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Faculty Detail    
Name VLADIMIR PARPURA
  
Campus Address SHEL 912 Zip 2182
Phone  (205) 934-0100
E-mail  vlad@uab.edu
Other websites https://www.uab.edu/medicine/neurobiology/faculty/parpura
http://www.ae-info.org/ae/User/Parpura_Vladimir
     

Education
Medical School  School of Medicine in Split, University of Zagreb, Croatia    1989  MD 
Graduate  Iowa State University, Ames, IA    1993  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurobiology  Neurobiology Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Engineering 
Neuroscience 

Biographical Sketch 
MEDICAL EXPERIENCE: 07/87 International Educational Exchange, Dept. of Haemodynamics, University Clinic Novi Sad, Yugoslavia 07/88 International Educational Exchange, Dept. of General Surgery, University General Hospital Cordoba, Spain 07/89 International Educational Exchange, University of Rome, Italy, declined 07/89-12/89 Rotating Internship in Medicine, Clinical Hospital Center, Split, University of Zagreb, Croatia POSTDOCTORAL TRAINING: Year Rank/Title Institution 01/94-11/94 Postdoctoral research associate Iowa State University, Ames, IA (Dr. P.G. Haydon) 09-10/94 Visiting postdoctoral research associate Yale University Medical Sch., New Haven, CT (Dr. R Jahn). 12/94-11/96 Postdoctoral research fellow Mayo Clinic, Rochester, MN (Dr. J.M. Fernandez) ACADEMIC APPOINTMENTS: (In reverse chronological order) Year Rank/Title Institution 10/1/15- Professor (with tenure) Dept. of Neurobiology Univ. of Alabama at Birmingham, Birmingham, AL 7/1/07-9/30/15 Associate Professor (with tenure) Dept. of Neurobiology Univ. of Alabama, Birmingham, AL Secondary appointments: Dept. of Cell Biology (8/27/07-3/6/12), which became Department of Cell Developmental and Integrative Biology (3/7/12-), Dept. of Vision Science (9/28/07-) and Dept. of Biomedical Engineering (1/1/09-) 4/16/13-5/26/15 Professor (with tenure) Dept. of Biotechnology, Univ. of Rijeka, Rijeka, Croatia 7/1/-9/15/07 Visiting Associate Researcher Dept. of Cell Biology & Neuroscience Univ. of California, Riverside, CA 7/06-6/07 Cooperative Faculty-Associate Professor Dept. of Physics & Astronomy Univ. of California, Riverside, CA 7/05-6/07 Associate Professor (with tenure); Dept. of Cell Biology & Neuroscience Sabbatical leave in residence (7/1/06-1/2/07) Univ. of California, Riverside, CA 7/00-6/05 Assistant Professor Dept. of Cell Biology & Neuroscience Univ. of California, Riverside, CA 12/96-7/00 Affiliate Assistant Professor Dept. of Zoology & Genetics Iowa State University, Ames, IA AWARDS/HONORS: 1988 Rector's Award, University of Zagreb 1988 Nikola Tesla's Award, Yugoslav Academy of Sciences and Arts 1990-1992 Premium for Academic Excellence (PACE) Award, Iowa State University 1993 Research Excellence Award, Iowa State University 1995-1996 Research Fellow, Mayo Foundation 1997 Travel Fellow, 6th International School on Biophysics: Supramolecular Structure and Function, Rovinj, Croatia. 1998 Short Term Fellowship, Human Frontier Science Program Organization (HFSPO), “Dopamine-induced morphological changes of spines and dendrites,” carried out at the Brain Research Institute, Zurich, Switzerland 2003 Winter Conference on Brain Research (WCBR) Travel Fellow, Snowbird, UT 2004 Institute for Complex Adaptive Matter Senior Fellow ($25,000) 2006-2007 Faculty mentor of the year, University Honors program, University of California, Riverside 2011 IKERBASQUE (The Basque Country Science Foundation) Visiting Professor, Spain 2012-15 Mentor, The Beckman Scholars Program at University of Alabama at Birmingham 2012- Member, Academia Europaea, Physiology and Medicine Section 1/1/2014- Member (3-year term), Physiology and Medicine Section Committee, Academia Europaea.

Society Memberships
Organization Name Position Held Org Link
American Physiological Society  Member-At-Large, Central Nervous System Section Steering Committee   
American Society for Neurochemistry  President-elect (2015-2017)   
American Society for Neurochemistry  Council (2009-2013); Secretary-elect (2011-2013) ; Secretary (2013-2015)   
American Society for Neurochemistry  2006, 2010, 2016 Scientific Program Committee    
American Society for Neurochemistry  Chair (2008-2013), Membership Committee    
Exocytosis/Endocytosis Subgroup, Biophysical Society   Executive Committee (2012-3013)   
Gordon Research Conferences  Council (2005-2007)   
Riverside/Inland Empire Chapter of the Society for Neuroscience  Founder and Representative (2005-2007)   
 



Research/Clinical Interest
Title
The role of glial cells in physiology of nervous system.
Description
My current research includes: i) studying the modulation of calcium-dependent glutamate release from astrocytes in health and disease; ii) assessing the role of the enteric glia in gut functions; iii) visualization of vesicular/receptor trafficking; iv) examination of the nature and energetics of interactions between exocytotic proteins using single molecule detection approaches; v) development of scaffolds and dispersible materials, most notably modified carbon nanotubes, which can be used in repair after brain injury, vi) development of biosensors (e.g. botulinum toxin and nanofabricated carbon-based detectors, and viii) bio-mimetic micro-robotics. It should be noted that the work done in these overlapping categories is highly interrelated. Parpura has been interfacing neuroscience with nanoscience/nanotechnology, synthetic biology and biomedical engineering.

