Appointment Type |
Department |
Division |
Rank |
Primary |
Pathology |
Molecular & Cellular Pathology |
Professor |
Secondary |
Periodontology |
Periodontology |
Professor |
Center |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
|
Cancer Biology |
Integrative Genetics Graduate Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Wang Y, Chen W, Hao L, McVicar A, Wu J, Gao N, Liu Y, Li YP. C1 Silencing Attenuates Inflammation and Alveolar Bone Resorption in Endodontic Disease. J Endod. 2019 Jul;45(7):898-906. doi: 10.1016/j.joen.2019.02.024. Epub 2019 May 16. PMID: 31104818 |
31104818 |
Li Z, Liu T, Gilmore A, Gómez NM, Fu C, Lim J, Yang S, Mitchell CH, Li YP, Oursler MJ, Yang S. Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gai-ERK Signaling. J Bone Miner Res. 2019 Apr;34(4):752-764. doi: 10.1002/jbmr.3645. Epub 2019 Jan 28. PubMed PMID: 30489658. |
30489658 |
Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Chen Q, Ma J, Li YP, Wang L. GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1. Cell Death Differ. 2018 Nov;25(11):1996-2009. doi: 10.1038/s41418-018-0083-x. Epub 2018 Mar 9. PubMed PMID: 29523871; PubMed Central PMCID: PMC6219484. |
29523871 |
Chen J, Deng L, Porter C, Alexander G, Patel D, Vines J, Zhang X, Chasteen-Boyd D, Sung HJ, Li YP, Javed A, Gilbert S, Cheon K, Jun HW. Angiogenic and Osteogenic Synergy of Human Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells Cocultured on a Nanomatrix. Sci Rep. 2018 Oct 24;8(1):15749. doi: 10.1038/s41598-018-34033-2. PubMed PMID: 30356078; PubMed Central PMCID: PMC6200728. |
30356078 |
Huang H, Wang J, Zhang Y, Zhu G, Li YP, Ping J, Chen W. Bone resorption deficiency affects tooth root development in RANKL mutant mice due to attenuated IGF-1 signaling in radicular odontoblasts. Bone. 2018 Sep;114:161-171. doi: 10.1016/j.bone.2017.12.026. |
29292230 |
Chen W, Zhu G, Jules J, Nguyen D, Li YP. Monocyte-specific knockout of C/ebpa results in osteopetrosis phenotype, blocks bone loss in ovariectomized mice and reveals an important function of C/ebpa in osteoclast differentiation and function. J Bone Miner Res. 2018 Apr;33(4):691-703. doi: 10.1002/jbmr.3342. |
29149533 |
Chen W, Zhu G, Tang J, Zhou HD, Li YP. C/ebpa controls osteoclast terminal differentiation, activation, function, and postnatal bone homeostasis through direct regulation of Nfatc1. J Pathol. 2018 Mar;244(3):271-282. doi: 10.1002/path.5001. |
29083488 |
Jules J, Li YP, Chen W. C/EBPa and PU.1 exhibit different responses to RANK signaling for osteoclastogenesis. Bone. 2018 Feb;107:104-114. doi: 10.1016/j.bone.2017.05.009. |
29032174 |
Jules J, Chen W, Feng X, Li YP. C/EBPa is Regulated by the RANK Cytoplasmic IVVY535-538 Motif and Stimulates Osteoclastogenesis more Strongly than c-Fos. J Biol Chem. 2018 Jan 26;293(4):1480-1492. doi: 10.1074/jbc.M116.736009. |
29122885 |
Wu M, Wang Y, Shao JZ, Wang J, Chen W, Li YP. Cbfb governs osteoblast-adipocyte lineage commitment through enhancing b-catenin signaling and suppressing adipogenesis gene expression. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10119-10124. |
28864530 |
Wu M, Chen W, Lu Y, Zhu G, Hao L, Li YP. Ga13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3b;-NFATc1 signalling pathway. Nature Communication. 2017 Jan 19;8:13700. |
28102206 |
Pan J, Wang J, Hao L, Zhu G, Nguyen DN, Li Q, Liu Y, Zhao Z, Li YP, Chen W. The Triple Functions of D2 Silencing in Treatment of Periapical Disease. Journal of endodontics. 2017 Feb 28; 43(2):272-8. |
28132712 |
Matthew McConnell, Shengmei Feng, Wei Chen, Guochun Zhu, Dejun Shen, Selvarangan Ponnazhagan, Lianfu Deng,, and Yi-Ping Li. Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity. Oncotarget. 2017 Jul 18;8(29):47675-47690. |
28504970 |
Ping Z, Siegal GP, Harada S, Eltoum IE, Youssef M., Shen T, He J, Huang Y, Chen D, Li Y, Bland KI, Chang HR, Shen D. ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast. Oncotarget. 2016, 7(49). |
27811364 |
Mengrui Wu, Guiqian Chen; & Li YP TGF-b and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone research. April 26, 2016. 4, 16009. |
