleth S, Grizzle WE, Manne U. Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinoma. Cancer Biomarkers 2005, 1:241-250.   17192048 
Grizzle WE, Semmes OJ, Bigbee W, Zhu L, Malik G, Oelschlager DK, Manne B, Manne U.The need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis.Cancer Inform., 2005;1:86-97.  19305634 
Grizzle WE, Semmes OJ, Bigbee W, Zhu L, Malik G, Oelschlager DK, Manne B, Manne U.The need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis.Cancer Inform. 2005;1:86-97.  19305634 
Baker AC, Eltoum I, Curry RO, Stockard CR, Manne U, Grizzle WE, Chhieng D.Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix.Arch Pathol Lab Med. 2006 Oct;130(10):1510-5.  17090193 
Jhala N, Jhala D, Vickers SM, Eltoum I, Batra SK, Manne U, Eloubeidi M, Jones JJ, Grizzle WE. Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates.
Am J Clin Pathol. 2006 Oct;126(4):572-9.
 		 17019794  
Verma M, Manne U. Genetic and epigenetic biomarkers in cancer diagnosis and identifying high risk populations. Crit Rev Oncol Hematol. 2006 Oct;60(1):9-18. 2006 Jul 10. Review.  16829121 
Benavides MA, Oelschlager DK, Zhang HG, Stockard CR, Vital-Reyes VS, Katkoori VR, Manne U, Wang W, Bland KI, Grizzle WE. Methionine inhibits cellular growth dependent on the p53 status of cells. Am J Surg. 2007 Feb;193(2):274-83.
 		 17236862 
Manne U. Understanding racial differences in colorectal cancer aids in individualized medicine. Future Oncol., 2007 Jun;3(3):235-41.  17547516 
Alexander DD, Waterbor J, Hughes T, Funkhouser E, Grizzle W, Manne U.African-American and Caucasian disparities in colorectal cancer mortality and survival by data source: an epidemiologic review.Cancer Biomark. 2007;3(6):301-13.   18048968 
Chhieng D, Hardin M, Anderson B, Manne U. Predicting 5-year survival of colorectal carcinoma patients using data mining methods. AMIA Proc. 2007 Oct 11:907.  18694007 
Matthews KS, Estes JM, Conner MG, Manne U, Whitworth JM, Huh WK, Alvarez RD, Straughn JM Jr, Barnes MN, Rocconi RP.Lynch syndrome in women less than 50 years of age with endometrial cancer. Obstet Gynecol. 2008 May;111(5):1161-6.  8448750 
Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U.Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.Front Biosci. 2008 Jan 1;13:1050-61.   17981610  
Shanmugam C, Katkoori VR, Jhala NC, Grizzle WE, Siegal GP, Manne U.p53 Nuclear Accumulation and Bcl-2 Expression in Contiguous Adenomatous Components of Colorectal Adenocarcinomas Predict Aggressive Tumor Behavior.J Histochem Cytochem. 2008 Mar;56(3):305-12.  18071066 
Shanmugam C, Katkoori VR, Jhala NC, Grizzle WE, Manne U.Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas.Biotech Histochem. 2009 Apr;84(2):39-45.   19212825 
Harrington W, Bond V, Huang MB, Powell M, Lillard J, Manne U, Bumpers H.HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis. Mol Cell Pharmacol. 2009 Aug 5;1(2):85-91.  20383296 
Katkoori VR, Jia X, Shanmugam C, Wan W, Meleth S, Bumpers H, Grizzle WE, Manne U.Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma.Clin Cancer Res. 2009;15(7):2406-16.  19339276 
Meleth S, Chatla C, Katkoori VR, Anderson B, Hardin JM, Jhala NC, Bartolucci A, Grizzle WE, Manne U.Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker database.Cancer Inform. 2007 Mar 2;3:115-22.  19455238 
Hines RB, Chatla C, Bumpers HL, Waterbor JW, McGwin G Jr, Funkhouser E, Coffey CS, Posey J, Manne U.Predictive capacity of three comorbidity indices in estimating mortality after surgery for colon cancer.J Clin Oncol. 2009 Sep 10;27(26):4339-45.  19652054 
Hines RB, Shanmugam C, Waterbor JW, McGwin G Jr, Funkhouser E, Coffey CS, Posey J, Manne U.Effect of comorbidity and body mass index on the survival of African-American and Caucasian patients with colon cancer.Cancer. 2009 Dec 15;115(24):5798-806.
