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Faculty Detail    
Name JAMES ROBINSON HACKNEY
  
Campus Address HSB 175D Zip 6823
Phone  (20-5) -840
E-mail  jrhackney@uabmc.edu
Other websites
Career Advisor     

Education
Medical School  University of South Alabama College of Medicine    1979  M.D. 

Certifications
Anatomic and Clinical Pathology  1983 
Hematopathology  1989 
Neuropathology  2012 


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor
Primary  Pathology   Neuropathology Associate Professor

Biographical Sketch 
Dr. Rob Hackney has come to Academic Pathology somewhat late in life, completing a Neuropathology Fellowship at UAB after a 25 year career spent in the private practice of Surgical Pathology and Hematopathology in New Orleans and Birmingham. Dr. Hackney completed his M.D. degree at the University of South Alabama College of Medicine in Mobile in 1979. This was followed by combined AP/CP training at Ochsner Clinic in New Orleans, and a Fellowship in Hematopathology at the Hospital of the University of Pennsylvania in Philadelphia. For the last 21 years of his career in private practice, Dr. Hackney practiced at St. Vincent’s Hospital, Birmingham, serving as Chief of Pathology from 2002 until departing for UAB in 2010 for a two-year Neuropathology Fellowship. His research year was spent in the newly organized Division of Informatics within the Department of Pathology, developing modular, browser-based web apps for diagnostic image analysis in partnership with Division Director Jonas Almeida, PhD. Dr. Hackney stepped into the role of Pragram Director of the Pathology Residency Program at UAB in 2016, and is now splitting time between surgical neuropathology and overseeing and participating in the training of the next generation of pathologists.

Society Memberships
Organization Name Position Held Org Link
American Association of Clinical Pathologists  Member  www.ascp.org 
American Association of Neuropathologists (AANP)  Member  www.neuropath.org 
Association of Pathology Chairs (PRODS Section)  Member  www.apcprods.org 
College of American Pathologists (CAP)  Fellow  www.cap.org 
United States and Canadian Academy of Pathology  Member  www.uscap.org 
 



Research/Clinical Interest
Title
Description
My research interests involve the development and deployment of modular web-based apps that perform image analysis tasks within the protected confines of the user’s web browser. The modules are written in JavaScript, the “assembly language of the web”, and are committed to one of the available public computer code repositories. The modular architecture promotes collaborative development of new modules that serve users’ specific needs, and the use of public code repositories means that the code is fully exposed to public scrutiny.

Selected Publications 
Publication PUBMEDID
Barrett OC, Hackney JR, McDonald AM, Willey CD, Bredel M, Fiveash JB. Pathologic predictors of local recurrence in atypical meningiomas following gross total resection, International Journal of Radiation Oncology, Biology, Physics, 2019 February; 103(2): 453-459.   PMID: 30253235 
Mercado JJ, Markert JM, Meador W, Chapman PR, Perry A, Hackney JR: Primary CNS non-amyloidogenic light chain deposition disease: Case report and brief review, Int J Surg Pathol. 2017 Dec;25(8):755-760. doi: 10.1177/1066896917717338. Epub 2017 Jul 2.  PMID: 28669250 
Scribner E, Hackney JR, Machemehl HC, Reina AF, Patel KR, Fathallah-Shaykh, H: Key rates for the grades and transformation ability of glioma: Model simulations and clinical cases, J Neurooncol. 2017 June, 13(2): 377-388. doi: 10.1007/s11060-017-2444-6. Epub: 2017 Apr 27.  PMID: 28451993 
Filippova N, Yang X, Ananthan S, Sorochinsky A, Hackney JR, Gentry Z, Bae S, King P, Nabors LB, Hu antigen R (HuR) multimerization contributes to glioma disease progression: J Biol Chem. 2017 Oct 13; 292 (41): 16999-17010. doi: 10.1074/jbc.M117.797878. Epub 2017 Aug 8.  PMID 28790173 
Whisenhunt TH JR, Rajneesh KF, Hackney, JR, Markert JM: Extended disease-free interval of 6 years
in the recurrent glioblastoma multiforme patient treat with G207 oncolytic viral therapy,
Oncolytic Virotherapy 2015: 4 33-38. 		 PMC4918376 
Boyd NH, Walker K, Fried J, Hackney JR, et al: Addition of Carbonic Anhydrase 9 Inhibitor SLC-0111 to Temozolomide Treatment Delays Glioblastoma Growth in vivo: JCI Insight, 2017 Dec 21; 2(24): 1-16.  PMID 29263302 
Tran AN, Walker K, Harrison DG, Chen W, Mobley J, Hocevar L, Hackney JR, Dedaka RS, Pollock JS, Goldberg MS, Hambardumyan D, Cooper SJ, Gillespie Y, Hjelmeland AB. Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance. Neuro Oncol 2018 Jul 5;20(8):1055-1067.   PMID: 29409010 
Liu Z, Che P, Mercado JJ, Hackney JR, Friedman GK, Zhang C, You Z, Zhao X, Ding Q, Kim K, Li H, Liu X, Markert JM, Nabors B, Gillespie GY, Zhao R, Han X. Characterization of IPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis. J Neurooncol. 2019 Jan;141(2):289-301.  PMID: 30460631 
Boyd NH, Walker K, Ayokanmbi A, Gordon ER, Whetsel J, Smith CM, Sanchez RG, Lubin FD, Chakraborty A, Tran AN, Herting C, Hambardzumyan D, Yancey Gillespie G, Hackney JR, Cooper SJ, Jiao K, Hjelmeland AB. Chromodomain helicase DNA-binding protein 7 is suppressed in the perinecrotic/ischemic microenvironment and is a novel regulator of glioblastoma angiogenesis. Stem Cells 2019 Jan 10.   PMID: 30629778 
 

Keywords
Neuropathology, Informatics, Image Analysis, Educational Wikis