27563484 |
*Joel Jules, Wei Chen, Xu Feng, and Li YP; CCAAT/enhancer binding protein a; (C/EBPa) is important for osteoclast differentiation and activity. J Biol Chem 2016 Apr 20. pii: jbc.M115.674598. [Epub ahead of print] |
27129246 |
*Wei Chen#, Bo Gaoa#, Liang Hao, Guochun Zhu, Mary J. Macdougall, Xiaozhe Han, Xuedong Zhou, and Li YP. The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation. Journal of Periodontal research 2016 Jan 11. doi: 10.1111/jre.12345. [Epub ahead of print] |
26754272 |
Yuan X, Cao J, Liu T, Li YP, Scannapieco F, He X, Oursler MJ, Zhang X, Vacher J, Li C, Olson D, Yang S. Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss. Cell Death Differ. 2015 Apr 24. |
25909889 |
Jules J, Yang S, Chen W, Li YP*. Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology. RGS Protein Physiology and Pathophysiology. Volume 133, 2015, Pages 47–75. |
26123302 |
Sheng Li, Liang Hao, Lin Wang, Yun Lu, Qian Li, Zheng Zhu, Jian-Zhong Shao, Li YP*, Wei Chen. Targeting Atp6v1c1 Prevents Inflammation and Bone Erosion Caused by Periodontitis and Reveals Its Critical Function in Osteoimmunology. Plos One. 2015 Aug; 10(8): e0134903. |
26274612 |
Liang Hao, Guochun Zhu, Yun Lu, Min Wang, Joel Jules, Xuedong Zhou, Li YP, Wei Chen*. Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role. FEBS Letters. 2015 May; 589 (12): 1331-1339. |
25896020 |
Zheng Zhu, Wei Chen, Liang Hao, Guochun Zhu, Yun Lu, Sheng Li, Lin Wang*, Yi-Ping Li*. Ac45 silencing mediated by AAV-sh-Ac45-RNAi prevents both bone loss and inflammation caused by periodontitis. Journal of Clinical Periodontology. J Clin Periodontol. 2015 May 7. |
25952706 |
Liang Hao, Wei Chen*, Matthew McConnell, Zheng Zhu, Sheng Li, Michael Reddy, Paul D. Eleazer, Min Wang* and Yi-Ping Li. A small molecule, Odanacatib, inhibits inflammation and bone loss caused by endodontic disease. Infection and immunity. 2015 Apr;83(4):1235-45. |
25583522 |
Hao L, Chen J, Zhu Z, Reddy MS, Mountz JD, Chen W, Li YP*. Odanacatib, Cathepsin K Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases. J Periodontol. 2015 Apr 16:1-18. |
25879791 |
Mengrui Wu, Chenguan Li, Guochun Zhu, Yiping Wang, Joel Jules, Yun Lu, Matthew McConnell, Yong-Jun Wang, Jian-Zhong Shao, Li Y-P, and Wei Chen. Chondrocyte-specific knockout of Cbfb reveals the indispensable function of Cbfb in chondrocyte maturation, growth plate development and trabecular bone formation in mice. Int J Biol Sci. 2014 Jul 29;10(8):861-72. |
25170300 |
*Mengrui Wu, Li Y-P, Guochun Zhu, Yun Lu, Yiping Wang, Joel Jules, Matthew McConnell, Rosa Serra, Jian-Zhong Shao, Wei Chen. Deletion of Core-binding factor beta; (Cbfb) in mesenchymal progenitor cells provides new insights into Cbfb/Runxs complex function in cartilage and bone development. Bone. 2014 Aug;65:49-59. |
24798493 |
Chen W, Ma J, Zhu G, Jules J, Wu M, McConnell M, Zhou X, Tain F, Paulson C, Wang L, and Li YP. Cbfb Deletion in Mice Recapitulates Cleidocranial Dysplasia and Reveals Multiple Functions of Cbfb; Required for Skeletal Development. Proc Natl Acad Sci U S A. PNAS. 2014 Jun 10;111(23):8482-7. |
24850862 |
Keinan D, Yang S, Cohen RE, Yuan X, Liu T, Li YP. Role of regulator of G protein signaling proteins in bone. Front Biosci (Landmark Ed). 2014 Jan 1;19:634-48. |
24389209 |
Fei Tian, Mengrui Wu, Deng L, Zhu G, Ma J, Gao B, Wang L, Li YP, Chen W. Core binding factor beta (Cbfb) controls the balance of chondrocyte proliferation and differentiation by up-regulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein Receptor (PPR) expression in postnatal cartilage and bone formation .J Bone Miner Res. 2014 Jul;29(7):1564-74. |
24821091 |
*Wang Y, Li Y-P, Christie Paulson, Jian-Zhong Shao, Xiaoling Zhang, Mengrui Wu, and Wei Chen. Wnt and the Wnt Signaling Pathway in Bone Development and Disease. Frontiers Biosci 2014 Jan 1;19:379-407. |
24389191 |
Chen GQ, Zhuang QY, Wang KC, Liu S, Shao JZ, Jiang WM, Hou GY, Li JP, Yu JM, Li Y-P, Chen JM. Identification and survey of a novel avian coronavirus in ducks. PLoS One. 2013 Aug 30; 8(8):e72918. |