Selected Publications 
Publication PUBMEDID
MANUSCRIPTS:
Journal articles already published
1. Cvitanovic, S., Grbic, D., Zekan, Lj., Boban, M., Vrdoljak, E., Parpura, V., Petrovic, S., Marusic, M. (1989). Hypersensitivity to P. officinalis pollen: Correlation of IgE with skin testing methods. Allergol. et Immunopathol., 17: 197-200.
*2. Cvitanovic, S., Grbic, D., Zekan, Lj., Petrovic, S., Vrdoljak, E., Parpura, V., Boban, M. (1989). Ketotifen and nasal steroids in the therapy of pollinosis. Pluc. Bol. 41: 205-208.
*3. Parpura, V., Kracun, I., Cosovic, C. (1990). Gangliosides-review. Jugoslav. Med. Biokem. 9: 3-15.
4. Parpura, V., Haydon, P. G., Henderson, E. (1993). Three-dimensional imaging of living neurons and glia with the Atomic Force Microscope. J. Cell Sci. 104: 427-432.
5. Parpura, V., Haydon, P.G., Sakaguchi, D.S., Henderson, E. (1993). Atomic Force Microscopy and manipulation of living glial cells. J.Vac. Sci. Technol. A 11:773-775.
6. Parpura, V., Basarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S., Haydon, P. G. (1994). Glutamate-mediated astrocyte-neuron signalling. Nature 369: 744-747.
7. Basarsky, T.A., Parpura, V., Haydon, P. G. (1994). Hippocampal synaptogenesis in cell culture: Developmental time course of synapse formation, calcium influx and synaptic protein distribution. J. Neurosci. 14: 6402-6411.
8. Parpura, V., Doyle, R.T., Basarsky, T.A., Henderson, E., Haydon, P.G. (1995). Dynamic imaging of individual purified synaptic vesicles. Neuroimage, 2: 3-7.
9. Parpura, V., Liu, F., Brethorst, S., Jeftinija, K., Jeftinija, S., Haydon, P.G. (1995). - latrotoxin stimulates glutamate release from cortical astrocytes. FEBS Lett., 360: 266-270.
10. Parpura, V., Liu, F., Jeftinija, K., Haydon, P.G., Jeftinija, S. (1995). Neuroligand-evoked calcium-dependent release of excitatory amino acids from Schwann cells. J. Neurosci. 15: 5831-5839.
11. Tan, W., Parpura, V., Haydon, P.G., Yeung, E.S. (1995). Neurotransmitter imaging in living cells based on native fluorescence detection. Anal. Chem. 67: 2575-2579.
12. Parpura, V., Fang, Y., Basarsky, T. A., Jahn, R., Haydon, P.G. (1995). Expression of synaptobrevin II, cellubrevin and syntaxin in cultured astrocytes. FEBS Lett. 377:489-492.
13. Haydon, P.G., Lartius, R.K., Parpura, V., Marchese-Ragona, S.P. (1996). Membrane deformation of living glial cells using atomic force microscopy. J. Microscopy 182: 114-120.
14. Parpura, V., Fernandez J.M. (1996). Atomic Force Microscopy study of the secretory granule lumen. Biophys J. 71: 2356-2366.
15. Araque, A., Parpura, V., Sanzgiri, R.P., Haydon, P.G. (1998). Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons. Eur. J. Neurosci. 10: 2129-2142.
16. Parpura, V., Tong, W., Yeung, E.S., Haydon, P.G. (1998). Laser-Induced Native Fluorescence (LINF) imaging of serotonin depletion in depolarized neurons. J. Neurosci. Meth. 82: 151-158.
17. Araque, A., Sanzgiri, R.P., Parpura, V., Haydon, P.G. (1998). Calcium elevation in astrocytes causes an NMDA receptor-dependent increase in the frequency of miniature synaptic currents in cultured hippocampal neurons. J. Neurosci. 18: 6822-6829.
18. Parpura, V., Haydon, P.G. (1999). UV photolysis using a micromanipulated optical fiber to deliver UV energy directly to the sample. J. Neurosci. Meth. 87: 25-34.
19. Araque, A., Parpura, V., Sanzgiri, R.P., Haydon, P.G. (1999). Tripartite synapses: Glia, the unacknowledged partner. Trends Neurosci. 22: 208-215.
20. Trudeau, L-E., Parpura, V., Haydon, P.G. (1999). Activation of neurotransmitter release in hippocampal nerve terminals during recovery from intracellular acidification. J. Neurophysiol. 81: 2627-2635.
21. Parpura, V., Haydon, P.G. (1999). “Uncaging” using optical fibers to deliver UV-light directly to the sample. Croat. Med. J. 40: 340-345.
22. Araque, A., Sanzgiri, R.P., Parpura, V., Haydon, P.G. (1999). Astrocyte-induced modulation of synaptic transmission. Can. J. Physiol. Pharmacol. 77: 699-706.
23. Innocenti, B., Parpura, V., Haydon, P.G. (2000). Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes. J. Neurosci. 20: 1800-1808.
24. Parpura, V., Haydon, P.G. (2000). Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons. Proc. Natl. Acad. Sci. USA. 97: 8629-8634.
25. Parvizi, J., Parpura, V., Greenleaf, J.F., Bolander, M.E. (2002). Calcium signaling is required for ultrasound-stimulated aggrecan synthesis by rat chondrocytes J. Orthopaedic Res. 20:51-57.
26. Grima G., Benz B., Parpura V., Cuenod M., Do K.Q. (2003).Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia. Schizophr Res. 62:213-24.
27. Liu, W., Montana, V., Chapman, E.R., Mohideen U., Parpura, V. (2003). Botulinum Toxin type B
Micromechanosensor, Proc. Natl. Acad. Sci. USA. 100: 13621-13625.
28. Li, Q.-J., Yao, M., Wong, L., Parpura, V., Martins-Green, M. (2004). The N- and C- terminal peptides of hIL-8/CXCL8 are ligands for hCXCR1 and hCXCR2. FASEB J. 18:776-778. (full version of this article available at http://www.fasebj.org, The FASEB Journal express article doi:10.1096/fj.02-1175fje)
29. Parpura, V., Scemes, E., Spray, D.C. (2004). Mechanisms of glutamate release from astrocytes: gap junction "hemichannels", purinergic receptors and exocytotic release. Neurochem Int. 45:259-264.
30. Hua, X., Malarkey E.B., Sunjara, V., Rosenwald, S.R., Li, W-H., Parpura, V. (2004). Ca2+-dependent glutamate release involves two classes of endoplasmic reticulum Ca2+ stores in astrocytes. J. Neurosci. Res. 76: 86-97.
31. Prasad, S., Zhang. X., Yang, M., Ni, Y., Parpura, V., Ozkan, C.S., Ozkan, M. (2004). Separation of
individual neurons using dielectrophoretic alternative current fields. J. Neurosci. Meth. 135:79-88.
32. Montana, V., Ni, Y., Sunjara, V., Hua, X., Parpura. V. (2004). Vesicular glutamate transporter-dependent glutamate release from astrocytes, J. Neurosci. 24:2633-2642.
33. Hu, H., Ni. Y., Montana, V., Haddon, R.C., Parpura, V. (2004). Chemically functionalized carbon nanotubes as substrates for neuronal growth. Nano Lett. 4: 507-511.
34. Parpura, V. (2005). Nanofabricated carbon-based detector. Anal. Chem. 77:681-686.
35. Bekyarova, E., Ni, Y., Malarkey, E.B., Montana, V., McWilliams, J.L., Haddon, R.C., Parpura, V. (2005). Applications of carbon nanotubes in biotechnology and biomedicine. J. Biomed. Nanotech. 1:3-17.
36. Li, Q.-J., Yao, M., Dueck, M., Fuegate, J.E., Parpura V., Martins-Green, M. (2005). cCXCR1 is a receptor for cIL8 (9E3/cCAF) and its N- and C-terminal peptides, and is also activated by hIL8 (CXCL8). J. Leukoc. Biol. 77: 421-431.
37. Hu, H., Ni. Y., Mandal, S.K., Montana, V., Zhao, B., Haddon, R.C., Parpura, V. (2005). Polyethyleneimine functionalized single-walled carbon nanotubes as a substrate for neuronal growth. J. Phys. Chem. B 109:4285-4289.
38. Ni, Y., Hu, H., Malarkey E.B., Zhao, B., Montana, V., Haddon, R.C., Parpura, V. (2005). Chemically functionalized water soluble single-walled carbon nanotubes modulate neurite outgrowth. J Nanosci. Nanotechnol. 5: 1707-1712.
39. Parpura, V., Chapman, E.R. (2005) Detection of botulinum toxins: micromechanical and fluorescence- based sensors. Croat. Med. J. 46:491-497.
40. Ponzio. T.A., Ni, Y., Montana, V., Parpura, V., Hatton, G.I. (2006). Vesicular glutamate transporter expression in supraoptic neurons suggests a glutamatergic phenotype. J. Neuroendocrinol. 18:253-265.
41. Liu, W., Montana, V., Bai, J., Chapman, E.R., Mohideen U., Parpura, V. (2006). Single molecule mechanical probing of the SNARE protein interactions. Biophys J. 91:744-58.
42. Montana, V., Malarkey E.B., Verderio, C., Matteoli, M. Parpura, V. (2006) Vesicular transmitter release from astrocytes. Glia 54:700-715.
43. Sun, K., Montana, V., Chellappa, K., Brelivet, Y., Moras, D, Maeda, Y., Parpura, V., Paschal, B.M., Sladek, F.M. (2007) Phosphorylation of a conserved serine in the DNA binding domain of nuclear receptors alters intracellular localization. Mol Endocrinol. 21: 1927-1311.
44. Malarkey, E.B., Parpura, V. (2007) Applications of carbon nanotubes in neurobiology. Neurodegenerative Dis. 4: 292- 299.
45. Ni, Y., Malarkey, E.B., Parpura, V. (2007) Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons. J. Neurochem. 103: 1273-1284.
46. Malarkey, E.B., Parpura, V. (2008) Mechanisms of glutamate release from astrocytes. Neurochem. Int. 52:142-154.
47. Malarkey, E.B., Ni, Y., Parpura, V. (2008) Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from astrocytes. Glia 56: 821-835.
