Undergraduate |
University of Surrey, UK |
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BSc (honors in applied chemistry) |
Graduate |
Imperial College, University of London, UK |
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PhD in Biochemistry |
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Appointment Type |
Department |
Division |
Rank |
Secondary |
Biochemistry & Molecular Genetics |
Biochemistry & Molecular Genetics |
Professor |
Center |
Center for AIDS Research |
Center for AIDS Research |
Professor Distinguished |
Center |
Center for Biophysical Sciences/Engineering |
Center for Biophysical Sciences/Engineering |
Professor Distinguished |
Center |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Professor Distinguished |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor Distinguished |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Professor Distinguished |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor Distinguished |
Center |
Cystic Fibrosis Research Center |
Cystic Fibrosis Research Center |
Professor Distinguished |
Secondary |
Environmental Health Sciences |
Environmental Health Sciences |
Professor |
Secondary |
Genetics Chair Office |
Genetics Chair Office |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor Distinguished |
Center |
Nephrology Research & Training Center |
Nephrology Research & Training Center |
Professor Distinguished |
Center |
Nutrition Sciences Research |
Nutrition Obesity Res Ctr (NORC) |
Professor Distinguished |
Primary |
Pharmacology/Toxicology Chair's Office |
Pharmacology/Toxicology Chair's Office |
Professor Distinguished |
Center |
Vision Science Research Center (Org-Ret) |
Vision Science Research Center (Org-Ret) |
Professor Distinguished |
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Biochemistry and Molecular Genetics Program |
Biochemistry and Structural Biology |
Cellular and Molecular Biology Program |
Integrative Biomedical Sciences |
Medical Scientist Training Program |
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Publication |
PUBMEDID |
Kim, H., Deshane, J., Barnes, S., and Meleth, S. Proteomics analysis of the actions of grape seed extract in rat brain: Technologic and biologic implications for the study of the actions of psychoactive compounds. Life Sciences, 78: 2060-2065, 2006. |
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Sarkar, P., Sarkar, S., Ramesh, V., Hayes, B.E., Thomas, R.L., Wilson, B.L., Kim, H., Barnes, S., Kulkarni, A., Pellis, N. and T. Ramesh, G.T. Proteomic analysis of mice hippocampus in simulated microgravity environment. Journal of Proteome Research, 5: 548-553, 2006. |
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Liu, C., Yu, S. Zinn, K., Wang, J., Zhang, L., Jia, Y., Kappes, J.C., Barnes, S., Kimberly, R.P., Grizzle, W.E. and Zhang, H-G. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. Journal of Immunology, 176, 1375-1385, 2006. |
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Horn-Ross, P.L., Barnes, S., Lee, V.S., Collins, C.N., Reynolds, P., Lee, M.M., Stewart, S.L., Canchola, A.J., Wilson, L., Jones, K. Reliability and Validity of an Assessment of Usual Phytoestrogen Consumption. Cancer Causes and Control, 17; 85-93, 2006. |
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Huang, C.M., Wang, C.C., Kawai, M., Barnes, S., and Elmets, C.A. Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics. Mol Cell Proteomics 5: 523-530, 2006. |
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Zakharkin S.O., Kim, K., Mehta, T., Chen, L., Barnes, S., Scheirer, K.E., Parrish, R.S., Allison, D.B., and Page, G.P. Sources of variation in Affymetrix microarray experiments. BMC Bioinformatics, 6:214, 2005. |