24023656 |
Feng S, Guochun Zhu, Matthew McConnell, Lianfu Deng, Qiang Zhao, Mengrui Wu, Qi Zhou, Jinshen Wang, Jin Qi, Li Y-P,and Wei Chen. Silencing of Atp6v1c1 Prevents Breast Cancer Growth and Bone Metastasis. International Journal of Biological Sciences 2013; 9(8): 853-862. |
24155661 |
Yang S, Liang Hao, McConnell Matthew, Xuedong Zhou, Min Wang, Xiaoyi Wang2 Li Y-P,Wei Chen. AAV RGS10 RNAi inhibits immune cells infiltration in periodontal disease lesion and prevents bone erosion by osteoclasts. Bone Research (2013) 3: 267-281. |
24761229 |
Chen W, Zhu G, Hao L, Wu M, Ci HL, and Li Y-P. C/EBPa is the Key Regulator of Osteoclast Lineage Commitment. Proc Natl Acad Sci U S A. PNAS. 2013; 110(18):7294-9. |
23580622 |
Jiang HB, Chen W, Zhu G, Zhang L, Tucker B, Hao L, Feng S, Ci H, Ma J, Wang L, Stashenko P, and Li YP. RNAi-Mediated Silencing of Atp6i and Atp6i Haploinsufficiency Prevents Both Bone Loss and Inflammation in a Mouse Model of Periodontal Disease. PLOS ONE. 2013;8(4):e58599. |
23577057 |
Yang S, Li YP, Liu T, He X, Yuan X, Li C, Cao J, Kim Y. Mx1-Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis. 2013 Mar;51(3):201-9. |
23349096 |
Ma, J, Chen W, Zhang L, Tucker B, Zhu G, Sasaki H, Hao L, Wang L, Ci H, Jiang H, Stashenko P, and Li YP. RNAi mediated silencing of Atp6i prevents both periapical bone erosion and periapical inflammation in the mouse model of endodontic disease. Infection and Immunity. 2013; 81 (4): 1021–1030. |
23166162 |
Bo Gao, Wei Chen, Liang Hao, Guochun Zhu, Shengmei Feng, Hongliang Ci, Xuedong Zhou, Philip Stashenko and Li Y-P. Inhibiting periapical lesions through AAV-RNAi silencing of Cathepsin K. J Dent Res 2013; 92 (2): 180 - 186. |
23166044 |
Yang DQ, Feng S, Chen W, Zhao H, Paulson C, Li YP. V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption. J Bone Miner Res. 2012 Aug;27(8):1695-707. |
22467241 |
Zuo C, Huang Y, Bajis R, Sahih M, Li YP, Dai K, Zhang X. Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int. 2012 Jan 31. [Epub ahead of print] |
22290242 |
Chen G, Deng C, Li YP. TGF-beta and BMP Signaling in Osteoblast Differentiation and Bone Formation. Int J Biol Sci. 2012;8(2):272-88. Epub 2012 Jan 21. |
22298955 |
Qin B, Wang Y, Liu S, Li Y-P. Osteoarthritis: genetic factors, animal models, mechanisms, and therapies. Frontiers Biosci. Front Biosci (Elite Ed). 2012 Jan 1;4:74-100 |
22201856 |
Haoa X, Wangb Y, Renb F, Zhub S, Renb Y, Jiac B, Li Y-P, Shie Y, Changa Z. SNX25 regulates TGF-beta signaling by enhancing the receptor degradation. Cell Signal. 2011; 23(5):935-46. |
21266196 |
Raheem O, Olufemi S-E, Bachinski L, Vihola A, Sirito M, Holmlund-Hampf J, Haapasalo H, Li Y-P, Udd B, Krahe R. Mutant (CCTG)n Expansion Causes Abnormal Expression of Zinc Finger Protein 9 in Myotonic Dystrophy Type 2. Am J Pathol. 2010;177:3025-36. |
20971734 |
Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M, Zhang X, Chen W, Li Y-P, Shivdasani1 RA, Libermann TA. Requirement of the Epithelial-Specific Ets Transcription Factor Spdef for Mucous Gland Cell Function in the Gastric Antrum. J Biol Chem. 2010; 285:35047-35055 |
20801882 |
Li C, Li Y-P, Fu X-Y, Deng C-X. Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice. Int J Biol Sci 2010;6:569-583. |
20941375 |
Wu M, Deng L, Zhu G, Li Y-P. G Protein and Its Signaling Pathway in Bone Development and Disease. Frontiers Biosci. Frontiers Biosci. 2010;15:957-85 |
20515736 |
Soltanoff CS, Chen W, Yang S, Li Y-P. The signaling networks that control the lineage commitment and differentiation of bone cells. Crit. Rev. Eukaryot. Gene Exp. 2009 19: (1)1-46. |
19191755 |
Wu, H; Xu, G; Li Y-P. Atp6v0d2 is an essential component of the osteoclast-specific proton pump and has a function in extracellular acidification. J Bone Miner Res 2009. 24:1–15. |
19113919 |
Feng M, Deng , Chen W, Shao J, Xu G, Li Y-P. Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclast. Biochem J 2009; 417 (1) 195-205. |
18657050 |
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