Back to Main

Faculty Detail    
Name LIZHONG WANG
 
Campus Address KAUL 740 Zip 0024
Phone  205-934-5948
E-mail  lwang12@uab.edu
Other websites
     

Education
Medical School  China Medical University    1988  M.D. 
Graduate  Akita University, Japan    2002  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Assistant Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Genetics, Genomics and Bioinformatics 

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research     
American Association for the Advancement of Science     

Research/Clinical Interest
Title
Cancer Genetics
Description
Our research interests focus on the cancer genetics and molecular epidemiology involved in prostate cancer and breast cancer. Our recent research showed that the somatic genetic alterations in a novel tumor suppressor gene FOXP3 with a single-hit mechanism have an important impact on developing both breast cancer and prostate cancer. We are going to investigate the molecular mechanisms of tumor development and progression in multiple signaling pathways. Our current projects include 1) identifying the cancer-causing genes, targets, and pathways; 2) determining the genetic mechanism of tumor invasion and metastasis; 3) establishing the principle of tumor suppressors relay between FOXP3 and noncoding RNA; 4) developing human-like animal models of prostate cancer.

Positions Available
Date Posted Position Title
11/9/2016  Postdoctoral Fellow, Graduate Student, and Research Technician  
For postdoctoral research positions, qualified candidates should have a recent PhD in cancer cell biology, biochemistry, genetics or immunology. Individuals with experience in analysis of fluorescence in situ hybridization (FISH), dCas9-mediated transcriptional modulation, RNA translation, or cancer stem cells are especially encouraged to apply.

The successful candidate will explore regulatory mechanisms of transcription and translation in cancer, especially prostate cancer and breast cancer. These projects will be focused on targeting reactivation of tumor suppression gene in tumor cells and identifying role of oncogenic RNA translation in tumor progression. The applicants will also be involved in other ongoing projects in the field of cancer genetics using 3D organotypic cell culture models, as well as mouse models. The candidate must be able to work in a group/team environment, while also being able to work independently. Strong communication skills are need for writing and presentation of research in a multi-disciplinary research environment.

Applicants should send a curriculum vita, a brief statement of research interests and goals, as well as contact information for three references to lwang12@uab.edu. Review of applications will begin immediately and continue until the position is filled.   

Selected Publications 
Publication PUBMEDID
Complete list of my published work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/lizhong.wang.1/bibliography/43154619/public/?sort=date&direction=descending
 
 
Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, LiuRH, Guinther N, Lima J, Zhou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. A Di-nucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases. PLoS Genetics, 2007 Apr 6;3(4):508-17.

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MWY, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang THM, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell, 2007 June 29; 129 (7): 1275-86.

Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, Zheng P. Laforin negatively regulates cell cycle progression through GSK-3{beta} dependent mechanisms. Mol Cell Biol. 2008 Dec; 28 (23):7236-44.

Liu R, Wang L, Chen C, Katoh H, Chen C, Zheng P, Liu Y. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/4 association to the locus. Cancer Res. 2009 Mar 15; 69 (6): 2252-9.

Wang L, Liu R, Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009 Oct 6; 16 (4):336-46.

Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011 Mar 15; 71 (6): 2162-71.

Wang L, Liu R, Li D, Lin S, Fang X, Backer G, Kain M, Rammoham K, Zheng P, Liu Y. A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. Am J Transl Res. 2012;4(3):347-56.

Wang CM, Brennan VC, Gutierrez NM, Wang X, Wang L, Yang WH. SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. J Cell Biochem. 2013;114(3):589-98.

Wang L, Liu R, Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W, Zhang P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015 Jan 20;6:5909.

Liu R, Yi B, Wei S, Yang WH, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu CG, Wang L. FOXP3-microRNA-146-NFkB axis and therapy for precancerous lesions in prostate. Cancer Res. 2015 Apr 15;75(8):1714-24.

Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L. FOXP3 controls an miR-146/NFkB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Res. 2015 Apr 15;75(8):1703-13.

Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LL, Yang WH, Lillard JW, Zhang X, Wang L, Liu R. Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells. Clin Cancer Res. 2016 May 15;22(10):2545-54.

Zhang G, Wang C, Sun M, Li J, Wang B, Jin C, Hua P, Song G, Zhang Y, Nguyen LL, Cui R, Liu R, Wang L, Zhang X. Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells. Oncotarget. 2016 May 17;7(20):28935-46. 
http//wwwncbinlmnihgov/pubmed?term=lizhong%20 

Keywords
Tumor Suppressor Gene, Tumor Development and Progression, Cancer Genetics