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Faculty Detail    
Name TATIANA T MARQUEZ-LAGO
Associate Professor
 
Campus Address BBRB 734
Phone  205-934-9183
E-mail  tmarquez@uab.edu
Other websites Personal website
Marquez-Lago Lab
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Associate Professor
Primary  Genetics   Genetics Research Div Associate Professor



Research/Clinical Interest
Title
Description
Research in the Marquez-Lago lab combines (wet lab) experiments involving bioengineering, micro- and molecular biology techniques, with (drylab) data analysis, AI, modeling and simulation techniques. In a nutshell, we investigate (1) host-microbiota interactions in complex human diseases, (2) microbial multi-drug resistance, and (3) gene expression and chromatin organization. In addition, we study (4) the role and effect of mechanical forces ('mechanobiology') and cell compartmentalization in pathogenesis. In our work, we integrate experiments and data (DNA/RNA/ATAC/ChIP-seq, metabolomics, proteomics, super-resolution microscopy, etc.) into calibrated models that have predictive power, revealing testable experiments in fundamental biology and translational research. Our research and methods are primarily aimed at identifying effective biomarkers and viable precision therapeutics.

Selected Publications 
Publication PUBMEDID
Botta, D., Fuller, M.J., et al. (2017) Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.
Nature Immunology 18, 1249–1260 
 
Song, J., Wang, H., et al. (2017). PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection.
Scientific Reports 7:6862 
 
Wang, J., Yang B., et al. (2017) POSSUM: a bioinformatics toolkit for generating numerical sequence feature descriptors based on PSSM profiles.
Bioinformatics, Vol 33, Issue 17: 2756–2758  
 
Buono, R.A., Leier, A. et al. (2017) ESCRT-mediated vesicle concatenation in plant endosomes.
J. Cell Biol. Vol 216, No. 7  
 
Tigges, M., Marquez-Lago, T., et al. (2009) A tunable synthetic mammalian oscillator.
Nature 457: 309-312  
 
Marquez-Lago, T. and Stelling, J. (2010) Counter-intuitive stochastic behavior of simple gene circuits with negative feedbacks.
Biophysical J. 98(9):1742-1750 
 
Boettcher, B., Marquez-Lago, T., et al. (2012) Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis.
J. Cell Biol. Vol. 197, Number 7: 921-937 
 
Barrio, M., Leier, A., and Marquez-Lago, T. (2013) Reduction of chemical reaction networks through delay distributions.
J. Chem. Phys. 138, 104114 
 
Leier, A., Barrio, M. and Marquez-Lago, T. (2014) Exact model reduction with delays: closed-form distributions and extensions to fully bi-directional monomolecular reactions.
J. Royal Society Interface 11: 20140108 
 
An, Y., Wang, J., et al. (2016) Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI.
Brief. Bioinf. bbw100:1-14 
 
You, C., Marquez-Lago, et al. (2016) Receptor dimer stabilization by hierarchical plasma membrane microcompartmets regulates cytokine signaling.
Science Advances Vol. 2, No. 12, e1600452 
 

Keywords
Systems biology | bioengineering (synthetic biology) | microbiota-host interactions | multi-omics analysis and integration, predictive models and simulations for precision medicine