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Faculty Detail    
Name RAKESH PRAVINCHANDRA PATEL
  
Campus Address BMR2 532 Zip 2186
Phone  (205) 975-9225
E-mail  rakeshpatel@uabmc.edu
Other websites
     

Education
Undergraduate  University of Essex    1993  BSc. Hons 
Graduate  University of Essex    1996  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Joint Pathology  Molecular & Cellular Pathology Professor
Secondary  Anesthesiology Chair Office  Anesthesiology Chair Office Associate Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Professor
Secondary  Surgery - General Surgery  Surgery - Gen Surg Trauma Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Med - Cardiovascular Disease  Ctr Cardiovasc Bio (Org Ret) Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Exercise Medicine (Org Ret)  Ctr for Exercise Medicine (Org Ret) Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor
Center  Nephrology Research & Training Center  Nephrology Research & Training Center Professor
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor
Center  UAB Immunology Institute  UAB Immunology Institute Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr Patel graduated from the University of Essex, UK, where he also obtained his Ph.D in 1996. He then joined the Department of Pathology, University of Alabama at Birmingham (UAB) as a post-doctoral fellow, where he is currently Professor and Vice Chair for Research, and Director of the UAB Center for Free Radical Biology. Dr Patel’s research centers on understanding the mechanisms that regulate acute and chronic inflammation with a goal of using these insights to develop and test therapeutics targeted to prevent or limit inflammatory injury. Current areas of research include i) investigating how heme proteins regulate reactive oxygen and nitrogen species (including nitric oxide and nitrite) to modulate transfusion toxicity, acute lung injury and ischemia reperfusion injury and ii) understanding how post-translational regulation of protein by N-glycans regulate endothelial cell reactivity and monocyte adhesion in the context of atherosclerosis.

Society Memberships
Organization Name Position Held Org Link
American Thoracic Society     
International Society for Free Radical Research     
Society for Free Radical Biology and Medicine     
 



Research/Clinical Interest
Title
Modulation of Inflammation by Reactive Species and N-glycans
Description
We incorporate basic science and translational studies in pursuit of our research interests which are to understand redox related mechanisms regulating inflammation in various pathogenic states and how these are integrated to environmental stresses. We have three primary areas of focus i) understanding the molecular basis of nitric oxide and nitrite interactions with different organs and red blood cells and how these impact upon biological processes associated with blood flow regulation and pulmonary function during hypoxia, inflammation (associated with bronchopulmonary dysplasia, Sepsis, trauma, transfusion, transplantation or in response to inhaled (environmental) irritants), ii) understanding the role and effects of free hemoglobin and heme on acute inflammatory stress in the lung (ALI, ARDS) with a focus on interactions with matrikines, and ii) understanding how post-translational modification of proteins by carbohydrates control endothelial cell function and immune cell trafficking to regulate the inflammatory responses. We employ an integrative approach utilizing biochemical, molecular, cell culture and pre-clinical models to develop and test hypotheses and use the insights gained from studies design and conduct translational / clinical studies to test promising therapeutics.

Selected Publications 
Publication PUBMEDID
Samal AA, Honavar J, Brandon A, Bradley KM, Doran S, Liu Y, Dunaway C, Steele C, Postlethwait EM, Squadrito GL, Fanucchi MV, Matalon S, Patel RP.(2012) Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Rad Biol Med 53(7):1431-9
 		 22917977 
El-Ferzli GT, Dreher M, Patel RP, Ambalavanan N.(2012) ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure. PLos One 7(9)  22984626 
Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Wyss JM, Townes T, Patel RP (2012) Free Rad Biol Med Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. [Epub ahead of print]

 		 23159546 
Shuai Yuan, Rakesh P Patel*, Christopher G Kevil* (2014) Working with nitric oxide and hydrogen sulfide in biological systems AJP Lung Cell Mol Physiol (2015); 308: L403
*Co-senior authors
 		 25550314  
Jaideep Honavar, Stephen Doran, Joo Yeon Oh, Chad Steele, Sadis Matalon, Rakesh P. Patel (2014) Nitrite therapy improves post-chlorine gas exposure survival. AJP Lung Cell Mol Physiol 307:L888 PMCID: PMC4254962  PMCID: PMC4254962 
R Stapley, C Rodriguez, JY Oh, A Brandon, BM Wagener, MB Marques, JA Weinberg, JD Kerby, JF Pittet, RP Patel (2015) RBC Washing, nitrite therapy, and anti-heme therapies prevent stored RBC toxicity after trauma-hemorrhage. Free Rad Biol. Med. 85:207-218 PMCID: PMC4508223  4508223 
Victoria Harper, Joo-Yeun Oh, Ryan Stapley Marisa Marques, Landon Wilson, Stephen Barnes, Chiao-Wang Sun, Tim Townes, Rakesh P. Patel (2015). Peroxiredoxin-2 cycling is inhibited during erythrocyte storage. Antioxidant Redox Signaling 22: 294  25264713  
John D Lang Jr, Alvin B Smith, Angela Brandon, Kelley M Bradley, Yuliang Liu,D. Ralph Crowe, Nirag Jhala, Richard C Cross, Luc Frenette, Kenneth Martay, Youri Vater1, Alexander Vitin, Gregory Dembo, Derek DuBay, J Steven Bynon, Jeff M. Szychowski, Jorge Reyes, Jeffrey Halldorson, Stephen Rayhill, Andre Dick, Ramasamy Bakthavatsalam, Jo Ann Broeckel-Elrod1, Laura Sisson-Roberts, Terry Jordan, Lucinda Chen, Arunotai Siriussawakul, Devin E Eckhoff and Rakesh P. Patel (2014) Inhaled Nitric Oxide Administered Preemptively Improves Allograft Function and Decreases Post-operative Complications in Human Liver Transplantation PLOS One 9, e86053   24533048 
Jaideep Honavar, Eddie Bradley, Kelley Bradley, Joo Yeun Oh, Matthew O Vallejo, Eric E. Kelley, Nadiezhda Cantu-Medellin, Stephen Doran, Louis J. Dell’italia, Sadis Matalon, Rakesh P. Patel (2014) Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature. Toxicology 321: 96  24769334  
Cornelia S Hahn, David W. Scott, Xin Xu, Mojtaba Abdulroda, Gregory A. Payne, J. Michael Wells, Liliana Viera, Colleen J. Winstead, Patricia L. Jackson, J. Edwin Blalock, Rakesh P. Patel*, Amit Gaggar (2015) The Matrikine N-α-PGP Couples Extracelllar Matrix Fragmentation to Endothelial Permeability. Science Advances In Press
*Co-Senior Author
 		  
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Keywords
vascular, hemoglobin, red cells, Inflammation, isoflavones, Nitric oxide, nitrite, N-glycan, matrikine