Back to Main

Faculty Detail    
Name MATTHEW S GOLDBERG
Associate Professor		  
Campus Address SRC 552A Zip 2182
Phone  (205) 934-5228
E-mail  mattgoldberg@uab.edu
Other websites Goldberg Lab
     

Education
Undergraduate  University of Michigan    1990  BS (Physics) 
Graduate  Yale    1998  PhD (Molecular Biophysics and Biochemistry) 
Fellowship  Harvard Medical School    2003  Postdoctoral Fellowship (Neurodegeneration) 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurology Chair Office  Neurology Chair Office Associate Professor
Secondary  Neurobiology  Neurobiology Associate Professor
Center  Civitan International Research Center  Civitan International Research Center Associate Professor
Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Associate Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Associate Professor
Center  Ctr Neurodegeneration & Exp Ther (CNET)  Ctr Neurodegeneration & Exp Ther (CNET) Associate Professor
Center  Evelyn F. McKnight Brain Institute  Evelyn F. McKnight Brain Institute Associate Professor

Graduate Biomedical Sciences Affiliations
Neuroscience 
Neuroscience Graduate Program 
Neurosciences 

Biographical Sketch 
Matthew S. Goldberg, Ph.D. is an Associate Professor of Neurology. He graduated with a bachelor’s degree in physics from the University of Michigan and he earned his Ph.D. in molecular biophysics and biochemistry from Yale University. He received his postdoctoral training at Harvard Medical School and Brigham and Women’s Hospital in Boston.

Society Memberships
Organization Name Position Held Org Link
Council on Undergraduate Research  Member   
Society for Neuroscience  Member   
 



Research/Clinical Interest
Title
Molecular mechanisms of Parkinson's disease pathogenesis
Description
Our research is focused on identifying the mechanisms of neuronal degeneration in Parkinson’s disease. There are currently no therapies proven to slow down the age-dependent loss of dopamine producing neurons in the substantia nigra, which is the cause of the primary clinical symptoms of Parkinson’s disease. We use animal models and cultured cells to study how genetic mutations cause inherited forms of Parkinson’s disease. Our goal is to gain sufficient understanding of the pathogenic mechanisms to develop therapies that can slow down or halt disease progression. Ongoing and previous grants from the National Institutes of Health, the Michael J. Fox Foundation for Parkinson’s Research, the Parkinson’s Disease Foundation, and the American Parkinson Disease Association support our studies of mitochondrial dysfunction and oxidative stress as the underlying cause of neurodegeneration in idiopathic Parkinson’s disease as well as familial Parkinson’s disease linked to mutations in alpha-synuclein, LRRK2, Parkin, DJ-1 and PINK1.