 		 19937953 
Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S.Smad signaling is required to maintain epigenetic silencing during breast cancer progression.Cancer Res. 2010 Feb 1;70(3):968-78.
 		 20086175 
Katkoori VR, Suerez-Curvo C, Shanmugam C, Bumpers, H, Posey J, Grizzle, WE, Manne U. Bax expression is a prognostic and predictive marker in colorectal cancer. J. Gastrointest Oncol, 2010;1:76-89.   22811811 
Grizzle WE, Srivastava S, Manne U. Translational pathology of neoplasia. Cancer Biomark. 2010;9(1-6):7-20 (Review).  22112467 
Wang CW, Manne U, Reddy VB, Oelschlager DK, Katkoori VR, Grizzle WE, Kapoor R.Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples.J Biomed Opt,2010; 15(6):067005.  21198209 
Atha DH, Manne U, Grizzle WE, Wagner PD, Srivastava S, Reipa V.Standards for immunohistochemical imaging: a protein reference device for biomarker quantitation. J Histochem Cytochem. 2010 Nov;58(11):1005-14.  20805583 
Anderson B, Hardin JM, Alexander DD, Grizzle WE, Meleth S, Manne U. Comparison of the predictive qualities of three prognostic models of colorectal cancer.Front Biosci (Elite Ed)., 2010 Jun 1;2:849-56.  20515758  
Shanmugam C, Jhala NC, Katkoori VR, Wan W, Meleth S, Grizzle WE, Manne U.Prognostic value of mucin 4 expression in colorectal adenocarcinomas.Cancer. 2010 Aug 1;116(15):3577-86.  20564074  
Manne U, Shanmugam C, Bovell L, Katkoori VR, Bumpers HL:miRNAs as biomarkers for management of patients with colorectal cancer.Biomark Med. 2010 Oct;4(5):761-70.  20945991  
Manne U, Shanmugam C, Katkoori VR, Bumpers HL, Grizzle WE.Development and progression of colorectal neoplasia (Review).Cancer Biomark., 2011;9(1-6):235-65.  22112479 
Kennedy RD, Bylesjo M, Kerr P, Davison T, Black JM, Kay EW, Holt RJ, Proutski V, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, McDyer F, Mulligan K, Mussen J, O'Brien E, Oliver G, Walker SM, Mulligan JM, Wilson C, Winter A, O'Donoghue D, Mulcahy H, O'Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe OF, Winqvist O, Manne U, Shanmugam C, Ramaswamy S, Leon EJ, Smith WI Jr, McDermott U, Wilson RH, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG, Harkin DP.Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue. J Clin Oncol. 2011 Dec 10;29(35):4620-6.  22067406 
Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey JA Jr, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U.Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer.J Hematol Oncol. 2011, 28;4:25.  21619690 
Bowman E, Oprea G, Okoli J, Gundry K, Rizzo M, Gabram-Mendola S, Manne U, Smith G, Pambuccian S, Bumpers HL. Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients.Breast J. 2012 May-Jun;18(3):242-7.   22583194 
Tuupanen S, Yan J, Turunen M, Gylfe AE, Kaasinen E, Li L, Eng C, Culver DA, Kalady MF, Pennison MJ, Pasche B, Manne U, de la Chapelle A, Hampel H, Henderson BE, Le Marchand L, Hautaniemi S, Askhtorab H, Smoot D, Sandler RS, Keku T, Kupfer SS, Ellis NA, Haiman CA, Taipale J, Aaltonen LA.Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583. Cancer Genet. 2012 Jan-Feb;205(1-2):25-33.  22429595 
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Keywords
Colorectal Cancer, GI malignancies, Breast Cancer, Molecular Biomarkers, Ancestry Differences, Population-based Studies, ancer Control & Prevention