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Faculty Detail    
Name GENE P SIEGAL
Executive Vice-Chair
Interim Vice Chair Research
 
Campus Address HSB 149K Zip 6823
Phone  205-934-6608
E-mail  gsiegal@uab.edu
Other websites
     

Education
Undergraduate  Adelphi University    1970  B.A. 
Medical School  University of Louisville    1974  M.D. 
Residency  Mayo Graduate School of Medicine    1976  Resident in Pathology 
Graduate  University of Minnesota     1979  Ph.D. 
Fellowship  NCI, NIH    1981  Post-Doctoral Fellowship 
Fellowship  University of Minnesota Medical School    1982  Fellow in Surgical Pathology 

Certifications
National Board of Medical Examiners  1975 
American Board of Pathology  1978 
Certificate in Hospital Management  1988 
American Board of Pathology - Recertification  2012 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Surgery   Surgery - General Surgery Professor
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Ctr for Healthy Aging  Comprehensive Ctr for Healthy Aging Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Medicine  Gene Therapy Center Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Siegal was born in New York where he attended college. He received his medical degree from the University of Louisville and his PhD from the University of Minnesota. He was a Resident and Research Fellow at the Mayo Graduate School of Medicine and completed both a post-doctoral fellowship at the National Cancer Institute, NIH and a surgical pathology fellowship at the University of Minnesota. Prior to coming to UAB in 1990, he was a tenured faculty member at the University of North Carolina at Chapel Hill. Dr. Siegal has been married for over 40 years and has 2 adult daughters and 4 grandchildren.

Society Memberships
Organization Name Position Held Org Link
Alpha Omega Alpha, the Medical Honor Society     
American Association for Cancer Research     
American Association for the Advancement of Science     
American Medical Association     
American Society for Clinical Pathology [Fellow]   Executive Committee   
American Society for Investigative Pathology   Past Executive Committee   
Arthur Purdy Stout Society of Surgical Pathologists   Past-President   
Association of Clinical Scientists [Fellow]     
Association of Directors of Anatomic and Surgical Pathology   Past Executive Committee   
College of American Pathologists [Fellow]   Chair-Publications Committee   

Research/Clinical Interest
Title
Gene therapy of solid tumors, cancer biology, tumors of bone
Description
Dr. Siegal is an extramurally funded experimental and diagnostic pathologist whose research interest for more than 3 decades has been focused in Cancer Biology. Specifically, he has been interested in studying tumor-matrix interactions during angiogenesis, tumor invasion and metastasis in breast cancer. Previous efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on prostate and breast cancer progression in humans. He has participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms, principally ovarian carcinoma. He was most recently funded to develop a conditionally replicating canine adenovirus model that could be used to study host-vector interactions for more effective antitumor oncolytic effect. Dr. Siegal also directs the Histomorphometry & Molecular Analysis Core of the UAB Core Center for Musculoskeletal Disorders. Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions. He is the Editor-in-Chief of Laboratory Investigation and serves on the editorial board of an additional twenty journals.

