Undergraduate |
University of Pennsylvania |
|
1980 |
B.A. |
Medical School |
Harvard Medical School |
|
1984 |
Medical |
Residency |
Barnes Hospital, Department of Internal Medicine, |
|
1987 |
Residency |
Residency |
Washington University School of Medicine |
|
1987 |
Residency |
Fellowship |
Endocrinology and Metabolism, Developmental Endocrinology Branch, National Institute of Child Health and Human Development |
|
1990 |
Fellowship |
Fellowship |
Medical Staff Fellow/Senior Staff Fellow. Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD. |
|
1991 |
Fellowship |
|
Biochemistry and Structural Biology |
Cancer Biology |
Cell, Molecular, & Developmental Biology |
Cellular and Molecular Biology Program |
Hughes Med-Grad Fellowship Program |
Integrative Biomedical Sciences |
Medical Scientist Training Program |
Pathobiology and Molecular Medicine |
Waiting to be Seated |
|
Publication |
PUBMEDID |
Zhang, Y., Jiang, J., Kopchick, J.J., Frank, S.J. Disulfide Linkage of Growth Hormone Receptors Reflects GH-induced GHR Dimerization: Association of JAK2 with the GHR is Enhanced by Receptor Dimerization. J. Biol. Chem. 274 (46): 33072-33084, 1999. |
10551877 |
Kim, S.-O., Houtman, J., Jiang, J., Ruppert, J.M., Bertics, P.J., Frank, S.J. Growth Hormone-induced Alteration in ErbB-2 Phosphorylation Status in 3T3-F442A Fibroblasts. J. Biol. Chem. 274 (50): 36015-36024, 1999. |
10585492 |
Liang, L., Jiang, J., Frank, S.J. Insulin Receptor Substrate-1-Mediated Enhancement of Growth Hormone-Induced MAP Kinase Activation. Endocrinology 141(9): 3328-3336, 2000. |
10965905 |
Zhang, Y., Jiang, J., Black, R.A., Baumann, G., Frank, S.J. Tumor Necrosis Factor-Alpha Converting Enzyme (TACE) is a Growth Hormone Binding Protein (GHBP) Sheddase: the Metalloprotease TACE/ADAM-17 is Critical for (PMA-induced) Growth Hormone Receptor Proteolysis and GHBP Generation. Endocrinology 141(12): 4342-4348, 2000. |
11108241 |
Guan, R., Zhang, Y., Jiang, J., Baumann, C.A., Black, R.A., Baumann, G., Frank, S.J. Phorbol Ester- and Growth Factor-induced Growth Hormone Receptor Proteolysis and Growth Hormone Binding Protein Shedding: Relationship to Growth Hormone Receptor Downregulation. Endocrinology 142(3):1137-1147, 2001. |
11181529 |
Zhang, Y., Guan, R., Jiang, J., Kopchick, J.J., Black, R.A., Baumann, G., Frank, S.J. GH-induced Dimerization Inhibits Phorbol Ester-stimulated GH Receptor Proteolysis., J. Biol. Chem. 276(27):24565-24573, 2001. |
11309389 |
Wang, X., He, K., Gerhart, M., Huang, Y., Jiang, J., Paxton, R.L., Yang, S., Lu, C., Menon, R.K., Black, R.A., Baumann, G., Frank, S.J. Metalloprotease-mediated GH Receptor Proteolysis and GHBP Shedding: Determination of Extracellular Domain Stem Region Cleavage Site., J. Biol. Chem., 277(52): 50510-50519, 2002. |
12403792 |
Kim, S.-O., Loesch, K., Wang, X., Jiang, J., Mei, L., Cunnick, J., Wu, J., Frank, S.J. A Role for Grb2-associated binder (Gab)-1 in Growth Hormone Signaling., Endocrinology, 143(12): 4856-4867, 2002. |
12446613 |
Huang Y, Kim SO, Jiang J, Frank SJ. Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling. J Biol Chem. 2003 May 23;278(21):18902-13, 2003 |
