Back to Main

Faculty Detail    
Name UPENDER MANNE
Director, Translational Anatomic Pathology
Co-Director, UAB Tissue Bioreposity		  
Campus Address SHEL 811
Phone  (205) 934-4276
E-mail  upendermanne@uabmc.edu
Other websites Google Scholar
Research Gate
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Clinical Pathology  Anatomic Pathology Professor
Secondary  Epidemiology  Epidemiology Professor
Secondary  Surgery - General Surgery  Surgery - Gen Surg Gastrointestinal Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Minority Health & Research Center  Minority Health & Research Center Professor
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Manne earned his M.S. in Biochemistry, Histochemistry, Parasitology, and Zoonosis, as well as his Ph.D. in energy metabolic pathways of an endoparasite from Osmania University, Hyderabad, India. His postdoctoral training included molecular immunology and vaccine development for malaria at the Malaria Research Center in Delhi, India; research on Helicobacter infections and mucosal immunology in the Department of Microbiology, at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia; and extensive work in histopathology, tissue sciences, molecular tumor biology, cancer biomarker development, experimental therapeutics, computational biology, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). Additionally, he earned certification in bioinformatics at UAB. Dr. Manne’s research on demographic differences in colorectal and breast cancers and population-based biomarker development has received significant national and international recognition. In 2009, as part of the President’s Cancer Panel, he focused on ‘Biologic Differences Among Ancestry Groups and Their Clinical Implications in Cancer Care,’ contributing to the 2010 President’s Report titled ‘America’s Demographic and Cultural Transformation: Implications for the Cancer Enterprise.’ For over two decades, he serves as the Principal Investigator of a Comprehensive Cancer Research Partnership (U54) between the UAB O’Neal Comprehensive Cancer Center, Tuskegee University (Tuskegee, AL), and Morehouse School of Medicine (Atlanta, GA). In recent years, he also led a partnership (P20) with Alabama State University (Montgomery, AL) to reduce cancer burden through innovative, multidisciplinary, collaborative, population-based cancer control and prevention research. These programs, funded by the National Cancer Institute (NCI) of the National Institutes of Health (NIH), have contributed significantly to education, training, and community outreach.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research  Active member   
American Society of Clinical Oncology  Active member   
 



Research/Clinical Interest
Title
Translational research in grastrointestinal malignancies and breast cancer
Description
Dr. Manne’s current research focuses on population-based translational studies in human malignancies, with an emphasis on gastrointestinal (GI) cancers, including colorectal, pancreatic, and liver cancers, as well as breast cancer. His laboratory, funded by the NCI and the Susan G. Komen Foundation, investigates molecular markers to identify molecular targets, aggressive tumor phenotypes, predict chemotherapy efficacy, and assess clinical outcomes. His collaborative research group comprises experts in molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. His studies have demonstrated that the clinical utility of molecular biomarkers varies based on tumor location, stage, ancestry, age, and gender (male and female). To validate these findings, his lab evaluates hundreds of GI cancer samples from African American and non-Hispanic Caucasian patients collected from multiple institutions. By integrating molecular markers with epidemiological, environmental, and socio-economic data, his team aims to understand region-specific and ancestry-based differences in cancer biology. These biomarker discovery and bioinformatics approaches will aid in developing predictive models for personalized patient care. Dr. Manne’s research interests also extend to genomics, proteomics, and computational biology for the identification of early-stage cancer biomarkers. Specifically, his work focuses on identifying molecular signatures in benign colonic epithelium at risk of developing colorectal neoplasms, as well as pre-malignant lesions in various cancers. These studies will contribute to the evaluation of molecular and pathological characteristics of cancer specimens and aid in the development of assays for early detection, diagnosis, prognosis, and treatment.

