Pathobiology and Molecular Medicine  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name PAUL D GAMLIN
Professor		  
Campus Address SHEL 1103 Zip 0000
Phone  (205) 934-0322
E-mail  pgamlin@uab.edu
Other websites
     

Education
Undergraduate  University of Cambridge, England    1978  BA 
Graduate  Stony Brook University    1984  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Ophthalmology  Ophthalmology Professor
Secondary  Biomedical Engineering  Biomedical Engineering Professor
Secondary  Neurobiology  Neurobiology Professor
Secondary  Psychology  Psychology Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Dev Func Imaging (CDFI) (Org-Ret)  Ctr for Dev Func Imaging (CDFI) (Org-Ret) Professor
Center  Evelyn F. McKnight Brain Institute  Evelyn F. McKnight Brain Institute Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor
Center  Vision Science Research Center (Org-Ret)  Vision Science Research Center (Org-Ret) Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Genetics, Genomics and Bioinformatics 
Medical Scientist Training Program 
Neuroscience 
Neuroscience Graduate Program 
Neurosciences 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Paul D.R. Gamlin (b. 1956) Professor of Ophthalmology, Neurobiology, Psychology, Biomedical Engineering, and Senior Scientist in the UAB Vision Science Research Center. He received his undergraduate training in zoology at University of Cambridge, England (B.A. 1978). He completed his doctoral studies in neurobiology and behavior at the State University of New York at Stony Brook (Ph.D. 1984). Following this, he continued his research training with Dr. Lawrence E. Mays in the Department of Physiological Optics at UAB.

Society Memberships
Organization Name Position Held Org Link
American Physiological Society     
Association for Research in Vision and Ophthalmology     
International Society for Autonomic Neuroscience     
International Society for Magnetic Resonance in Medicine     
Sigma Xi     
Society for Neuroscience     
Society for the Neural Control of Movement     
 



Research/Clinical Interest
Title
Studies of the Neural Bases of Vision & Eye Movements
Description
is interested in vision and the neural control of eye movements. Our studies of vision are currently focused on using AAV vectors to express light-sensitive proteins in inner retinal neurons in those individuals who are blind due to photoreceptor loss. This approach holds the promise of restoring vision to blind individuals. Another goal of my laboratory is to characterize the role that melanopsin-containing, intrinsically-photoreceptive retinal ganglion cells play in mediating the pupillary light reflex and entraining circadian rhythms. Our interest in eye movement control is concentrated on determining how the brain controls those eye movements that are required to look at objects at different distances i.e. vergence, ocular accommodation, and pupillary responses. To investigate these questions, we use electrophysiological, behavioral, fMRI, and neuroanatomical techniques.

Selected Publications 
Publication PUBMEDID
Ward MK, Bolding MS, Schultz KP, Gamlin PD. Mapping the macaque superior temporal sulcus: functional delineation of vergence and version eye-movement-related activity. J Neurosci. 2015 May 13;35(19):7428-42.  25972171 
McDougal DH, Gamlin PD. Autonomic control of the eye. Compr Physiol. 2015 Jan;5(1):439-73.  25589275 
Bolding MS, Lahti AC, White D, Moore C, Gurler D, Gawne TJ, Gamlin PD. Vergence eye movements in patients with schizophrenia. Vision Res. 2014 Sep;102:64-70.  25088242 
Hannibal J, Kankipati L, Strang CE, Peterson BB, Dacey D, Gamlin PD. Central projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey. J Comp Neurol. 2014 Jul 1;522(10):2231-48.  24752373 
Barrionuevo PA, Nicandro N, McAnany JJ, Zele AJ, Gamlin P, Cao D. Assessing rod, cone, and melanopsin contributions to human pupil flicker responses. Invest Ophthalmol Vis Sci. 2014 Feb 4;55(2):719-27. doi: 10.1167/iovs.13-13252.   24408974 
Lucas RJ, Peirson SN, Berson DM, Brown TM, Cooper HM, Czeisler CA, Figueiro MG, Gamlin PD, Lockley SW, O'Hagan JB, Price LL, Provencio I, Skene DJ, Brainard GC. (20130 Measuring and using light in the melanopsin age. Trends Neurosci. pii: S0166-2236(13)00197-5. doi: 10.1016/j.tins.2013.10.004.  24287308 
Gamlin PD, Miller JM (2012) Extraocular muscle motor units characterized by spike-triggered averaging in alert monkey. Journal of Neuroscience Methods, 204, pgs 159-167  22108141 
Boye SE, Alexander JJ, Boye SL, Witherspoon CD, Sandefer KJ, Conlon TJ, Erger K, Sun J, Ryals R, Chiodo VA, Clark ME, Girkin CA, Hauswirth WW, Gamlin PD (2012) The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina. Hum Gene Ther. 23(10):1101-15.   22845794 
Miller JM, Davison RC, Gamlin PD. (2011) Motor Nucleus Activity Fails to Predict Extraocular Muscle Forces in Ocular Convergence. J Neurophysiol. 105:2863-73.  21451064 
Kankipati L, C.A. Girkin and P.D. Gamlin (2011) The post-illumination pupil response is reduced in glaucoma patients. Invest Ophthalmol Vis Sci. 52:2287-92  21212172 
Kankipati L, C.A .Girkin, and P.D. Gamlin (2010) Post-illumination pupil response in subjects without ocular disease. Invest Ophthalmol Vis Sci 51:2764-9   20007832 
McDougal, DH and P.D. Gamlin (2010) The influence of intrinsically photosensitive retinal ganglion cells on the spectral sensitivity and response dynamics of the human pupillary light reflex. Vision Research 50(1):72-87  19850061 
Gamlin, P.D., McDougal, D.H., Pokorny, J., Smith, V.C., Yau, K-W., Dacey, D.M. (2007) Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells. Vision Research.47:946-54.   17320141 
Gamlin, PD, MK Ward, MS Bolding, JK Grossmann, and DB Twieg (2006) Developing functional magnetic resonance imaging techniques for alert macaque monkeys. Methods, 38:210-220.  16481198 
Dacey, DM, H Liao, B Peterson, F Robinson, V Smith, J Pokorny, KW Yau, and PD Gamlin (2005) Melanopsin-expressing ganglion cells in primate retina signal color and irradiance and project to the LGN. Nature 433:749-754  15716953 
Clarke, R.J., H.Y. Zhang, and P. D. R. Gamlin (2003) Characteristics of the Pupillary Light Reflex in the Alert Rhesus Monkey. J Neurophysiol. 2003 Jan 15 [epub ahead of print]  12611973 
Clarke, R.J. H. Zhang, and P.D.R. Gamlin (2003) The primate pupillary light reflex: receptive field characteristics of pretectal luminance neurons. J Neurophysiol. 2003 Jan 15 [epub ahead of print]  12611972 
Dacey, D. M., B. B. Peterson, P.D. Gamlin, and F.R. Robinson. (2003) Fireworks in the primate retina: in Vitro Photodynamics Reveals Diverse LGN-Projecting Ganglion Cell Types. Neuron. 2003 Jan 9;37(1):15-27.  12526769 
Gamlin, P.D.R.(2002) Neural Mechanisms for the Control of Vergence Eye Movements. Annals of the New York Academy of Sciences. 956:264-272.  11960810 
Gamlin, P.D and K. Yoon (2000) An Area for Vergence Eye Movement in Primate Frontal Cortex. Nature, 407:1003-1007.  11069179 
 

Keywords
pupil, vergence, gene therapy, fMRI