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| Cancer Biology |
| Cell, Molecular, & Developmental Biology |
| Molecular and Cellular Pathology Program |
| Pathobiology and Molecular Medicine |
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| Publication |
PUBMEDID |
Chen Y, Billadello JJ, Schneider DJ.
Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene.
Arterioscler Thromb Vasc Biol. 2000, 20(12):2696-701. |
11116074 |
Chen Y*, Budd RC, Kelm RJ Jr, Sobel BE, Schneider DJ.
Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1.
Arterioscler Thromb Vasc Biol. 2006, 26(8):1777-83 |
16709941 |
Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, McDonald JM, Chen Y.
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx-2 by Akt signaling.
J Biol Chem. 2008;283(22):15319-27
-- A featured Article in vascualr biology, selected by NAVBO in 2008 |
18378684 |
Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michalek S, He Y, Yu M, Fu YX, Wen R, Wu H, Wang D
Phospholipase Cgamma 2 mediates RANKL-stimulated lymph-node organogenesis and osteoclastogenesis.
J Biol Chem. 2008; 283(43):29593-601. |
18728019 |
Pawar P, Ma L, Byon CH, Liu H, Ahn EY, Jhala N, Arnoletti JP, McDonald JM, Chen Y.
Molecular Mechanisms of Tamoxifen Therapy for Cholangiocarcinoma: Role of Calmodulin.
Clin Cancer Res. 2009;15(4):1288-1296. |
19228732 |
Chen J, Sun Y, Mao X, Liu Q, Wu H, Chen Y.
RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.
J Biol Chem. 2010 Nov 19;285(47):36315-21. Epub 2010 Sep 13. |
20837480 |
Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y.
Runx2-Upregulated Receptor Activator of Nuclear Factor {kappa}B Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages.
Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1387-96. Epub 2011 Mar 31
-- Published with an accompanying editoral. |
21454810 |
Chen J, Yuan K, Mao X, Miano JM, Wu H, Chen Y.
Serum response factor regulates bone formation via IGF-1 and Runx2 signals.
J Bone Miner Res. 2012 Aug;27(8):1659-68. Epub 2012 Mar 20 |
22434656 |
Mao X, Debenedittis P, Sun Y, Chen J, Yuan K, Jiao K, Chen Y.
Vascular smooth muscle cell smad4 gene is important for mouse vascular development.
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2171-7. Epub 2012 Jul 5. |
22772757 |
Sun Y, Byon CH, Yuan K, Chen J, Mao X, Heath JM, Javed A, Zhang K, Anderson PG, Chen Y.
Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.
Circ Res. 2012 Aug 17;111(5):543-52. Epub 2012 Jul 6.
-- A top downloaded article in Circ Res journal in July 2012
-- Highlighted in the Circ Res Thematic Synosis on Atherosclerosis. |
22773442 |
Yuan K, Sun Y, Zhou T, McDonald JM, Chen Y.
PARP-1 Regulates Resistance of Pancreatic Cancer to TRAIL Therapy
Clin Cancer Res. 2013, 19(17):4750-9. |
23833311 |
Heath J, Sun Y, Yuan K, Bradley WE, Litovsky S, Dell'italia LJ, Chatham JC, Wu H, Chen Y.
Activation of AKT by O-GlcNAcylation Induces Vascular Calcification in Diabetes.
Circ Res. 2014 Mar 28;114(7):1094-102
-- An Editor's pick
-- Published with an accompanying editorial
-- A most often read paper in Circ Res journal in Aug 2014 |
24526702 |
Deng L, Huang L, Sun Y, Heath JM, Wu H, Chen Y.
Inhibition of FOXO1/3 promotes vascular calcification.
Arterioscler Thromb Vasc Biol. 2015 35(1):175-83 |
25378413 |
Sun Y, Byon CH, Yang Y, Bradley WE, Dell'Italia LJ, Sanders PW, Agarwal A, Wu H, Chen Y
Dietary potassium regulates vascular calcification and arterial stiffness.
JCI Insight. 2017 Oct 5;2(19)
-- An Editor's pick
-- Highlighted in JCI This Month
-- A top-read paper with views over 11,500 within first week |
28978809 |
Yang Y, Sun Y, Chen J, Bradley WE, Dell'Italia LJ, Wu H, Chen Y.
AKT-independent activation of p38 MAP kinase promotes vascular calcification.
Redox Biol. 2018;16:97-103. doi: 10.1016/j.redox.2018.02.009. |
29495001 |
Xu F, Sun Y, Yang SZ, Zhou T, Jhala N, McDonald JM and Chen Y.
Cytoplasmic PARP-1 Promotes TRAIL Resistance in Pancreatic Cancer.
Int J Cancer. 2019, July, 15;145(2):474-483. doi: 10.1002/ijc.32108. |
30614530 |
Chen Y, Zhao X, Wu H.
Metabolic Stress and Cardiovascular Disease in Diabetes Mellitus: The Role of Protein O-GlcNAc Modification.
Arterioscler Thromb Vasc Biol. 2019 Aug 29:ATVBAHA119312192. |
31462094 |
Yang SZ, Xu F, Yuan K, Sun Y, Zhou T, Zhao X, McDonald JM, Chen Y.
Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation.
Lab Invest. 2020, 100(5):777-785. doi: 10.1038/s41374-019-0365-z. |
31896813 |
Li Z, Zhao Z, Cai Z, Sun Y, Li L, Yao F, Yang L, Zhou Y, Zhu H, Fu Y, Wang L, Fang W*, Chen Y*, Kong W*.
Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm.
Arterioscler Thromb Vasc Biol. 2020, 40(5):1352-1369. doi: 10.1161/ATVBAHA.119.314113. |
32212850 |
Chen Y, Zhao X, Wu H.
Arterial Stiffness: A Focus on Vascular Calcification and Its Link to Bone Mineralization.
Arterioscler Thromb Vasc Biol. 2020, 40(5):1078-1093. doi: 10.1161/ ATVBAHA.120.313131. |
32237904 |
Chen Y, Zhao X, Wu H.
Transcriptional Programming in Arteriosclerotic Disease: A Multifaceted Function of the Runt-related Transcription Factor 2 (Runx2)
Arterioscler Thromb Vasc Biol. 2021, 41(1):20-34. |
33115268 |
Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, Sun CW, Zhu Y, Zhao Q, Chen Y, Cable L, Shen Y, Liu J, Qu CK, Han X, Klug CA, Bhatia R, Chen Y, Nimer SD, Zheng YG, Iancu-Rubin C, Jin J, Deng H, Krause DS, Xiang J, Verma A, Luo M, Zhao X.
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Cell Rep. 2021 Jul 27;36(4):109421. doi: 10.1016/j.celrep.2021.109421.
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34320342 |
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