Undergraduate |
Bharathidhasan University, Trichy, India |
|
1992 |
B.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1994 |
M.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1996 |
M.Phil. |
Graduate |
University of Madras, Chennai, India |
|
2001 |
Ph.D. |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Associate Professor |
Secondary |
Dept of Biomedical Engineering |
Dept of Biomedical Engineering |
Assistant Professor |
Center |
Ctr for Exercise Medicine (Org Ret) |
Ctr for Exercise Medicine (Org Ret) |
Associate Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Associate Professor |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Associate Professor |
|
Cellular and Molecular Biology Program |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Shanmugam, G., Crossman, D., Rajasingh, J., Dalley, B., Zhang, J. and Rajasekaran, N.S., 2019. Impaired Regulation of Redox Transcriptome during the Differentiation of iPSCs into Induced Cardiomyocytes (iCMs). bioRxiv, p.519793. |
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Jyothidasan, A., Shanmugam, G., Zhang, J., Dally, B., Crossman, D. and Rajasekaran, N.S., 2018. Basal Role for Nrf2-transgne on transcriptional (mRNA/miRNA) regulation in the mouse myocardium. bioRxiv, p.490953. |
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Narasimhan, G., Henderson, J., Luong, H.T., Rajasekaran, N.S., Qin, G., Zhang, J. and Krishnamurthy, P., 2019. OBG‐like ATP ase 1 inhibition attenuates angiotensin II‐induced hypertrophic response in human ventricular myocytes via GSK‐3beta/beta‐catenin signalling. Clinical and Experimental Pharmacology and Physiology, 46(8), pp.743-751. |
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Sunny, S., Challa, A.K., Barchue, J.P., Ramamurthy, M.T., Crossman, D.K., Pogwizd, S., Cinghu, S. and Namakkal-Soorappan, R., 2020. Transcriptional regulation of structural and functional adaptations in a developing adulthood myocardium. bioRxiv. |
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Rajasekaran NS, Devaraj NS, Devaraj H.Vitamin E prevents buthionine sulfoximine-induced biochemical disorders in the rat. J Pharm Pharmacol. 2004 Jan;56(1):91-9.
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14983899 |
Rajasekaran NS, Devaraj NS, Devaraj H. Modulation of rat erythrocyte antioxidant defense system by buthionine sulfoximine and its reversal by glutathione monoester therapy. Biochim Biophys Acta. 2004 Mar 2;1688(2):121-9.
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14990342 |
Rajasekaran NS, Nithya M, Rose C, Chandra TS. The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats. Biochim Biophys Acta. 2004 Aug 4;1689(3):190-201.
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15276645 |
Yan LJ, Rajasekaran NS, Sathyanarayanan S, Benjamin IJ. Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):465-71.
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15706094 |
Rajasekaran NS, Sathyanarayanan S, Devaraj NS, Devaraj H. Chronic depletion of glutathione (GSH) and minimal modification of LDL in vivo: its prevention by glutathione mono ester (GME) therapy. Biochim Biophys Acta. 2005 Jun 30;1741(1-2):103-12. |
15955453 |
Mariappan, N., Soorappan, R.N., Haque, M., Sriramula, S. and Francis, J., 2007. TNF-α-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. American Journal of Physiology-Heart and Circulatory Physiology, 293(5), pp.H2726-H2737. |
17675574 |
Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10;130(3):427-39. |
17693254 |
Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS. Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 2008 Jan;22(1):84-92. |
17846079 |
Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3201-9. |
17873008 |
Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA, Hill JA.Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9745-50. |
18621691 |
Rajasekaran NS, Firpo MA, Milash BA, Weiss RB, Benjamin IJ. Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice. Physiol Genomics. 2008 Oct 8;35(2):165-72. |
18628338 |
Rajasekaran NS, Devaraj H, Devaraj SN. The effect of glutathione monoester (GME) on glutathione (GSH) depleted rat liver. J Nutr Biochem. 2002 May;13(5):302-306.
