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Faculty Detail    
Name DALE A PARKS
  
Campus Address JT 880D Zip 6810
Phone  (205) 934-1789
E-mail  dalep@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Anesthesiology Chair Office  Anesthesiology Chair Office Professor Adjunct
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor Adjunct
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor Adjunct

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 

Biographical Sketch 
Dale A. Parks (b. 1954), professor, received his B.S. degree in Chemistry and Biology at Western Michigan University in 1977. Dr. Parks complete a B.M.S. degree in Basic Medical Sciences and followed by a Ph.D. in Physiology at the University of South Alabama, Mobile, in 1983 under the guidance of Drs. F. Neil Granger and Joe M. McCord. Postdoctoral training was received at the University of Cincinnati under the tutelage of Dr. Eugene Jacobson. He joined the faculty of UAB in June 1985.

Society Memberships
Organization Name Position Held Org Link
American Heart Association  Fellow   
Free Radical Biology and Medicine  Editorial Board   
 



Research/Clinical Interest
Title
Reactive Oxygen and Nitrogen Species in Cardiovascular Disease
Description
In a variety of pathologic conditions, including coronary heart disease, ischemia-reperfusion and certain inflammatory states, reactive oxygen and nitrogen species overwhelm tissue antioxidant defenses, impair essential biochemical processes and produce extensive damage to tissues such as the vasculature and the heart. My overall research interest focuses on defining the mechanisms of reactive oxygen and nitrogen species in the cardiovascular complications associated coronary heart disease, and in particular atherosclerosis. Considerable epidemiologic data indicate that dietary polyphenols often found in red wine, reduces the morbidity and mortality associated with coronary heart disease. We have evidence that provides insight as to the mechanism by which principal components of red wine(alcohol and polyphenols) and mimetic of HDL reduce hepatic, renal, pulmonary, myocardial and vascular injury. The mechanism of this cardiovascular protection appears to be at the level of transcriptional regulation of essential cardioprotective proteins, including nitric oxide-producing (nitric oxide synthases) and superoxide scavenging proteins (superoxide dismutase isoforms). My research interests include the study of the physiologic, biochemical and cellular aspects of reactive oxygen and nitrogen metabolism. A major thrust of our investigative efforts are the identification of the source of these cytotoxic reactive species and characterization of the mechanisms of the interaction of these oxidants with biologic target molecules and the consequent altered tissue function (e.g. hepatic, pulmonary, renal, myocardial compromise and vascular dysfunction). We utilize whole animal models of disease (mouse models of atherosclerosis), ex vivo assessments of tissue function (video dimension analysis), cellular models (mouse endothelial cells from knock out animals and transfection) for study of regulation of these cardioprotective proteins and molecular systems for identification of oxidant/antioxidant-responsive elements and transcription factors. It is the ultimate goal of these projects to provide mechanistic insight into the pathoetiology of the cardiovascular disease as well as providing a rationale basis for the development of therapeutic agents designed to limit the oxidant-induced injury.

Selected Publications 
Publication PUBMEDID
Skinner KA, White CR, Rakesh P, Tan S, Barnes S, Kirk M, Darley-Usmar V, Parks DA. Nitrosation of uric acid by peroxynitrite: formation of a vasoactive nitric oxide donor. J Biol Chem, 273(38):24491-24498, 1998.  9733742 
Tan S, McAdams M, Liu YY, Freeman BA, Parks DA. Endothelial cell damage from a circulating mediator released during ischemia reperfusion of the rat liver. Free Radic Biol Med, 24:427-434,1998.  9438555 
Booyse,F.M.; Pan,W.; Grenett,H.E.; Parks,D.A.; Darley-Usmar,V.M.; Bradley,K.M.; Tabengwa,E.M. Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk. Ann Epidemiol 17:S24-31, 2007.
 		 17478321 
Wu,T.J.; Khoo,N.H.; Zhou,F.; Day,B.J.; Parks,D.A.
Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes. Free Radic Res 41:127-134 2007. 		 17364938 
DeLano,F.A.; Parks,D.A.; Ruedi,J.M.; Babior,B.M.; Schmid-Schonbein,G.W. Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation 13:551-566, 2006.
 		 16990214 
Abou-agag L, Binsack R, White CR, Darley-Usmar V, Grennett H, Booyse FM, Thompson JA, Zhou F, and Parks DA. Induction of Cardiovascular Protection by Moderate Alcohol: Role of Nitric Oxide. Free Radic Biol Med, 39(4):540-548, 2005.  16043025 
White CR, Parks DA, Patel RP, Shelton J, Tarpey MM, Freeman BA and Darley-Usmar VM. L-arginine inhibits xanthine-oxidase-dependent endothelial dysfunction in hypercholestemia. FEBS Lett, 18136:1-5, 2004.  15013757 
Ghio AJ, Kennedy TP, Stonehuerner J, Carter JD, Skinner KA, Skinner HB, Parks DA, Hoidal JR. Iron regulates xanthine oxidase activity in the lung. Am J Physiol Lung Cell Mol Physiol 283:L563-L572, 2002.  12169576 
Aslan M, Ryan T, Adler B, Townes T, Parks DA, Tousson A, Patel R, Gladwin MT, Tarpey MM, White Cr and Freeman BA. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Nat Acad Sci, USA 98:15215-20, 2001.  11752464 
Binsack R, Boersma BJ, Patel RP, Kirk M, Darley-Usmar VM, Barnes S, Parks DA. Enhanced antioxidant activity following chlorination of quercetin by hypochlorous acid. Alcohol Clin Exp Res., 25:434-443, 2001.  11290856 
Sakawi Y, Tarpey M, Chen YF, Calhoun D, Connor M, Viera L, Freeman BA, Chestnut D, Parks DA. The Role of Nitric Oxide and Reactive Oxygen Species in Preeclampsia. Anesthesiology, 93:1446-1455, 2000.  11149440 
Tan S, Zhou F, Nielsen VG, Wang Z, Gladson CL, and Parks DA. Increased injury following intermittent fetal hypoxia-reoxygenation is associated with increased free radical production in fetal rabbit brain. J Neuropathol Exp Neurol, 58:972-981, 1999.  10499439 
 

Keywords
Free Radical Biology, ischemia, liver, transplantation, nitric oxide