Selected Publications 
Publication PUBMEDID
Manne U, Weiss HL, Myers RB, Danner OK, Moron C, Srivastava S, Grizzle WE. Nuclear accumulation of p53 in colorectal adenocarcinoma: prognostic significance differs with race and location of the tumor. CANCER, 1998; 83(12): 2456-67.  9874449 
Manne U, Myers RB, Moron C, Poczatek RB, Dillard S, Weiss HL, Brown D, Srivastava S, Grizzle WE. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. INT. J. CANCER, 1997;74(3): 346-58.  9221816 
Manne U, Myers RB, Srivastava S, Grizzle WE. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. J. NATL. CANCER. INST., 1997; 89(8): 585-6.  9106651 
Matthews KS, Estes JM, Conner MG, Manne U, Whitworth JM, Huh WK, Alvarez RD, Straughn JM Jr, Barnes MN, Rocconi RP.Lynch syndrome in women less than 50 years of age with endometrial cancer. Obstet Gynecol. 2008 May;111(5):1161-6.  8448750 
Doidge C, Crust I, Lee A, Buck F, Hazell S, Manne U: Therapeutic immunisation against helicobacter infection. LANCET,1994; 343 (8902):914-5.  7908372 
Katkoori VR, Basson MD, Bond VC, Manne U, Bumpers HL.Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers.Oncotarget. 2015;6(29):27763-77.   6318034 
Chandrashekar DS, Afaq F, Karthikeyan SK, Athar M, Shrestha S, Singh R, Manne U, Varambally S.Bromodomain inhibitor treatment leads to overexpression of multiple kinases in cancer cells. Neoplasia. 2024 Sep 5;57:101046. doi: 10.1016/j.neo.2024.101046.  39241280  
Manne A, Esnakula A, Sheel A, Sara A, Manne U, Paluri RK, He K, Yang W, Sohal D, Kasi A, Noonan AM, Mittra A, Hays J, Roychowdhury S, Malalur P, Rahman S, Jin N, Cloyd JM, Tsai S, Ejaz A, Pitter K, Miller E, Thanikachalam K, Dillhoff M, Yu L. Mature MUC5AC Expression in Resected Pancreatic Ductal Adenocarcinoma Predicts Treatment Response and Outcomes. Int J Mol Sci. 2024 Aug 20;25(16):9041.  39201728 
Bajpai P, Agarwal S, Afaq F, Al Diffalha S, Chandrashekar DS, Kim HG, Shelton A, Miller CR, Singh SK, Singh R, Varambally S, Nagaraju GP, Manne A, Paluri R, Khushman M, Manne U. Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer. J Exp Clin Cancer Res. 2024 Jul 11;43(1):192.  38992681  
Gunturu DR, Hassan M, Bedi D, Datta P, Manne U, Samuel T. Unlocking the Potential of Therapy-Induced Cytokine Responses: Illuminating New Pathways in Cancer Precision Medicine. Curr Oncol. 2024 Feb 23;31(3):1195-1206.  38534922  
Foote JB, Mattox TE, Keeton AB, Chen X, Smith F, Berry KL, Holmes T, Wang J, Huang CH, Ward AB, Mitra AK, Ramirez-Alcantara V, Hardy C, Fleten KG, Flatmark K, Yoon KJ, Sarvesh S, Nagaraju GP, Maxuitenko Y, Valiyaveettil J, Carstens JL, Buchsbaum DJ, Yang J, Zhou G, Nurmemmedov E, Babic I, Gaponenko V, Abdelkarim H, Boyd MR, Gorman GS, Manne U, Bae S, El-Rayes BF, Piazza GA. A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer. bioRxiv [Preprint]. 2024 Jun 5:2023.05.17.541233.  38328254 
Dhasmana S, Dhasmana A, Rios S, Enriquez-Perez IA, Khan S, Afaq F, Haque S, Manne U, Yallapu MM, Chauhan SC. An integrated computational biology approach defines the crucial role of TRIP13 in pancreatic cancer. Comput Struct Biotechnol J. 2023 Nov 17;21:5765-5775.   38074464  
