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Faculty Detail    
Name SUZANNE E. LAPI
Cyclotron Facility Director
Professor of Radiology
Professor of Chemistry
Vice Chair of Research, Radiology		  
Campus Address WTI 310F Zip 6830
Phone  (205) 975-8689
E-mail  lapi@uab.edu
Other websites www.lapilab.com
     

Education
Graduate  Simon Fraser University    2007  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Radiology Chair Office  Radiology Chair Office Professor
Center  Alzheimer's Disease Center  Alzheimer's Disease Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 

Biographical Sketch 
Suzanne E. Lapi, Ph.D. is currently a Professor of Radiology and Chemistry and Cyclotron Facility Director at the University of Alabama at Birmingham. She is also the Vice Chair of Research in the Department of Radiology. Her research interests are in the development and translation of new PET radionuclides and molecular imaging agents. She has over 140 publications and is PI on active research grants from NIH and DOE as well as industry partners. She oversees production of PET radionuclides and imaging radiopharmaceuticals for preclinical research and clinical trials. Her group holds >15 approved INDs and supplies 64Cu, 89Zr, 52Mn and other isotopes to groups across the USA and internationally. She is a Fellow of the SNMMI and a strong advocate of radiopharmaceutical sciences and the training of future nuclear and radiochemists at the graduate, postdoctoral and faculty levels

Society Memberships
Organization Name Position Held Org Link
Amercial Chemical Society  Nuclear Division Board Member  http://www.nucl-acs.org/ 
Society of Nuclear Medicine and Molecular Imaging  Board Member  https://www.snmmi.org/ 
 



Research/Clinical Interest
Title
Radiopharmaceuticals for Molecular Imaging
Description
My research includes the production and purification of novel radioisotopes for biomedical applications with a focus on metal radionuclides. Our group also has significant interest in radiochemistry development of new molecular imaging agents and translation of these agents into clinical trials.

Selected Publications 
Publication PUBMEDID
Last two years (from 144 total)