12642595 |
Wang X, He K, Gerhart M, Jiang J, Paxton RJ, Menon RK, Black RA, Baumann G, Frank SJ. Reduced proteolysis of rabbit growth hormone (GH) receptor substituted with mouse GH receptor cleavage site. Mol Endocrinol. 2003 Oct;17(10):1931-43. 2003 |
12829808 |
He K, Wang X, Jiang J, Guan R, Bernstein KE, Sayeski PP, Frank SJ. Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol Endocrinol. 2003 Nov;17(11):2211-27. 2003 |
12920237 |
Yang N, Huang Y, Jiang J, Frank SJ. Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling. J Biol Chem. 2004 May 14;279(20):20898-905. 2004 |
15010456 |
Huang Y, Kim SO, Yang N, Jiang J, Frank SJ. Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elements. Mol Endocrinol. 2004 Jun;18(6):1471-85. 2004 |
15044591 |
Huang Y, Chang Y, Wang X, Jiang J, Frank SJ. Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 3T3-F442A cells. Endocrinology. 2004 Jul;145(7):3297-306. 2004 |
15070853 |
Jiang J, Wang X, He K, Li X, Chen C, Sayeski PP, Waters MJ, Frank SJ A conformationally-sensitive growth hormone receptor antibody: impact on GH signaling and GHR proteolysis. Mol. Endocrinol. 2004 Dec;18(12):2981-96. |
15345746 |
Cowan JW, Wang X, Guan R, He K, Jiang J, Baumann G, Black RA, Wolfe MS, Frank SJ. Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. J Biol Chem. 2005 May 13;280(19):19331-42. |
15743767 |
He K, Loesch K, Cowan JW, Li X, Deng L, Wang X, Jiang J, Frank SJ. Janus kinase 2 enhances the stability of the mature growth hormone receptor. Endocrinology. 2005 Nov;146(11):4755-65. |
16081639 |
Loesch K, Deng L, Cowan JW, Wang X, He K, Jiang J, Black RA, Frank SJ. Janus kinase 2 influences growth hormone receptor metalloproteolysis. Endocrinology. 2006 Jun;147(6):2839-49. |
16497804 |
Huang Y, Li X, Jiang J, Frank SJ. Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells. Oncogene. 2006 Dec 7;25(58):7565-76. |
16785991 |
Frank SJ, Wang X, He K, Yang N, Fang P, Rosenfeld RG, Hwa V, Chaudhuri TR, Deng L, Zinn KR. In vivo Imaging of Hepatic Growth Hormone Signaling. Mol Endocrinol. 2006 Nov;20(11):2819-30. |
16803867 |
Frank, S.J. Growth hormone, insulin-like growth factor I, and growth: local knowledge. Endocrinology. 2007 Apr;148(4):1486-8. |
17369499 |
Yang, N., Wang, X., Jiang, J., Frank, S.J. Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation. Mol Endocrinol. 2007 Jul;21(7):1642-55. |
17456794 |
Deng, L., He, K., Wang, X., Yang, N., Thangavel, C., Jiang, J., Fuchs, S.Y., Frank, S.J. Determinants of growth hormone receptor down-regulation. Mol Endocrinol. 2007 Jul;21(7):1537-51. |
17488973 |
Asa, S.L., Digiovanni, R., Jiang, J., Ward, M.L., Loesch, K., Yamada, S., Sano, T., Yoshimoto, K., Frank, S.J., Ezzat, S. A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors. Cancer Res. 2007 Aug 1;67(15):7505-11. |
17671221 |
DiGirolamo, D.J., Mukherjee, A., Fulzele, K., Gan, Y., Cao, X., Frank, S.J., Clemens, T.L. Mode of growth hormone action in osteoblasts.J Biol Chem. 2007 Oct 26;282(43):31666-74 |
17698843 |
Loesch, K., Deng, L., Wang, X., He, K., Jiang, J., Frank, S.J. Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells. Endocrinology 148(12):5955-65, 2007. |