48. Montana, V., Liu, W., Mohideen, U., Parpura, V. (2008) Single molecule probing of exocytotic protein interactions using force spectroscopy. Croat. Chem. Acta 81: 31-40.
49. Liu, W., Montana, V., Parpura, V., Mohideen, U. (2008). Comparative energy measurements in single molecule interactions. Biophys. J. 95: 419-425.
50. Parpura, V., Mohideen, U. (2008). Molecular form follows function: (un)snaring the SNAREs. Trends Neurosci. 31: 435-443.
51. Reyes, R.C., Parpura, V. (2008) Models of astrocytic Ca2+ dynamics and epilepsy. Drug Discov Today Dis Models 5: 13-18.
52. Malarkey, E.B., Reyes, R.C., Zhao, B., Haddon, R.C., Parpura, V. (2008) Water soluble single-walled carbon nanotubes inhibit stimulated endocytosis in neurons. Nano Lett. 8:3538-3542.
53. Reyes, R.C., Parpura, V. (2008) Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes. J. Neurosci. 28: 9682-9691.
54. Lee, W., Malarkey, E.B., Reyes, R.C., Parpura V. (2008) Micropit: A new cell culturing approach for characterization of solitary astrocytes and small networks of these glial cells, Front. Neuroengineering 1:2. doi:10.3389/neuro.16.002.2008 (18 pp).
55. Malarkey, E.B., Fisher, K.A., Bekyarova, E., Liu, W., Haddon, R.C, Parpura, V. (2009) Conductive single-walled carbon nanotube substrates modulate neuronal growth. Nano Lett. 9: 264-268.
56. Reyes, R.C., Parpura, V. (2008). The trinity of Ca2+ sources for the exocytotic glutamate release from astrocytes. Neurochem Int, 55:2-8.
57. Montana, V., Liu, W., Mohideen, U., Parpura, V. (2009) Single molecule measurements of mechanical interactions within ternary SNARE complexes and dynamics of their disassembly: SNAP25 vs. SNAP23. J Physiol. 587.9: 1943-1960.
58. Sucapane, A., Cellot, G., Prato, M., Giugliano. K., Parpura, V., Ballerini, L. (2009) Interactions between cultured neurons and carbon nanotubes: A nanoneuroscience vignette. J Nanoneurosci. 1:10-16
59. Ni, Y., Parpura V. (2009) Dual regulation of Ca2+-dependent glutamate release from astrocytes: Vesicular glutamate transporters and cytosolic glutamate levels, Glia 57: 1296-1305.
60. Liu, W., Montana, V., Parpura, V., Mohideen, U. (2009). Single molecule measurements of interaction free energies between the proteins within binary and ternary SNARE complexes. J Nanoneurosci. 1: 120-129.
61. Lee, W., Parpura V. (2009) Micropatterned substrates for studying astrocytes in culture. Front Neurosci, doi:10.3389/neuro.01.033.2009 (7 pp)
62. Osborne K.D., Lee, W., Malarkey E.B., Irving A.J., Parpura, V. (2009) Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes. ASN Neuro 1(5). doi: pii: AN20090040. 10.1042/AN20090040 (14 pp).
63. Parpura V., Zorec, R. (2010) Gliotransmission: Exocytotic release from astrocytes. Brain Res Rev. 63: 83-92.
64. Parpura V., Baker, B.J., Jeras, M., Zorec, R. (2010) Regulated exocytosis in astrocytic signal integration. Neurochem Int 57: 451-459.
65. Liu W, Parpura, V. (2010) SNAREs: Could they be the answer to an energy landscape riddle in exocytosis? Scientific World Journal 10, 1258–1268. DOI 10.1100/tsw.2010.137.
66. Verkhratsky, A., Parpura, V. (2010) Recent advances in (patho)physiology of astroglia. Acta Pharmcol Sin. 31: 1044-1054.
67. Verkhratsky A., Parpura, V., Rodríguez, J.J. (2011) Where the thoughts dwell: The physiology of neuronal-glial “diffuse neural net” Brain Res Rev 66: 133-151.
68. Reyes, R.C., Perry, G., Lesort, M., Parpura, V. (2011) Immunophilin Deficiency Augments Ca2+-Dependent Glutamate Release from Mouse Cortical Astrocytes. Cell Calcium 49: 21-34.
69. Losón, O.C., Ha, C.H., Parpura, V. (2011) Age-dependent spatial segregation of synaptobrevin 2-containing vesicles in astrocytes. J Neurochem 116:909-915.
70. Parpura , V., Grubišić, V., Verkhratsky, A. (2011) Ca2+ sources for the exocytotic release of glutamate from astrocytes. Biochim Biophys Acta 1813: 984-991.
71. Lalo, U., Pankratov, Y., Parpura, V., Verkhratsky, A. (2011) Ionotropic receptors in neuronal-astroglial signalling: What is the role of “excitable” molecules in non-excitable cells. Biochim Biophys Acta 992-1002.
72. Kapoor, N., Lee, W., Clark, E., Bartoszewski, R., McNicholas, C.M., Latham, C.B., Bebok, Z., Parpura, V., Fuller, C.M., Palmer, C.A., Benos, D.J. (2011). Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am J Physiol Cell Physiol, 300:C1246-C1259.
73. Jorgačevski, J., Potokar, M., Grilc, S., Kreft, M., Liu, W., Barclay, J.W., Bückers, J., Medda, R., Hell, S.W., Parpura, V., Burgoyne, R.D, Zorec, R. (2011) Munc18-1 tuning of vesicle merger and fusion pore properties. J Neurosci 31: 9055–9066.
74. Stout, R.F.Jr, Parpura, V. (2011) Voltage-gated calcium channel types in cultured C. elegans CEPsh glial cells. Cell Calcium 50: 98-108.
75. Malarkey, E.B., Parpura, V. (2011) Temporal characteristics of vesicular fusion in astrocytes: Examination of synaptobrevin 2 laden vesicles at single vesicle resolution. J Physiol 589.17: 4271-4300.
76. Liu, W., Montana, V., Parpura, V., Mohideen, U. (2011) Single molecule measurements of dissociation rates and energy landscapes of binary trans SNARE complexes in parallel versus antiparallel orientation. Biophys J, 101: 1864-1862.
77. Roman, J.A, Niedzielko, T.A., Haddon, R.C., Parpura, V., Floyd, C.L. (2011) Single-Walled Carbon Nanotubes Chemically-Functionalized with Polyethylene Glycol Promote Tissue Repair in a Rat Model of Spinal Cord Injury. J Neurotrauma, 28:2349-2362.
78. Reyes, R.C., Verkhratsky A., Parpura, V. (2012) Plasmalemmal Na+/ Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes. ASN Neuro, 4(1). doi: pii: e00075. 10.1042/AN20110059. (13 pp).
79. Verkhratsky A., Rodríguez, J.J., Parpura, V. (2012) Calcium signalling in astroglia. Mol Cell Endocrinol, 353: 45-56
80. Parpura, V., Heneka, M.T., Montana, V., Oliet, S.H.R., Schousboe, A., Haydon, P.G., Stout, R.F., Spray, D.C., Reichenbach, A., Pannicke, T., Pekny, M., Pekna, M., Zorec, R., Verkhratsky A. (2012). Glial cells in (patho)physiology. J Neurochem. 121: 4-27.
81. Zorec, R., Araque, A., Carmignoto, G., Haydon, P.G., Verkhratsky, A., Parpura, V. (2012) Astroglial excitability and gliotransmission: An appraisal of Ca2+ as a signalling route. ASN Neuro. 4(2). doi: pii:e00080. 10.1042/AN20110061. (17 pp)
82. Qadri, Y.I., Cormet-Boyaka, E., Rooj, A.K., Lee, V., Parpura, V., Fuller, C.M., Berdiev, B.K. (2012) Low Temperature and Chemical Rescue Affect Molecular Proximity of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Epithelial Sodium Channel (ENaC). J Biol Chem. 287: 16781-16790.
83. Kirischuk, S., Parpura, V., Verkhratsky, A. (2012) Sodium dynamics: another key to astroglial excitability? Kirischuk, S., Parpura, V., Verkhratsky, A. (2012) Sodium dynamics: another key to astroglial excitability? Trends Neurosci. 35:497-506.
84. Trkov,S., Stenovec, M., Kreft ,M., Potokar, M., Parpura, V., Davletov, B., Zorec, R. (2012) Fingolimod−A sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes. Glia 60:1406–1416.
85. Liu, W., Stout, R.F.Jr, Parpura, V. (2012) Ternary SNARE complexes in parallel versus anti-parallel orientation: examination of their disassembly using single-molecule force spectroscopy. Cell Calcium 52: 241– 249.
86. Parpura, V., Verkhratsky, A. (2012) The astrocyte excitability brief: From receptors to gliotransmission. Neurochem Int 61: 610-621.
87. Gottipati, M.K., Kalinina, I., Bekyarova, E., Haddon, R.C., Parpura, V. (2012) Chemically-functionalized water-soluble single-walled carbon nanotubes modulate morpho-functional characteristics of astrocytes. Nano Lett 12: 4742−4747.
88. Verkhratsky A., Rodríguez, J.J., Parpura, V. (2012) Neurotransmitters and integration in neuronal-astroglial networks. Neurochem Res 37:2326-2338.
89. Parpura, V., Verkhratsky, A. (2012) Homeostatic function of astrocytes: Ca2+ and Na+ signaling. Translat Neurosci. 3: 334-344.
90. De Pittà, M., Volman, V., Berry, H., Parpura, V., Volterra, A., Ben-Jacob, E. (2012) Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity. Front Comput Neurosci 6: 98. doi:10.3389/fncom.2012.00098 (25 pp).
91. Parpura, V., Verkhratsky, A. (2012) Astrocytes revisited: Concise historic outlook on glutamate homeostasis and signaling. Croat Med J. 53:518-528.
92. Parpura, V., Silva, G.A., Tass, P.A., Bennet. K.E., Meyyappan, M., Koehne, J., Lee, K.H., Andrews, R.J. (2013) Neuromodulation: Selected approaches and challenges. J Neurochem.124: 436-453.
93. Wang, Y-F., Sun, M-Y, Hou, Q., Parpura, V. (2013) Hyposmolality differentially and spatiotemporally modulates levels of glutamine synthetase and serine racemase in rat supraoptic nucleus. Glia 61:529-538.
