Biochemistry and Molecular Genetics Program |
Biochemistry and Structural Biology |
Cancer Biology |
Cell, Molecular, & Developmental Biology |
Cell, Molecular, & Developmental Biology |
Cellular and Molecular Biology Program |
Genetics, Genomics and Bioinformatics |
Hughes Med-Grad Fellowship Program |
Immunology |
Integrative Genetics Graduate Program |
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Publication |
PUBMEDID |
de Guzman, C.G., Johnson, A., and Klug, C.A. (2002) The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo. Blood Cells, Mol. Dis. In press. |
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Klug, C.A., Cheshier, S., and Weissman, I.L. (2000) Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny. Blood 96, 894-901. |
10910902 |
Park, I-K, Klug, C.A., Weissman, I.L., Li, L., Hood, L., Nanamori, M., Neubig, R.R., and Clarke, M.F. (2001) Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J. Biol. Chem. 276, 915-923. |
11042171 |
Ernst, P., Hahm, K., Cobb, B.S., Brown, K.E., Trinh, L.A., McCarty, A.S., Merkenschlager, M., Klug, C.A., Fisher, A.G., and Smale, S.T. (1999) Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. Cold Spring Harb. Symp. Quant. Biol. 64: 87-97 |
11232341 |
Park, I-K., He, Y., Lin, F., Laerum O., Bumgarner, R., Klug, C.A., Cheshier, S., Li, K., Doyle, M.J., Kuhr, C., Sun, Y., Schummer, M., Goldsmith, A., Clarke, M.F., Weissman, I.L., Hood, L., and Li, L. (2002) Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells. Blood 99, 488-498. |
11781229 |
de Guzman, C.G., Warren, A.J., Zhang, J., Gartland, L., Erickson, P., Drabkin, H., Hiebert, S.W., and Klug, C.A. (2002) Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol. Cell. Biol. 22, 5506-5517. |
12101243 |
Cotta, C.V., Zhang, Z., and Klug, C.A. (2003) Pax5 determines B versus T cell fate and does not block early myeloid-lineage development. Blood. In press. |
12560221 |
Witt, C. M., Won, W-J., Hurez, V., and Klug, C.A. (2003) Notch2 haplo-insufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J. Immunol. 171:2783-2788. |
12960298 |
Zheng, Z., Cotta, C.V., Stephan, R.P., de Guzman, C.G., and Klug, C.A. (2003) Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage. EMBO J. 22:4759-4769. |
12970188 |
Purohit, S. J., Stephan, R. P., Kim, H. G., Herrin, B. R., Gartland, L., and Klug, C.A. (2003) Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor. EMBO J. 22:5511-5521. |
14532123 |
Swindle, C. S., Kim, H. G., and Klug, C.A. (2004) CpG mutations in the U3 and R regions of the MSCV LTR repress silencing in embryonic stem cells. J. Biol. Chem. 279:34-41. |
14559924 |
Witt, C. M., Hurez, V., Swindle, C. S., Hamada, Y., and Klug, C.A. (2003) Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Mol. Cell. Biol. 23:8637-8650. |
14612407 |
Kim, H-G., de Guzman, C. G., Swindle, C. S., Cotta, C. V., Gartland, G., Scott, E. W., and Klug, C.A. (2004) The ETS-family transcription factor, PU.1, is necessary for the maintenance of fetal liver hematopoietic stem cells. Blood 104:3894-3900. |
15328162 |
Moreno-Miralles, I., Pan, L., Keates-Baleeiro, J., Durst-Goodwin, K., Yang, C., Kim, H.G., Thompson, M.A., Klug, C.A., Cleveland, J.L., Hiebert, S.W. (2005) The INV(16) cooperates with ARF haploinsuffiency to induce acute myeloid leukemia. J. Biol. Chem. 280:40097-40103. |
16199529 |
Wang, N., Kim, H-G., Cotta, C. V., Wan, M., Tang, Y., Klug, C.A., and Cao, X. (2006) TGF?/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability. EMBO J. 25:1469-1480. |
16525506 |
Zhang, Z., Swindle, C. S., Bates, J. T., Ko, R., Cotta, C. V., and Klug, C.A. (2007) Expression of a non-DNA-binding isoform of Helios induces T cell lymphoma in mice. Blood 109:2190-2197. |
17110463 |
Kojima, K., Vickers, S. M., Adsay, N. V., Jhala, N. C., Kim, H-G., Schoeb, T. R., Grizzle, W. E., and Klug, C. A. (2007) Inactivation of Smad4 accelerates KrasG12D-mediated pancreatic neoplasia. Cancer Res. 67:8121-8130. |
17804724 |
Kim, H-G., Kojima, K, Swindle, C. S., Cotta, C. V., Huo, Y., Reddy, V., and Klug, C. A. (2008) FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia. Blood 111:1567-1574. |
17967943 |
Ko, R. M., Kim, H-G., Wolff, L., and Klug, C. A. (2008) Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia. Leuk. Res. 32:1101-1111. |
18037485 |
Thal, M.A., Carvalho, T.L., He, T., Kim, H-G., Gao, H., Hagman, J., and Klug, C.A. (2009) Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc. Natl. Acad. Sci. USA 106:552-557. |
19122139 |
Klug, C.A., Gerety, S.J., Shah, P., Chen, Y., Rice, N.R., Rosenberg, N., and Singh, H. (1994) The v-abl tyrosine kinase negatively regulates NF-?B/rel factors and blocks kappa gene transcription in pre-B lymphocytes, Genes and Development 8, 678-687. |
7926758 |
Klug, C.A., Morrison, S.J., Masek, M., Hahm, K., Smale S.T., and Weissman, I.L. (1998) Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc. Natl. Acad. Sci. USA 95, 657-662. |
9435248 |
Hahm, K., Cobb, B.S., McCarty, A.S., Brown, K.E., Klug, C.A., Lee, R., Akashi, K., Weissman, I.L., Fisher, A.G., and Smale, S.T. (1998) Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes and Development 12, 782-796. |
9512513 |
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