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Meezan, E., Meezan, E.M., Jones, K., Moore II, D.R., Barnes, S., and Prasain, J.K. Contrasting effects of the isoflavones glucosides puerarin and daidzein on glucose metabolism in mice. Journal of Agricultural and Food Chemistry, 53: 8760-8767, 2005. |
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Barnes, S., D’Alessandro, T., Kirk, M.C., Patel, R.P., Boersma, B.J., and Darley-Usmar, V.M. The importance of in vivo metabolism of polyphenols and their biological actions. In: “Phytochemicals – mechanisms of action”, Mesin, M.S., Bidlack, W.R., Davies, A.J., Lewis, D.S., Rudolph, R.K., CRC Press, Boca Raton, pp 51-59, 2003 |
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Kim, K., Page, G.P., Beasley, T. M., Barnes, S., Scheirer, K.E., and Allison, D.B. A proposed metric for assessing the measurement quality of individual microarrays. BMC Bioinformatics, 7: 35, 2006. |
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Barnes, S., Prasain, J.K., Wang, C-C., Moore, D.R., II. Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements. Life Sciences, 78: 2054-2059, 2006. |
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Huang, C.M., Wang, C-C., Kawai, M., Barnes, S., Elmets, C.A. In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomics. J Chromatogr A, 1109: 144-151, 2006. |
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Huang, C.M, Wang, C-C., Barnes, S., Elmets, C. In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics. Proteomics 6: 5805-5814, 2006. |
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Huang CM, Ananthaswamy HN, Barnes S, Ma Y, Kawai M, Elmets CA. Mass spectrometric proteomics profiles of in vivo tumor secretomes: Capillary ultrafiltration sampling of regressive tumor masses. Proteomics 6: 6107-6116, 2006. |
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Prasain, J.K., Reppert, A., Jones, K., Moore, D.R., II, Barnes, S., and Lila, M.A. Isoflavones in Pueraria lobata cell cultures. Phytochemical Analysis, 18: 50-59, 2006. |
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Prasain, J.K., Xu, J., Kirk, M., Smith, M., Sfakianos, J., and Barnes, S. Differential biliary excretion of genistein metabolites following intraduodenal and intravenous infusion of genistin in female rats. Journal of Nutrition, 136:2975-2979, 2006. |
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Cheong, J.M.K., Martin, B.R., Jackson, G.J., Elmore, D., McCabe, G.P., Nolan, J.R., Barnes, S., Peacock, M., and Weaver, C.M. Soy isoflavones do not affect bone resorption in postmenopausal women: A dose response study using a novel approach with 41Ca. Journal of Clinical Endocrinology & Medicine, 92: 577-582, 2007. |
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Prasain, J., Peng, N., Acosta, E., Moore, D.R., Arabshahi, A., Meezan, E., Barnes, S., Wyss, J.M. Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. Biomedical Chromatography, 21:410-414, 2007. |
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Ye, Y., Celia Quijano, C., Robinson, K.M., Ricart, K.C., Strayer, A.L., Shacka, J.J., Kirk, M., Barnes, S., Radi, R., Beckman, J.S., Estévez, A.G. Tyrosine nitration in peroxynitrite-induced apoptosis of motor neurons and PC12 cells. Journal of Biological Chemistry, 282: 6324-6337, 2007 |
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Chacko, B.K., Chandler, R.T., D’Alessandro, T.L., Mundhekar, A., Khoo, N.K., Botting, N., Barnes, S., Patel, R.P. Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARγ. Journal of Nutrition, 137: 351-356, 2007. |