Selected Publications 
Publication PUBMEDID
Wei, S. and Siegal, G.P.: Metastatic Organotropism: An intrinic property of breat cancer subtypes. Advances in Anatomic Pathology. 24(2):78-81, 2017.  28098572 
Hensel, J.A>, Khattar, V., Ashton, R., Lee, C., Siegal, G.P. and Ponnazhagan, S.: Location of Tumor Affects Local and Distant Immune Cell Type and Number. Immunity, inflammation, and Disease. 5(1):85-94, 2017.  28250928 
Ma, Y.R., Siegal, G.P. and Wei, S.:Reacquisition of E-cadherin Expression in Metastatic Deposits of Signet-Ring Cell Carcinoma of the Upper Gastrointestinal System: A Potential Anchor for Metastatic Deposition. Journal of Clinical Pathology. 2016.  27864451 
Kropp, L., Siegal, G.P., Frampton, G.M., Rodriquez, M.G., McKee, S., and Conry, R.M.: Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization. Rare Tumors. 8(4): 155-158, 2016, doi: 10.4081/rt.2016.6507.   
Ping, Z., Siegal, G.P. Harada, S., Eltoum, I.-E., Youssef, M., Shen, T., He, J., Huang, Y., Chen, D., Li, Y., Bland, K.I., Chang, H.R. and Shen, D.: ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast. Oncotarget 2016.  27811364 
Shen, T., Zhang, K., Siegal, G.P. and Wei, S.: Prognostic value of E-cadherin and b-catenin in triple-negative breast cancer. The American Journal of Clinical Pathology 146:603-610, 2016.  27780797 
Shen, T., Siegal, G.P. and Wei, S.: Clinicopathologic factors associated with de novo metastatic breast cancer. Pathology Research and Practice. 212(12):1167-1173, 2016.  27692496 
Ping, Z., Xia, Y., Shen, T., Parekh, V., Siegal, G.P., Eltoum, I.E., He, J., Chen, D., Deng, M., Xi, R.and Shen, D.: A microscopic landscape of the invasive breast cancer genome. Nature: Scientific Reports. 6:27545, 2016.  27811364 
Ma, Y.R., Ren, Z., Conner, M.G., Siegal, G.P. and Wei, S.: Reduced E-cadherin and aberrant ß catenin expression are associated with advanced disease in signet-ring cell carcinoma. Applied Immunohistochemistry & Molecular Morphology In Press, 2016.   26808130 
Ren, Z., Li, Y., Shen, T., Hameed, O., Siegal, G.P. and Wei, S.: Prognostic factors in advanced breast cancer: Race and receptor status are significant after development of metastasis. Pathology Research and Practice. 212(1):24-30, 2016.   26616114 
Li, R., Zhang, K., Penedo, T.L., Kragel, C.P., Grizzle, W.E., Hameed, O., Siegal, G.P. and Wei, S.: The RANK pathway in advanced breast cancer: Does Src Play a Role? Applied Immunohisto chemistry & Molecular Morphology. 24(1):42-50, 2016  26200837 
McCleskey, B.C., Penedo, T.L., Zhang, K., Hameed, O., Siegal, G.P. and Wei, S.: GATA3 expression in advanced breast cancer: Prognostic value and organ-specific relapse. American Journal of Clinical Pathology 144:756-763, 2015.  26486740 
Shen, T., Brandwein-Gensler, M.S., Hameed, 0., Siegal, G.P. and Wei, S.: Characterization of estrogen receptor negative/progesterone resceptor positive breast cancer. Human Pathology. 46(11):1776-1784, 2015.  26363528 
Mrug, M., Zhou, J., Yang, C., Aronow, B.J., Cui, X., Schoeb, T.R., Siegal, G.P., Yoder, B.K., and Guay-Woodford, L.M.: Genetic and informatic analyses implicate Kif12 as the Mpkd2 locus that modulates renal cystic disease severity in the cpk mouse. PLoS One. 2015.  26295839 
Soni, A., Weil, A., Wei, S., Jaffe, K.A. and Siegal, G.P.: Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones. World Journal of Orthopedics. 6(7):559-563, 2015.  26301184 
Watson, J.A., Bhattacharyya, B.J., Vaden, J.H., Wilson, J.A., Icyuz, M., Howard, A.D. Phillips, E., DeSilva, T.M., Siegal, G.P., Bean, A.J., King, G.D., Phillips, S.E., Miller, R.J.and Wilson, S.M.: Motor and sensory deficits in the teetering mice result from mutation of the ESCRT component HRS. PLoS Genetics 11(6):e1005290, 2015.  26115514 
Stevens T.M., Kovalovsky, A.O.,Velosa, C., Shi, Q., Dai, Q., Owen, R.P., Bel W.C., Wei, S., Althof, P.A., Sanmann, J.N., Sweeny, L., Carroll, W.R., Siegal, G.P., Bullock, M.J., Brandwein-Gensler, M.: Mammary analogue secretory carcinoma, low grade salivary duct carcinoma, and mimickers: A comparative study. Modern Pathology. In Press, 2015. PMID:26089091, doi: 10.1038/modpathol.2015.64. See also: Modern Pathology 30(2):312, 2017 doi: 10.1038/modpathol.2016.195.  26089091 
Sas, K.M., Yin, H., Fitzgibbon, W.R., Baicu, C.F., Zile, M.R., Steele, S.L., Amria, M.Y., Saigusa, T., Funk, J.A., Bunni, M.A., Siegal, G.P., Siroky, B.J., Bissler, J.J. and Bell, P.D.: Hyperglycemia in the absense of cilia accelerates cystogenesis and induces renal damage. American Journal of Physiology - Renal Physiology. 2015.  25904703 