Selected Publications 
Publication PUBMEDID
Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function.
Creed RB, Memon AA, Komaragiri SP, Barodia SK, Goldberg MS. Acta Neuropathol Commun. 2022 May 23;10(1):78. doi: 10.1186/s40478-022-01374-z. 		 35606853  
BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage.
Francelin C, Mitter SK, Qian Q, Barodia SK, Ip C, Qi X, Gu H, Quigley J, Goldberg MS, Grant MB, Boulton ME. Antioxidants (Basel). 2021 Sep 28;10(10):1539. doi: 10.3390/antiox10101539. 		 34679674  
Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats.
Memon AA, Bagley ME, Creed RB, Amara AW, Goldberg MS, McMahon LL. Front Neurosci. 2021 Aug 13;15:655901. doi: 10.3389/fnins.2021.655901. eCollection 2021. 		 34483814 
Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats.
Creed RB, Roberts RC, Farmer CB, McMahon LL, Goldberg MS.
Neurobiol Dis. 2021 Mar;150:105246. doi: 10.1016/j.nbd.2020.105246. 		 33387634 
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples.
Watzlawik JO, Hou X, Fricova D, Ramnarine C, Barodia SK, Gendron TF, Heckman MG, DeTure M, Siuda J, Wszolek ZK, Scherzer CR, Ross OA, Bu G, Dickson DW, Goldberg MS, Fiesel FC, Springer W.
Autophagy. 2020 Oct 28;:1-16. doi: 10.1080/15548627.2020.1834712.  		 33112198 
Enhanced Susceptibility of PINK1 Knockout Rats to Alpha-Synuclein Fibrils.
Creed RB, Goldberg MS.
Neuroscience. 2020 Jun 15;437:64-75. doi: 10.1016/j.neuroscience.2020.04.032. 		 32353461 
PINK1 phosphorylates ubiquitin predominantly in astrocytes.
Barodia SK, McMeekin LJ, Creed RB, Quinones EK, Cowell RM, Goldberg MS.
NPJ Parkinsons Dis. 2019;5:29. doi: 10.1038/s41531-019-0101-9. eCollection 2019. 		 31840043 
Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.
Ernst P, Xu N, Qu J, Chen H, Goldberg MS, Darley-Usmar V, Zhang JJ, O'Rourke B, Liu X, Zhou L.
Biophys J. 2019 Aug 20;117(4):631-645. doi: 10.1016/j.bpj.2019.06.038. 		 31400914 
Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum.
Creed RB, Menalled L, Casey B, Dave KD, Janssens HB, Veinbergs I, van der Hart M, Rassoulpour A, Goldberg MS.
Neuroscience. 2019 Jun 15;409:169-179. doi: 10.1016/j.neuroscience.2019.04.033. 		 31029729 
Analysis of Alpha-Synuclein Pathology in PINK1 Knockout Rat Brains
Creed RB, Goldberg MS.
Front Neurosci. 2019 Jan 9;12:1034. doi: 10.3389/fnins.2018.01034. eCollection 2018. 		 30686993 
New Developments in Genetic rat models of Parkinson's Disease.
Creed RB, Goldberg MS.
Mov Disord. 2018 May;33(5):717-729. doi: 10.1002/mds.27296. 		 29418019 
Reactive Species Balance via GTP Cyclohydrolase I Regulates Glioblastoma Growth and Tumor Initiating Cell Maintenance.
Nhat Tran A, Walker K, Harrison DG, Chen W, Mobley J, Hocevar L, Hackney JR, Sedaka RS, Pollock JS, Goldberg MS, et al.
Neuro Oncol. 2018 Feb 2. doi: 10.1093/neuonc/noy012. 		 29409010 
Parkin and PINK1 function in oxidative stress and neurodegeneration.
Barodia SK, Creed RB, Goldberg MS.
Brain Research Bulletin. 2017 Jul;133:51-59. 		 28017782 
Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.
Ding X, Barodia SK, Ma L, Goldberg MS.
Neurobiol Dis. 2017 Feb;98:122-136. 		 27890708 
The role of ventral striatal cAMP signaling in stress-induced behaviors.
Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA.
Nat Neurosci. 2015 Aug;18(8):1094-100. 		 26192746 
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.
Dave KD, De Silva S, Sheth NP, Ramboz S, Beck MJ, Quang C, Switzer RC 3rd, Ahmad SO, Sunkin SM, Walker D, Cui X, Fisher DA, McCoy AM, Gamber K, Ding X, Goldberg MS, Benkovic SA, Haupt M, Baptista MA, Fiske BK, Sherer TB, Frasier MA.
Neurobiol Dis. 2014 Oct;70:190-203. 		 24969022 
Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.
Hennis MR, Marvin MA, Taylor CM 2nd, Goldberg MS.
Neurobiol Dis. 2014 Feb;62:113-23. 		 24075852 
Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.
Hennis MR, Seamans KW, Marvin MA, Casey BH, Goldberg MS.
PLoS One. 2013 Dec 26;8(12):e84894. 		 24386432 
Parkin-dependent degradation of the F-box protein Fbw7b promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1.
Ekholm-Reed S, Goldberg MS, Schlossmacher MG, Reed SI.
Mol Cell Biol. 2013 Sep;33(18):3627-43. 		 23858059 
Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice.
Nguyen TA, Frank-Cannon T, Martinez TN, Ruhn KA, Marvin M, Casey B, Treviño I, Hong JJ, Goldberg MS, Tansey MG.
J Neuroinflammation. 2013 Apr 28;10:50. 		 23622116  
A mutation in CLOCK leads to altered dopamine receptor function.