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Lee, S.A., Wen, W, Xiang, Y.B., Barnes, S., Liu, D.K., Cai, Q., Zheng, W., Shu, X.O. Assessment of dietary isoflavone intake among middle age Chinese men. Journal of Nutrition, 137: 1011-1016, 2007. |
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Sites, C.K., Cooper, B.C., Toth, M.J., Gastaldelli, A.,Arabshahi, A. Barnes, S. Effect of a Daily Supplement of Soy Isoflavones on Body Composition and Insulin Secretion in Postmenopausal Women. Fertility and Sterility, in press, 2007. |
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Brand, J.P.L., Beasley, T.M., Page, G.P., Bartolucci, A.A., Kim, K., Barnes, S., and Allison, D.B. An adaptive weighted p-value algorithm for more powerful multiplicity control in high dimensional biology: an application to inferential testing in microarray data analysis. Bioinformation, 1:384, 2007. |
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Styles, N.A, Falany, J.L., Barnes. S., Falany. C.N. Quantification and Regulation of the Subcellular Distribution of Bile acid CoA:amino acid N-acyltransferase Activity in Rat Liver. Journal of Lipid Research, 48: 1305-1315, 2007. |
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Zhang, H-G., Kim, H., Liu, C., Yu, S., Wang, J, Zhang, L., Grizzle, W.E., Kimberly, R.P., and Barnes, S. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochimica et Biophysica Acta, 1773: 1116-1123, 2007. |
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Kim H, Eliuk S, Deshane J, Meleth S, Sanderson T, Pinner A, Robinson G, Wilson L, Kirk M, Barnes S. 2D gel proteomics: an approach to study age-related differences in protein abundance or isoform complexity in biological samples. Methods in Molecular Biology 371:349-391, 2007. |
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Ashwell, M., Stone, E., Mathers, J., Barnes, S., Compston, J., Francis, R.M., Key, T., Cashman, K.D., Cooper, C., Khaw, K.T., Lanham-New, S., Macdonald, H., Prentice, A., Shearer, M. and Stephen, A. Nutrition and bone health projects funded by the UK Food Standards Agency: have they helped to inform public health policy? British Journal of Nutrition, in press, 2007 |
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Boersma, B.J., Patel, R.P., Kirk, M., Darley-Usmar, V.M. and S. Barnes. Chlorination and Nitration of Soy Isoflavones. Archives of Biochemistry & Biophysics, 368: 265-275, 1999. |
10441377 |
King, L. III, S. Barnes, U. Glufke, M.E. Henz, M. Kirk, K.A. Merkler, J.C. Vederas, B.J. Wilcoz, and D.J. Merkler. The enzymatic formation of novel bile acid primary amides. A possible class of new mammalian hormones. Archives of Biochemistry and Biophysics, 374: 107-117, 2000. |
10666288 |
Sfakianos, M., Wilson, L., Sakalian, M., Falany, C.N., and Barnes, S. Conserved Residues in the Putative Catalytic Triad of Human Bile Acid Coenzyme A: Amino Acid N-acyltransferase. Journal of Biological Chemistry, 277: 47270-47275, 2002. |
12239217 |
Wang, C-C., Prasain, J., and Barnes, S. Methods used in the analysis of phytoestrogens. Journal of Chromatography, 777: 3-28, 2002. |
12270197 |
Aslan, M, Barnes, S., Kirk, M, Rosenfeld, S, Townes, T, Ryan, T and BA Freeman. Nitric oxide-dependent generation of reactive species in sickle cell disease: renal and hepatocellular actin tyrosine nitration. Journal of Biological Chemistry, 278: 4194-4204, 2003. |
12401783 |
Falany, C.N., Xie, X, Wheeler, J.B., Wang, J., Smith, M., He, D., and Barnes, S. Molecular cloning and expression of rat liver bile acid CoA ligase. Journal of Lipid Research, 43: 2062-2071, 2002. |
12454267 |
Belenky, M, Kim, H., Prasain, J., and Barnes, S. DING – a protein without a gene. J Nutr, 133: 2497S-2501S, 2003 |
12480230 |