Soni, A., Ren, Z., Hameed, O., Chanda, D., Morgan,C.J., Siegal, G.P., and Wei, S.: Breast cancer subtypes predispose the site of distant metastases. American Journal of Clinical Pathology. 143:471-478, 2015.  25779997 
Maddox, G.E., Ludwig, J., Craig, E.R., Woods, D., Joiner, A., Chaudhari, N., Killingsworth, C., Siegal, G.P.,Eberhardt, A., and Ponce, B.: Flexor Tendon Repair with a Knotless, Bidirectional Barbed Suture: An In Vivo Biomechanical Analysis. The Journal of Hand Surgery (American). 40(5):963-968, 2015.  25747739 
Garib, G., Siegal, G.P. and Andea, A.A.: Autosomal dominant familial angiolipomatosis: A case report and review of the literature. Cutis 95(1):E26-E29, 2015.   25671454 
Cui, X., Harada, S., Shen, D., Siegal, G.P. And Wei, S.: The utility of phosphohistone H3 in breast cancer grading. Applied Immunohistochemistry and Molecular Morphology. 23(10):689-695, 2015.   25611243 
Rohrbach, T.D., Jarboe, J.S., Anderson, J.C., Trummell, H.Q., Hicks, P.H., Weaver, A.N., Yang, E.S., Oster, R.A., Deshane, J.S., Steele, C., Siegal, G.P., Bonner,J.A. and Willey, C.D.: Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. International Journal of Oncology,. 46(3):1079-1088, 2015.  25524703 
Deshane, J.S., Redden, D.T., Zeng, M., Spell, M.L., Zmijewski, J.W., Anderson, J.T., Deshane, R.J., Gaggar, A., Siegal, G.P., Abraham, E., Dransfield, M.T., and Chaplin, D.D.: Subsets of airway myeloid-derived regulatory cells distinquish mild asthma from chronic obstructive pulmonary disease. Journal of Allergy and Clinical Immunology. 35(2):413-424, 2015.  25420684 
Ma, Y., Siegal, G.P. and Wei, S.: Solitary, adult-onset, intraosseous myofibroma of the finger: Report of a case and review of the literature. Hand. 2014.  26330794 
Andea, A., Patel, R., Ponnazhagan, S., Isayeva, T., Kumar, S., and Siegal, G.P.: Detection of Merkel cell polyomavirus in formalin fixed, paraffin embedded tissue of Merkel cell carcinoma and correlation with prognosis. Romanian Journal of Morphology and embryology. 55(3 Suppl): 1057-1062, 2014.  25607385 
Park, D.W., Jiang, S., Liu, Y., Siegal, G.P., Inoki, K., Abraham, E. and Zmijewski, J.: GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages, and enhances severity of acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology, 307(10):L735-L745, doi:10.1152/ajplung.00165.2014.  25239914 
Shen, M.-C. Zhao, X., Siegal, G.P. and Hardy, R.W.: Reduction of visceral fat by dietary stearate is mediated by apoptosis of preadipocytes. PloS Once 9(9):e104083, 2014.  25222131 
Wei, S. and Siegal, G.P.: Round cell tumors of bone: An update on recent molecular genetic advances. Advances in Anatomic Pathology. 21(5):359-372, 2014.  25105937 
Hu, M., Che, P., Cai, G-Q, Liu, G., Antony, V., Luckhardt, T., Siegal, G.P., Zhou, Y., Liu, R.M., Desai, L.P., O’Reilly, P.J., Thannickal, V.J. and Ding, Q.: Therapeutic targeting of Src kinase in myofibroblast activation and pulmonary fibrosis. Journal of Pharmacology and Experimental Therapeutics. 351(1):87-95, 2014.  25047515 
Dodd, L., Wei, S. and Siegal, G.P.: Opitmal handling of bone tumor specimens. Methods in Molecular Biology. 1180:353-368, 2014.  25015159 
Xing, D., Qasem, S.A., Owusu, K., Zhang, K., Siegal, G.P., and Wei, S.: Changing Prognostic Factors in Osteosarcoma: Analysis of 381 Cases from Two Institutions. Human Pathology. 45(8):1688-1696, 2014.  24931466 
Zhao, X., Rezonzew, G., Wang, D., Siegal, G.P. and Hardy, R.: Diet Modulation is an Effective Complementary Agent in Preventing Breast Cancer Lung Metastasis. Clinical and Experimental Metstasis. 2014.  24832758 
Ma, Y., Nix, J.W., Siegal, G.P. and Shen, D.: Extensive urinary malakoplakia with lymph node involvement: A Case Report. Austin Journal of Clinical Pathology. 1(3):1-3, 2014.   
Ren, Z., Hameed, O., Li, Y., Siegal, G., and Wei, S.: Prognostic factors in patients with metastatic breast cancer. Pathology – Research and Practice. 210(5):301-306, 2014,  24635972 
Chanda, D., Lee, J.H., Sawant, A., Hensel, J., Isayeva, T., Reilly, S.D., Siegal, G.P., Smith, C., Grizzle, W., Singh, R. and Ponnazhagan, S.: Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancer. PLoS One. 9(2): e89940, 2014.  24587138 
Ping, Z., Siegal, G.P., Almeida, J.S., Schnitt, S.J. and Shen, D.: Mining genome sequencing data to identify the genomic features linked to breast cancer histopathology. Journal of Pathology Informatics. 5:3-12, 2014.  24672738 

Keywords
Bone Tumors, Cancer Gene Therapy, Invasion and Metastasis