Graduate |
West Virginia University, West Virginia |
|
2008 |
Ph.D. |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Medicine |
Med - Endocrinology, Diabetes & Metabolism |
Assistant Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Assistant Professor |
Center |
Nutrition Sciences |
Nutrition Obesity Res Ctr (NORC) |
Assistant Professor |
|
Biochemistry and Structural Biology |
Cell, Molecular, & Developmental Biology |
Medical Scientist Training Program |
Pathobiology and Molecular Medicine |
|
Date Posted |
Position Title |
10/31/2018 |
Postdoctoral Scholar |
A postdoctoral position is immediately available within the basic, translational, and preclinical research program of the Department of Medicine in the Division of Endocrinology, Diabetes, Metabolism to study islet biology with the focus on understanding the regulation of insulin granule fusion from pancreatic beta-cells. The successful candidate will utilize knockout mouse models, molecular, pharmacological, and imaging (confocal with TIRFM) approaches to decipher the signaling pathways that regulate the formation of the SNARE complex in physiology, pathophysiology, and pathology states. The scope of this project also allows for the use of knockout mouse models to understand regulated secretion from non-beta cells in the disease states. Background in energy metabolism/secretory processes/islet biology is highly desirable. Prior experience in animal handling, cell culture, cloning, protein- and molecular-based assays is essential. Candidates with a Ph.D. in cell/molecular biology/physiology/pharmacology or a related discipline are encouraged to apply. Enthusiastic and highly-motivated candidates should submit a CV, a cover letter detailing research experience, and contact information of three references to Sushant Bhatnagar (Email: Sushantbhatnagar@uabmc.edu). Web links (https://www.bhatnagarlab.com and https://www.uab.edu/medicine/endocrinology/faculty).
About the University: UAB pursues the frontiers of education, research and health care and strives to be one of the most dynamic and productive universities of the 21st century. Our strategic plan, Forging the Future, is our roadmap for the next five years of growth. It outlines goals that share three themes: increasing access to our world-class educational programs, patient care, and research; enhancing the alignment of people and programs to reflect the interdisciplinary nature of 21st-century curricula, scientific investigation, and creative scholarship; and investing in grand ideas to tackle major problems facing society.
The University of Alabama at Birmingham is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of, race, national origin, age, genetic or family medical history, gender, faith, gender identity and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.
For more information on Equal Opportunity and Affirmative Action at UAB, visit the UAB Office of Diversity, Equity and Inclusion or call (205) 934-8762. Or contact the office at 701 20th Street South, AB 336, Birmingham, AL 35294-0103. About our Postdoc office: UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines, including dentistry, engineering, health professions, medicine, natural sciences and mathematics, public health, optometry, and social and behavioral sciences. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The OPE strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They may also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits. |
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Publication |
PUBMEDID |
Hae-Suk Kim, Ren, G., Kim, T., Bhatnagar, S., Yang, Q., Bahk, Y.Y., and Kim, Jeong-a (2018). Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells. Under review, FASEB |
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Bethea, M., Liu, Y., Wade, A. K., Mullen, R., Gupta, R., Gelfanov, V., DiMarchi, R., Bhatnagar, S., Behringer, R., Habegger, K.M., Hunter, C (2018). Lhx1 is required for β-cell function via regulation of Glp1 receptor expression. Under revision, AJP-Endocrinology |
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Koltes, J.E., Gupta, R., Schiad, M., Appakalai, B., Kim, J-a., Kimple, M.E., and Bhatnagar, S (2018). A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q-like-3 secreted protein as a regulator of beta-cell function. Under review, Scientific Reports |
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Gupta, R., Koltes, J.E., Schiad, M., Appakalai, B., Kim, J-a., Kimple, M.E., and Bhatnagar, S (2018). The C1ql3 secreted protein inhibits insulin secretion by cell adhesion G-protein coupled receptor, BAI3 from pancreatic beta-cells. In press Journal of Biological Chemistry. |
30228187 |
ASF1B Chaperones Histone 3.3 to the beta-cell cycle dance. Banerjee RR, Bhatnagar S. Cell Cycle. 2016 Nov 18:0. |
27860543 |
Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, Soni MS, Wrighton LS, Hebert AS, Zhou AS, Paul PK, Gregg T, Rabaglia ME, Keller MP, Coon JJ, Attie AD. J Biol Chem. 2014 Sep 5;289(36):25276-86. doi: 10.1074/jbc.M114.575985. Epub 2014 Jul 7. |
25002582 |
Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD. Diabetes. 2014 Nov;63(11):3805-14. doi: 10.2337/db13-1677. Epub 2014 Jun 26. |
24969106 |
Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, Attie AD. PLoS Genet. 2011 Oct;7(10):e1002323. doi: 10.1371/journal.pgen.1002323. Epub 2011 Oct 6. |
21998599 |
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. Bhatnagar S, Damron HA, Hillgartner FB. J Biol Chem. 2009 Apr 10;284(15):10023-33. doi: 10.1074/jbc.M808818200. Epub 2009 Feb 20. |
19233843 |
Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. Talukdar S, Bhatnagar S, Dridi S, Hillgartner FB. J Lipid Res. 2007 Dec;48(12):2647-63. Epub 2007 Sep 6. |
17823458 |
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