94. Verkhratsky A., Rodríguez, J.J., Parpura, V. (2013) Astroglia in neurological diseases. Future Neurol. 8: 149-158
95. Parpura, V., Verkhratsky, A. (2013) Astroglial amino acid-based transmitter receptors. Amino Acids 44:1151-1158.
96. Parnis, J., Montana, V., Delgado-Martinez, I., Matyash, V., Parpura, V., Kettenmann, H., Sekler, I., Nolte, C. (2013) Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission and proliferation of astrocytes. J Neurosci 33:7206-7219.
97. Parpura, V., Verkhratsky, A. (2013) Astrogliopathology: Could nanotechnology restore aberrant calcium signalling and pathological astroglial remodelling? Biochim Biophys Acta 1833:1625-1631.
98. Lee, W., Reyes, R.C., Gottipati, K. Lewis, K., Lesort, M., Parpura, V., Gray, M. (2013) Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington’s disease mouse model. Neurobiol Dis. 58C:192-199.
99. Reyes, R.C., Verkhratsky, A., Parpura, V. (2013) TRPC1-mediated Ca2+ and Na+ signalling in astroglia: Differential filtering of extracellular cations. Cell Calcium 54: 120-125.
100. Kim, H-S., Montana, V., Jang, H-J., Parpura, V. Kim, J. (2013) Epigallocatechin-gallate (EGCG) stimulates autophagy in vascular endothelial cells: A potential role for reducing lipid accumulation. J Biol Chem 288:22693-22705.
101. Gottipati, M.K., Samuelson, J.J., Kalinina, I., Bekyarova, E., Haddon, R.C., Parpura, V. (2013) Chemically Functionalized Single-Walled Carbon Nanotube Films Modulate the Morpho-Functional and Proliferative Characteristics of Astrocytes. Nano Lett 13: 4387-4392.
102. Tewari, S., Parpura, V. (2013) A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework. Front Comput Neurosci 7:145. doi:10.3389/fncom.2013.00145
103. Rose, C.F., Verkhratsky, A., Parpura, V. (2013) Astrocyte glutamine synthetase: pivotal in health and disease. Biochem Soc Trans 41: 1518-1524
104. Stout, R.F.Jr, Grubišić, V., Parpura, V. (2013) A Caenorhabditis elegans locomotion phenotype caused by transgenic repeats of the hlh-17 promoter sequence. PLoS ONE 8: e81771. doi:10.1371/journal.pone.0081771
105. Grubišić, V., Gottipati, M.K., Stout, R.F.Jr., Grammer, J.R, Parpura, V. (2014) Heterogeneity of myotubes generated by the MyoD and E12 basic helix-loop-helix transcription factors in otherwise non-differentiation growth conditions. Biomaterials 35:2188-2198
106. Verkhratsky, A., Parpura, V. (2014) Store-operated calcium entry in neuroglia. Neurosci Bull 30:125-133
107. McClain, J., Grubišić, V., Fried, D., Gomez-Suarez, R.A., Leinninger, G.M., Sévigny, J., Galligan, J.J., Parpura, V., Gulbransen, B.D. (2014) Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice. Gastroenterology 146:497-507.
108. Stout, R.F.Jr, Verkhratsky, A., Parpura V. (2014) Caenorhabditis elegans glia modulate neuronal activity and behavior. Front Cell Neurosci 8: 64. doi: 10.3389/fncel.2014.00067
109. Singh, P., Jorgačevski, J., Kreft, M., Grubišić, V., Stout, R.F. Jr., Potokar, M., Parpura, V., Zorec R. (2014) Single-vesicle architecture of synaptobrevin 2 in astrocytes. Nat Commun 5: 3780
110. Verkhratsky, A., Reyes, R.C., Parpura, V. (2014) TRP channels coordinate ion signalling in astroglia. Rev Physiol Biochem Pharmacol 166:1-22.
111. Martineau, M., Parpura, V., Mothet, J.-P. (2014) Cell-type specific mechanisms of D-serine uptake and release in the brain. Front. Synaptic Neurosci 6:12. doi: 10.3389/fnsyn.2014.00012
112. Gottipati, M.K., Bekyarova, E., Brenner, M., Haddon, R.C., Parpura, V. (2014) Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein. Nano Lett 14:3720-3727.
113. Verkhratsky, A., Parpura V. (2014) Calcium signalling and calcium channels: Evolution and general principles. Eur J Pharmacol 739: 1–3.
114. Verkhratsky A., Rodríguez, J.J., Parpura, V. (2014) Neuroglia in ageing and disease. Cell Tissue Res 357:493–503
115. Verkhratsky A., Parpura, V. (2014) Neurological and psychiatric disorders as a neuroglial failure. Period Biol 116: 115–124.
116. Figueiredo, M., Lane, S., Stout, R.F. Jr., Liu, B.H., Parpura, V., Teschemacher, A.G., Kasparov, S. (2014) Comparative analysis of optogenetic actuators in cultured astrocytes. Cell Calcium 56: 208–214.
117. Gottipati, M.K., Verkhratsky A., Parpura, V. (2014) Probing astroglia with carbon nanotubes: modulation of form and function. Phil Trans R Soc B Biol Sci. 369: 20130598. http://dx.doi.org/10.1098/rstb.2013.0598
118. Verkhratsky A., Parpura, V. Pekna, M., Pekny, M., Sofroniew, M. (2014) Glia in the pathogenesis of neurodegenerative diseases. Biochem Soc Trans 42: 1291–1301.
119. Montana, V., Verkhratsky A., Parpura, V. (2014) Pathological role for exocytotic glutamate release from astrocytes in hepatic encephalopathy. Curr Neuropharmacol. 12: 324-333.
120. Li, H., Wang, X., Zhang, N., Gottipati, M.K., Parpura, V., Ding, S. (2014). Imaging of mitochondrial Ca2+ dynamics in astrocytes using cell-specific mitochondria-targeted GCaMP5G/6s: Mitochondrial Ca2+ uptake and cytosolic Ca2+ availability via the endoplasmic reticulum store. Cell Calcium. 56: 457–466
121. Wang, Y., Montana, V., Grubišić, V., Stout, R.F.Jr., Parpura, V, Gu, L-Q. (2015) Nanopore sensing of botulinum toxin type B by discriminating an enzymatically cleaved peptide from a synaptic protein synaptobrevin 2 derivative. ACS Appl Mat Int 7:184−192.
122. Cavender, C.E., Gottipati, M.K., Parpura, V. (2015) Trafficking of excitatory amino acid transporter 2- laden vesicles in cultured astrocytes: a comparison between approximate and exact determination of trajectory angles. Amino acids 47:357-367.
123. Grubišić, V., Parpura, V. (2015) Diversity in the utilization of glucose and lactate in synthetic mammalian myotubes generated by engineered configurations of MyoD and E12 in otherwise non-differentiation growth conditions. Biomaterials 43: 50-60.
124. Gottipati, M.K., Bekyarova, E., Haddon, R.C., Parpura, V. (2015) Chemically-functionalized single-walled carbon nanotubes enhance the glutamate uptake characteristics of mouse cortical astrocytes. Amino Acids 47:1379-1388
125. Grubišić, V. Kennedy, A.J., Sweatt, J.D., Parpura, V. (2015) Pitt-Hopkins mouse model has altered particular gastrointestinal transits in vivo. Autism Res 8: 629–633.
126. Verkhratsky, A., Zorec, R., Rodríguez, J.J., Parpura, V. (2016) Astroglia dynamics in ageing and Alzheimer’s disease. Curr Opin Pharmacol 26:74–79
127. Verkhratsky, A, Parpura, V. (2016) Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders. Neurobiol Dis 85:254–261
128. Stenovec, M., Trkov, S., Terzieva, S., Kreft, M., Rodriguez, J.J., Parpura, V., Verkhratsky, A., Zorec, R. (2016) Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment. Glia 64:317–329
129. Verkhratsky, A., Matteoli, M., Parpura, V, Mothet, J-P., Zorec, R. (2016) Astrocytes as secretory cells of the central nervous system: Idiosyncrasies of vesicular secretion. EMBO J. 35:239-257
130. Pekny, M., Pekna, M., Messing, A., Steinhäuser, S., Lee, J.-M., Wilhelmsson, U., Parpura, V., Hol, E., Sofroniew, M.V., Verkhratsky, A. (2015) Astrocytes: a central element in neurological diseases. Acta Neuropathol. 131:323–345
131. Verkhratsky, A., Zorec, R., Rodríguez, J.J., Parpura, V. (2016) Pathobiology of neurodegeneration: The role for astroglia. Opera Med Physiol. 1: 13-22.
132. Rodríguez, J.J., Butt, A.M., Gardenal, E., Parpura, V., Verkhratsky, A. (2016) Complex and differential glial responses in Alzheimer´s disease and ageing. Curr Alzheimer Res 13, 343-358.
133. Lim, D., Rodriguez, J.J., Parpura, V., Zorec, R., Zeidan-Chulia, F., Genazzani, A.A., Verkhratsky, A. (2015) Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease. Curr Alzheimer Res 13, 359-369.
134. Vardjan, N., Parpura, V., Zorec, R. (2016) Loose excitation-secretion coupling in astrocytes. Glia 64:655–667
135. Zorec, R., Verkhratsky, A., Rodríguez, J.J., Parpura, V. (2016) Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture. Neuroscience 323: 67–75.
136. Rodríguez-Arellano, J.J, Parpura, V., Zorec, R., Verkhratsky, A. (2015) Astrocytes in physiological aging and Alzheimer´s disease. Neuroscience 323: 170–182
137. Lee, W., Parpura, V. (2016) Spatio-temporal characteristics of metabotropic glutamate receptor 5 traffic at or near the plasma membrane in astrocytes. Glia 64:1050–1065
138. Wang, Y-F., Parpura, V. (2016). Central role of maladapted astrocytic plasticity in ischemic brain edema formation. Front Cell Neurosci 10:129. doi: 10.3389/fncel.2016.00129
139. Parpura, V., Sekler, I., Fern, R. (2015) Plasmalemmal and mitochondrial Na+-Ca2+ exchange in neuroglia. Glia 64:1646–1654