Lanman, J., Lam, T., Barnes, S., Sakalian, M., Emmett, M.R., Marshall, A.G., and Prevelige, P.E., Jr. Identification of novel interactions in HIV-1 capsid protein assembly by high resolution mass spectrometry. Journal of Molecular Biology, 325:759-772, 2003. |
12507478 |
Barnes, S. Phytoestrogens and osteoporosis – what is a safe dose? British Journal of Nutrition, 89: S101-S108, 2003. |
12725659 |
Prasain, J.K., Jones, K., Kirk, M., Wilson, L., Smith-Johnson, M., Weaver, C.M., Barnes, S. Identification and quantitation of isoflavonoids in Kudzu Dietary Supplements by HPLC and electrospray ionization tandem mass spectrometry. J Agric Food Chem, 51:4213-4218, 2003 |
12848487 |
Prasain, J.K., Boersma, B.J., Kirk, M., Wilson, L., Patel, R., Darley-Usmar, V.M., Botting, N. and Barnes, S. ESI-tandem Mass Spectrometric Analysis of Chlorinated and Nitrated Isoflavones. J Mass Spect, 38: 764-771, 2003 |
12898636 |
Carballal, S., Radi, R., Kirk, M.C., Barnes, S., Freeman, B.A. and Alvarez, B. Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. Biochemistry, 42: 9906-9914, 2003. |
12924939 |
He, D., Barnes, S, Falany, C.N. Rat Liver Bile Acid CoA: Amino Acid N-acyltransferase: Expression, Characterization and Peroxisomal Localization J Lip Res, on line September 1, 2003. |
12951368 |
D’Alessandro, T., Prasain, J., Botting, N.P, Moore, R., Darley-Usmar, V.M., Patel, R.P., and Barnes, S. Polyphenols, Inflammatory Response, and Cancer Prevention: Chlorination of Isoflavones by Human Neutrophils. J Nutr,133:3773S-3777S, 2003. |
14608113 |
Page G.P., Edwards J.W., Barnes S., and Allison, D.B. A Design & Statistical Perspective on Microarray Gene. Expression Studies in Nutrition – the need for playful creativity and scientific hard-mindedness. Nutrition, 19: 997-1000, 2003. |
14624952 |
Boersma, B.J., Patel, R.P., Benton, M.R., Kirk, M., Wilson, L.S., Botting, N.P., Barnes, S., and Darley-Usmar, V.M. Neutrophil myeloperoxidase chlorinates soy isoflavones and enhances their antioxidant properties. Free Radical Biology and Medicine, 35:1417-1430, 2003. |
14642389 |
Boersma, B.J., D’Alessandro, T., Benton, M.R., Kirk, M., Wilson, L.S., Prasain, J., Botting, N.P., Barnes, S., Darley-Usmar, V.M. and Patel, R.P. Neutrophil myeloperoxidase chlorinates soy isoflavones and enhances their antioxidant properties. Free Radical Biology and Medicine, 35:1417-1430, 2003. |
14642389 |
Kim, H., Page, G.P., and Barnes, S. Proteomics and mass spectrometry in nutrition research. Nutrition, 20: 155-165, 2004. |
14698031 |
Barnes, S., and Kim, H. Nutriproteomics: Identifying the molecular targets of nutritive and non-nutritive components of the diet. Journal of Biochemistry and Molecular Biology 37:59-74, 2004. |
14761304 |
Schuler, A.M., Barnes, S., Gower, B.A., and Wood, P.A. Role of dietary phytoestrogens on cold tolerance in long-chain acyl-CoA dehydrogenase deficient mice. Journal of Nutrition, 134: 1028-1031, 2004. |
15113940 |
Barnes, S. Soy isoflavones: phytoestrogens and what else? Journal of Nutrition 134: 1225S-1228S, 2004 |
15113976 |
Zafar TA, Weaver CM, Jones K, Moore DR 2nd, Barnes S. Inulin effects on bioavailability of soy isoflavones and their calcium absorption enhancing ability. Journal of Agricultural Food Chemistry 52:2827-2831, 2004. |
15137821 |
Prasain, J.K., Jones, K., Brissie, N., Moore, D.R. II, Wyss, J.M., Barnes, S. Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. Journal of Agricultural Food Chemistry, 52: 3708-3712, 2004. |
15186086 |
Isom, A.I., Wilson, L., Kirk, M., Coward, L., Darley-Usmar, V.M. and Barnes, S. Modification of cytochrome c by 4-hydroxy-2-nonenal: evidence for histidine, lysine and arginine-aldehyde adducts. Journal of American Society of Mass Spectrometry 15: 1136-1147, 2004. |
15276160 |
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