Spencer S, Torres-Altoro MI, Falcon E, Arey R, Marvin M, Goldberg M, Bibb JA, McClung CA.
J Neurochem. 2012 Oct;123(1):124-34 		 22757753 
Number and brightness analysis of LRRK2 oligomerization in live cells.
James NG, Digman MA, Gratton E, Barylko B, Ding X, Albanesi JP, Goldberg MS, Jameson DM.
Biophys J. 2012 Jun 6;102(11):L41-3. 		 22713584 
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
Yamaguchi S, Yamane T, Takahashi-Niki K, Kato I, Niki T, Goldberg MS, Shen J, Ishimoto K, Doi T, Iguchi-Ariga SM, Ariga H.
PLoS One. 2012;7(5):e38144.  		 22666465 
Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.
Tran TA, Nguyen AD, Chang J, Goldberg MS, Lee JK, Tansey MG.
PLoS One. 2011;6(8):e23660 		 21858193 
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.
Wen Y, Li W, Poteet EC, Xie L, Tan C, Yan LJ, Ju X, Liu R, Qian H, Marvin MA, Goldberg MS, She H, Mao Z, Simpkins JW, Yang SH.
J Biol Chem. 2011 May 6;286(18):16504-15 		 21454572  
Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockD19 mouse model of mania.
Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA.
Neuropsychopharmacology. 2011 Jun;36(7):1478-88. 		 21430648  
Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35.
Drerup JM, Hayashi K, Cui H, Mettlach GL, Long MA, Marvin M, Sun X, Goldberg MS, Lutter M, Bibb JA.
Biol Psychiatry. 2010 Dec 15;68(12):1163-71. 		 20832057  
Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention.
Tansey MG, Goldberg MS.
Neurobiol Dis. 2010 Mar;37(3):510-8 		 19913097 
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.
Giaime E, Sunyach C, Druon C, Scarzello S, Robert G, Grosso S, Auberger P, Goldberg MS, Shen J, Heutink P, Pouysségur J, Pagès G, Checler F, Alves da Costa C.
Cell Death Differ. 2010 Jan;17(1):158-69. 		 19680261 
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
da Costa CA, Sunyach C, Giaime E, West A, Corti O, Brice A, Safe S, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F.
Nat Cell Biol. 2009 Nov;11(11):1370-5. 		 19801972 
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.
Ding X, Goldberg MS.
PLoS One. 2009 Jun 17;4(6):e5949. 		 19536328 
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.
Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W.
Mol Neurodegener. 2009 Feb 25;4:12. 		 19243613 
Parkin-mediated ubiquitination regulates phospholipase C-gamma1.
Dehvari N, Sandebring A, Flores-Morales A, Mateos L, Chuan YC, Goldberg MS, Cookson MR, Cowburn RF, Cedazo-Mínguez A.
J Cell Mol Med. 2009 Sep;13(9B):3061-8 		 18671761 
Parkin deficiency increases vulnerability to inflammation-related nigral degeneration.
Frank-Cannon TC, Tran T, Ruhn KA, Martinez TN, Hong J, Marvin M, Hartley M, Treviño I, O'Brien DE, Casey B, Goldberg MS, Tansey MG.
J Neurosci. 2008 Oct 22;28(43):10825-34. 		 18945890 
Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.
Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW.
J Biol Chem. 2006 May 5;281(18):12809-16. Epub 2006 Mar 3. 		 16517603  
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1.
Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J.
Neuron. 2005 Feb 17;45(4):489-96. 		 15721235 
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice.
Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J.
J Biol Chem. 2004 Apr 30;279(18):18614-22. Epub 2004 Feb 24. 		 14985362 
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.
Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, Shen J.
J Biol Chem. 2003 Oct 31;278(44):43628-35. Epub 2003 Aug 20. 		 12930822 
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T.
Nat Cell Biol. 2002 Feb;4(2):160-4. 		 11813001 
alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.
Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ.
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9110-5. 		 11481478 
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?
Goldberg MS, Lansbury PT Jr.
Nat Cell Biol. 2000 Jul;2(7):E115-9. 		 10878819 
Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL.
Goldberg MS, Zhang J, Sondek S, Matthews CR, Fox RO, Horwich AL.
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1080-5. 		 9037009 
The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structures.
Hyberts SG, Goldberg MS, Havel TF, Wagner G.
Protein Sci. 1992 Jun;1(6):736-51. 		 1304915 
NMR studies of structure and dynamics of isotope enriched proteins.
Wagner G, Thanabal V, Stockman BJ, Peng JW, Nirmala NR, Hyberts SG, Goldberg MS, Detlefsen DJ, Clubb RT, Adler M.
Biopolymers. 1992 Apr;32(4):381-90. 		 1320418