Journal articles in press
140. Verkhratsky, A., Zorec, R., Rodríguez, J.J., Parpura, V. (2015) Astrogliopathology in neurodegeneration. Eur J Neurodeg Disease
141. Verkhratsky, A., Steardo, L., Parpura, V., Montana, V. (2015) Translational potential of astrocytes in brain disorders. Prog Neurobiol
142. Stenovec, M., Lasič, E., Božić, M., Trkov, S., Stout, R.F. Jr., Grubišić, V., Parpura, V., Zorec, R. (2015) Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived Neurotrophic Factor from Single Vesicles in Cultured Rat Astrocytes. Mol Neurobiol
143. Parpura, V., Fisher, E., Lechleiter, J.D., Schousboe, A., Waagepetersen, H.S., Brunet, S., Baltan, S., Verkhratsky, A. (2016) Glutamate and ATP on interface between signaling and metabolism in astroglia: examples from pathology. Neurochem Res
144. Buscemi, L., Ginet, V., Lopatar, J., Montana, V. Pucci, L., Spagnuolo, P., Zehnder, S., Grubišić, V., Truttman, A., Sala, C., Hirt, L., Parpura, V., Puyal, J,. Bezzi, P. (2016) Homer1 scaffold proteins govern Ca2+ dynamics in normal and reactive astrocytes. Cereb Cortex
145. Zorec, R., Parpura, V., Vardjan, N., Verkhratsky, A. (2016) Astrocytic Face of Alzheimer’s Disease Behav Brain Res
146. Verkhratsky, A., Rodríguez, J.J., Parpura, V., Zorec, R. (2016) Astroglial calcium signalling in Alzheimer's disease. Biochem Biophys Res Commun.

