Undergraduate |
Bharathidhasan University, Trichy, India |
|
1992 |
B.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1994 |
M.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1996 |
M.Phil. |
Graduate |
University of Madras, Chennai, India |
|
2001 |
Ph.D. |
|
Appointment Type |
Department |
Division |
Rank |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Associate Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Associate Professor |
Center |
Ctr for Exercise Medicine (Org Ret) |
Ctr for Exercise Medicine (Org Ret) |
Associate Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Associate Professor |
Secondary |
Dept of Biomedical Engineering |
Dept of Biomedical Engineering |
Assistant Professor |
|
Cellular and Molecular Biology Program |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG.The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. PLoS Genet. 2013 Jun;9(6):e1003544. |
23818860 |
Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS.Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. 2013 Oct 1;100(1):63-73. |
23761402 |
Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Odelberg SJ, Firpo MA, Paine R 3rd, Hoidal JR, Abel ED, Rajasekaran NS.Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One. 2012;7(9):e45697. |
23029187 |
Brewer AC, Mustafi SB, Murray TV, Rajasekaran NS, Benjamin IJ. Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. Antioxid Redox Signal. 2013 Mar 20;18(9):1114-27. |
22938199 |
Miller CJ, Gounder SS, Kannan S, Goutam K, Muthusamy VR, Firpo MA, Symons JD, Paine R 3rd, Hoidal JR, Rajasekaran NS.Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. Biochim Biophys Acta. 2012 Jun;1822(6):1038-50. |
22366763 |
Muthusamy VR, Kannan S, Sadhaasivam K, Gounder SS, Davidson CJ, Boeheme C, Hoidal JR, Wang L, Rajasekaran NS. Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium. Free Radic Biol Med. 2012 Jan 15;52(2):366-76. |
22051043 |
Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ. Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. Antioxid Redox Signal. 2011 Mar 15;14(6):957-71. |
21126175 |
Zhang H, Rajasekaran NS, Orosz A, Xiao X, Rechsteiner M, Benjamin IJ. Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways. J Mol Cell Cardiol. 2010 Dec;49(6):918-30. |
20863832 |
Rajasekaran NS, Devaraj H, Devaraj SN. The effect of glutathione monoester (GME) on glutathione (GSH) depleted rat liver. J Nutr Biochem. 2002 May;13(5):302-306.
|
2015161 |
Rajasekaran NS, Firpo MA, Milash BA, Weiss RB, Benjamin IJ. Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice. Physiol Genomics. 2008 Oct 8;35(2):165-72. |
18628338 |
Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA, Hill JA.Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9745-50. |
18621691 |
Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3201-9. |
17873008 |
Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS. Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 2008 Jan;22(1):84-92. |
17846079 |
Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10;130(3):427-39. |
17693254 |
Mariappan, N., Soorappan, R.N., Haque, M., Sriramula, S. and Francis, J., 2007. TNF-α-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. American Journal of Physiology-Heart and Circulatory Physiology, 293(5), pp.H2726-H2737. |
17675574 |
Rajasekaran NS, Sathyanarayanan S, Devaraj NS, Devaraj H. Chronic depletion of glutathione (GSH) and minimal modification of LDL in vivo: its prevention by glutathione mono ester (GME) therapy. Biochim Biophys Acta. 2005 Jun 30;1741(1-2):103-12. |
15955453 |
Yan LJ, Rajasekaran NS, Sathyanarayanan S, Benjamin IJ. Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):465-71.
|
15706094 |
Rajasekaran NS, Nithya M, Rose C, Chandra TS. The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats. Biochim Biophys Acta. 2004 Aug 4;1689(3):190-201.
|
15276645 |
Rajasekaran NS, Devaraj NS, Devaraj H. Modulation of rat erythrocyte antioxidant defense system by buthionine sulfoximine and its reversal by glutathione monoester therapy. Biochim Biophys Acta. 2004 Mar 2;1688(2):121-9.
|
14990342 |
Rajasekaran NS, Devaraj NS, Devaraj H.Vitamin E prevents buthionine sulfoximine-induced biochemical disorders in the rat. J Pharm Pharmacol. 2004 Jan;56(1):91-9.
|
14983899 |
Sunny, S., Challa, A.K., Barchue, J.P., Ramamurthy, M.T., Crossman, D.K., Pogwizd, S., Cinghu, S. and Namakkal-Soorappan, R., 2020. Transcriptional regulation of structural and functional adaptations in a developing adulthood myocardium. bioRxiv. |
|
Narasimhan, G., Henderson, J., Luong, H.T., Rajasekaran, N.S., Qin, G., Zhang, J. and Krishnamurthy, P., 2019. OBG‐like ATP ase 1 inhibition attenuates angiotensin II‐induced hypertrophic response in human ventricular myocytes via GSK‐3beta/beta‐catenin signalling. Clinical and Experimental Pharmacology and Physiology, 46(8), pp.743-751. |
|
Jyothidasan, A., Shanmugam, G., Zhang, J., Dally, B., Crossman, D. and Rajasekaran, N.S., 2018. Basal Role for Nrf2-transgne on transcriptional (mRNA/miRNA) regulation in the mouse myocardium. bioRxiv, p.490953. |
|
Shanmugam, G., Crossman, D., Rajasingh, J., Dalley, B., Zhang, J. and Rajasekaran, N.S., 2019. Impaired Regulation of Redox Transcriptome during the Differentiation of iPSCs into Induced Cardiomyocytes (iCMs). bioRxiv, p.519793. |
|
|
|