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Faculty Detail    
Name BRADFORD A. WOODWORTH
 
Campus Address FOT 1158 Zip 3412
Phone  (20-5) -801
E-mail  bwoodwo@uab.edu
Other websites
Career Advisor     

Education
Medical School  Tulane University School of Medicine    2001  MD 
Graduate  Medical University of South Carolina Medical Center    2002  Surgery 
Residency  Medical University of South Carolina Medical Center    2006  Otolaryngology 
Fellowship  University of Pennsylvania Hospital    2007  Rhinology  


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Otolaryngology   Otolaryngology Chair Office Professor
Secondary  Surgery   Surgery - Gen Surg Gastrointestinal Section Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor

Biographical Sketch 
Dr. Woodworth is an Associate Professor of Surgery at UAB School of Medicine and holds the James J. Hicks Endowed Chair of Otolaryngology. He graduated from Tulane University School of Medicine and completed residency training in Otolaryngology-Head and Neck Surgery at Medical University of South Carolina. Dr. Woodworth completed fellowship training in Rhinology and Sinus Surgery at the University of Pennsylvania. Dr. Woodworth is an NIH funded researcher with over 1 million dollars in grants investigating therapeutic interventions that enhance mucociliary clearance in both cystic fibrosis (where chronic rhinosinusitis is virtually universal) and non-cystic fibrosis chronic rhinosinusitis. He is also nationally and internationally recognized regarding his research on cerebrospinal fluid leak/skull base defect repair. He has published over 100 journal articles and chapters dealing primarily with sinus and skull base disorders. Dr. Woodworth and his mentored students/residents have also been awarded numerous regional, national, and international honors for the research and manuscripts related to these topics.

Society Memberships
Organization Name Position Held Org Link
American College of Surgeons  Fellow    
Triological Society  Fellow   



Research/Clinical Interest
Title
Chloride secretagogues for acquired CFTR dysfunction in chronic rhinosinusitis,Pathophysiologic Mechanisms in Chronic Rhinosinusitis
Description
The major goals of the first project is to provide a means to understand the pathogenic mechanism underlying CRS, and a new therapeutic strategy for restoring and/or increasing CFTR activity in sinus and nasal epithelium. The major goals of the second award provides ongoing research support for several long-term objectives: 1) Develop a human sinonasal mucosa tissue bank from patients undergoing endoscopic sinus surgery for future investigations into expression patterns of innate and adaptive immunity proteins, 2) Use transgenic mouse knockouts to specifically address gene product involvement in sinonasal mucosal inflammation and mucociliary dysfunction, 3) Develop potential therapies to enhance mucociliary clearance

Selected Publications 
Publication PUBMEDID
Zhang S, Skinner D, Hicks SB, Bevensee MO, Sorscher EJ, Lazrak A, Matalon S,McNicholas CM, Woodworth BA. Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance. PLoS One. 2014 Aug 12;9(8):e104090. doi: 10.1371/journal.pone.0104090.
eCollection 2014. PubMed PMID: 25117505; PubMed Central PMCID: PMC4130514 
25117505 
Zhang S, Ranganath NK, Skinner D, Bedwell DM, Buckley-Lanier JA, Sorscher EJ, Woodworth BA. Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model. J Cyst Fibros. 2014 May;13(3):351-2. doi: 10.1016/j.jcf.2013.11.009. Epub
2013 Dec 27. PubMed PMID: 24378376; PubMed Central PMCID: PMC4300118 
24378376 
Alexander NS, Hatch N, Zhang S, Skinner D, Fortenberry J, Sorscher EJ, Woodworth BA. Resveratrol has salutary effects on mucociliary transport and inflammation in sinonasal epithelium. Laryngoscope. 2011 Jun;121(6):1313-9. doi:
10.1002/lary.21798. Epub 2011 Apr 7. PubMed PMID: 21480283; PubMed Central PMCID:PMC3100379 
21480283 
Woodworth BA, Tamashiro E, Bhargave G, Cohen NA, Palmer JN. An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers. Am J Rhinol. 2008 May-Jun;22(3):235-8. doi: 10.2500/ajr.2008.22.3178.   18588754 

Keywords
chronic rhinosinusitis, sinus research