Journal articles submitted but not yet accepted
147. Sammons, J.D., Cavender, C.E., Gottipati, M.K., Parpura, V., Gross, A.K. (2015) Monitoring GPCR trafficking kinetics in healthy and diseased knock-in mouse retinas
148. Zorec, R., Parpura, V., Verkhratsky, A. (2016) Astroglial vesicular trafficking in neurodegenerative diseases
149. Verkhratsky, A., Rodríguez, J.J., Parpura, V. (2016) Historic Outlook on Astroglia: Evolution of the concept

Other Publications (letters to the author, book reviews, etc.)

Commentaries:

1. Parpura, V. (2008) Instrumentation: Carbon nanotubes on the brain. Nat Nanotechnol. 3: 384-385. [news&views]
2. Stout, R.F.Jr, Spray, D.C., Parpura, V. (2009) Astrocytic “power-grid”: Delivery upon neuronal demand. Cellscience, 5(3); 34-43. [commentary]
3. Lee, W, Parpura, V. (2009) Wiring neurons with carbon nanotubes. Front Neuroengineering (2009) 2:8. doi: 10.3389/neuro.16.008.2009 (3 pp). [commentary]
4. Liu, W, Parpura, V. (2009) Energetics of (dis)assembly of the ternary SNARE complex. Front Neuroenergetics 1:5. doi: 10.3389/neuro.14.005.2009 (2 pp). [commentary]
5. Parpura V. (2009) Carbon nanotubes as electrical shortcuts for neurons. Front Neurosci 3: 118 [research highlight]
6. Parpura V., Zorec, R. (2011) Gliologists in Ljubljana 2011. ASN Neuro http://www.asnneuro.org/an/news/default.htm; and Neurochemistry News 39: 6. [News]
7. Parpura, V. (2012) Bionanoelectronics: Getting close to the action Nat Nanotechnol. 7:143-145. [news&views]
8. Parpura V., Verkhratsky, A. (2012) Neuroglia at the crossroads of homeostasis, metabolism and signaling: Evolution of the concept. ASN Neuro Parpura V., Verkhratsky, A. (2012) Neuroglia at the crossroads of homeostasis, metabolism and signaling: Evolution of the concept. ASN Neuro 4(4):201-205.doi:10.1042/AN20120019 [Editorial-commentary] (5 pp)
9. Parpura, V. (2013) American Society for Neurochemistry (ASN) Report. Neurochemistry News 42: 11-12. [Report]
10. Tewari, S., Parpura, V. (2014) Data and model tango to aid the understanding of astrocyte-neuron signaling. Front Comput Neurosci 8:3. doi:10.3389/fncom.2014.00003 [opinion]
11. Parpura V. (Ed.) American Society for Neurochemistry (ASN) Newsletters. July, 2014 issue.
12. Peng, L., Parpura, V., Verkhratsky, A. (2014) Neuroglia as a central element of neurological diseases: An underappreciated target for therapeutic intervention. Curr Neuropharmacol. 12: 303-309. [Editorial]
13. Grubišić, V., Parpura, V. (2015) The second brain in autism spectrum disorder: Could connexin 43 expressed in enteric glial cells play a role? Front. Cell. Neurosci. 9:242. doi: 10.3389/fncel.2015.00242 [opinion]
14. Hoogland, T.M., Parpura, V. (2015) Editorial: The role of glia in plasticity and behavior. Front Cel. Neurosci 9:356. doi: 10.3389/fncel.2015.00356 [editorial]
15. Tewari, S.G., Parpura V (2015) Astrocytes Modulate Local Field Potential Rhythm. Front. Integr. Neurosci. 9:69. doi: 10.3389/fnint.2015.00069 [opinion]
16. Tewari, S.G., Gottipati, K.M., Parpura, V. (2016) Mathematical modeling in Neuroscience: Neuronal activity and its modulation by astrocytes. Front. Integr. Neurosci. 10:3. doi: 10.3389/fnint.2016.00003 [opinion]

Commentaries submitted but not yet accepted
NA

Conference Proceedings:

1. Henderson, E., Parpura, V., Sakaguchi, D., Haydon. P.G. (1993). Atomic Force Microscopy of living cells. Polymer Preprints 34: 330-331.
2. Prasad, S., Yang, M., Zhang, X., Ni, Y., Parpura, V., Ozkan, C.S., Ozkan, M. (2003) Electric Field Assisted Localization of Neurons on Pt Microelectrode Arrays. Mat. Res. Soc. Symp. Proc. 773: N4.6.1-9.
3. Liu, W., Parpura, V. (2009) Single molecule probing of SNARE proteins by atomic force microscopy. Ann. N. Y. Acad. Sci. 1152 (Mechanisms of Exocytosis):113-120
4. Malarkey E.B., Parpura, V. (2010). Carbon nanotubes in neuroscience. Acta Neurochir Suppl. 106: 337-341.

