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Faculty Detail    
Name WENGUANG FENG
  
Campus Address LHRB 421 Zip 0006
Phone  (205) 996-6383
E-mail  wfeng@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Med - Nephrology  Med - Nephrology Assistant Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Assistant Professor
Center  Nephrology Research & Training Center  Nephrology Research & Training Center Assistant Professor

Biographical Sketch 
Dr. Feng graduated from Medical College of Jinan University and received his PhD from Guangdong Cardiovascular Disease Research Institute in China. He pursued his postdoctoral research training in the Vascular Biology and Hypertension Program in UAB, under the supervision of Dr Oparil between 2002 and 2006. In 2008, Dr Feng joint Division of Nephrology as research associate. He was promoted to Instructor in 2012, and assistant professor in February 2016.

Society Memberships
Organization Name Position Held Org Link
American Society of Nephrology     
American Heart Association     
 



Research/Clinical Interest
Title
The Role of Transcription Factor ETS-1 in Hypertensive Renal Damage and Vascular Disease
Description
Dr Feng’s research interest has been focused on the role of transcription factor ETS-1 in the acute vascular injury response. The major achievements, published in 2010 in Hypertension, were the demonstration that ETS-1 is up-regulated in acute arterial injury, triggering a robust inflammatory response followed by vascular remodeling and neointima formation. He showed that blocking ETS-1 with a dominant negative peptide reduced the expression of inflammatory mediators and neointima formation in a rat model of acute carotid injury. In another project he demonstrated the role of ETS-1 in renal injury and inflammation induced by angiotensin II. In this study, Dr Feng demonstrated that blockade of ETS-1, not only decreased angiotensin II induced macrophage infiltration, but also reduced TGF-beta; and CTGF expression, reduced oxidative stress and improved renal function. These studies were also recently published in Hypertension 2012. Since 2012, we has focused his efforts on defining the role of the ETS-1 in the pathogenesis of the neointima formation in a mouse model of arteriovenous fistula (AVF). AVF dysfunction is extremely important complications of hemodialysis patients with end stage kidney failure. The long term goal of this study is development of novel therapeutic strategies for the treatment and prevention of AVF dysfunction.

Selected Publications 
Publication PUBMEDID
Feng W, Chumley P, Hua P, Rezonzew G, Jaimes D, Duckworth MW, Xing D, Jaimes EA. Role of the Transcription Factor Erythroblastosis Virus E26 Oncogen Homolog-1 (ETS-1) as Mediator of the Renal Proinflammatory and Profibrotic Effects of Angiotensin II. Hypertension. 2012 Nov;60(5):1226-33.   22966006 
Xing D, Oparil S, Yu H, Gong K, Feng W, Black J, Chen YF, Nozell S. Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β. PLoS One. 2012;7(6):e36890.   22723832 
Nguyen Dinh Cat A, Escoubet B, Agrapart V, Griol-Charhbili V, Schoeb T, Feng W, Jaimes E, Warnock DG, Jaisser F.Cardiomyopathy and response to enzyme replacement therapy in a male mouse model for Fabry disease.PLoS One. 2012;7(5):e33743.   22574107 
Rezonzew G, Chumley P, Feng W, Hua P, Siegal GP, Jaimes EA. Nicotine exposure and the progression of chronic kidney disease: role of the α7-nicotinic acetylcholine receptor. Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F304-12.   22552933  
Hua P, Feng W, Rezonzew G, Chumley P, Jaimes EA. The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells. Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1418-29.   22357921 
Xing D, Gong K, Feng W, Nozell SE, Chen YF, Chatham JC, Oparil S. O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells. PLoS One. 2011;6(8):e24021.   21904602  
Obert DM, Hua P, Pilkerton ME, Feng W, Jaimes EA.Environmental tobacco smoke furthers progression of diabetic nephropathy. Am J Med Sci. 2011 Feb;341(2):126-30.  20924282 
Hua P, Feng W, Ji S, Raij L, Jaimes EA. Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers. Am J Physiol Renal Physiol. 2010 Oct;299(4):F732-9.   20685820 
Feng W, Xing D, Hua P, Zhang Y, Chen YF, Oparil S, Jaimes EA. The transcription factor ETS-1 mediates proinflammatory responses and neointima formation in carotid artery endoluminal vascular injury.Hypertension. 2010 Jun;55(6):1381-8.   20368503 
Xing D, Feng W, Nöt LG, Miller AP, Zhang Y, Chen YF, Majid-Hassan E, Chatham JC, Oparil S.Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury.
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H335-42. 		 18469144  
Xing D, Hage FG, Chen YF, McCrory MA, Feng W, Skibinski GA, Majid-Hassan E, Oparil S, Szalai AJ.Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent. Am J Pathol. 2008 Jan;172(1):22-30.   18063701  
 

Keywords
ETS-1, Vascular Injury, Arteriovenous Fistula Dysfunction, Neointima, Inflammation, Cytokines, Hypertension, Renal Injury