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Faculty Detail    
Name PALANIAPPAN SETHU
Associate Professor of Medicine and Biomedical Engineering
 
Campus Address MCLM 290A Zip 0005
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Education
Undergraduate  PSG College of Technology    1998  B.E. Mechanical Engineering 
Graduate  University of Michigan    2000  M.S.E. Industrial Engineering 
Graduate  University of Michigan    2002  M.S. Biomedical Engineering 
Graduate  University of Michigan    2002  Ph.D. Biomedical Engineering 
Fellowship  Harvard Medical School, Massachusetts General Hospital and Shriners Burns Hospital    2005  Postdoctoral Fellowship 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Associate Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Engineering 

Biographical Sketch 
Dr. Palaniappan Sethu is an Associate Professor of Medicine and Biomedical Engineering at the University of Alabama-Birmingham (UAB) where he directs the Cardiovascular Bioengineering Laboratory and the UAB Microfabrication Facility. Dr. Sethu is an engineer by training and received his B.Eng in Mechanical Engineering from PSG College of Technology in India. He then earned his M.S. and Ph.D. in Biomedical Engineering and an M.Eng degree in Industrial Engineering all from the University of Michigan at Ann Arbor. He trained as a postdoctoral scholar in the Center for Engineering in Medicine at Harvard Medical School, Massachusetts General Hospital and Shriners Burns Hospital.

He started his academic career as an Assistant Professor in the Bioengineering Department at the University of Louisville. In 2012 he was promoted to Associate Professor with Tenure and in 2013 moved to UAB and setup his research and training program in Cardiovascular Bioengineering. Dr. Sethu has over 40 peer-reviewed journal publications, over 60 conference abstracts. He is the recipient of the National Science Foundation CAREER award, the Center for Environmental Genomics (CEGIB) Young Investigator Award and the Wallace H. Coulter Foundation Early Career Award for Translational Research.

His research is and has been funded by the National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), the Wallace H. Coulter Foundation, The Alabama Institute of Medicine and the Kentucky Science and Technology Corporation (KSTC). He is an active teacher and has taught courses in Introductory Bioengineering, Introductory Biomechanics, Biomechanics of Organs and Tissue, Cardiovascular Dynamics, Micro and Nanotechnology, Cell and Tissue Laboratory at the University of Louisville. At UAB he teaches undergraduate and graduate courses related to Biological Transport Phenomena in the Department of Biomedical Engineering.

Society Memberships
Organization Name Position Held Org Link
American Heart Association     
Biomedical Engineering Society     

Selected Publications 
Publication PUBMEDID
Guruprasad Giridharan, Mai-Dung Nguyen, Vahidreza Parichehreh, Rosendo Estrada, Tariq Hamid, Mohammed Ismahil, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Cardiac Cell Culture Model”, Anal Chem. 2010 Sep 15;82(18):7581-7  20795703 
Rosendo Estrada, Guruprasad A. Giridharan, Mai-Dung Nguyen, Thomas J. Roussel, Mostafa Shakeri, Vahidreza Parichehreh, Sumanth D. Prabhu and Palaniappan Sethu, “Endothelial Cell Culture Model (ECCM) for Replication of Physiological Profiles of Pressure, Flow, Strain and Shear Stress In-Vitro”, Anal Chem. 2011 Apr 15;83(8):3170-7  21413699 
Krishnakiran Medepalli, Bruce Alphenaar, Ashok Raj and Palaniappan Sethu, “Evaluation of the Direct and Indirect Response of Blood Leukocytes to Carbon Nanotubes (CNTs)”, Nanomedicine. 2011 Dec;7(6):983-91. Epub 2011 May 4  21616167 
Lorelei D. Shoemaker, Achal S. Achrol, Palaniappan Sethu, Gary K. Steinberg and Steven D. Chang, “Clinical Neuroproteomics and Biomarkers: From Basic Research to Clinical Decision-making”, Neurosurgery. 2012 Mar;70(3):518-25  21866062 
Balaji Panchapakesan, Palaniappan Sethu, Benjamin King, Brittany Book, Madhusuduna Rao and Joseph Irudayraj, “Gold Nanoprobes for Theranogstics”, Invited Review, Nanomedicine (Lond). 2011 Dec;6(10):1787-811  22122586 
Rosendo Estrada, Guruprasad Giridharan, Mai-Dung Nguyen, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Endothelial Cell Culture Model to Replicate Disturbed Flow Conditions Seen in Atherosclerosis Susceptible Regions”, Biomicrofluidics, 5, 032006, 2011   21413699 
Vahidreza Parichehreh and Palaniappan Sethu, “Inertial lift enhanced phase partitioning for continuous microfluidic charge based sorting of particles and cells”, Lab Chip. 2012 Mar 7;12(7):1296-301. Epub 2012 Feb 16  22336961 
Vahidreza Parichehreh, Krishnakiran Medepalli, Karan Babbarwal and Palaniappan Sethu, “Microfluidic Inertia Enhanced Phase Partitioning for Enriching Nucleated in Blood”, Lab Chip. 2013 Mar 7;13(5):892-900. doi: 10.1039/c2lc40663b. Epub 2013 Jan 10  23307172 
Kalyani Putty, Sarah A. Marcus, Peer R.E. Mittl, Lindsey E. Bogadi, Allison M. Hunter, Swathi Arur, Douglas E. Berg, Palaniappan Sethu, and Awdhesh Kalia, “Robustness of H. pylori Infection Conferred by Context-Variable Redundancy among Cysteine-Rich Paralogs”,PLoS ONE 8(3): e59560. doi:10.1371/journal.pone.0059560  23555707 
Krishnakiran Medepalli, Bruce W. Alphennar, Robert S. Keynton and Palaniappan Sethu, “A new technique for reversible permeablization of live cells for delivery of quantum dots”, Nanotechnology. 2013 May 24;24(20):205101. doi: 10.1088/0957-4484/24/20/205101. Epub 2013 Apr 19  23598366 
Phanikumar Patibandla, Rosendo Estrada, Manasaa Kannan and Palaniappan Sethu, “A Microfluidics Based Technique for Automated and Rapid Labeling of Cells for Flow Cytometry”, Journal of Micromechanics and Microengineering, Volume 24, Issue 3, Pages 034002, Jan 2014   
Mai-Dung Nguyen, Joseph P. Tinney, Fanping Yuan, Thomas J. Roussel, Ayman El-Baz, Guruprasad Giridharan, Bradley B. Keller and Palaniappan Sethu, “Cardiac Cell Culture Model (CCCM) as a Left Ventricle Mimic for Cardiac Tissue Generation”, Anal Chem. 2013 Aug 16.  23952579 
Xiaoyan Zhang, Ran Cheng, Dylan Rowe, Palaniappan Sethu, Alan Daugherty, Guoqiang Yu, and Hainsworth Shin “The shear-sensitive regulation of neutrophil flow behavior and its putative role in microvascular blood flow dysregulation in hypercholesterolemia”, Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):587-93. doi: 10.1161/ATVBAHA.113.302868. Epub 2014 Jan 23  24458712 
Ralph J. Knipp, Rosendo Estrada, Palaniappan Sethu and Michael H. Nantz, “Thermally-Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates”, Tetrahedron, 70, 3422-3429  25061237 

Keywords
cardiac and vascular models, mechanical stresses, cardiac regeneration, normal and disturbed flow