Undergraduate Journal Articles:
1. Cavender, C.E., Gottipati, M.K., Malarkey, E.B., Parpura, V. (2013) Method for the determination of trajectory angles of directional secretory vesicles in cultured astrocytes. Inquiro 7:48-52.

Books:

1. Hatton, G.I, Parpura, V. (Eds.) Glial Neuronal Signaling. Kluwer Academic Publishers, Boston, MA. (2004) (May 31, 2004; 456 pp) ISBN: 978-1-4020-7936-8.
2. Parpura V., Haydon P.G. (Eds.) Astrocytes in (patho)physiology of the nervous system. Springer, New York, NY (2009) (Dec 28, 2008; 700 pp) ISBN: 978-0-387-79491-4.
3. Silva, G.A., Parpura, V. (Eds.) Nanotechnology for biology and medicine: At the building block level. Springer, New York, NY (2012) (Nov 02, 2011; 234 pp) ISBN 978-0-387-31282-8.
4. Verkhratsky, A., Parpura, V. Introduction to Neuroglia. In: Colloquium Series on Neuroglia in biology and medicine: From physiology to disease (Verkhratsky, A., Parpura, V., Eds). Morgan & Claypool Publishers, Colloquium Digital Library of Life Sciences; DOI: 10.4199/C00102ED1V01Y201401NGL001(2014) (February, 2014; 74 pp)
5. Parpura, V., Verkhratsky, A. (Eds.) Pathological potential of neuroglia: Possible new targets for medical intervention. Springer, New York, NY (2014) (Sept 28, 2014; 541 pp) ISBN-13: 978-1493909735
6. Parpura, V., Schousboe, A., Verkhratsky, A. (Eds.) Glutamate and ATP at interface of metabolism and signaling in the brain (Advances in Neurobiology Vol. 11). Springer, New York, NY (2014) (Nov 14, 2014; 261 pp) DOI 10.1007/978-3-319-08894-5
7. Verkhratsky, A., Parpura, V. Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission. In: Colloquium Series on Neuroglia in biology and medicine: From physiology to disease (Verkhratsky, A., Parpura, V., Eds). Morgan & Claypool Publishers, Colloquium Digital Library of Life Sciences; DOI: 10.4199/C00123ED1V01Y201501NGL004 (March 2015; 174 pp)

Book in Press:
NA

Book Chapters:

1. Parpura, V., Basarsky, T.A., Haydon, P.G. (1996) Astrocyte-neuron signalling. In: Excitatory amino acids and the cerebral cortex (Conti, F., Hicks, T.P., Eds). MIT Press/ Bradford Books, Cambridge, MA pp 167-174.
2. Parpura, V., Fernanadez, J.M. (1997). Nanofabricated carbon detector (NACAD). In: Cornell
Nanofabrication Facility 1996- 1997 research accomplishments. Cornell University, Ithaca, NY pp 24-25.
3. Cardullo, R.A., Parpura, V. (2003). Fluorescence Resonance Energy Transfer: Theory and Instrumentation, Methods Cell Biol. 72:415-430.
4. Parpura, V. (2004). Glutamate-mediated bi-directional signaling between neurons and astrocytes. In: Glial Neuronal Signaling (Hatton, G.I, Parpura, V., Eds). Kluwer Academic Publishers, Boston, MA, pp. 365-395.
5. Bekyarova, E., Haddon, R.C., Parpura, V. (2005). Biofunctionalization of Carbon Nanotubes. In: Nanotechnologies for the life sciences. Vol. 1 Biofunctionalization of nanomaterials (Kumar, C.S.S.R., Ed.) Wiley-VCH, Wienhein-Berlin, Germany, pp 41-71.
6. Malarkey, E.B., Parpura, V. (2006) Glutamate release from astrocytes: impact on neuronal function. In: Hepatic Encephalopathy and Nitrogen Metabolism. (Häussinger, D., Kircheis, G., Schliess, F., Eds.) Springer, London-Heidelberg, pp 60-86.
7. Lee, W., Parpura, V. (2007) Exocytotic release of glutamate from astrocytes: comparison to neurons. In: Protein trafficking in neurons (Bean, A., Ed.) Elsevier, Amsterdam, The Nederlands, pp 329-365.
8. Malarkey, E.B., Parpura, V. (2009) Mechanisms of transmitter release from astrocytes. In: Astrocytes in (patho)physiology of the nervous system (Parpura V., Haydon P.G., Eds.) Springer, New York, NY , pp 301-350.
9. Lee, W., Parpura, V. (2009) Chapter 6 - Carbon nanotubes as substrates/scaffolds for neural cell growth. Prog. Brain Res. 180: 110-125.
10. Lee, W., Parpura, V. (2010) Carbon nanotubes as electrical interfaces with neurons. In: Ritsner, M.S. (Ed.) Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Springer, Dordrecht, The Nederlands, pp 325-340.
11. Reyes, R.C, Parpura, V. (2012) Carbon nanotubes as modulators of neuronal growth. In: Silva, G.A., Parpura, V. (Eds.) Nanotechnology for biology and medicine: At the building block level, Springer, New York, NY, pp 209-223.
12. Stout, R.F.Jr., Parpura V. (2012) Cell culturing of C. elegans glial cells for the assessment of
cytosolic Ca2+ dynamics. Methods Mol Biol, 814:153-74.
13. Lee, W., Parpura, V. (2012) Dissociated cell culture for testing effects of carbon nanotubes on neuronal growth. Methods Mol Biol, 846:261-276.
14. Verkhratsky, A., Parpura V. (2012) Astroglial calcium signalling and calcium waves. In: Dere, E. (Ed.) Gap Junctions in the Nervous System: Physiological and Pathological Roles. Elsevier, pp 51-68.
15. Verkhratsky, A., Noda, M., Parpura, V., Kirischuk, S. (2013) Sodium fluxes and astroglial function. Adv Exp Med Biol, 961:295-305
16. Verkhratsky, A., Parpura V. (2013) Calcium signalling in neuroglia. In: Kettenmann, H, Ransom, B.R. (Eds.). Neuorglia, 3rd edition, Oxford University Press, New York, pp 320-332.
17. Verkhratsky, A., Parpura V., Kettenmann, H. (2014) Astrocytes. In: Aminoff, M.J., Daroff, R.B. (Eds.) Encyclopedia of Neurological Sciences, 2nd edition, Elsevier, Vol 1. pp 290-295.
18. Verkhratsky, A., Parpura V. (2014) History of electrophysiology and the patch-clamp. Methods Mol Biol 1183:1-19.
19. Verkhratsky, A., Schousboe, A., Parpura, V. (2014) Glutamate and ATP: The crossroads of signaling and metabolism in the brain. Adv Neurobiol. 11:1-12.
20. Verkhratsky, A., Parpura V. (2014) General pathophysiology of neuroglia: Neurological and psychiatric disorders as gliopathies. In: Parpura, V., Verkhratsky, A. (Eds.) Pathological potential of neuroglia: Possible new targets for medical intervention. Springer, New York, NY; pp 1-12
21. Verkhratsky, A., Parpura V. (2014) Ionic signalling in physiology and pathophysiology of astroglia. In: Parpura, V., Verkhratsky, A. (Eds.) Pathological potential of neuroglia: Possible new targets for medical intervention. Springer, New York, NY; pp 13-31.
22. Verkhratsky, A., Parpura V., Rodríguez, J.J. (2014) Neurodegeneration and neuroglia: Emphasis on astroglia in Alzheimer's disease. In: Parpura, V., Verkhratsky, A. (Eds.) Pathological potential of neuroglia: Possible new targets for medical intervention. Springer, New York, NY; pp 265-291.
23. Verkhratsky, A., Butt, A.M., Rodríguez, J.J., Parpura V. (2015) Astrocytes, Oligodendrocytes, and NG2 glia: Structure and Function. In: Toga, A.W. (Ed.) Brain Mapping: An Encyclopedic Reference. Vol. 2, Elsevier, New York, NY; pp 101-107.
24. Verkhratsky, A., Noda. M., Parpura, V. (2015) Microglia: Structure and Function. In: Toga, A.W., (Ed.) Brain Mapping: An Encyclopedic Reference. Vol. 2, Elsevier, New York, NY; pp 109-113.