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2015161 |
Zhang H, Rajasekaran NS, Orosz A, Xiao X, Rechsteiner M, Benjamin IJ. Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways. J Mol Cell Cardiol. 2010 Dec;49(6):918-30. |
20863832 |
Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ. Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. Antioxid Redox Signal. 2011 Mar 15;14(6):957-71. |
21126175 |
Muthusamy VR, Kannan S, Sadhaasivam K, Gounder SS, Davidson CJ, Boeheme C, Hoidal JR, Wang L, Rajasekaran NS. Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium. Free Radic Biol Med. 2012 Jan 15;52(2):366-76. |
22051043 |
Miller CJ, Gounder SS, Kannan S, Goutam K, Muthusamy VR, Firpo MA, Symons JD, Paine R 3rd, Hoidal JR, Rajasekaran NS.Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. Biochim Biophys Acta. 2012 Jun;1822(6):1038-50. |
22366763 |
Brewer AC, Mustafi SB, Murray TV, Rajasekaran NS, Benjamin IJ. Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. Antioxid Redox Signal. 2013 Mar 20;18(9):1114-27. |
22938199 |
Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Odelberg SJ, Firpo MA, Paine R 3rd, Hoidal JR, Abel ED, Rajasekaran NS.Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One. 2012;7(9):e45697. |
23029187 |
Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS.Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. 2013 Oct 1;100(1):63-73. |
23761402 |
Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG.The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. PLoS Genet. 2013 Jun;9(6):e1003544. |
23818860 |
Narasimhan M, Hong J, Atieno N, Muthusamy VR, Davidson CJ, Abu-Rmaileh N, Richardson RS, Gomes AV, Hoidal JR, Rajasekaran NS.Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells. Free Radic Biol Med. 2014 Jun;71:402-14. |
24613379 |
Haldar M, Kohyama M, So AY, Kc W, Wu X, Briseño CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL, Murphy KM.Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34. |
24630724 |
Narasimhan M, Rajasekaran NS.Reductive potential - a savior turns stressor in protein aggregation cardiomyopathy. Biochim Biophys Acta. 2015 Jan;1852(1):53-60. |
25446995 |
Verma DR, Khan MF, Tandar A, Rajasekaran NS, Neuharth R, Patel AN, Muhlestein JB, Badger RS.Nickel elution properties of contemporary interatrial shunt closure devices.J Invasive Cardiol. 2015 Feb;27(2):99-104. |
25661761 |
Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J.KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.Biochem J. 2015 Aug 1;469(3):347-55. |
26205490 |
Gomes AV, Rajasekaran NS, Pi X. Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015;2015:849095. |
26523200 |
Narasimhan M, Shelar SB, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS.Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle.FASEB J. 2016 Feb 2. pii: fj.201500153. [Epub ahead of print]. |
26839378 |
Swamy, S.M., Rajasekaran, N.S. and Thannickal, V.J., 2016. Nuclear factor–erythroid-2–related factor 2 in aging and lung fibrosis. The American journal of pathology, 186(7), pp.1712-1723. |
26839378 |
Kumar, R.R., Narasimhan, M., Shanmugam, G., Hong, J., Devarajan, A., Palaniappan, S., Zhang, J., Halade, G.V., Darley-Usmar, V.M., Hoidal, J.R. and Rajasekaran, N.S., 2016. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. Journal of translational medicine, 14(1), pp.1-16. |
27048381 |
Patibandla, P.K., Rajasekaran, N.S., Shelar, S.B., Giridharan, G.A., Litovsky, S.H. and Sethu, P., 2016. Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function. The Journal of Heart and Lung Transplantation, 35(7), pp.930-932. |
27138701 |
Wende, A.R., Young, M.E., Chatham, J., Zhang, J., Rajasekaran, N.S. and Darley-Usmar, V.M., 2016. Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radical Biology and Medicine, 100, pp.94-107. |
27242268 |