Afaq F, Agarwal S, Bajpai P, Diffalha SA, Kim HG, Peter S, Khushman M, Chauhan SC, Mukherjee P, Varambally S, Manne U. Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma. Neoplasia. 2024 Jan;47:100951.   38039923 
Paluri RK, Haris H, Li P, Gbolahan O, Jacob R, Manne U. Role of chemoradiation in gallbladder cancer-a single institution retrospective analysis.J Gastrointest Oncol. 2023 Oct 31;14(5):2212-2220.  37969821 
Yamada HY, Xu C, Jones KL, O'Neill PH, Venkateshwar M, Chiliveru S, Kim HG, Doescher M, Morris KT, Manne U, Rao CV. Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians. NPJ Precis Oncol. 2023 Aug 19;7(1):79.  37598287  
Elkholy A, Avuthu N, Abdalla M, Behring M, Bajpai P, Kim HG, Header D, Abo Elwafa RA, Saed H, Embaby A, El-Nikhely N, Obuya S, Mohamed M, Badawy AA, Nawar A, Afaq F, Rogers LQ, Bae S, Shikany JM, Bateman LB, Fouad M, Saleh M, Samuel T, Varambally S, Guda C, Arafat W, Manne U. Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients. Heliyon. 2023 Jul 7;9(7):e18035.  37483698  
Zimmer K, Kocher F, Untergasser G, Kircher B, Amann A, Baca Y, Xiu J, Korn WM, Berger MD, Lenz HJ, Puccini A, Fontana E, Shields AF, Marshall JL, Hall M, El-Deiry WS, Hsiehchen D, Macarulla T, Tabernero J, Pichler R, Khushman M, Manne U, Lou E, Wolf D, Sokolova V, Schnaiter S, Zeimet AG, Gulhati P, Widmann G, Seeber A. PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system. NPJ Precis Oncol. 2023 Jul 3;7(1):64.   37400502 
Orandi BJ, Li G, Dhall D, Bajpai P, Manne U, Arora N, Lu A, Coronado AC, Kassel R, Pinninti S, Lewis CE, Chapleau C, Locke JE, Gutierrez Sanchez LH. JPGN Rep. Acute Liver Failure in a Healthy Young Female With COVID-19. 2021 Jul 22;2(3):e108.   37205955 
Agarwal S, Afaq F, Bajpai P, Behring M, Kim HG, Varambally A, Chandrashekar DS, Peter S, Diffalha SA, Khushman M, Seeber A, Varambally S, Manne U. BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis. Mol Cancer Res. 2023 Jul 5;21(7):698-712.  37067340  
Southekal S, Shakyawar SK, Bajpai P, Elkholy A, Manne U, Mishra NK, Guda C. Molecular Subtyping and Survival Analysis of Osteosarcoma Reveals Prognostic Biomarkers and Key Canonical Pathways. Cancers (Basel). 2023 Apr 4;15(7):2134.   37046795 
Patel C, Behring M, Al Diffalha S, Dhall D, Lee G, Shanmugam C, Grizzle WE, Manne U. Immunophenotypic profiles and prognosis for colorectal mucinous adenocarcinomas are dependent on anatomic location. Cancer Med. 2023 Apr;12(8):9637-9643.   36916704 
Karthikeyan SK, Xu N, Ferguson Rd JE, Rais-Bahrami S, Qin ZS, Manne U, Netto GJ, S Chandrashekar D, Varambally S. Identification of androgen response-related lncRNAs in prostate cancer. Prostate. 2023 May;83(6):590-601.  3676020 
Dhall D, Makhoul E, Taguibao R, Waters K, Zhang W, Vail E, Lee G, Diffalha SA, Patel C, Manne U, Behring M, Chopra S, Harada S. Molecular characterization of visible low-grade dysplastic lesions in patients with inflammatory bowel disease. Hum Pathol. 2023 May;135:108-116.   36754311 
Bajpai P, Banerjee NS, Moore DW, Kim HG, Afaq F, Contreras CM, Heslin MJ, Reddy VB, Peter S, Varambally S, Al Diffalha S, Manne U.