Book chapters in press
25. Verkhratsky, A., Steardo, L., Peng, L., Parpura, V. (2015). Astroglia, glutamatergic transmission and psychiatric diseases. Adv. Neurobiol
26. Verkhratsky, A., Parpura, V. (2016). Astrocytes. In: Stein, J. (Ed). Reference Module on Neuroscience and Biobehavioral Psychology, Elsevier, Oxford, UK
27. Verkhratsky, A., Zorec, R., Rodríguez, J.J., Parpura V. (2016). Neuroglia: Functional paralysis and reactivity in Alzheimer's disease and other neurodegenerative pathologies. Adv. Neurobiol

Book chapters submitted
NA

Edited volumes/series

1. Verkhratsky, A., Parpura, V. (Eds.) Physiology and Pathophysiology of Neuroglia. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/main/browse_talks.php?father_id=584&c=252) (2011) (Talk series); last updated: January, 2014.
2. Parpura, V., Verkhratsky, A. (Guest Eds.) Online collection: Neuroglia - more than a nervenkitt. ASN Neuro (online at http://www.asnneuro.org/an/online_collection.htm)( 2012) (Journal-Special Issue)
3. Verkhratsky, A., Parpura, V. (Eds.) Colloquium Series on Neuroglia in biology and medicine: From physiology to disease. Morgan & Claypool Publishers, Colloquium Digital Library of Life Sciences (2014); Series ISSNs: 23759933 (print) and 23759917(electronic), Last updated: August 2015 (http://www.morganclaypool.com/toc/ngl/1/1)
4. Verkhratsky, A., Parpura, V. (Guest Eds.) Special Issue on Calcium Channels. European Journal of Pharmacology, Volume 739: 1-106 (2014) (Journal-Special Issue)
5. Peng, L, Parpura, V., Verkhratsky, P. (Guest Eds.) Thematic Issue on Neuroglia as a Central Element of Neurological Diseases: An Underappreciated Target for Therapeutic Intervention. Current Neuropharmacology Volume 12 (4): 303-386 (2014) (Journal-Special Issue)
6. A) Hoogland, T.M., Parpura, V., (Guest Eds.) Research Topic: The Role of Glia in Plasticity and Behavior (2015) Front Cell Neurosci (Sept 9, 2015) (Journal-Special Issue)
B) Parpura, V., Hoogland, T.M, eds. (2015). The Role of Glia in Plasticity and Behavior. Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-690-6 (December, 2015) (e-book)

Talks

1. Parpura, V. (2011) Mechanisms of glutamate release from astrocytes. In: Verkhratsky, A., Parpura, V. (Eds.) Physiology and Pathophysiology of Neuroglia. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1272941-Parpura); CME accredited
2. Parpura, V. (2012) Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons. In: Verkhratsky, A., Parpura, V. (Eds.) Physiology and Pathophysiology of Neuroglia. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1273172-Parpura); CME accredited

Disclosures

1. Mohideen, U., Parpura, V. Micromechanical Sensor for Rapid Botulinum Toxin Detection. UC Case No.: 2003-440-1; Date Disclosed: May 2, 2003
2. Parpura, V. Nanofabricated carbon-based detector. UC Case No.: 2005-015-1; Date Disclosed: July 20, 2004
3. Parpura, V. Water soluble carbon nanotubes as modulators of calcium influx and neuronal growth. UC Case No. 2005-669-1; Date Disclosed: May 10, 2005
4. Parpura, V., Mohideen, Umar. Botulinum toxin type B sensor based on nanomanipulation. UC Case No. 2006-531-1; Date Disclosed: March 23, 2006
5. Parpura, V., Mohideen, Umar. Biological nanozippers and nanocuffs. UC Case No. 2006-532-1; Date Disclosed: March 23, 2006
6. Parpura, V. Water soluble single-walled carbon nanotubes inhibit stimulated endocytosis in neurons. UAB Case No. U2009-0027; Date Disclosed: Nov 21, 2008
7. Parpura, V. Micropit: A new cell culturing approach for characterization of solitary astrocytes and small networks of these glial cells. UAB Case No. U2009-0026; Date Disclosed: Nov 21, 2008
8. Parpura, V. Conductive single-walled carbon nanotube substrates modulate neuronal growth. UAB Case No. U2009-0025; Date Disclosed: Nov 21, 2008
9. Parpura, V., Stout, R.F. Endoplasmic reticulum-targeted light-gated ion channels. UAB Case No. U2011-0037; Date Disclosed: March 15, 2011
10. Parpura, V., Stout, R.F. Vesicle-targeted yellow pHluorins. UAB Case No. U2011-0036; Date Disclosed: March 15, 2011
 		  
 

Keywords
astrocyte, autism spectrum disorder, carbon nanotubes, glial biology, gliomas, enteric glia, exocytosis, glutamate, glial-neuronal signaling, intellectual disability, nanotechnology, neural prosthesis, optogenetics, physiology, pathology