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Faculty Detail    
Name HEMANT TIWARI
 
Campus Address RPHB 420C Zip 0022
Phone  (20-5) -907
E-mail  htiwari@ms.soph.uab.edu
Other websites http://www.soph.uab.edu/Statgenetics/
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Biostatistics  Biostatistics Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Medicine  Ctr Cardiovasc Bio (Org Ret) Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Genetics, Genomics and Bioinformatics 
Integrative Biomedical Sciences 
Integrative Genetics Graduate Program 

Biographical Sketch 
Dr. Tiwari received his Ph.D. in mathematics from the University of Notre Dame, South Bend, Indiana. While being a faculty at the University of Maine, he got interested in statistical genetics, and completed a post-doctoral fellowship in Statistical Genetics under Prof. Robert Elston in the Department of Biometry and Genetics at Louisiana State University Medical Center, New Orleans and at the Case Western Reserve University in Cleveland. Subsequently, he worked as a faculty member in the Department of Epidemiology and Biostatistics at Case Western Reserve University. In January 2002, he joined as a faculty in the Department of Biostatistics (Section on Statistical Genetics) at UAB. As of Dec 2002, he has been a primary faculty in the Department of Pathology.

Society Memberships
Organization Name Position Held Org Link
International Biometric Society     
Institute of Mathematical Statistics     
International Genetic Epidemiology Society     
American Society of Human Genetics     



Research/Clinical Interest
Title
Genetic association/linkage analysis
Description
His research interests include Genetic Association/Linkage Analysis, Disequilibrium Mapping, Population Genetics, Molecular Evolution, Bioinformatics, and Genetics of Infectious Diseases. Currently, he is involved in gene mapping studies of Epilepsy, SLE, Rheumatoid Arthritis, Phonological disorders, and Obesity related traits. He has developed methods for analysis of quantitative traits for sib pairs data using variance components modeling, QTDT method for pedigree data, joint tests for linkage/ association mapping of complex diseases, and X-linkage for sib pair data.

Selected Publications 
Publication PUBMEDID
Tiwari HK, Holt J, George V, Beasley TM, Amos CI, Allison DB (2005): New Joint Covariance- and Marginal-based Tests for Association & Linkage for Quantitative Traits for random and non-random sampling. Genet Epidemiol 28(1): 48-57.   
George V, Elston RC & Tiwari HK (2004): Two-Stage Designs for Gene-Disease Association Studies. The 2004 JSM Proceedings.   
Tiwari HK, Holt J, George V, Beasley TM, Amos CI, Allison DB (2004): Power and cost consideration in joint tests of association & linkage for quantitative traits. The 2004 JSM proceedings.   
Criswell LA, Lum RF, Turner KN, Woehl B, Tiwari HK, Edberg JC, Kimberly RP, Finck BK, Leff J, Whitmore J, Moreland LW, Seldin MF, and Bridges, Jr. SL (2004): The Influence of Genetic Variations in the HLA Class II and TNF-LTA Regions on Response to Treatment of Early Rheumatoid Arthritis with Methotrexate or Etanercept. Arthritis & Rheumatism, September 2004, 50:9; pp. 2750-2756.   
Rankinen T, Tiwari HK (2004): Genome scans for Human Nutritional Traits. What have we learned? Nutrition 20(1):9-13.   
Tiwari HK, Zhu X, Elston RC, Shu Y, George V (1999): Association and linkage analysis of ICD-10 diagnosis of alcoholism. Genet Epidemiol 17: S343-347.   
Tiwari HK, Allison DB (2003): Do allelic variants of SLC6A14 predispose to obesity? J Clin Invest 112 (11):1633-1636. (editorial)   
Bridges, Jr. SL, Hughes LB, Mikuls TR, Howard G, Tiwari HK, McNicholl JM, Alarcón GS, and Moreland LW for CLEAR Investigators (2003): Early Rheumatoid Arthritis in African-Americans: The CLEAR Registry. Clin Exp Rheumatol 21(Suppl. 31): S138-S145.   
Stein CM, Song Y, Elston RC, Jun G, Tiwari HK, Iyenger SK (2003): Structural equation model-based genome scan for metabolic syndrome. BMC Genetics 4 (Suppl 1):S99.   
Wiener H, Elston RC, Tiwari HK (2003): X-linked Extension of the Revised Haseman-Elston Algorithm for Linkage Analysis in Sib Pairs. Hum Hered 55:97-107.   
Stein CM, Guwatudde D, Nakakeeto M, Peters P, Elston RC, Tiwari HK, Mugerwa R, Whalen C (2003): Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis 187: 1679-85.   
Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Fairburn C, Goodwin G, Neale M, , Fiddy S, Mott R, Allison DB, Flint J (2003): Linkage analysis of extremely discordant and concordant sibling pairs identifies QTL that influence variation in the human personality trait neuroticism. Am J Hum Genet 72(4):879-90.   
Thiel BA, Chakravarti A, Cooper RS, Luke Amy, Lewis S, Lynn A, Tiwari HK, Schork NJ, Weder AB (2003): A genome wide linkage analysis investigating the determinants of blood pressure in Caucasians and African Americans Am J Hypertens. 16: 151-153.   
Gass JU, Valiathan M, Tiwari HK, Hans MG, Elston RC (2003): Familial correlations and heritability of maxillary midline diastema. Am J Orthod Dentofacial Orthop 2003;123:29-34.   
Valiathan M, Tiwari HK, Elston RC, Hans MB (2002): Genetic epidemiology: dental phenotypes in focus. Craniofacial Growth Series. , Vol 39: 237-255.    
Hall MA, Norman P, Thiel B, Tiwari H, Peiffer A, Vaughan RW, Prescott S, Leppert M, Schork NJ, Lanchbury JS (2002): Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12 and 18 control variation in levels of T and B lymphocyte sub-populations. Am. J. Hum. Genet. 70:1172-1182.   
Jedrey CM, Chen C-H, Moser KL, Wedig G, George V, Tiwari HK (2001): Transmission/Disequilibrium test analysis of total serum IgE levels in Hutterite and Collaborative Study on the Genetics of Asthma data sets. Genet Epidemiol 21:298-302.   
Shete S, Tiwari HK, Elston RC (2000): On estimating the heterozygosity and polymorphism information content value. Theor Popul Biol 57:265-271.   
George V, Tiwari HK, Shu Y, Zhu X, Elston RC (1999): Linkage analysis of alcoholism by regression of parental transmission. Genet Epidemiol 17: S157-161.   
Tiwari HK, Elston RC (1997): Deriving Components of Genetic Variance for Multilocus Models. Genet Epidemiol 14: 1131-1136.   
George V, Tiwari HK, Zhu X, Elston RC (1999): A Test of Transmission/ Disequilibrium for Quantitative traits in Pedigree Data using Multiple Regression. Am J Hum Genet 65: 236-245.   
Tiwari HK, Elston RC (1999): The Approximate Variance of a Function of Random Variables. Biometrical Journal 41: 351-357.    
Tiwari HK, Elston RC (1998):Restrictions on Components of Variance for Epistatic Models. Theor Popul Biol. 54:161-174.   
Tiwari HK, Elston RC (1997): Linkage of Multilocus Components of Variance to Polymorphic Markers. Ann Hum Genet 61: 253-261.   
Knight A, Batzer MA, Stoneking M, Tiwari HK, Scheer WD, Herrera RJ, Deininger PL (1996): DNA Sequences of Alu Elements Indicate a Recent, Single Origin for Modern Humans. Proc Nat Acad Sci USA 93:4360-4364.   

Keywords
Obesity, SLE, RA, Epilepsy