Developing 3D Organoid Raft Cultures from Patient-Derived Xenografts as Rapid Models to Screen Efficacy of Experimental Therapeutics. Int J Mol Sci. 2022 Nov 19;23(22):14392. 		 36430867 
Obuya S, Elkholy A, Avuthu N, Behring M, Bajpai P, Agarwal S, Kim HG, El-Nikhely N, Akinyi P, Orwa J, Afaq F, Abdalla M, Michael A, Farouk M, Bateman LB, Fouad M, Saleh M, Guda C, Manne U, Arafat W. A signature of Prevotella copri and Faecalibacterium prausnitzii depletion, and a link with bacterial glutamate degradation in the Kenyan colorectal cancer patients. J Gastrointest Oncol. 2022 Oct;13(5):2282-2292.  36388691 
Behring M, Bajpai P, Afaq F, Elkholy A, Kim HG, Al Diffalha S, Shrestha S, Manne U. Age-Dependent Heterogeneity of Lymph Node Metastases and Survival Identified by Analysis of a National Breast Cancer Registry. J Pharm Pharmacol Res. 2022;6(3):147-157.  36304424 
Wells G, Glasgow JN, Nargan K, Lumamba K, Madansein R, Maharaj K, Perumal LY, Matthew M, Hunter RL, Pacl H, Peabody Lever JE, Stanford DD, Singh SP, Bajpai P, Manne U, Benson PV, Rowe SM, le Roux S, Sigal A, Tshibalanganda M, Wells C, du Plessis A, Msimang M, Naidoo T, Steyn AJC. A high-resolution 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions. EMBO Mol Med. 2022 Nov 8;14(11):e16283.  36285507 
Martini R, Delpe P, Chu TR, Arora K, Lord B, Verma A, Bedi D, Karanam B, Elhussin I, Chen Y, Gebregzabher E, Oppong JK, Adjei EK, Jibril Suleiman A, Awuah B, Muleta MB, Abebe E, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, Osei-Bonsu EB, Chitale DA, Bensenhaver JM, Nathanson DS, Jackson L, Petersen LF, Proctor E, Stonaker B, Gyan KK, Gibbs LD, Monojlovic Z, Kittles RA, White J, Yates CC, Manne U, Gardner K, Mongan N, Cheng E, Ginter P, Hoda S, Elemento O, Robine N, Sboner A, Carpten JD, Newman L, Davis MB. African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. Cancer Discov. 2022 Nov 2;12(11):2530-2551.  36121736 
Rehman H, Chandrashekar DS, Balabhadrapatruni C, Nepal S, Balasubramanya SAH, Shelton AK, Skinner KR, Ma AH, Rao T, Agarwal S, Eich ML, Robinson AD, Naik G, Manne U, Netto GJ, Miller CR, Pan CX, Sonpavde G, Varambally S, Ferguson JE 3rd. ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors. JCI Insight. 2022 Aug 22;7(16):e155899  35852858  
Shanmugam C, Behring M, Luthra V, Leal SM, Varambally S, Netto GJ, Manne U. Meta-analysis of the robustness of COVID-19 diagnostic kit performance during the early pandemic. BMJ Open. 2022 Apr 21;12(4):e053912.  35450897 
Burkett AE, Sher SB, Patel CR, Ildin-Eltoum I, Dhall D, Margaroli C, Peter S, Lee G, Bajpai P, Benson PV, Manne U, Al Diffalha S. Gastrointestinal Manifestations of COVID-19 Infection: Clinicopathologic Findings in Intestinal Resections Performed at Single Institution. Front Med (Lausanne). 2022 Feb 14;9:811546.  35237625 
Agarwal S, Afaq F, Bajpai P, Kim HG, Elkholy A, Behring M, Chandrashekar DS, Diffalha SA, Khushman M, Sugandha SP, Varambally S, Manne U. DCZ0415, a small-molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β-catenin pathway in colorectal cancer. Mol Oncol. 2022 Apr;16(8):1728-1745.  35194944 
Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, Creighton CJ, Varambally S. UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 2022 Mar;25:18-27. doi  35078134 
Haynes T, Oprea-Ilies G, Manne U, Singh R, Singh S, Mir H. The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity. Transl Oncol. 2022 Feb;16:101330.   34990909 
Malik S, Stokes Iii J, Manne U, Singh R, Mishra MK. Understanding the significance of biological clock and its impact on cancer incidence. Cancer Lett. 2022 Feb 28;527:80-94.   34906624 
Mani C, Tripathi K, Omy TR, Reedy M, Manne U, Palle K. GLI1-targeting drugs induce replication stress and homologous recombination deficiency and synergize with PARP-targeted therapies in triple-negative breast cancer cells Biochim Biophys Acta Mol Basis Dis. 2022 Feb 1;1868(2):166300.   34748904 
Espinoza I, Agarwal S, Sakiyama M, Shenoy V, Orr WS, Diffalha SA, Prizment A, Varambally S, Manne U, Gomez CR. Expression of MHC class I polypeptide-related sequence A (MICA) in colorectal cancer. Front Biosci (Landmark Ed). 2021 Oct 30;26(10):765-776.   34719204  
Vu T, Datta A, Banister C, Jin L, Yuan G, Samuel T, Bae S, Eltoum IE, Manne U, Zhang B, Welner RS, Mitra K, Buckhaults P, Datta PK. STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism. Gastroenterology. Gastroenterology. 2022 Jan;162(1):193-208. doi: 10.1053/j.gastro.2021.09.010.  34520730 
Burkett A, McElwee S, Margaroli C, Bajpai P, Elkholy A, Manne U, Wille K, Benson P. Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. Case Rep Pulmonol. 2021 Aug 28;2021:5484239. doi: 10.1155/2021/5484239. eCollection 2021.
