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Faculty Detail    
Name HARRY W SCHROEDER, JR
  
Campus Address SHEL 211 Zip 2182
Phone  (205) 934-4769
E-mail  hwsj@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Med - Immunology/Rheumatology  Med - Immunology/Rheumatology Professor Emeritus

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Hughes Med-Grad Fellowship Program 
Immunology 
Integrative Genetics Graduate Program 
Medical Scientist Training Program 

Biographical Sketch 
Harry W. Schroeder, Jr. (b. 1952), Professor, completed his undergraduate studies in Chemistry (B.S., 1974) at Texas A&M University (College Station, TX). He earned his M.D. (1981) and Ph.D. (1979) with Dr. Bert O'Malley at Baylor College of Medicine (Houston, TX). After completing an Internal Medicine residency at the University of Kentucky (Lexington, KY) in 1984, he trained in Clinical Genetics with Dr. Arno Motulsky at the University of Washington (Seattle, WA), and in molecular immunology with Dr. Roger Perlmutter at the Howard Hughes Medical Institute (Seattle, WA). He was recruited to UAB in 1988 where he has continued to pursue interests in the genetics of diseases of immune function. In 1995-1996, he spent a sabbatical year in the laboratory of Dr. Klaus Rajewsky at the Institute for Genetics of the University of Cologne (Cologne, Germany).



Research/Clinical Interest
Title
The Development and Function of Lymphocyte Antigen Receptors. &Genetics of Primary Immune Deficiency Diseases
Description
Although at first glance the power of the mechanisms used to diversify the B- and T-cell antigen receptors appear generate repertoires of random diversity, closer examination reveals striking constraints that are preserved across evolution. The implication is that violation of these constraints programs could lead to immune dysfunction, and thus to disease. Dr. Schroeders group has shown that immunoglobulins belonging to categories outside these constraints are progressive eliminated during development. He has used cre-loxP gene targeting to generate mice wherein the DH locus has been altered to force expression of polyclonal antibody repertoires that lie outside these normal constraints. In these mice, B cell numbers are reduced, responses to T-independent antigens decline in a co-dominant manner, responses to T-dependent antigens and autoantigens are affected in a dominant manner, and autoantibodies can be detected at a very young age. The mechanisms that regulate the normally regulate the repertoire the contribution of violations of these constraints to the development of disease, including autoimmune disorders, are a major focus of the laboratory. A second focus in the laboratory is the use of classic reverse genetics techniques to elucidate the mechanisms that underlie the development of common variable immune deficiency, the most common primary immune deficiency under the care of clinical immunologists.

Selected Publications 
Publication PUBMEDID
Khass M*, Buckley K*, Kapoor P, Schelonka RL, Watkins LS, Zhuang Y, Schroeder HW Jr. (2013) Recirculating, mature bone marrow B cells from C57BL/6 mice are more tolerant of charged CDR-H3s than BALB/c. Eur J Immunol 43(3):629-40  23225217  
Cha SC, Qin H, Kannan S, Rawal S, Watkins LS, Baio FE, Wu W, Ong J, Wei J, Kwak B, Kim S, Popescu MS, Paick DS, Kim K, Luong A, Davis RE, Schroeder HW Jr, Kwak LW, Neelapu SS. (2013) Nonstereotyped lymphoma B cell receptors recognize vimentin as a shared autoantigen. J Immunol.2013 May 1;190(9):4887-98. doi: 10.4049/jimmunol.1300179. Epub 2013 Mar 27  23536634 
Vale AM, Kapoor P, Skibinski G, Elgavish A, Mahmoud T, Zemlin C, Zemlin M, Burrows PD, Nobrega A, Kearney JF, Briles DE, Schroeder HW Jr. (2013) The link between antibodies to OxLDL and natural protection against pneumococci depends on DH gene conservation. J Exp Med 210(5) 875-890  23589567  
Szymanska-Mroczek E, Ippolito GC, Rogosch T, Hoi KH, Hwangpo TA, Brand MG, Zhuang Y, Liu CR, Schneider DA, Zemlin M, Brown EE, Georgiou G, Schroeder HW Jr. (2014) Differences in the composition of the human antibody repertoire by B cell subsets in the blood. Front Immunol 19 March 2014 | doi: 10.3389/fimmu.2014.00096.  24678310 
Trad A, Tanasa RI, Lange H, Zemlin M, Schroeder HW Jr, Lemke H. (2014) Clonal progression during the T cell-dependent B cell antibody response depends on the immunoglobulin DH gene segment repertoire. Front Immunol Aug 11;5:385. doi: 10.3389/fimmu.2014.00385.  25157256 
Silva-Sanchez A, Liu C, Kapoor P, Vale AM, Khass M, Ivanov II, Zhuang Y, Schoeb TR, Burrows PD, Schroeder HW Jr. (2015) Violation of a conserved Ig DH sequence preference promotes production of dsDNA-specific IgG antibodies. PLoS One. Feb 23;10(2):e0118171. doi: 10.1371/journal.pone.0118171. eCollection 2015.  25706374 
 

Keywords
Common Variable Immune Deficiency, Hypogammaglobulinemia, Antibody Repertoire, B cell Development, TCR repertoire, T cell development, Systemic Lupus Erythematosus, Mouse Models of Autoimmune Disease