Shanmugam G, Narasimhan M, Sakthivel R, Kumar R R, Davidson C, Palaniappan S, Claycomb WC, Hoidal JR, Darley-Usmar VM, Rajasekaran NS. A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes. Redox Biol. 2016 Jun 27; 9:77-89. |
27423013 |
Ahmed, M.I., Guichard, J.L., Rajasekaran, N.S., Ahmad, S., Mariappan, N., Litovsky, S., Gupta, H., Lloyd, S.G., Denney, T.S., Powell, P.C. and Aban, I., 2016. Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function. The Journal of thoracic and cardiovascular surgery, 152(4), pp.1059-1070. |
27464577 |
Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, and Rajasekaran NS. 2017. Constitutive Activation of Nrf2 Induces a Stable Reductive State in the Mouse Myocardium. Redox Biology, 12;937–945. |
28482326 |
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, and Rajasekaran NS. 2017. Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling. Frontiers in Physiology 8 (268). |
28515695 |
Quiles, J.M., Narasimhan, N., Shanmugam, G., Milash, B., Hoidal, J.R., and Rajasekaran NS. Differential Regulation of miRNA and mRNA Expression in the Myocardium of Nrf2 Knockout Mice. BMC Genomics. 2017 Jul 3;18(1):509. |
28673258 |
McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. 2017. Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. J Mol Cell Cardiol. 110:80-95. |
28736261 |
Quiles JM, Narasimhan M, Mosbruger T, Shanmugam G, Crossman D, Rajasekaran NS. 2017. Identification of transcriptome signature for myocardial reductive stress. Redox Biol. 13:568-580. |
28768233 |
Kain, V., Ingle, K.A., Kachman, M., Baum, H., Shanmugam, G., Rajasekaran, N.S., Young, M.E. and Halade, G.V., 2018. Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation. American Journal of Physiology-Heart and Circulatory Physiology, 314(2), pp.H160-H169. |
28986357 |
Narasimhan, K.K.S., Jayakumar, D., Velusamy, P., Srinivasan, A., Mohan, T., Ravi, D.B., Uthamaraman, S., Sathyamoorthy, Y.K., Rajasekaran, N.S. and Periandavan, K., 2019. Morinda citrifolia and its active principle scopoletin mitigate protein aggregation and neuronal apoptosis through augmenting the DJ-1/Nrf2/ARE signaling pathway. Oxidative medicine and cellular longevity, 2019. |
28986357 |
Narasimhan, M. and Rajasekaran, N.S., 2017. Cardiac Aging–Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling. In Exercise for Cardiovascular Disease Prevention and Treatment (pp. 231-255). Springer, Singapore. |
29022266 |
Thiagarajan Sairam, Amit N Patel, Meenu Subrahmanian, Rajendran Gopalan, Steven M Pogwizd, Sudha Ramalingam, Sankaran Ramalingam, Rajasekaran NS (2018). Evidence for hyper-reductive redox in a subset of heart failure patients. Journal of Translational Medicine (In press). |
29022266 |
Narasimhan, M. and Rajasekaran, N.S., 2016. Exercise, Nrf2 and antioxidant signaling in cardiac aging. Frontiers in physiology, 7, p.241. |
29022266 |
Bharat D, Cavalcanti RRM, Petersen C, Begaye N, Cutler BR, Costa MMA, Ramos RKLG, Ferreira MR, Li Y, Bharath LP, Toolson E, Sebahar P, Looper RE, Jalili T, Rajasekaran NS, Jia Z, Symons JD, Pon Velayutham AB. 2017. Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction. Mol Nutr Food Res. doi: 10.1002/mnfr.201700601. |
29024402 |
Bolus DJ, Shanmugam G, Narasimhan M, Rajasekaran NS. 2017. Recurrent heat shock impairs the proliferation and differentiation of C2C12 myoblasts. Cell Stress Chaperones. doi: 10.1007/s12192-017-0851-4. |
29063376 |
Rachel A. Brewer, Helen E. Collins, Ryan D. Berry, Manoja K. Brahma, Brian A. Tirado, Rodrigo A. Peliciari-Garcia, Haley L. Stanley, Adam R. Wende, Heinrich Taegtmeyer, Rajasekaran NS, Victor Darley-Usmar, Jianhua Zhang, Stuart J. Frank, John C. Chatham, Martin E. Young. Temporal partitioning of adaptive responses of the murine heart to fasting. Life Sciences 197 (2018) 30–39. |
29410090 |
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