17761766 |
Yang, N., Langenheim, J.F., Wang, X., Jiang, J., Chen, W.Y., Frank, S.J. Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering. Mol Endocrinol 22(4):978-88, 2008. |
18096690 |
Zinn, K.R., Chaudhuri, T.R., Szafran, A.A., O'Quinn, D., Weaver, C., Dugger, K., Lamar, D., Kesterson, R.A., Wang, X., Frank, S.J. Noninvasive bioluminescence imaging in small animals. ILAR J: 49(1):103-15, 2008 |
18172337 |
Frank, S.J. Mechanistic Aspects of Crosstalk Between GH and PRL and ErbB Receptor Family Signaling. J Mammary Gland Biol Neoplasia 13(1):119-29, 2008 |
18236142 |
Wang, X., Jiang, J., Warram, J., Baumann, G., Gan, Y., Menon, R.K., Denson, L.A., Zinn, K.R., Frank, S.J. Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity. Mol. Endocrinol., 22(6):1427-1437, 2008. |
18323468 |
Li, X., Huang, Y., Jiang, J., Frank, S.J. ERK-mediated threonine phosphorylation of EGF receptor: impact on receptor downregulation and signaling. Cellular Signalling, 20(11):2145-2155, 2008. |
18762250 |
Wang, X., Yang, N., Deng, L., Li, X., Jiang, J., Gan, Y., Frank, S.J. Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1. Mol. Endocrinol. 23(4): 486-496, 2009. |
19164446 |
Yang, N., Jiang, J., Deng, L., Waters, M.J., Wang, X., Frank, S.J. Growth hormone receptor targeting to lipid rafts requires extracellular subdomain 2. Bioch. Biophys. Res. Comm., 391(1): 414-418, 2010. |
19914217 |
Gan, Y., Zhang, Y., DiGirolamo, D., Jiang, J., Wang, X., Cao, X., Zinn, K.R., Carbone, D.P., Clemens, T.L., Frank, S.J. Deletion of Insulin-like Growth Factor-1 Receptor (IGF-1R) in primary osteoblasts reduces GH-induced STAT5 signaling. Mol. Endocrinol. 24(3): 644-656, 2010. |
20133448 |
Mavalli, M.D., DiGirolamo, D.J., Riddle, R.C., Fan, Y., Campbell, K.S., Sperling, M.A., van Groen, T., Frank, S.J., Bamman, M.M., Clemens, T.L. Distinct growth hormone receptor signaling modes control skeletal muscle development and insulin sensitivity. J. Clin. Invest., 120(11): 4007-4020, 2010. |
20921627 |
Li, X., Huang, Y., Jiang, J., Frank, S.J. Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptors. Cellular Signalling, 23(2):417-424, 2011. |
20946955 |
Xu, J., Zhang, Y., Berry, P.A., Jiang, J., Lobie, P.E., Langenheim J.F., Chen, W.Y., Frank, S.J. Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex. Mol. Endocrinol. 25(4): 597-610, 2011. |
21310852 |
Wang, X., Cowan, J.W., Gerhart, M., Zelickson, B.R., Jiang, J., He, K., Wolfe, M.S., Black, R.A., Frank, S.J. gamma-Secretase-mediated growth hormone receptor proteolysis: mapping of the intramembranous cleavage site. Bioch. Biophys. Res. Comm. 408(3): 432-436, 2011 |
21514282 |
Kim, S.-O., Jiang, J., Yi, W., Feng, G.-S., Frank, S.J. Involvement of the SH2-containing Tyrosine Phosphatase SHP-2 in Growth Hormone Signalling. J. Biol. Chem. 273(4): 2344-2354, 1998. |
9442080 |
Alele, J., Jiang, J., Goldsmith, J.F., Yang, X., Maheshwari, H.G., Black, R.A., Baumann, G., Frank, S.J. Blockade of Growth Hormone Receptor Shedding by a Metalloprotease Inhibitor. Endocrinology 139 (4): 1927-1935, 1998. |
9528979 |
|
|