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Faculty Detail    
Name LOUIS J DELL'ITALIA
Professor		  
Campus Address BMR2 432 Zip 2180
Phone
E-mail
Other websites PubMed Listings
     

Education
Undergraduate  Holy Cross College    1974  BA Biology 
Medical School  Georgetown University School of Medicine    1978  Medicine 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Med - Cardiovascular Disease  Med - Cardiovascular Disease Professor Emeritus
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor Emeritus
Center  Nephrology Research & Training Center  Nephrology Research & Training Center Professor Emeritus

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Medical Scientist Training Program 

Biographical Sketch 
Dr. Louis J. Dell’Italia was born in Newark, NJ. He received his M.D. from Georgetown University School of Medicine in 1978. He subsequently received Internal Medicine training at Georgetown and Cardiology fellowship training at the University of Texas Health Science Center at San Antonio. Before coming to UAB in 1988, Dr. Dell’Italia was an Assistant Professor in the Division of Cardiology at the University of Texas Health Science Center, San Antonio, Texas.



Research/Clinical Interest
Title
Mechanisms of Remodeling of the Heart in Heart Failure
Description
The overarching theme of my research is to understand the biochemical and molecular mechanisms that regulate left ventricular (LV) remodeling in various forms of heart failure. Over the past 20 years our laboratory has implemented a multi-disciplinary approach incorporating in vitro and in vivo systems and more recently translational / clinical studies that have provided the impetus for the research proposed in this application. We have three specific areas of interest in the laboratory: 1) understanding the unique pattern of LV remodeling in patients with volume overload of mitral regurgitation, 2) understanding how inflammation oxidative stress causes cardiomyocyte remodeling and failure, 3) understanding how the cardiomyocyte mitochondria are both targets and sources of oxidative stress in the cardiomyocyte subjected to stretch in vitro and volume overload in vivo.

Selected Publications 
Publication PUBMEDID
Stewart JA, Wei C-C, Brower GL, Rynders PE, Hankes GH, Dillon AR, Lucchesi P, Janicki JS, Dell’Italia LJ. Cardiac mast cell and chymase mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog. In Press, J Mol Cell Cardiol, 2003.  12676546 
Wei C-C, Tian B, Chen Y-F, Perry G, Meng QC, Oparil S, Dell?Italia LJ. Differential angiotensin II generation in plasma and tissue of mice lacking the angiotensin converting enzyme gene. Am J Physiology 282H2254-H2258, 2002.  12003835 
Perry, GJ, Wei CC, Su X, Bishop SP, Hankes GH, Dillon GH, Mukherjee R, Spinale FG Dell?Italia LJ. Afterload reduction and blockade of the tissue renin angiotensin system does not improve left ventricular and cardiomyocyte remodeling in chronic mitral regurgitation. J Am Coll Cardiol 39:1374-1379, 2002.  11955858 
Hunton DL, Lucchesi PA, Pang Y, Dell’Italia LJ, Marchase RB. Capacitative calcium entry contributes to NFAT nuclear translocation and hypertrophy in cardiomyocytes. J Biol Chem 277:14266-14273, 2002.  11827959 
Wei CC, Ferrario CM, Brosnihan KB, Farrell DM, Bradley WE, Jaffa A, Dell’Italia LJ. Angiotensin peptides modulate bradykinin production in the dog heart in-vivo. J Pharm Exp Therapeut 300:324-329, 2002.  11752132 
Calhoun D, Wei CC, Bradley WE, Dell’Italia LJ. Enalaprilat blunts reflexive increases in cardiac interstitial norepinephrine in conscious rats. J Hypertension 19:2025-2029, 2001.  11677368 
Wei S, Rothstein E, Dell’Italia LJ, Fliegel L, Lucchesi P. Activation of multiple map kinases by H202 is associated with Na+/H+ exchanger phosphorylation in adult rat ventricular cardiomyocytes. Am J Physiol 281:C1542-C1550, 2001.  11600417 
Farrell DM, Wei CC, Tallaj J, Ardell JL, Hageman GR, Armour JA, Hageman GR, Bradley WE, Dell’Italia LJ. Angiotensin II modulates catecholamine release into the interstitial fluid of the canine myocardium in-vivo. Am J Physiol (Heart Circ Physiol) 281:H813-H822, 2001.  11454586 
Tallaj J, Wei CC, Hankes GH, Holland M, Rynders P, Dillon AR, Ardell JL, Armour JA, Lucchesi PA, Dell’Italia LJ. ??-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation. In Press, Circulation, 2003.   
Schultz D, Su X, Wei C-C, Bishop SP, Powell P, Hankes GH, Dillon AR, Rynders P, Spinale FG, Walcott G, Ideker R, Dell’Italia LJ. Increased angiotensin II concentrations and decreased angiotensin II receptor density results in compensated pressure overload in the dog heart. Am J Physiology, 51:H749-H756, 2002.