122. Chaple IF, Houson HA, Koller A, Pandey A, Boros E, Lapi SE. 45Ti targeted tracers for PET imaging of PSMA. Nucl Med Biol. 2022 Feb 4;108-109:16-23. doi: 10.1016/j.nucmedbio.2022.01.005. Epub ahead of print. PMID: 35189565.
123. Song PN, Mansur A, Lu Y, Della Manna D, Burns A, Samuel S, Heinzman K, Lapi SE, Yang ES, Sorace AG. Modulation of the Tumor Microenvironment with Trastuzumab Enables Radiosensitization in HER2+ Breast Cancer. Cancers (Basel). 2022 Feb 17;14(4):1015. doi: 10.3390/cancers14041015. PMID: 35205763; PMCID: PMC8869800.
124. Koller AJ, Saini S, Chaple IF, Joaqui-Joaqui MA, Paterson BM, Ma MT, Blower PJ, Pierre VC, Robinson JR, Lapi SE, Boros E. A General Design Strategy Enabling the Synthesis of Hydrolysis-Resistant, Water-Stable Titanium(IV) Complexes. Angew Chem Int Ed Engl. 2022 Mar 9. doi: 10.1002/anie.202201211. Epub ahead of print. PMID: 35263017.
125. Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, Roybal KT, Wilson DM. Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma. J Nucl Med. 2022 Aug 18:jnumed.122.264284. doi:10.2967/jnumed.122.264284. Epub ahead of print. PMID: 35981900.
126. Ducharme M, Houson HA, Fernandez SR, Lapi SE. Evaluation of 68Ga-Radiolabeled Peptides for HER2 PET Imaging. Diagnostics (Basel). 2022 Nov 5;12(11):2710. doi: 10.3390/diagnostics12112710. PMID: 36359554; PMCID: PMC9689602.
127. Houson HA, Tekin V, Lin W, Aluicio-Sarduy E, Engle JW, Lapi SE. PET Imaging of the Neurotensin Targeting Peptide NOTA-NT-20.3 Using Cobalt-55, Copper-64 and Gallium-68. Pharmaceutics. 2022 Dec 6;14(12):2724. doi: 10.3390/pharmaceutics14122724. PMID: 36559218; PMCID: PMC9781609.
128. Pyles JM, Omweri JM, Lapi SE Natural and enriched Cr target development for production of Manganese-52. Sci Rep. 2023 Jan 20;13(1):1167
129. Phipps MD, Cingoranelli S, Bhupathiraju NVSDK, Younes A, Cao M, Sanders VA, Neary MC, Devany MH, Cutler CS, Lopez GE, Saini S, Parker CC, Fernandez SR, Lewis JS, Lapi SE, Francesconi LC, Deri MA. Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals Inorg Chem 2023 Feb 1. Online ahead of print
130. Lin W, Aluicio-Sarduy E, Houson HA, Barnhart TE, Tekin V, Jeffery JJ, Weichmann AM, Barrett KE, Lapi SE, Engle JW. Theranostic cobalt-55/58m for neurotensin receptor-mediated radiotherapy in vivo: A pilot study with dosimetry Nucl Med Biol 2023 Feb 13;118-119:108329
131. Bartels JL, Fernandez SR, Arnold JS, Parker CC, Tekin V, O'Malley G, Ralph DA, Lapi SE. In vivo Assessment of the Impact of Molecular Weight on Constructs of 68Ga-DOTA-Manocept in a Syngeneic Mouse Tumor Model Mol Imaging Biol. 2023 Mar 7.
132. Kozlovskaya V, Ducharme M, Dolmat M, Omweri JM, Tekin V, Lapi SE, Kharlampieva E. Direct Radiolabeling of Trastuzumab-Targeting Triblock Copolymer Vesicles with 89Zr for Positron Emission Tomography Imaging Biomacromolecules. 2023 Mar 16.
133. Larson-Casey JL, Liu S, Pyles JM, Lapi SE, Saleem K, Antony VB, Gonzalez ML, Crossman DK, Carter AB. Impaired PPARɣ activation by cadmium exacerbates infection-induced lung injury JCI Insight. 2023 Mar 16;e166608.
134. Parker CC, Bin Salam A, Song PN, Gallegos C, Hunt A, Yates C, Jaynes J, Lopez H, Massicano AVF, Sorace AG, Fernandez S, Houson HA, Lapi SE. Evaluation of a CD206-Targeted Peptide for PET Imaging of Macrophages in Syngeneic Mouse Models of Cancer Mol Pharm 2023 Apr 4. doi: 10.1021/acs.molpharmaceut.2c00977.
135. Massicano AVF, Song PN, Mansur A, White SL, Sorace AG, Lapi SE. [89Zr]-Atezolizumab-PET Imaging Reveals Longitudinal Alterations in PDL1 during Therapy in TNBC Preclinical Models. Cancers (Basel). 2023 May 11;15(10):2708. doi: 10.3390/cancers15102708. PMID: 37345044; PMCID: PMC10216761.
136. Ducharme M, Mansur A, Sligh L, Ulaner GA, Lapi SE, Sorace AG. Human Epidermal Growth Factor Receptor 2/Human Epidermal Growth Factor Receptor 3 PET Imaging: Challenges and Opportunities. PET Clin. 2023 Jun 18:S1556-8598(23)00051-2. doi: 10.1016/j.cpet.2023.04.009. Epub ahead of print. PMID: 37339919.
137. Mueller C, Fang YD, Jones C, McConathy JE, Raman F, Lapi SE, Younger JW. Evidence of neuroinflammation in fibromyalgia syndrome: a [18F]DPA-714 positron emission tomography study. Pain. 2023 Jun 15. doi: 10.1097/j.pain.0000000000002927. Epub ahead of print. PMID: 37326674.
138. Saini S, Bartels JL, Appiah JK, Rider JH, Baumhover N, Schultz MK, Lapi SE. Optimized Methods for the Production of High-Purity 203Pb Using Electroplated Thallium Targets. J Nucl Med. 2023 Aug 31:jnumed.123.265976. doi: 10.2967/jnumed.123.265976. Epub ahead of print. PMID: 37652545.
139. Ducharme M, Hall L, Eckenroad W, Cingoranelli SJ, Houson HA, Jaskowski L, Hunter C, Larimer BM, Lapi SE. Evaluation of [89Zr]Zr-DFO-2Rs15d Nanobody for Imaging of HER2-Positive Breast Cancer. Mol Pharm. 2023 Sep 4;20(9):4629-4639. doi: 10.1021/acs.molpharmaceut.3c00360. Epub 2023 Aug 8. PMID: 37552575.
140. Gimblet GR, Whitt J, Houson HA, Lin D, Guenter R, Rao TC, Wang D, Ness J, Gonzalez ML, Murphy MS, Gillis A, Chen H, Copland JA, Kenderian SS, Lloyd RV, Szkudlinski MW, Lapi SE, Jaskula-Sztul R. Thyroid-stimulating hormone receptor (TSHR) as a target for imaging differentiated thyroid cancer. Surgery. 2024 Jan;175(1):199-206. doi: 10.1016/j.surg.2023.05.045. Epub 2023 Oct 31. PMID: 37919223.
141. Jalilian A, Decristoforo C, Denecke M, Elsinga PH, Hoehr C, Korde A, Lapi SE, Scott PJH. Proceedings of international symposium of trends in radiopharmaceuticals 2023 (ISTR-2023). EJNMMI Radiopharm Chem. 2023 Nov 10;8(1):39. doi: 10.1186/s41181-023-00224-0. PMID: 37950112; PMCID: PMC10638263.
142. Cingoranelli SJ, Bartels JL, Kankanamalage PHA, Loveless CS, Rotsch DA, Lapi SE. Production and purification of 43Sc and 47Sc from enriched [46Ti]TiO2 and [50Ti]TiO2 targets. Sci Rep. 2023 Dec 19;13(1):22683. doi: 10.1038/s41598-023-49377-7. PMID: 38114543; PMCID: PMC10730517.
143. Omweri JM, Tekin V, Saini S, Houson HA, Jayawardana SB, Decato DA, Wijeratne GB, Lapi SE. Chelation chemistry of manganese-52 for PET imaging applications. Nucl Med Biol. 2023 Dec 23;128-129:108874. doi: 10.1016/j.nucmedbio.2023.108874. Epub ahead of print. PMID: 38154167.
144. Saini S, Mullen GED, Blower PJ, Lapi SE. Radiochemistry and In Vivo Imaging of [45Ti]Ti-THP-PSMA. Mol Pharm. 2024 Jan 3. doi: 10.1021/acs.molpharmaceut.3c00917. Epub ahead of print. PMID: 38173242.
 		  
 

Keywords
PET, Cyclotron, radioisotopes,