 		 34513107 
Chandrashekar DS, Athar M, Manne U, Varambally S. Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells.Sci Rep. 2021 Aug 10;11(1):16212. doi: 10.1038/s41598-021-95733-w  34376762 
Behring M, Ye Y, Elkholy A, Bajpai P, Agarwal S, Kim HG, Ojesina AI, Wiener HW, Manne U, Shrestha S, Vazquez AI. Immunophenotype-associated gene signature in ductal breast tumors varies by receptor subtype, but the expression of individual signature genes remains consistent. Cancer Med. 2021 Aug;10(16):5712-5720. doi: 10.1002/cam4.4095. Epub 2021 Jun 29.  34189853  
Robinson AD, Chakravarthi BVSK, Agarwal S, Chandrashekar DS, Davenport ML, Chen G, Manne U, Beer DG, Edmonds MD, Varambally S.Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Transl Oncol. 2021 Aug;14(8):101128. doi: 10.1016/j.tranon.2021.101128. Epub 2021 May 25.  34049151  
Saleh M, Chandrashekar DS, Shahin S, Agarwal S, Kim HG, Behring M, Shaikh AJ, Moloo Z, Eltoum IA, Yates C, Varambally S, Manne U. Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women.Transl Oncol. 2021 Jul;14(7):101086. doi: 10.1016/j.tranon.2021.101086. Epub 2021 Apr 8.  33839593  
Shanmugam C, Behring M, Luthra V, Leal SM, Diffalha SA, Varambally S, Netto GJ, Manne U.Meta-Analysis of Robustness of COVID-19 Diagnostic Kits During Early Pandemic. MedRxiv. 2021 Jan 20:2021.01.16.21249937. doi: 10.1101/2021.01.16.21249937.  33501458  
Espinoza I, Agarwal S, Reddy A, Shenoy V, Subramony C, Sakiyama M, Fair L, Poosarla T, Zhou X, Shannon Orr W, Lahr C, Bae S, Al Diffalha S, Manne U, Gomez CR. Expression of trefoil factor 3 is decreased in colorectal cancer.
Oncol Rep. 2021 Jan;45(1):254-264. doi: 10.3892/or.2020.7829. 		 33210724  
Mishra NK, Niu M, Southekal S, Bajpai P, Elkholy A, Manne U, Guda C. Identification of Prognostic Markers in Cholangiocarcinoma Using Altered DNA Methylation and Gene Expression Profiles. Front Genet. 2020 Oct 20;11:522125. doi: 10.3389/fgene.2020.522125.  33193605  
Gibson JT, Orlandella RM, Turbitt WJ, Behring M, Manne U, Sorge RE, Norian LA. Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer.
Front Immunol. 2020 Oct 6;11:590794. doi: 10.3389/fimmu.2020.590794. 		 33123173 
Stokes Iii J, Vinayak S, Williams J, Malik S, Singh R, Manne U, Owonikoko TK, Mishra MK.
Optimum health and inhibition of cancer progression by microbiome and resveratrol. Front Biosci (Landmark Ed). 2021 Jan 1;26:496-517.  		 33049680 
Agarwal S, Behring M, Kim HG, Chandrashekar DS, Chakravarthi BVSK, Gupta N, Bajpai P, Elkholy A, Al Diffalha S, Datta PK, Heslin MJ, Varambally S, Manne U. TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status. Mol Oncol. 2020 Dec;14(12):3007-3029. doi: 10.1002/1878-0261.12821.   33037736 
Memon RA, Granada CNP, Patel C, Manne U, Heslin MJ, Gbolahan OB, Harada S, Diffalha SA. Gastric Sclerosing Epithelioid Fibrosarcoma Harboring a Rare FUS- CREM Fusion. Int J Surg Pathol. 2020 Sep 23:1066896920961174. doi: 10.1177/1066896920961174.  32964769 
First Prev   1 2 3 4 of  4  Next Last  

Keywords
Colorectal Cancer, GI malignancies, Breast Cancer, Molecular Biomarkers, Ancestry Differences, Population-based Studies, ancer Control & Prevention