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Faculty Detail    
Name LIZHONG WANG
  
Campus Address MCLM 631 Zip 0024
Phone  (205) 934-5948
E-mail  lwang12@uab.edu
Other websites
     

Education
Medical School  China Medical University    1988  M.D. 
Graduate  Akita University, Japan    2002  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics Research Div  Genetics Research Div Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Genetics, Genomics and Bioinformatics 

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research     
American Association for the Advancement of Science     
 



Research/Clinical Interest
Title
Cancer Genetics
Description
Our research interests focus on the cancer genetics and molecular epidemiology involved in prostate cancer and breast cancer. Our recent research showed that the somatic genetic alterations in a novel tumor suppressor gene FOXP3 with a single-hit mechanism have an important impact on developing both breast cancer and prostate cancer. We are going to investigate the molecular mechanisms of tumor development and progression in multiple signaling pathways. Our current projects include 1) identifying the cancer-causing genes, targets, and pathways; 2) determining the genetic mechanism of tumor invasion and metastasis; 3) establishing the principle of tumor suppressors relay between FOXP3 and noncoding RNA; 4) developing human-like animal models of prostate cancer.

Selected Publications 
Publication PUBMEDID
Complete list of my published work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/lizhong.wang.1/bibliography/43154619/public/?sort=date&direction=descending
 		  
Gao S, Wang S, Zhao Z, Zhang C, Liu Z, Ye P, Xu Z, Yi B, Jiao K, Naik G A., Wei S, Rais- Bahrami S, Bae S, Yang WH, Sonpavde G, Liu R and Wang L. TUBB4A interacts with MYH9 to protect the nucleus during cell migration and to promote tumor progression via GSK3β/β-catenin signaling in prostate cancer. Nat Commun. 2022 May 19; 13(1):2792. PMID: 35589707; PMCID: PMC9120517.

Cui X, Zhang C, Xu Z, Wang S, Li X, Stringer-Reasor E, Bea S, Zeng L, Zhao D, Liu R, Qi LS, Wang L*. Dual CRISPR interference and activation for targeted reactivation of X- linked endogenous FOXP3 in human breast cancer cells. Mol Cancer, 2022 Feb 7;21(1):38. PMID: 35130925 PMCID: PMC8819949.

Zhang Y, Xu Z, Wen W, Zhang C, Li M, Wei S, Bae S, Liu R, and Wang L. MicroRNA- 3622 family at 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression. Oncogene, 2022, 2022 May 2. Online ahead of print. PMID: 35501464.

Wu L, Yi B, Wei S, Yao D, He Y, Naik G, Bae S, Liu XM, Yang WH, Sonpavde G, Liu R*,
Wang L*. Loss of Foxp3 and Tsc1 Accelerate Prostate Cancer Progression through a Synergistic Transcriptional and Post-translational Regulation of c-MYC. Cancer Res. 2019 April 1;79(7):1413-1425. PMID: 3073319.

Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LL, Yang WH, Lillard JW, Zhang X, Wang L, Liu R. Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells. Clin Cancer Res. 2016 May 15;22(10):2545-54.

Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L. FOXP3 controls an miR-146/NFkB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Res. 2015 Apr 15;75(8):1703-13.

Liu R, Yi B, Wei S, Yang WH, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu CG, Wang L. FOXP3-microRNA-146-NFkB axis and therapy for precancerous lesions in prostate. Cancer Res. 2015 Apr 15;75(8):1714-24.

Wang L, Liu R, Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W, Zhang P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015 Jan 20;6:5909.

Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011 Mar 15; 71 (6): 2162-71.

Wang L, Liu R, Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009 Oct 6; 16 (4):336-46.

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MWY, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang THM, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell, 2007 June 29; 129 (7): 1275-86.













 		  
 

Keywords
Tumor Suppressor Gene, Tumor Development and Progression, Cancer Genetics